| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A 1H-imidazol-4-yl group substituted at position C-4 by a 2-aminoethyl group. (Chemical Entities of Biological Interest Ontology, CHEBI_18295) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/774 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Histamine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 1.56 |
| ANKRD24 | ankyrin repeat domain 24 | 1.06 |
| LPIN1 | lipin 1 | 0.95 |
| TIGD1 | tigger transposable element derived 1 | 0.85 |
| ODF2L | outer dense fiber of sperm tails 2-like | 0.81 |
| MT1X | metallothionein 1X | 0.74 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.69 |
| ADCY10 | adenylate cyclase 10 (soluble) | 0.68 |
| H1-5 | H1.5 linker histone, cluster member | 0.67 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.66 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.64 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.63 |
| H1-4 | H1.4 linker histone, cluster member | 0.61 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.6 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.59 |
| ZNF142 | zinc finger protein 142 | 0.59 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.58 |
| SLC2A4RG | SLC2A4 regulator | 0.55 |
| ZNF275 | zinc finger protein 275 | 0.48 |
| PRDX1 | peroxiredoxin 1 | 0.44 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.43 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | 0.43 |
| HIST2H3A | histone cluster 2, H3a | 0.43 |
| KIAA0556 | KIAA0556 | 0.42 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.42 |
| RPL32 | ribosomal protein L32 | 0.42 |
| SLC25A39 | solute carrier family 25, member 39 | 0.41 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.4 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.4 |
| RPL35A | ribosomal protein L35a | 0.39 |
| XBP1 | X-box binding protein 1 | 0.39 |
| MAP3K21 | mitogen-activated protein kinase kinase kinase 21 | 0.38 |
| CNTNAP4 | contactin associated protein-like 4 | 0.38 |
| RBM8A | RNA binding motif protein 8A | 0.38 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.37 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.37 |
| ANKRD10 | ankyrin repeat domain 10 | 0.37 |
| S100A6 | S100 calcium binding protein A6 | 0.37 |
| ASPHD2 | aspartate beta-hydroxylase domain containing 2 | 0.36 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | 0.36 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.35 |
| RPL27A | ribosomal protein L27a | 0.35 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.35 |
| ANGPTL4 | angiopoietin-like 4 | 0.35 |
| H2AZ1 | H2A.Z variant histone 1 | 0.35 |
| ZNF778 | zinc finger protein 778 | 0.34 |
| HNRNPF | heterogeneous nuclear ribonucleoprotein F | 0.34 |
| DEPDC1 | DEP domain containing 1 | 0.34 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.34 |
| H1-2 | H1.2 linker histone, cluster member | 0.34 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.33 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.33 |
| CORO2B | coronin, actin binding protein, 2B | 0.33 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.32 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.32 |
| FAN1 | FANCD2/FANCI-associated nuclease 1 | 0.32 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.32 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.31 |
| KIAA0753 | KIAA0753 | 0.31 |
| TMEM64 | transmembrane protein 64 | 0.31 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.31 |
| RPS8 | ribosomal protein S8 | 0.31 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.31 |
| RLIM | ring finger protein, LIM domain interacting | 0.31 |
| SMIM12 | small integral membrane protein 12 | 0.31 |
| NEK4 | NIMA-related kinase 4 | 0.31 |
| MTAP | methylthioadenosine phosphorylase | 0.31 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.31 |
| PTMA | prothymosin, alpha | 0.3 |
| ZNF57 | zinc finger protein 57 | 0.3 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 0.3 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.3 |
| ZNF692 | zinc finger protein 692 | 0.3 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.29 |
| HIST2H2AB | histone cluster 2, H2ab | 0.29 |
| CENPP | centromere protein P | 0.29 |
| PROS1 | protein S (alpha) | 0.29 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.29 |
| ZNF2 | zinc finger protein 2 | 0.29 |
| PEX19 | peroxisomal biogenesis factor 19 | 0.29 |
| ENO3 | enolase 3 (beta, muscle) | 0.29 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.29 |
| PTGES | prostaglandin E synthase | 0.29 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.29 |
| EPN3 | epsin 3 | 0.29 |
| SPTBN4 | spectrin, beta, non-erythrocytic 4 | 0.29 |
| FNIP1 | folliculin interacting protein 1 | 0.29 |
| UBQLN1 | ubiquilin 1 | 0.28 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.28 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.28 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.28 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.28 |
| RNF17 | ring finger protein 17 | 0.28 |
| UBE2A | ubiquitin-conjugating enzyme E2A | 0.28 |
| RPLP2 | ribosomal protein, large, P2 | 0.27 |
| GINS4 | GINS complex subunit 4 (Sld5 homolog) | 0.27 |
| MYCBP | MYC binding protein | 0.27 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.27 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.27 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.89 |
| FAM193B | family with sequence similarity 193, member B | -0.87 |
| SBSN | suprabasin | -0.81 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.8 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.78 |
| ATF3 | activating transcription factor 3 | -0.69 |
| RETREG2 | reticulophagy regulator family member 2 | -0.62 |
| MTSS1 | metastasis suppressor 1 | -0.56 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.54 |
| ZNF264 | zinc finger protein 264 | -0.53 |
| DNAH2 | dynein, axonemal, heavy chain 2 | -0.52 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | -0.49 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | -0.48 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.48 |
| MFF | mitochondrial fission factor | -0.47 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.47 |
| CUX2 | cut-like homeobox 2 | -0.45 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.44 |
| HKDC1 | hexokinase domain containing 1 | -0.43 |
| ZBED8L | ZBED8 like | -0.42 |
| PIK3C2B | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta | -0.42 |
| NHEJ1 | nonhomologous end-joining factor 1 | -0.42 |
| MID2 | midline 2 | -0.41 |
| FTL | ferritin, light polypeptide | -0.41 |
| HIPK3 | homeodomain interacting protein kinase 3 | -0.4 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | -0.4 |
| ZNF410 | zinc finger protein 410 | -0.39 |
| KLHL22 | kelch-like family member 22 | -0.39 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.38 |
| HOXB7 | homeobox B7 | -0.38 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | -0.38 |
| B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | -0.37 |
| BRD7 | bromodomain containing 7 | -0.37 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.37 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.37 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.36 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.35 |
| VWA5B2 | von Willebrand factor A domain containing 5B2 | -0.35 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.35 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | -0.34 |
| SLC30A6 | solute carrier family 30 (zinc transporter), member 6 | -0.34 |
| PRG4 | proteoglycan 4 | -0.34 |
| PIP | prolactin-induced protein | -0.34 |
| CMIP | c-Maf inducing protein | -0.33 |
| HELB | helicase (DNA) B | -0.33 |
| FOXO1 | forkhead box O1 | -0.33 |
| CEP295 | centrosomal protein 295kDa | -0.32 |
| LIPT2 | lipoyl(octanoyl) transferase 2 (putative) | -0.32 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.32 |
| SMIM19 | small integral membrane protein 19 | -0.32 |
| RAB5IF | RAB5 interacting factor | -0.32 |
| CHKB | choline kinase beta | -0.31 |
| STARD3NL | STARD3 N-terminal like | -0.31 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.31 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.31 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | -0.3 |
| CCDC158 | coiled-coil domain containing 158 | -0.3 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.3 |
| JAK2 | Janus kinase 2 | -0.3 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.3 |
| KLHDC8B | kelch domain containing 8B | -0.3 |
| FIG4 | FIG4 phosphoinositide 5-phosphatase | -0.3 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.3 |
| EPDR1 | ependymin related 1 | -0.3 |
| CCDC88A | coiled-coil domain containing 88A | -0.29 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.29 |
| DNM1 | dynamin 1 | -0.29 |
| ZMYND19 | zinc finger, MYND-type containing 19 | -0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.29 |
| CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 | -0.29 |
| ZNF616 | zinc finger protein 616 | -0.29 |
| SERINC1 | serine incorporator 1 | -0.29 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.29 |
| TMEM192 | transmembrane protein 192 | -0.28 |
| TMEM135 | transmembrane protein 135 | -0.28 |
| PTK2B | protein tyrosine kinase 2 beta | -0.28 |
| CGNL1 | cingulin-like 1 | -0.28 |
| TBC1D16 | TBC1 domain family, member 16 | -0.27 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.27 |
| C4BPA | complement component 4 binding protein, alpha | -0.27 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.27 |
| GPRASP2 | G protein-coupled receptor associated sorting protein 2 | -0.27 |
| ZER1 | zyg-11 related, cell cycle regulator | -0.27 |
| ZSCAN26 | zinc finger and SCAN domain containing 26 | -0.26 |
| TMEM199 | transmembrane protein 199 | -0.26 |
| ABCC10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 10 | -0.26 |
| ZNF227 | zinc finger protein 227 | -0.26 |
| ANKRD16 | ankyrin repeat domain 16 | -0.26 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.26 |
| ERCC6 | excision repair cross-complementation group 6 | -0.26 |
| BBS10 | Bardet-Biedl syndrome 10 | -0.26 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.26 |
| AKTIP | AKT interacting protein | -0.25 |
| CYBRD1 | cytochrome b reductase 1 | -0.25 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.25 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.25 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.25 |
| B9D1 | B9 protein domain 1 | -0.25 |
| APOE | apolipoprotein E | -0.25 |
| DENND2D | DENN/MADD domain containing 2D | -0.25 |
