Hexylresorcinol_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SMAD3 SMAD family member 3 0.0458427
AKAP12 A kinase (PRKA) anchor protein 12 0.0431995
MSN moesin 0.0421909
PRELID2 PRELI domain containing 2 0.037931
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0368981
NCEH1 neutral cholesterol ester hydrolase 1 0.0304891
RPS17 ribosomal protein S17 0.0277238
DGKD diacylglycerol kinase, delta 130kDa 0.0265238
VMP1 vacuole membrane protein 1 0.0258336
NCOR2 nuclear receptor corepressor 2 0.0249498
CAPRIN2 caprin family member 2 0.024898
EGR1 early growth response 1 0.0246752
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0242863
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0238084
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0233966
RPLP1 ribosomal protein, large, P1 0.0219855
TIMP1 TIMP metallopeptidase inhibitor 1 0.0217846
CIB1 calcium and integrin binding 1 (calmyrin) 0.0214027
HIPK3 homeodomain interacting protein kinase 3 0.0213308
PLEK2 pleckstrin 2 0.0212293
ANO6 anoctamin 6 0.020693
YBX3 Y box binding protein 3 0.0204376
NIBAN2 niban apoptosis regulator 2 0.0204259
EFL1 elongation factor like GTPase 1 0.0197538
SDCCAG8 serologically defined colon cancer antigen 8 0.0187397
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0186975
SET SET nuclear proto-oncogene 0.0186496
KTN1 kinectin 1 (kinesin receptor) 0.0186357
TOP1 topoisomerase (DNA) I 0.0183942
ELL2 elongation factor, RNA polymerase II, 2 0.0181667
RPS19 ribosomal protein S19 0.0179809
FN1 fibronectin 1 0.0179604
PCBP2 poly(rC) binding protein 2 0.0178964
MYO10 myosin X 0.0177164
IER2 immediate early response 2 0.0175558
MOSMO modulator of smoothened 0.0175514
CDCP1 CUB domain containing protein 1 0.0174504
ATXN3 ataxin 3 0.0174468
EXOC6B exocyst complex component 6B 0.0173737
GOLIM4 golgi integral membrane protein 4 0.0173629
MINK1 misshapen-like kinase 1 0.017354
RPL36 ribosomal protein L36 0.0172001
RPL35 ribosomal protein L35 0.0171703
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0171644
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0170284
IL6ST interleukin 6 signal transducer 0.0169523
EFCAB14 EF-hand calcium binding domain 14 0.0168342
AHNAK AHNAK nucleoprotein 0.0166893
SASH1 SAM and SH3 domain containing 1 0.016684
RPS12 ribosomal protein S12 0.0166203
CLASP1 cytoplasmic linker associated protein 1 0.0164373
PRRC2B proline-rich coiled-coil 2B 0.016316
RACK1 receptor for activated C kinase 1 0.0162502
MYO9B myosin IXB 0.0162409
UGCG UDP-glucose ceramide glucosyltransferase 0.0162341
RPL11 ribosomal protein L11 0.0162084
TGM2 transglutaminase 2 0.0161617
NOCT nocturnin 0.0161463
RPL28 ribosomal protein L28 0.0159519
TRA2A transformer 2 alpha homolog (Drosophila) 0.0156946
SMAD5 SMAD family member 5 0.015647
TUT7 terminal uridylyl transferase 7 0.0155892
CHD1 chromodomain helicase DNA binding protein 1 0.0153434
CDK19 cyclin-dependent kinase 19 0.0151797
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0151784
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0151683
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0151528
SNED1 sushi, nidogen and EGF-like domains 1 0.0148152
HDGF hepatoma-derived growth factor 0.0147862
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0147281
VEGFA vascular endothelial growth factor A 0.0147037
ODF2 outer dense fiber of sperm tails 2 0.0146971
SRSF4 serine/arginine-rich splicing factor 4 0.0146674
RPS6 ribosomal protein S6 0.0143776
TNRC6A trinucleotide repeat containing 6A 0.0143493
RPL4 ribosomal protein L4 0.0143187
BRD2 bromodomain containing 2 0.0142401
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0142065
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0141554
ADAM17 ADAM metallopeptidase domain 17 0.0141325
SETD5 SET domain containing 5 0.014112
TM4SF1 transmembrane 4 L six family member 1 0.0140364
FOXP1 forkhead box P1 0.0140269
TMPO thymopoietin 0.0138399
WNK1 WNK lysine deficient protein kinase 1 0.0137737
ARHGAP21 Rho GTPase activating protein 21 0.0137176
CCDC91 coiled-coil domain containing 91 0.0136213
TRIM44 tripartite motif containing 44 0.0136046
HLA-B major histocompatibility complex, class I, B 0.0135089
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0135059
SMYD3 SET and MYND domain containing 3 0.0134731
SSR1 signal sequence receptor, alpha 0.0134478
EIF5B eukaryotic translation initiation factor 5B 0.0133412
TBL1X transducin (beta)-like 1X-linked 0.0133239
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0130853
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0130008
HBEGF heparin-binding EGF-like growth factor 0.0129938
CEP170 centrosomal protein 170kDa 0.0129306
PRRC2C proline-rich coiled-coil 2C 0.0129133
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0128984

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.177648
LDHA lactate dehydrogenase A -0.0999601
CANX calnexin -0.0807551
VIM vimentin -0.0797524
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0728856
PTMA prothymosin, alpha -0.0490279
GPC6 glypican 6 -0.0445408
DPYD dihydropyrimidine dehydrogenase -0.0443219
TRIO trio Rho guanine nucleotide exchange factor -0.044299
ATM ATM serine/threonine kinase -0.0419527
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0408262
ANLN anillin, actin binding protein -0.0408094
TMSB10 thymosin beta 10 -0.0406368
PHF3 PHD finger protein 3 -0.0400383
NCOR1 nuclear receptor corepressor 1 -0.0389182
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0387708
FMN1 formin 1 -0.0386396
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0385373
ZBTB20 zinc finger and BTB domain containing 20 -0.0374581
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0372395
DLG1 discs, large homolog 1 (Drosophila) -0.0367689
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0367499
HILPDA hypoxia inducible lipid droplet-associated -0.0366252
PARD3 par-3 family cell polarity regulator -0.0365626
IGF2 insulin-like growth factor 2 -0.0363771
PHF21A PHD finger protein 21A -0.0360334
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0351959
ITCH itchy E3 ubiquitin protein ligase -0.0337049
BZW1 basic leucine zipper and W2 domains 1 -0.033674
ATXN1 ataxin 1 -0.0326797
FBXL17 F-box and leucine-rich repeat protein 17 -0.0324141
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0310566
ENO1 enolase 1, (alpha) -0.030709
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0304984
APOLD1 apolipoprotein L domain containing 1 -0.0301155
AKAP13 A kinase (PRKA) anchor protein 13 -0.0299407
TMEM123 transmembrane protein 123 -0.0298352
BIRC3 baculoviral IAP repeat containing 3 -0.0290139
ANXA2 annexin A2 -0.0289545
TAOK1 TAO kinase 1 -0.0288053
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0287804
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0286729
FNDC3B fibronectin type III domain containing 3B -0.0286406
SRPK1 SRSF protein kinase 1 -0.0285167
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0285042
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0284024
TCF12 transcription factor 12 -0.0280404
PYGL phosphorylase, glycogen, liver -0.0279528
SAMD4A sterile alpha motif domain containing 4A -0.0278256
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.027717
NUP58 nucleoporin 58 -0.0274023
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0272603
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0272222
NALCN sodium leak channel, non selective -0.0272049
RBM39 RNA binding motif protein 39 -0.0270811
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0270056
MCTP1 multiple C2 domains, transmembrane 1 -0.0266429
SMC4 structural maintenance of chromosomes 4 -0.0264687
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0263253
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0263029
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0261171
MYO9A myosin IXA -0.0259475
WAC WW domain containing adaptor with coiled-coil -0.0257408
EFNA5 ephrin-A5 -0.0257362
LCORL ligand dependent nuclear receptor corepressor-like -0.0256738
TPX2 TPX2, microtubule-associated -0.0256279
DNER delta/notch-like EGF repeat containing -0.0251996
BRCA2 breast cancer 2, early onset -0.02481
RAB5A RAB5A, member RAS oncogene family -0.0247708
ACTG1 actin gamma 1 -0.024748
DERA deoxyribose-phosphate aldolase (putative) -0.024744
MAML3 mastermind-like 3 (Drosophila) -0.0246638
ZFR zinc finger RNA binding protein -0.0245877
FNIP1 folliculin interacting protein 1 -0.0245183
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -0.0244531
ANXA1 annexin A1 -0.0244211
ERBIN erbb2 interacting protein -0.0244116
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0243373
SGO2 shugoshin 2 -0.0242539
DENND5B DENN/MADD domain containing 5B -0.0241882
TBC1D5 TBC1 domain family, member 5 -0.0240212
TTC17 tetratricopeptide repeat domain 17 -0.0236335
LMO7 LIM domain 7 -0.0236014
GSK3B glycogen synthase kinase 3 beta -0.023566
RPLP0 ribosomal protein, large, P0 -0.0234186
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0233249
COPB1 coatomer protein complex, subunit beta 1 -0.0230591
BABAM2 BRISC and BRCA1 A complex member 2 -0.0229968
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0227386
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0225781
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0221792
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0220807
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0220596
ACER3 alkaline ceramidase 3 -0.022009
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0218124
ZMYM4 zinc finger, MYM-type 4 -0.0216388
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0215832
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0214457
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0214352
ADGRG6 adhesion G protein-coupled receptor G6 -0.0214078