Hexylresorcinol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.0935455
FN1 fibronectin 1 0.0770559
AKAP12 A kinase (PRKA) anchor protein 12 0.0647596
IGFBP7 insulin-like growth factor binding protein 7 0.0613664
TGFBI transforming growth factor, beta-induced, 68kDa 0.0607576
COL6A3 collagen, type VI, alpha 3 0.0606224
AHNAK AHNAK nucleoprotein 0.0582244
MT2A metallothionein 2A 0.058035
COL6A1 collagen, type VI, alpha 1 0.0533962
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.048915
ERRFI1 ERBB receptor feedback inhibitor 1 0.0470142
WNT5A wingless-type MMTV integration site family, member 5A 0.0425769
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0415297
STC1 stanniocalcin 1 0.0414354
ELL2 elongation factor, RNA polymerase II, 2 0.037408
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0371446
LOX lysyl oxidase 0.0369211
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0312038
EXT1 exostosin glycosyltransferase 1 0.0298232
RAI14 retinoic acid induced 14 0.0280629
HLA-B major histocompatibility complex, class I, B 0.0269441
FAM20C family with sequence similarity 20, member C 0.0268507
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0255291
TM4SF1 transmembrane 4 L six family member 1 0.0253618
SAMD4A sterile alpha motif domain containing 4A 0.0247425
CLMP CXADR-like membrane protein 0.0241192
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0239389
THBS1 thrombospondin 1 0.0232584
MAP1B microtubule-associated protein 1B 0.0221557
INHBA inhibin, beta A 0.0218474
SHB Src homology 2 domain containing adaptor protein B 0.021847
CALR calreticulin 0.0218013
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0215434
FAM13B family with sequence similarity 13, member B 0.0211161
NDRG1 N-myc downstream regulated 1 0.0207246
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0207238
PRSS23 protease, serine, 23 0.020546
IL6 interleukin 6 0.0205361
MAP4 microtubule-associated protein 4 0.0204552
CSNK1A1 casein kinase 1, alpha 1 0.0203464
VEGFA vascular endothelial growth factor A 0.0198828
NCOR2 nuclear receptor corepressor 2 0.0198107
HIPK2 homeodomain interacting protein kinase 2 0.0196573
ERBIN erbb2 interacting protein 0.0196248
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0193
CDH13 cadherin 13 0.0191924
CD99 CD99 molecule 0.0191111
ECE1 endothelin converting enzyme 1 0.0190155
KMT2C lysine (K)-specific methyltransferase 2C 0.0188077
HIP1 huntingtin interacting protein 1 0.0187158
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0181317
MYO10 myosin X 0.0178536
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0177266
COL5A1 collagen, type V, alpha 1 0.0175428
NOP58 NOP58 ribonucleoprotein 0.0173547
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0172806
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0169026
TXNRD1 thioredoxin reductase 1 0.0166894
NAV1 neuron navigator 1 0.0164833
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0162223
CKAP4 cytoskeleton-associated protein 4 0.0161667
SBF2 SET binding factor 2 0.0160521
AVL9 AVL9 homolog (S. cerevisiase) 0.0159756
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0159484
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0158045
FGFR1 fibroblast growth factor receptor 1 0.0157807
UGCG UDP-glucose ceramide glucosyltransferase 0.015767
TMEM165 transmembrane protein 165 0.0155938
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0155907
DUSP6 dual specificity phosphatase 6 0.0154973
JARID2 jumonji, AT rich interactive domain 2 0.0154659
XPO1 exportin 1 0.0153776
EHD2 EH-domain containing 2 0.0153086
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0151728
NCOA3 nuclear receptor coactivator 3 0.0150629
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0149803
TET3 tet methylcytosine dioxygenase 3 0.0147974
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0147935
RRM2 ribonucleotide reductase M2 0.014576
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0144515
TNS3 tensin 3 0.0144302
TRIO trio Rho guanine nucleotide exchange factor 0.0143394
PLD3 phospholipase D family, member 3 0.0142783
RPL31 ribosomal protein L31 0.0140548
CLIP1 CAP-GLY domain containing linker protein 1 0.0140365
MPRIP myosin phosphatase Rho interacting protein 0.0140131
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0140101
MTPN myotrophin 0.0139969
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0139722
ITSN1 intersectin 1 (SH3 domain protein) 0.013743
HLA-C major histocompatibility complex, class I, C 0.0137072
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0136726
QKI QKI, KH domain containing, RNA binding 0.0136724
UBE2B ubiquitin-conjugating enzyme E2B 0.0136574
MFF mitochondrial fission factor 0.0136143
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0134539
RSL1D1 ribosomal L1 domain containing 1 0.0133213
CSNK1E casein kinase 1, epsilon 0.0133182
STC2 stanniocalcin 2 0.0133098
RPS6 ribosomal protein S6 0.013308

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.0518317
ENO1 enolase 1, (alpha) -0.0450766
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0394836
GRB10 growth factor receptor-bound protein 10 -0.0378009
IGFBP3 insulin-like growth factor binding protein 3 -0.0363599
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0334919
CALD1 caldesmon 1 -0.0334139
DSCAM Down syndrome cell adhesion molecule -0.0314358
MBD5 methyl-CpG binding domain protein 5 -0.0308384
ZBTB20 zinc finger and BTB domain containing 20 -0.0290321
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0285929
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0275939
COL1A2 collagen, type I, alpha 2 -0.0275871
SPAG9 sperm associated antigen 9 -0.0261429
GLS2 glutaminase 2 (liver, mitochondrial) -0.0258407
JMJD1C jumonji domain containing 1C -0.0253491
TTC3 tetratricopeptide repeat domain 3 -0.0245006
DPYD dihydropyrimidine dehydrogenase -0.024423
COL1A1 collagen, type I, alpha 1 -0.0236839
ARF4 ADP-ribosylation factor 4 -0.0229979
SEC24D SEC24 family member D -0.0225742
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0225191
FNIP1 folliculin interacting protein 1 -0.0222165
ITCH itchy E3 ubiquitin protein ligase -0.0222016
SDC4 syndecan 4 -0.0219696
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0218214
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0212875
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0210144
VDAC1 voltage-dependent anion channel 1 -0.0194832
CANX calnexin -0.0194063
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0193801
CFDP1 craniofacial development protein 1 -0.0192244
UBC ubiquitin C -0.0191362
METTL15 methyltransferase like 15 -0.018299
LMO7 LIM domain 7 -0.0182262
ZNF207 zinc finger protein 207 -0.0181599
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0181237
PTN pleiotrophin -0.0175983
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0175417
AFF3 AF4/FMR2 family, member 3 -0.0173678
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0171563
COL5A2 collagen, type V, alpha 2 -0.01692
CALU calumenin -0.0165976
LCOR ligand dependent nuclear receptor corepressor -0.0165135
DSTN destrin (actin depolymerizing factor) -0.0164686
RSRP1 arginine/serine-rich protein 1 -0.0163866
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0162659
NAV2 neuron navigator 2 -0.0162018
PURA purine-rich element binding protein A -0.0161148
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0160396
AFF4 AF4/FMR2 family, member 4 -0.0159283
RIGI RNA sensor RIG-I -0.0159131
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0155786
NAP1L1 nucleosome assembly protein 1-like 1 -0.0155352
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0153915
GOLGA4 golgin A4 -0.0153491
KIF1B kinesin family member 1B -0.0153371
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0152784
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0152629
PHF14 PHD finger protein 14 -0.0151957
THOC2 THO complex 2 -0.0151579
CHD9 chromodomain helicase DNA binding protein 9 -0.0150884
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0150426
CAV1 caveolin 1, caveolae protein, 22kDa -0.0149271
LMNA lamin A/C -0.0149209
UBE2O ubiquitin-conjugating enzyme E2O -0.0148643
PRRC1 proline-rich coiled-coil 1 -0.0148603
WTAP Wilms tumor 1 associated protein -0.014858
SEPTIN7 septin 7 -0.0148528
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0146944
AFDN afadin, adherens junction formation factor -0.0146744
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0146591
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0146447
KAZN kazrin, periplakin interacting protein -0.0146446
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) -0.0146133
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0146022
EFHD2 EF-hand domain family, member D2 -0.0145984
CENPF centromere protein F, 350/400kDa -0.014497
KMT2E lysine (K)-specific methyltransferase 2E -0.0143169
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0142849
FBXW8 F-box and WD repeat domain containing 8 -0.0141609
VCL vinculin -0.0140612
SERINC5 serine incorporator 5 -0.014001
GOLGA2 golgin A2 -0.0139962
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0139944
ANKRD12 ankyrin repeat domain 12 -0.0139887
CTSB cathepsin B -0.0139096
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0138831
TPM4 tropomyosin 4 -0.013796
SEC61G Sec61 gamma subunit -0.0137903
PRELID2 PRELI domain containing 2 -0.0137882
NUP205 nucleoporin 205kDa -0.0137574
ESYT2 extended synaptotagmin-like protein 2 -0.0136645
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0133285
FBN1 fibrillin 1 -0.0133253
UBE2H ubiquitin-conjugating enzyme E2H -0.0132832
SRSF11 serine/arginine-rich splicing factor 11 -0.013204
TMOD3 tropomodulin 3 (ubiquitous) -0.013179
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0131335
CUL4B cullin 4B -0.0130879