Histiocytosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A lymphatic system disease that is characterized by an excessive number of histiocytes. (Human Disease Ontology, DOID_3405)
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Genes

317 genes co-occuring with the disease Histiocytosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CD1A CD1a molecule 4.0
CD1E CD1e molecule 4.0
CD1B CD1b molecule 4.0
CD1C CD1c molecule 4.0
CD1D CD1d molecule 3.98
CD207 CD207 molecule, langerin 3.823
CD68 CD68 molecule 3.476
BRAF B-Raf proto-oncogene, serine/threonine kinase 3.307
CD163 CD163 molecule 2.867
MAP2K1 mitogen-activated protein kinase kinase 1 2.863
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.759
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 2.709
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.457
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 2.426
ALK anaplastic lymphoma receptor tyrosine kinase 2.401
CD34 CD34 molecule 2.364
FSCN1 fascin actin-bundling protein 1 2.36
IFNA17 interferon, alpha 17 2.329
IFNA7 interferon, alpha 7 2.325
IFNA5 interferon, alpha 5 2.323
IFNA16 interferon, alpha 16 2.321
IFNA21 interferon, alpha 21 2.32
IFNA14 interferon, alpha 14 2.32
IFNA6 interferon, alpha 6 2.32
IFNA10 interferon, alpha 10 2.32
IFNA8 interferon, alpha 8 2.32
IFNA4 interferon, alpha 4 2.318
IFNA13 interferon, alpha 13 2.317
IFNA1 interferon, alpha 1 2.304
IFNA2 interferon, alpha 2 2.303
CD4 CD4 molecule 2.235
CR2 complement component (3d/Epstein Barr virus) receptor 2 2.205
KRAS Kirsten rat sarcoma viral oncogene homolog 2.19
NF1 neurofibromin 1 2.188
CRP C-reactive protein, pentraxin-related 2.169
PGM1 phosphoglucomutase 1 2.148
KIF5B kinesin family member 5B 2.133
ETV3 ets variant 3 2.132
PTPRC protein tyrosine phosphatase, receptor type, C 2.128
UNC13D unc-13 homolog D (C. elegans) 2.12
CD8A CD8a molecule 2.098
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.08
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.058
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 2.056
S100A9 S100 calcium binding protein A9 2.053
FLCN folliculin 2.04
STX11 syntaxin 11 2.02
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.97
NCAM1 neural cell adhesion molecule 1 1.961
TNF tumor necrosis factor 1.946
CD5 CD5 molecule 1.945
STXBP2 syntaxin binding protein 2 1.929
PAX5 paired box 5 1.926
IL6 interleukin 6 1.923
IFNG interferon, gamma 1.915
SDC1 syndecan 1 1.909
CD79A CD79a molecule, immunoglobulin-associated alpha 1.905
AVP arginine vasopressin 1.896
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 1.876
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.868
IL1B interleukin 1, beta 1.868
MPO myeloperoxidase 1.861
SPN sialophorin 1.861
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.849
CSF1R colony stimulating factor 1 receptor 1.837
IL1A interleukin 1, alpha 1.818
PECAM1 platelet/endothelial cell adhesion molecule 1 1.808
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 1.799
POMC proopiomelanocortin 1.792
CD19 CD19 molecule 1.766
IL3RA interleukin 3 receptor, alpha (low affinity) 1.765
VEGFD vascular endothelial growth factor D 1.76
PRL prolactin 1.756
MME membrane metallo-endopeptidase 1.749
CD2 CD2 molecule 1.746
CD99 CD99 molecule 1.741
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.738
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.732
TP53 tumor protein p53 1.73
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.729
IL10 interleukin 10 1.709
MIGA1 mitoguardin 1 1.701
ALB albumin 1.698
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.693
CCND1 cyclin D1 1.693
SH2D1A SH2 domain containing 1A 1.691
CD7 CD7 molecule 1.691
CD38 CD38 molecule 1.688
CD99L2 CD99 molecule-like 2 1.68
CD33 CD33 molecule 1.667
MAP2K2 mitogen-activated protein kinase kinase 2 1.664
PRF1 perforin 1 (pore forming protein) 1.661
IL2 interleukin 2 1.651
IL4 interleukin 4 1.642
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.632
CDKN2A cyclin-dependent kinase inhibitor 2A 1.63
IL17A interleukin 17A 1.625
CD83 CD83 molecule 1.597
LYST lysosomal trafficking regulator 1.586
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.585
RPH3A rabphilin 3A 1.578
CSF1 colony stimulating factor 1 (macrophage) 1.578
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.575
BCL2 B-cell CLL/lymphoma 2 1.574
ACE angiotensin I converting enzyme 1.57
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.57
EWSR1 EWS RNA-binding protein 1 1.561
BCL6 B-cell CLL/lymphoma 6 1.555
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.544
IL1RN interleukin 1 receptor antagonist 1.53
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.529
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.527
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.525
SOX10 SRY (sex determining region Y)-box 10 1.523
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.521
IGF1 insulin-like growth factor 1 (somatomedin C) 1.52
NCOA2 nuclear receptor coactivator 2 1.517
TGFB1 transforming growth factor, beta 1 1.514
CCL2 chemokine (C-C motif) ligand 2 1.511
AFP alpha-fetoprotein 1.504
RNF11 ring finger protein 11 1.503
EGFR epidermal growth factor receptor 1.502
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.502
TSC2 tuberous sclerosis 2 1.498
MYOG myogenin (myogenic factor 4) 1.498
FLT3 fms-related tyrosine kinase 3 1.491
CCR7 chemokine (C-C motif) receptor 7 1.487
ERBB3 erb-b2 receptor tyrosine kinase 3 1.483
SYP synaptophysin 1.48
ASXL1 additional sex combs like transcriptional regulator 1 1.473
CD274 CD274 molecule 1.468
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.457
IL3 interleukin 3 1.454
TET2 tet methylcytosine dioxygenase 2 1.452
RET ret proto-oncogene 1.451
CXCL8 chemokine (C-X-C motif) ligand 8 1.449
KRT7 keratin 7, type II 1.446
LAMP3 lysosomal-associated membrane protein 3 1.44
RAB27A RAB27A, member RAS oncogene family 1.434
KIAA1549 KIAA1549 1.434
ANPEP alanyl (membrane) aminopeptidase 1.433
HRAS Harvey rat sarcoma viral oncogene homolog 1.422
B2M beta-2-microglobulin 1.419
CSF3 colony stimulating factor 3 (granulocyte) 1.419
ETV6 ets variant 6 1.416
EML4 echinoderm microtubule associated protein like 4 1.413
ZBTB46 zinc finger and BTB domain containing 46 1.409
TPM3 tropomyosin 3 1.407
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.407
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.4
PRTN3 proteinase 3 1.399
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.395
PDPN podoplanin 1.391
JAK2 Janus kinase 2 1.39
IL18 interleukin 18 1.382
CD52 CD52 molecule 1.382
PTEN phosphatase and tensin homolog 1.38
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 1.376
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.375
ALPP alkaline phosphatase, placental 1.374
MYOM2 myomesin 2 1.37
F3 coagulation factor III (thromboplastin, tissue factor) 1.369
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.369
MSR1 macrophage scavenger receptor 1 1.359
IL5 interleukin 5 1.355
SPP1 secreted phosphoprotein 1 1.352
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.352
CD22 CD22 molecule 1.351
HAVCR1 hepatitis A virus cellular receptor 1 1.346
F2 coagulation factor II (thrombin) 1.341
ACR acrosin 1.339
CD86 CD86 molecule 1.337
FOXP3 forkhead box P3 1.33
GFAP glial fibrillary acidic protein 1.328
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.328
SRSF2 serine/arginine-rich splicing factor 2 1.322
NF2 neurofibromin 2 (merlin) 1.32
CD40LG CD40 ligand 1.318
SFTPC surfactant protein C 1.317
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.31
WT1 Wilms tumor 1 1.309
CXCL10 chemokine (C-X-C motif) ligand 10 1.306
ERBB2 erb-b2 receptor tyrosine kinase 2 1.302
IL13 interleukin 13 1.3
CXCL9 chemokine (C-X-C motif) ligand 9 1.295
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.295
OAT ornithine aminotransferase 1.29
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.288
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.288
CPQ carboxypeptidase Q 1.285
AIF1 allograft inflammatory factor 1 1.284
PTH parathyroid hormone 1.278
DNTT DNA nucleotidylexotransferase 1.273
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.273
ENO2 enolase 2 (gamma, neuronal) 1.271
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.271
PXDN peroxidasin 1.269
CD40 CD40 molecule, TNF receptor superfamily member 5 1.268
PXDNL peroxidasin-like 1.266
MAPK1 mitogen-activated protein kinase 1 1.262
STX19 syntaxin 19 1.262
SPI1 Spi-1 proto-oncogene 1.243
IRF4 interferon regulatory factor 4 1.241
MITF microphthalmia-associated transcription factor 1.236
CCL20 chemokine (C-C motif) ligand 20 1.234
PROP1 PROP paired-like homeobox 1 1.233
CD80 CD80 molecule 1.233
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.228
CLTC clathrin, heavy chain (Hc) 1.228
TRH thyrotropin-releasing hormone 1.226
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.223
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.222
MAPK3 mitogen-activated protein kinase 3 1.22
BCR breakpoint cluster region 1.218
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 1.217
TERT telomerase reverse transcriptase 1.214
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.214
KRT20 keratin 20, type I 1.214
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.208
SPRED1 sprouty-related, EVH1 domain containing 1 1.206
CCR6 chemokine (C-C motif) receptor 6 1.205
TBX19 T-box 19 1.204
IL7 interleukin 7 1.204
RUNX1 runt-related transcription factor 1 1.204
CCL5 chemokine (C-C motif) ligand 5 1.197
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.195
CLEC4C C-type lectin domain family 4, member C 1.194
ACE2 angiotensin I converting enzyme 2 1.193
IL2RA interleukin 2 receptor, alpha 1.191
IFNGR1 interferon gamma receptor 1 1.189
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.187
PDCD1 programmed cell death 1 1.184
CCL3 chemokine (C-C motif) ligand 3 1.183
CTSK cathepsin K 1.182
CD27 CD27 molecule 1.181
LPIN2 lipin 2 1.18
MYD88 myeloid differentiation primary response 88 1.179
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.173
CCRL2 chemokine (C-C motif) receptor-like 2 1.168
BTK Bruton agammaglobulinemia tyrosine kinase 1.163
AR androgen receptor 1.159
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.155
ITGAD integrin, alpha D 1.151
NKX2-1 NK2 homeobox 1 1.148
CCL19 chemokine (C-C motif) ligand 19 1.145
NOTCH1 notch 1 1.144
SALL4 spalt-like transcription factor 4 1.144
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.143
U2AF1 U2 small nuclear RNA auxiliary factor 1 1.142
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.142
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 1.14
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.138
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.138
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.137
MB myoglobin 1.137
LMNA lamin A/C 1.134
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.134
MUC1 mucin 1, cell surface associated 1.133
INS insulin 1.121
HP haptoglobin 1.118
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.117
SETBP1 SET binding protein 1 1.115
GHRH growth hormone releasing hormone 1.115
KMT2D lysine (K)-specific methyltransferase 2D 1.112
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.111
BATF3 basic leucine zipper transcription factor, ATF-like 3 1.107
FAS Fas cell surface death receptor 1.098
GATA2 GATA binding protein 2 1.096
FIP1L1 factor interacting with PAPOLA and CPSF1 1.091
CCL4 chemokine (C-C motif) ligand 4 1.09
TG thyroglobulin 1.087
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 1.084
STAT1 signal transducer and activator of transcription 1, 91kDa 1.084
TSC1 tuberous sclerosis 1 1.082
MAN2C1 mannosidase, alpha, class 2C, member 1 1.082
LY75 lymphocyte antigen 75 1.081
LY75-CD302 LY75-CD302 readthrough 1.079
KITLG KIT ligand 1.078
CALB2 calbindin 2 1.075
JAG2 jagged 2 1.073
BCL2L1 BCL2-like 1 1.071
B3GAT1 beta-1,3-glucuronyltransferase 1 1.069
JAK3 Janus kinase 3 1.068
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.068
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.067
CXCR4 chemokine (C-X-C motif) receptor 4 1.058
ACP5 acid phosphatase 5, tartrate resistant 1.055
STAB1 stabilin 1 1.055
CALR calreticulin 1.055
KMT2A lysine (K)-specific methyltransferase 2A 1.051
IGLON5 IgLON family member 5 1.051
CKM creatine kinase, muscle 1.047
FGFR3 fibroblast growth factor receptor 3 1.047
CCL11 chemokine (C-C motif) ligand 11 1.046
CCL17 chemokine (C-C motif) ligand 17 1.044
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.043
CKMT1B creatine kinase, mitochondrial 1B 1.042
CKB creatine kinase, brain 1.039
FLT3LG fms-related tyrosine kinase 3 ligand 1.037
MYOD1 myogenic differentiation 1 1.033
CDK4 cyclin-dependent kinase 4 1.031
CD209 CD209 molecule 1.031
USP6 ubiquitin specific peptidase 6 1.03
GNAS GNAS complex locus 1.029
CD58 CD58 molecule 1.028
MAP3K15 mitogen-activated protein kinase kinase kinase 15 1.028
TLR7 toll-like receptor 7 1.028
TFE3 transcription factor binding to IGHM enhancer 3 1.02
NLRC4 NLR family, CARD domain containing 4 1.019
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 1.019
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.016
IRF8 interferon regulatory factor 8 1.015
MMP12 matrix metallopeptidase 12 1.01
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.008
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 1.005
KRT5 keratin 5, type II 1.004
PAX8 paired box 8 1.002