Histoplasmosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains. (Human Disease Ontology, DOID_1731)
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Genes

216 genes co-occuring with the disease Histoplasmosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CD4 CD4 molecule 2.935
CLEC7A C-type lectin domain family 7, member A 2.567
IFNG interferon, gamma 2.55
TNF tumor necrosis factor 2.524
CLEC6A C-type lectin domain family 6, member A 2.286
CD8A CD8a molecule 2.27
IL12RB1 interleukin 12 receptor, beta 1 2.265
CARD9 caspase recruitment domain family, member 9 2.214
CRP C-reactive protein, pentraxin-related 2.202
IL17A interleukin 17A 2.191
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.136
IFNGR1 interferon gamma receptor 1 2.104
STAT1 signal transducer and activator of transcription 1, 91kDa 2.1
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.078
IL6 interleukin 6 2.052
IL10 interleukin 10 2.043
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.998
ALB albumin 1.979
ACE angiotensin I converting enzyme 1.975
IL1B interleukin 1, beta 1.957
IL2 interleukin 2 1.924
IL4 interleukin 4 1.893
DOCK8 dedicator of cytokinesis 8 1.881
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.878
IL1A interleukin 1, alpha 1.856
CLEC4E C-type lectin domain family 4, member E 1.848
GATA2 GATA binding protein 2 1.782
IL17RA interleukin 17 receptor A 1.782
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.753
IL17F interleukin 17F 1.749
IL22 interleukin 22 1.738
EMB embigin 1.726
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 1.72
CD80 CD80 molecule 1.68
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 1.672
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.669
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.646
IFNA1 interferon, alpha 1 1.642
SYK spleen tyrosine kinase 1.64
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 1.635
TYK2 tyrosine kinase 2 1.633
POMC proopiomelanocortin 1.632
TLR2 toll-like receptor 2 1.623
SIDT1 SID1 transmembrane family, member 1 1.619
CD40LG CD40 ligand 1.618
IL17RC interleukin 17 receptor C 1.615
CLEC4D C-type lectin domain family 4, member D 1.612
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 1.602
PRTN3 proteinase 3 1.586
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1 1.568
CSF3 colony stimulating factor 3 (granulocyte) 1.563
LAMA1 laminin, alpha 1 1.543
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.527
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.52
ERV3-1 endogenous retrovirus group 3, member 1 1.52
IL5 interleukin 5 1.516
UNC13D unc-13 homolog D (C. elegans) 1.513
LAMB1 laminin, beta 1 1.51
AIRE autoimmune regulator 1.501
CXCL8 chemokine (C-X-C motif) ligand 8 1.498
STX11 syntaxin 11 1.483
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.482
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.481
CABP1 calcium binding protein 1 1.474
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.472
TGFB1 transforming growth factor, beta 1 1.47
MYD88 myeloid differentiation primary response 88 1.464
PRF1 perforin 1 (pore forming protein) 1.458
ERVW-1 endogenous retrovirus group W, member 1 1.455
ZNF341 zinc finger protein 341 1.454
IL13 interleukin 13 1.435
LAMA2 laminin, alpha 2 1.433
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.424
ADA adenosine deaminase 1.418
MPO myeloperoxidase 1.411
PTH parathyroid hormone 1.411
SH2D1A SH2 domain containing 1A 1.403
ARMS2 age-related maculopathy susceptibility 2 1.403
TYRP1 tyrosinase-related protein 1 1.397
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.395
ACR acrosin 1.393
JAK1 Janus kinase 1 1.386
TLR9 toll-like receptor 9 1.38
IL18 interleukin 18 1.379
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.37
CD40 CD40 molecule, TNF receptor superfamily member 5 1.364
STXBP2 syntaxin binding protein 2 1.361
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.36
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.357
RORC RAR-related orphan receptor C 1.354
CD209 CD209 molecule 1.352
CD68 CD68 molecule 1.347
F2 coagulation factor II (thrombin) 1.343
CCL2 chemokine (C-C motif) ligand 2 1.339
TLR4 toll-like receptor 4 1.334
CCR2 chemokine (C-C motif) receptor 2 1.331
CXCL10 chemokine (C-X-C motif) ligand 10 1.325
F3 coagulation factor III (thromboplastin, tissue factor) 1.314
FOXP3 forkhead box P3 1.313
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 1.311
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.308
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 1.306
HTN3 histatin 3 1.301
PTPRC protein tyrosine phosphatase, receptor type, C 1.301
CD86 CD86 molecule 1.294
CCL4 chemokine (C-C motif) ligand 4 1.293
C3 complement component 3 1.29
TLR7 toll-like receptor 7 1.287
CCL3 chemokine (C-C motif) ligand 3 1.287
CFH complement factor H 1.286
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.283
BCL10 B-cell CLL/lymphoma 10 1.283
RPH3AL rabphilin 3A-like (without C2 domains) 1.279
NELFCD negative elongation factor complex member C/D 1.272
ALOX5 arachidonate 5-lipoxygenase 1.266
CD52 CD52 molecule 1.258
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.258
IL23A interleukin 23, alpha subunit p19 1.249
HLA-B major histocompatibility complex, class I, B 1.247
LTB4R leukotriene B4 receptor 1.245
RABAC1 Rab acceptor 1 (prenylated) 1.244
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.24
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.238
MALT1 MALT1 paracaspase 1.238
IFNB1 interferon, beta 1, fibroblast 1.236
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 1.227
PLG plasminogen 1.223
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.22
HSPA4 heat shock 70kDa protein 4 1.22
JAK3 Janus kinase 3 1.217
CHIT1 chitinase 1 (chitotriosidase) 1.216
NCF4 neutrophil cytosolic factor 4, 40kDa 1.213
IL1R1 interleukin 1 receptor, type I 1.212
LYST lysosomal trafficking regulator 1.211
IFNA2 interferon, alpha 2 1.209
BTK Bruton agammaglobulinemia tyrosine kinase 1.207
JAK2 Janus kinase 2 1.204
PPIG peptidylprolyl isomerase G (cyclophilin G) 1.202
CD38 CD38 molecule 1.189
CD28 CD28 molecule 1.182
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.182
IRF8 interferon regulatory factor 8 1.178
IFNA4 interferon, alpha 4 1.173
ICAM3 intercellular adhesion molecule 3 1.169
NLRP3 NLR family, pyrin domain containing 3 1.168
CYBB cytochrome b-245, beta polypeptide 1.168
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.167
STAC3 SH3 and cysteine rich domain 3 1.165
CD19 CD19 molecule 1.164
IFNA17 interferon, alpha 17 1.164
LTF lactotransferrin 1.16
H2BC21 H2B clustered histone 21 1.158
STAT4 signal transducer and activator of transcription 4 1.157
OCM2 oncomodulin 2 1.155
SELL selectin L 1.152
IL2RA interleukin 2 receptor, alpha 1.148
IFNA16 interferon, alpha 16 1.147
IFNA14 interferon, alpha 14 1.147
IFNA10 interferon, alpha 10 1.147
IFNA7 interferon, alpha 7 1.147
IFNA6 interferon, alpha 6 1.146
IFNA8 interferon, alpha 8 1.146
IFNA21 interferon, alpha 21 1.146
IFNA5 interferon, alpha 5 1.145
IFNA13 interferon, alpha 13 1.144
FN1 fibronectin 1 1.144
NOD2 nucleotide-binding oligomerization domain containing 2 1.138
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.136
CCL5 chemokine (C-C motif) ligand 5 1.131
SQLE squalene epoxidase 1.123
IL12RB2 interleukin 12 receptor, beta 2 1.123
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.118
CLEC1A C-type lectin domain family 1, member A 1.116
CXCL9 chemokine (C-X-C motif) ligand 9 1.116
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 1.115
PTX3 pentraxin 3, long 1.114
LGALS3 lectin, galactoside-binding, soluble, 3 1.113
PEX19 peroxisomal biogenesis factor 19 1.112
ISG15 ISG15 ubiquitin-like modifier 1.112
CLYBL citrate lyase beta like 1.106
ALOX5AP arachidonate 5-lipoxygenase-activating protein 1.105
IL23R interleukin 23 receptor 1.101
STAT5B signal transducer and activator of transcription 5B 1.1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 1.092
CXCL2 chemokine (C-X-C motif) ligand 2 1.086
RPAP1 RNA polymerase II associated protein 1 1.085
RAG1 recombination activating gene 1 1.08
CD163 CD163 molecule 1.074
IL1RN interleukin 1 receptor antagonist 1.068
RAG2 recombination activating gene 2 1.068
SPI1 Spi-1 proto-oncogene 1.067
HSPA14 heat shock 70kDa protein 14 1.067
RAB27A RAB27A, member RAS oncogene family 1.062
PGM3 phosphoglucomutase 3 1.061
MBL2 mannose-binding lectin (protein C) 2, soluble 1.059
CCR6 chemokine (C-C motif) receptor 6 1.058
CCRL2 chemokine (C-C motif) receptor-like 2 1.057
TRAF3IP2 TRAF3 interacting protein 2 1.055
NCF1 neutrophil cytosolic factor 1 1.053
TLR3 toll-like receptor 3 1.05
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.048
HP haptoglobin 1.048
IL15 interleukin 15 1.046
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.041
S100A9 S100 calcium binding protein A9 1.039
STAT2 signal transducer and activator of transcription 2, 113kDa 1.038
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.033
BPI bactericidal/permeability-increasing protein 1.028
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae) 1.026
CD34 CD34 molecule 1.021
LTA lymphotoxin alpha 1.018
DHODH dihydroorotate dehydrogenase (quinone) 1.017
CD1A CD1a molecule 1.014
ICAM1 intercellular adhesion molecule 1 1.011
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 1.01
H2AC21 H2A clustered histone 21 1.005