Hippo signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors. (Kyoto Encyclopedia of Genes and Genomes, hsa04390)
External Link https://www.kegg.jp/entry/hsa04390
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Genes

155 proteins participating in the Hippo signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ACTG1 actin gamma 1
AJUBA ajuba LIM protein
AMH anti-Mullerian hormone
AMOT angiomotin
AREG amphiregulin
AXIN1 axin 1
AXIN2 axin 2
BBC3 BCL2 binding component 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BIRC5 baculoviral IAP repeat containing 5
BMP2 bone morphogenetic protein 2
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BMP8A bone morphogenetic protein 8a
BMP8B bone morphogenetic protein 8b
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCN2 cellular communication network factor 2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRB2 crumbs family member 2
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNNA3 catenin (cadherin-associated protein), alpha 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DLG1 discs, large homolog 1 (Drosophila)
DLG5 discs, large homolog 5 (Drosophila)
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
FBXW11 F-box and WD repeat domain containing 11
FGF1 fibroblast growth factor 1 (acidic)
FRMD1 FERM domain containing 1
FRMD6 FERM domain containing 6
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GDF5 growth differentiation factor 5
GDF6 growth differentiation factor 6
GDF7 growth differentiation factor 7
GLI2 GLI family zinc finger 2
GSK3B glycogen synthase kinase 3 beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LATS1 large tumor suppressor kinase 1
LATS2 large tumor suppressor kinase 2
LEF1 lymphoid enhancer-binding factor 1
LIMD1 LIM domains containing 1
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MOB1A MOB kinase activator 1A
MOB1B MOB kinase activator 1B
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NF2 neurofibromin 2 (merlin)
NKD1 naked cuticle homolog 1 (Drosophila)
NKD2 naked cuticle homolog 2 (Drosophila)
PALS1 protein associated with LIN7 1, MAGUK p55 family member
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PATJ PATJ crumbs cell polarity complex component
POTEF POTE ankyrin domain family, member F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF6 Ras association (RalGDS/AF-6) domain family member 6
SAV1 salvador family WW domain containing protein 1
SCRIB scribbled planar cell polarity protein
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOX2 SRY (sex determining region Y)-box 2
STK24 serine/threonine kinase 24
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEAD2 TEA domain family member 2
TEAD3 TEA domain family member 3
TEAD4 TEA domain family member 4
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFB3 transforming growth factor, beta 3
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough
TRIM26 tripartite motif containing 26
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B
WTIP Wilms tumor 1 interacting protein
WWC1 WW and C2 domain containing 1
WWTR1 WW domain containing transcription regulator 1
YAP1 Yes-associated protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta