Hexylresorcinol_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hexylresorcinol perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hexylresorcinol_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.212886
NRG1 neuregulin 1 0.186022
HMGA2 high mobility group AT-hook 2 0.181881
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0940494
TMSB10 thymosin beta 10 0.0845769
STC2 stanniocalcin 2 0.0835536
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0776795
HIPK2 homeodomain interacting protein kinase 2 0.0749262
EXT1 exostosin glycosyltransferase 1 0.0740643
EFNA5 ephrin-A5 0.0669088
SFTPA2 surfactant protein A2 0.0638162
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0637713
ASPH aspartate beta-hydroxylase 0.057959
LIMCH1 LIM and calponin homology domains 1 0.0541746
GLIS3 GLIS family zinc finger 3 0.0541225
TMEM156 transmembrane protein 156 0.0525867
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0487564
AEBP2 AE binding protein 2 0.0482574
HLA-B major histocompatibility complex, class I, B 0.0477273
AKAP12 A kinase (PRKA) anchor protein 12 0.0473722
AHNAK AHNAK nucleoprotein 0.0472018
NPAS2 neuronal PAS domain protein 2 0.0458057
LOC112694756 uncharaterized LOC112694756 0.0457746
GRB10 growth factor receptor-bound protein 10 0.0445949
ITGA1 integrin, alpha 1 0.0423681
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0422072
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0400889
FAM20C family with sequence similarity 20, member C 0.0390881
ENO2 enolase 2 (gamma, neuronal) 0.0388953
ARHGAP35 Rho GTPase activating protein 35 0.0388439
SOX4 SRY (sex determining region Y)-box 4 0.0384806
FTH1 ferritin, heavy polypeptide 1 0.0380162
SYT1 synaptotagmin I 0.0374096
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0371305
RASAL2 RAS protein activator like 2 0.0371238
PALLD palladin, cytoskeletal associated protein 0.0357806
LOXL2 lysyl oxidase-like 2 0.0352017
SLC35F3 solute carrier family 35, member F3 0.0346211
VCL vinculin 0.0338141
NTN4 netrin 4 0.0337866
SQSTM1 sequestosome 1 0.03378
NDRG1 N-myc downstream regulated 1 0.0335774
NRP1 neuropilin 1 0.032015
NRIP1 nuclear receptor interacting protein 1 0.031307
OSMR oncostatin M receptor 0.0309736
PDLIM5 PDZ and LIM domain 5 0.0306398
FLNA filamin A, alpha 0.0304294
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0303114
MRPS6 mitochondrial ribosomal protein S6 0.0302162
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.030164
BICD1 bicaudal D homolog 1 (Drosophila) 0.0297874
ERRFI1 ERBB receptor feedback inhibitor 1 0.0296644
RPLP1 ribosomal protein, large, P1 0.0295796
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0290457
FHL2 four and a half LIM domains 2 0.0289602
MT2A metallothionein 2A 0.0287149
S100A6 S100 calcium binding protein A6 0.0285804
MBD5 methyl-CpG binding domain protein 5 0.0284497
ABR active BCR-related 0.0280277
NPC1 Niemann-Pick disease, type C1 0.0276019
TNS3 tensin 3 0.027379
RNF213 ring finger protein 213 0.0271906
FTL ferritin, light polypeptide 0.0265807
RPL36 ribosomal protein L36 0.026318
RPL23 ribosomal protein L23 0.0261191
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0260401
JARID2 jumonji, AT rich interactive domain 2 0.0259615
TGFA transforming growth factor, alpha 0.0258278
PRKCA protein kinase C, alpha 0.025615
TENM4 teneurin transmembrane protein 4 0.025264
RPS29 ribosomal protein S29 0.0252211
EGR1 early growth response 1 0.0239925
EGFR epidermal growth factor receptor 0.0239112
RPS27 ribosomal protein S27 0.0238748
MYH9 myosin, heavy chain 9, non-muscle 0.0238384
ZBTB20 zinc finger and BTB domain containing 20 0.0236674
LTBP1 latent transforming growth factor beta binding protein 1 0.0234043
KLHL5 kelch-like family member 5 0.023133
GPC6 glypican 6 0.0229459
DUSP6 dual specificity phosphatase 6 0.0228782
RPL37 ribosomal protein L37 0.0226131
RPL28 ribosomal protein L28 0.0224173
HLA-A major histocompatibility complex, class I, A 0.0223915
PSD3 pleckstrin and Sec7 domain containing 3 0.0222758
ACTG1 actin gamma 1 0.0222125
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0221493
SEPTIN9 septin 9 0.022028
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0219394
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0219109
CUX1 cut-like homeobox 1 0.0218658
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0217029
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0215421
IFI16 interferon, gamma-inducible protein 16 0.021522
LOX lysyl oxidase 0.0213757
RPL31 ribosomal protein L31 0.0213275
HPCAL1 hippocalcin-like 1 0.0212551
RAI14 retinoic acid induced 14 0.0209438
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0208182
NCOA7 nuclear receptor coactivator 7 0.0206557
TSHZ2 teashirt zinc finger homeobox 2 0.0205015

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.159892
CXCL8 chemokine (C-X-C motif) ligand 8 -0.117546
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.111617
CENPF centromere protein F, 350/400kDa -0.0885817
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0841609
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0833083
CANX calnexin -0.081663
RNF145 ring finger protein 145 -0.0736971
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0708393
ZNF292 zinc finger protein 292 -0.0699528
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0673638
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0661904
NEK7 NIMA-related kinase 7 -0.059486
KMT2E lysine (K)-specific methyltransferase 2E -0.0581933
WAC WW domain containing adaptor with coiled-coil -0.0574357
SUCO SUN domain containing ossification factor -0.0565752
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0553349
FAM13A family with sequence similarity 13, member A -0.0513045
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0505349
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0501733
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.049655
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0493016
TFG TRK-fused gene -0.0481408
SPAG9 sperm associated antigen 9 -0.0473794
FNDC3B fibronectin type III domain containing 3B -0.0472016
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0467701
TRA2A transformer 2 alpha homolog (Drosophila) -0.0465831
RBM39 RNA binding motif protein 39 -0.0462568
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0460769
NUP58 nucleoporin 58 -0.0454432
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.045227
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0450729
AHR aryl hydrocarbon receptor -0.0448832
NAP1L1 nucleosome assembly protein 1-like 1 -0.0447076
HELZ helicase with zinc finger -0.0437668
ANLN anillin, actin binding protein -0.0436743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.043559
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0421053
PTK2 protein tyrosine kinase 2 -0.0418586
KTN1 kinectin 1 (kinesin receptor) -0.0412965
PTMA prothymosin, alpha -0.039897
TOP2A topoisomerase (DNA) II alpha 170kDa -0.039418
GOLGA4 golgin A4 -0.0392444
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0391706
INSIG2 insulin induced gene 2 -0.0389771
MIS18BP1 MIS18 binding protein 1 -0.0389632
SOD2 superoxide dismutase 2, mitochondrial -0.0388858
TPR translocated promoter region, nuclear basket protein -0.0386769
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0383671
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0381777
RAD21 RAD21 homolog (S. pombe) -0.0378144
NIPBL Nipped-B homolog (Drosophila) -0.0375774
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0370687
GPBP1 GC-rich promoter binding protein 1 -0.0370152
PUM2 pumilio RNA-binding family member 2 -0.036868
MARCHF6 membrane associated ring-CH-type finger 6 -0.0367345
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0358252
TENT2 terminal nucleotidyltransferase 2 -0.0352268
RHEB Ras homolog enriched in brain -0.0342676
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0340596
ERBIN erbb2 interacting protein -0.0337727
PAPOLA poly(A) polymerase alpha -0.0336276
BIRC3 baculoviral IAP repeat containing 3 -0.0335707
RSRC2 arginine/serine-rich coiled-coil 2 -0.0335536
TXNRD1 thioredoxin reductase 1 -0.033315
WDR45B WD repeat domain 45B -0.0332447
ETNK1 ethanolamine kinase 1 -0.0331388
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0330182
CD109 CD109 molecule -0.0329572
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0327096
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0325846
RAB8B RAB8B, member RAS oncogene family -0.0323848
ECT2 epithelial cell transforming 2 -0.032317
ELL2 elongation factor, RNA polymerase II, 2 -0.0322832
ZMYM2 zinc finger, MYM-type 2 -0.0322018
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0321803
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0320864
SETD5 SET domain containing 5 -0.0320642
RPS2 ribosomal protein S2 -0.0319939
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0319614
TPX2 TPX2, microtubule-associated -0.0318563
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.031805
RLF rearranged L-myc fusion -0.031805
SEC23A Sec23 homolog A (S. cerevisiae) -0.031772
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0317587
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0313429
QKI QKI, KH domain containing, RNA binding -0.0312864
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0312842
RBM25 RNA binding motif protein 25 -0.03093
RAB1A RAB1A, member RAS oncogene family -0.0308082
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0304876
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.030393
ANXA5 annexin A5 -0.0303746
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0303701
NCKAP1 NCK-associated protein 1 -0.0303621
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0303373
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0303297
TRAM1 translocation associated membrane protein 1 -0.0302958
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0302647
OGA O-GlcNAcase -0.0298556