Holoprosencephaly Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies. (Human Disease Ontology, DOID_4621)
Similar Terms
Downloads & Tools

Genes

545 genes co-occuring with the disease Holoprosencephaly in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SHH sonic hedgehog 3.503
ZIC2 Zic family member 2 3.503
SIX3 SIX homeobox 3 3.448
CDON cell adhesion associated, oncogene regulated 3.121
GLI2 GLI family zinc finger 2 3.046
TGIF1 TGFB-induced factor homeobox 1 2.986
PTCH1 patched 1 2.963
SMO smoothened, frizzled class receptor 2.797
DISP1 dispatched homolog 1 (Drosophila) 2.772
GLI3 GLI family zinc finger 3 2.746
GLI1 GLI family zinc finger 1 2.736
GAS1 growth arrest-specific 1 2.702
HESX1 HESX homeobox 1 2.664
IHH indian hedgehog 2.577
LHX4 LIM homeobox 4 2.523
ESX1 ESX homeobox 1 2.517
DHCR7 7-dehydrocholesterol reductase 2.501
OTX2 orthodenticle homeobox 2 2.455
ZIC1 Zic family member 1 2.434
LHX3 LIM homeobox 3 2.428
PROP1 PROP paired-like homeobox 1 2.417
SUFU suppressor of fused homolog (Drosophila) 2.415
TGIF2 TGFB-induced factor homeobox 2 2.405
FGF8 fibroblast growth factor 8 (androgen-induced) 2.392
SOX3 SRY (sex determining region Y)-box 3 2.389
CHRD chordin 2.344
NODAL nodal growth differentiation factor 2.33
KIF7 kinesin family member 7 2.326
POU1F1 POU class 1 homeobox 1 2.316
LRP2 low density lipoprotein receptor-related protein 2 2.313
HHAT hedgehog acyltransferase 2.281
BOC BOC cell adhesion associated, oncogene regulated 2.274
PAX6 paired box 6 2.267
DHH desert hedgehog 2.255
BMP4 bone morphogenetic protein 4 2.244
HHIP hedgehog interacting protein 2.242
PTCH2 patched 2 2.2
FOXH1 forkhead box H1 2.199
ZIC5 Zic family member 5 2.174
ZIC3 Zic family member 3 2.16
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.101
KIF3A kinesin family member 3A 2.087
SIX6 SIX homeobox 6 2.083
ARL13B ADP-ribosylation factor-like 13B 2.038
FOXG1 forkhead box G1 2.035
VAX1 ventral anterior homeobox 1 2.026
TMEM216 transmembrane protein 216 2.011
TCTN1 tectonic family member 1 1.996
FOXA2 forkhead box A2 1.994
IFT88 intraflagellar transport 88 1.991
CHD7 chromodomain helicase DNA binding protein 7 1.986
NKX2-2 NK2 homeobox 2 1.977
FGFR1 fibroblast growth factor receptor 1 1.975
LMBR1 limb development membrane protein 1 1.974
TCTN2 tectonic family member 2 1.963
STIL SCL/TAL1 interrupting locus 1.948
TCTN3 tectonic family member 3 1.943
PROKR2 prokineticin receptor 2 1.942
IFT172 intraflagellar transport 172 1.936
NKX2-1 NK2 homeobox 1 1.934
MNX1 motor neuron and pancreas homeobox 1 1.908
GPR161 G protein-coupled receptor 161 1.904
DLX2 distal-less homeobox 2 1.895
CC2D2A coiled-coil and C2 domain containing 2A 1.895
SOX2 SRY (sex determining region Y)-box 2 1.877
TMEM67 transmembrane protein 67 1.873
MSX1 msh homeobox 1 1.871
FGF10 fibroblast growth factor 10 1.863
PGAP1 post-GPI attachment to proteins 1 1.856
OFD1 oral-facial-digital syndrome 1 1.856
PITX2 paired-like homeodomain 2 1.855
HYLS1 hydrolethalus syndrome 1 1.838
NOG noggin 1.834
TRAPPC10 trafficking protein particle complex 10 1.824
CNOT1 CCR4-NOT transcription complex, subunit 1 1.824
VANGL2 VANGL planar cell polarity protein 2 1.822
STAG2 stromal antigen 2 1.819
EMX1 empty spiracles homeobox 1 1.806
LHX2 LIM homeobox 2 1.803
FGF17 fibroblast growth factor 17 1.794
ISL1 ISL LIM homeobox 1 1.793
EMX2 empty spiracles homeobox 2 1.779
SIX2 SIX homeobox 2 1.778
PAX9 paired box 9 1.764
PAX2 paired box 2 1.762
HOXD13 homeobox D13 1.754
TBX1 T-box 1 1.75
FGF4 fibroblast growth factor 4 1.747
VAX2 ventral anterior homeobox 2 1.746
FGF18 fibroblast growth factor 18 1.741
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.731
SIX4 SIX homeobox 4 1.717
FGF20 fibroblast growth factor 20 1.707
FGF3 fibroblast growth factor 3 1.706
MOSMO modulator of smoothened 1.704
FGF5 fibroblast growth factor 5 1.702
TMEM161B transmembrane protein 161B 1.697
TGFB1 transforming growth factor, beta 1 1.697
KIAA0586 KIAA0586 1.696
TWSG1 twisted gastrulation BMP signaling modulator 1 1.695
GBX2 gastrulation brain homeobox 2 1.695
RPGRIP1L RPGRIP1-like 1.691
FGF22 fibroblast growth factor 22 1.686
FGF16 fibroblast growth factor 16 1.685
FGF6 fibroblast growth factor 6 1.679
SIX1 SIX homeobox 1 1.673
FGF9 fibroblast growth factor 9 1.672
EAPP E2F-associated phosphoprotein 1.669
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.665
FOXL2 forkhead box L2 1.663
TULP3 tubby like protein 3 1.662
TTC21B tetratricopeptide repeat domain 21B 1.661
ALX4 ALX homeobox 4 1.654
FGF7 fibroblast growth factor 7 1.653
POMC proopiomelanocortin 1.649
MKS1 Meckel syndrome, type 1 1.649
OLIG2 oligodendrocyte lineage transcription factor 2 1.641
PRCP prolylcarboxypeptidase (angiotensinase C) 1.638
MSX2 msh homeobox 2 1.636
WNT8B wingless-type MMTV integration site family, member 8B 1.635
SOX9 SRY (sex determining region Y)-box 9 1.633
NOSIP nitric oxide synthase interacting protein 1.633
CEP164 centrosomal protein 164kDa 1.624
PRDM15 PR domain containing 15 1.623
WNT1 wingless-type MMTV integration site family, member 1 1.617
BMPR1A bone morphogenetic protein receptor, type IA 1.609
WDR62 WD repeat domain 62 1.603
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.603
RAB23 RAB23, member RAS oncogene family 1.602
CNTLN centlein, centrosomal protein 1.594
SMIM23 small integral membrane protein 23 1.591
RAD21 RAD21 homolog (S. pombe) 1.591
BMP7 bone morphogenetic protein 7 1.591
CALB2 calbindin 2 1.587
PITX1 paired-like homeodomain 1 1.586
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 1.585
ZIC4 Zic family member 4 1.584
CEP290 centrosomal protein 290kDa 1.583
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 1.581
NKX6-2 NK6 homeobox 2 1.579
VSX2 visual system homeobox 2 1.571
NPAS3 neuronal PAS domain protein 3 1.558
DLL1 delta-like 1 (Drosophila) 1.555
PCNT pericentrin 1.545
TBX19 T-box 19 1.539
GSX2 GS homeobox 2 1.538
EVC2 Ellis van Creveld syndrome 2 1.534
EYA1 EYA transcriptional coactivator and phosphatase 1 1.532
LHX5 LIM homeobox 5 1.531
B9D1 B9 protein domain 1 1.53
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.53
LHX6 LIM homeobox 6 1.529
FGFR2 fibroblast growth factor receptor 2 1.524
ZBTB14 zinc finger and BTB domain containing 14 1.521
NKX6-1 NK6 homeobox 1 1.521
IRF6 interferon regulatory factor 6 1.519
ARX aristaless related homeobox 1.519
AVP arginine vasopressin 1.518
DLX5 distal-less homeobox 5 1.517
SMC1A structural maintenance of chromosomes 1A 1.515
PAX3 paired box 3 1.513
RNF32 ring finger protein 32 1.512
AHI1 Abelson helper integration site 1 1.512
NES nestin 1.511
RELN reelin 1.51
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.508
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.505
SMC3 structural maintenance of chromosomes 3 1.502
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.502
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.501
TUBA1A tubulin, alpha 1a 1.499
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.498
DLX1 distal-less homeobox 1 1.497
CEP41 centrosomal protein 41kDa 1.496
RTTN rotatin 1.494
WNT5A wingless-type MMTV integration site family, member 5A 1.493
NEUROG2 neurogenin 2 1.488
L1CAM L1 cell adhesion molecule 1.485
CDK5RAP2 CDK5 regulatory subunit associated protein 2 1.482
PABPN1 poly(A) binding protein, nuclear 1 1.482
SATB2 SATB homeobox 2 1.478
RUNX2 runt-related transcription factor 2 1.474
SMAD2 SMAD family member 2 1.474
COL2A1 collagen, type II, alpha 1 1.47
HOXA13 homeobox A13 1.469
ALX3 ALX homeobox 3 1.469
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 1.467
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 1.467
BMPR1B bone morphogenetic protein receptor, type IB 1.467
NIPBL Nipped-B homolog (Drosophila) 1.466
ALX1 ALX homeobox 1 1.464
CFC1 cripto, FRL-1, cryptic family 1 1.463
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.461
TBC1D32 TBC1 domain family, member 32 1.46
FOXF1 forkhead box F1 1.458
HOXA2 homeobox A2 1.457
ANOS1 anosmin 1 1.457
CDC42 cell division cycle 42 1.457
EOMES eomesodermin 1.454
BMP2 bone morphogenetic protein 2 1.454
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 1.451
PRRX1 paired related homeobox 1 1.451
PPP1R12A protein phosphatase 1, regulatory subunit 12A 1.447
TBX22 T-box 22 1.443
ASCL1 achaete-scute family bHLH transcription factor 1 1.441
GLI4 GLI family zinc finger 4 1.439
CTBP1 C-terminal binding protein 1 1.435
VANGL1 VANGL planar cell polarity protein 1 1.435
STRA6 stimulated by retinoic acid 6 1.428
GHRHR growth hormone releasing hormone receptor 1.426
PORCN porcupine homolog (Drosophila) 1.422
FOXC1 forkhead box C1 1.422
NDE1 nudE neurodevelopment protein 1 1.421
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 1.415
EN2 engrailed homeobox 2 1.413
EYA4 EYA transcriptional coactivator and phosphatase 4 1.41
NPHP1 nephronophthisis 1 (juvenile) 1.405
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 1.404
DCHS1 dachsous cadherin-related 1 1.403
BMP5 bone morphogenetic protein 5 1.4
IFT140 intraflagellar transport 140 1.399
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 1.393
EVC Ellis van Creveld protein 1.392
OTX1 orthodenticle homeobox 1 1.391
ACVR2A activin A receptor, type IIA 1.391
BARX1 BARX homeobox 1 1.391
SIX5 SIX homeobox 5 1.378
B9D2 B9 protein domain 2 1.378
CUBN cubilin (intrinsic factor-cobalamin receptor) 1.377
C2CD3 C2 calcium-dependent domain containing 3 1.375
CSTB cystatin B (stefin B) 1.373
FOXP2 forkhead box P2 1.373
BBS4 Bardet-Biedl syndrome 4 1.371
FEZF1 FEZ family zinc finger 1 1.369
KMT2D lysine (K)-specific methyltransferase 2D 1.367
NEUROG1 neurogenin 1 1.367
OR1F1 olfactory receptor, family 1, subfamily F, member 1 1.365
SNX6 sorting nexin 6 1.364
TIGD7 tigger transposable element derived 7 1.362
TMEM231 transmembrane protein 231 1.357
TMPPE transmembrane protein with metallophosphoesterase domain 1.357
SAP18 Sin3A-associated protein, 18kDa 1.356
BBS1 Bardet-Biedl syndrome 1 1.354
STK36 serine/threonine kinase 36 1.352
SASS6 spindle assembly 6 homolog (C. elegans) 1.348
FUZ fuzzy planar cell polarity protein 1.343
HINFP histone H4 transcription factor 1.343
SOX10 SRY (sex determining region Y)-box 10 1.34
LHX1 LIM homeobox 1 1.339
IL17RD interleukin 17 receptor D 1.339
PAX7 paired box 7 1.338
RBP2 retinol binding protein 2, cellular 1.336
CEP63 centrosomal protein 63kDa 1.335
POMT1 protein-O-mannosyltransferase 1 1.328
DKK1 dickkopf WNT signaling pathway inhibitor 1 1.323
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma 1.323
TSHB thyroid stimulating hormone, beta 1.32
MAB21L2 mab-21-like 2 (C. elegans) 1.317
TBR1 T-box, brain, 1 1.317
BBS2 Bardet-Biedl syndrome 2 1.317
SRY sex determining region Y 1.312
NPC1 Niemann-Pick disease, type C1 1.311
TRH thyrotropin-releasing hormone 1.311
FLNA filamin A, alpha 1.311
FOXB1 forkhead box B1 1.304
HES5 hes family bHLH transcription factor 5 1.303
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 1.303
WNT3A wingless-type MMTV integration site family, member 3A 1.294
GRK2 G protein-coupled receptor kinase 2 1.293
IFT80 intraflagellar transport 80 1.292
GPC5 glypican 5 1.292
OR14J1 olfactory receptor, family 14, subfamily J, member 1 1.29
KIF27 kinesin family member 27 1.284
IFT20 intraflagellar transport 20 1.283
OTP orthopedia homeobox 1.283
AXIN2 axin 2 1.277
TBX3 T-box 3 1.276
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 1.275
ALG10B ALG10B, alpha-1,2-glucosyltransferase 1.275
ULK3 unc-51 like kinase 3 1.272
GHRH growth hormone releasing hormone 1.271
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 1.269
KNCN kinocilin 1.266
SALL1 spalt-like transcription factor 1 1.265
TMEM237 transmembrane protein 237 1.263
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.263
WDR19 WD repeat domain 19 1.263
FBXW11 F-box and WD repeat domain containing 11 1.262
AMN amnion associated transmembrane protein 1.26
FEZF2 FEZ family zinc finger 2 1.259
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 1.259
CCP110 centriolar coiled coil protein 110kDa 1.257
RHOA ras homolog family member A 1.254
KATNAL2 katanin p60 subunit A-like 2 1.252
FGFR3 fibroblast growth factor receptor 3 1.251
WNT4 wingless-type MMTV integration site family, member 4 1.25
TBX6 T-box 6 1.249
VENTX VENT homeobox 1.248
EFCAB7 EF-hand calcium binding domain 7 1.248
L3MBTL4 l(3)mbt-like 4 (Drosophila) 1.247
PHC3 polyhomeotic homolog 3 (Drosophila) 1.247
TBX2 T-box 2 1.247
IGF1 insulin-like growth factor 1 (somatomedin C) 1.245
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.244
KATNBL1 katanin p80 subunit B-like 1 1.243
NR2F1 nuclear receptor subfamily 2, group F, member 1 1.242
MYOM1 myomesin 1 1.241
IFT57 intraflagellar transport 57 1.239
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1.238
SHOX short stature homeobox 1.237
CEP83 centrosomal protein 83kDa 1.236
FOXD3 forkhead box D3 1.233
SIM1 single-minded family bHLH transcription factor 1 1.231
PRL prolactin 1.23
ADCY3 adenylate cyclase 3 1.227
DCX doublecortin 1.226
LRP6 low density lipoprotein receptor-related protein 6 1.226
GREM2 gremlin 2, DAN family BMP antagonist 1.225
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.225
RAB8A RAB8A, member RAS oncogene family 1.224
GDF1 growth differentiation factor 1 1.224
ZNF526 zinc finger protein 526 1.223
FLRT3 fibronectin leucine rich transmembrane protein 3 1.222
WDR11 WD repeat domain 11 1.221
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.221
CALB1 calbindin 1, 28kDa 1.22
H3C13 H3 clustered histone 13 1.218
SMAD6 SMAD family member 6 1.218
H3C12 H3 clustered histone 12 1.216
HAND2 heart and neural crest derivatives expressed 2 1.215
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.214
OTUD4 OTU deubiquitinase 4 1.214
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 1.213
ACVR1 activin A receptor, type I 1.209
LRP5 low density lipoprotein receptor-related protein 5 1.209
H3-5 H3.5 histone 1.209
H3-4 H3.4 histone, cluster member 1.209
PVALB parvalbumin 1.209
POLR1D polymerase (RNA) I polypeptide D, 16kDa 1.209
ZNF200 zinc finger protein 200 1.208
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.207
PRICKLE1 prickle homolog 1 (Drosophila) 1.206
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 1.205
BBS7 Bardet-Biedl syndrome 7 1.203
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 1.202
POMT2 protein-O-mannosyltransferase 2 1.201
NKX2-5 NK2 homeobox 5 1.201
DVL1 dishevelled segment polarity protein 1 1.2
H3-3B H3.3 histone B 1.199
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.199
INVS inversin 1.199
XKR9 XK, Kell blood group complex subunit-related family, member 9 1.197
WNT9B wingless-type MMTV integration site family, member 9B 1.197
FAT2 FAT atypical cadherin 2 1.197
PHOX2B paired-like homeobox 2b 1.196
SSTR3 somatostatin receptor 3 1.195
GSK3B glycogen synthase kinase 3 beta 1.193
TBX4 T-box 4 1.192
AKAIN1 A-kinase anchor inhibitor 1 1.191
IFT27 intraflagellar transport 27 1.191
CHAMP1 chromosome alignment maintaining phosphoprotein 1 1.19
FOXD1 forkhead box D1 1.19
FAT1 FAT atypical cadherin 1 1.188
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.185
IFT52 intraflagellar transport 52 1.185
SP8 Sp8 transcription factor 1.184
TACR3 tachykinin receptor 3 1.183
EGF epidermal growth factor 1.179
TP53 tumor protein p53 1.178
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 1.177
LRRC45 leucine rich repeat containing 45 1.176
GPSM2 G-protein signaling modulator 2 1.175
FGF2 fibroblast growth factor 2 (basic) 1.174
GPC6 glypican 6 1.172
FOXE1 forkhead box E1 1.17
CNOT10 CCR4-NOT transcription complex, subunit 10 1.17
NEK1 NIMA-related kinase 1 1.168
OLIG1 oligodendrocyte transcription factor 1 1.167
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.165
FREM1 FRAS1 related extracellular matrix 1 1.163
CEP135 centrosomal protein 135kDa 1.159
CCDC141 coiled-coil domain containing 141 1.158
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 1.158
SCLT1 sodium channel and clathrin linker 1 1.155
SST somatostatin 1.154
CCND1 cyclin D1 1.153
DMXL2 Dmx-like 2 1.152
TBX5 T-box 5 1.151
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 1.15
TTBK2 tau tubulin kinase 2 1.149
KIF3B kinesin family member 3B 1.149
NUMBL numb homolog (Drosophila)-like 1.149
ZNF205 zinc finger protein 205 1.148
ZNF263 zinc finger protein 263 1.148
GATA4 GATA binding protein 4 1.148
CEP89 centrosomal protein 89kDa 1.146
RBPJ recombination signal binding protein for immunoglobulin kappa J region 1.145
WAPL WAPL cohesin release factor 1.144
FOXJ1 forkhead box J1 1.143
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 1.143
CHMP1A charged multivesicular body protein 1A 1.142
RFX4 regulatory factor X, 4 (influences HLA class II expression) 1.142
GREM1 gremlin 1, DAN family BMP antagonist 1.142
SCRIB scribbled planar cell polarity protein 1.141
NUMB numb homolog (Drosophila) 1.141
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.14
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 1.139
TUBB3 tubulin, beta 3 class III 1.139
SMAD3 SMAD family member 3 1.133
DBX1 developing brain homeobox 1 1.133
SOX1 SRY (sex determining region Y)-box 1 1.132
SPRY2 sprouty homolog 2 (Drosophila) 1.131
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 1.131
IGSF1 immunoglobulin superfamily, member 1 1.13
FGF13 fibroblast growth factor 13 1.129
ULK4 unc-51 like kinase 4 1.129
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.126
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.125
ERMARD ER membrane-associated RNA degradation 1.123
MECP2 methyl CpG binding protein 2 1.123
FMR1 fragile X mental retardation 1 1.123
FST follistatin 1.122
MTHFSD methenyltetrahydrofolate synthetase domain containing 1.12
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 1.119
INS insulin 1.117
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 1.117
LGALS4 lectin, galactoside-binding, soluble, 4 1.117
GRHL3 grainyhead-like 3 (Drosophila) 1.117
WDR26 WD repeat domain 26 1.116
EVI5L ecotropic viral integration site 5-like 1.116
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.115
UROD uroporphyrinogen decarboxylase 1.115
CTCF CCCTC-binding factor (zinc finger protein) 1.112
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 1.111
FRAS1 Fraser extracellular matrix complex subunit 1 1.111
RHO rhodopsin 1.111
OCRL oculocerebrorenal syndrome of Lowe 1.109
SPOP speckle-type POZ protein 1.109
EBP emopamil binding protein (sterol isomerase) 1.108
NTN1 netrin 1 1.108
COL4A1 collagen, type IV, alpha 1 1.107
DGCR2 DiGeorge syndrome critical region gene 2 1.104
SPRY4 sprouty homolog 4 (Drosophila) 1.101
TXNDC15 thioredoxin domain containing 15 1.1
PTK7 protein tyrosine kinase 7 (inactive) 1.099
ZNF862 zinc finger protein 862 1.099
ZNF708 zinc finger protein 708 1.098
PGAP2 post-GPI attachment to proteins 2 1.096
KISS1R KISS1 receptor 1.096
RND2 Rho family GTPase 2 1.094
NEUROD1 neuronal differentiation 1 1.093
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.092
RARA retinoic acid receptor, alpha 1.092
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 1.092
TMEM161A transmembrane protein 161A 1.092
ADGRG1 adhesion G protein-coupled receptor G1 1.091
LDLR low density lipoprotein receptor 1.09
CEP152 centrosomal protein 152kDa 1.09
TET1 tet methylcytosine dioxygenase 1 1.09
FOXC2 forkhead box C2 1.089
MCHR1 melanin-concentrating hormone receptor 1 1.089
POU3F2 POU class 3 homeobox 2 1.089
DMBX1 diencephalon/mesencephalon homeobox 1 1.089
WNT11 wingless-type MMTV integration site family, member 11 1.089
FBF1 Fas (TNFRSF6) binding factor 1 1.087
SMAD9 SMAD family member 9 1.086
DNAH11 dynein, axonemal, heavy chain 11 1.085
TRAPPC9 trafficking protein particle complex 9 1.085
CCDC88C coiled-coil domain containing 88C 1.081
LAMA1 laminin, alpha 1 1.077
NANOG Nanog homeobox 1.075
POU4F2 POU class 4 homeobox 2 1.075
DZIP1 DAZ interacting zinc finger protein 1 1.074
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.074
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 1.072
RNF216 ring finger protein 216 1.071
PHC1 polyhomeotic homolog 1 (Drosophila) 1.071
TUBB2B tubulin, beta 2B class IIb 1.068
GFAP glial fibrillary acidic protein 1.066
BBS9 Bardet-Biedl syndrome 9 1.066
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 1.064
LHX8 LIM homeobox 8 1.063
RFX1 regulatory factor X, 1 (influences HLA class II expression) 1.063
LEFTY2 left-right determination factor 2 1.063
VIPR2 vasoactive intestinal peptide receptor 2 1.063
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.061
POU5F1 POU class 5 homeobox 1 1.061
NPY neuropeptide Y 1.059
FOXI1 forkhead box I1 1.058
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.057
KDM6A lysine (K)-specific demethylase 6A 1.056
TP63 tumor protein p63 1.055
CSNK1A1 casein kinase 1, alpha 1 1.053
DHCR24 24-dehydrocholesterol reductase 1.053
TGIF2LY TGFB-induced factor homeobox 2-like, Y-linked 1.052
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.052
CCND2 cyclin D2 1.051
GPC1 glypican 1 1.049
IRX3 iroquois homeobox 3 1.048
GATA2 GATA binding protein 2 1.048
ZSCAN10 zinc finger and SCAN domain containing 10 1.048
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 1.047
UBTD2 ubiquitin domain containing 2 1.046
TOGARAM1 TOG array regulator of axonemal microtubules 1 1.044
HES3 hes family bHLH transcription factor 3 1.043
AXIN1 axin 1 1.042
MEIS1 Meis homeobox 1 1.041
TMEM138 transmembrane protein 138 1.039
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.037
WNT7A wingless-type MMTV integration site family, member 7A 1.037
DSCAM Down syndrome cell adhesion molecule 1.037
CREBBP CREB binding protein 1.035
SKIL SKI-like proto-oncogene 1.034
IGFBP3 insulin-like growth factor binding protein 3 1.034
ISL2 ISL LIM homeobox 2 1.032
ACVR2B activin A receptor, type IIB 1.03
DCHS2 dachsous cadherin-related 2 1.028
WDR81 WD repeat domain 81 1.028
SMOC1 SPARC related modular calcium binding 1 1.028
LEF1 lymphoid enhancer-binding factor 1 1.027
SF3B4 splicing factor 3b, subunit 4, 49kDa 1.026
FJX1 four jointed box 1 (Drosophila) 1.025
IRX6 iroquois homeobox 6 1.024
SMAD4 SMAD family member 4 1.024
HMGXB3 HMG box domain containing 3 1.023
SC5D sterol-C5-desaturase 1.021
GNRHR gonadotropin-releasing hormone receptor 1.02
CUX1 cut-like homeobox 1 1.02
NALCN sodium leak channel, non selective 1.019
EFNB2 ephrin-B2 1.017
ARRB2 arrestin, beta 2 1.015
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 1.015
MAML1 mastermind-like 1 (Drosophila) 1.013
ZSWIM6 zinc finger, SWIM-type containing 6 1.012
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 1.012
EPHA1 EPH receptor A1 1.012
ACTB actin, beta 1.01
ARHGAP28 Rho GTPase activating protein 28 1.007
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.007
HNF4A hepatocyte nuclear factor 4, alpha 1.007
FKRP fukutin related protein 1.005
NOTCH2NLB notch 2 N-terminal like B 1.005
AUTS2 autism susceptibility candidate 2 1.002
CLUL1 clusterin-like 1 (retinal) 1.0
FN1 fibronectin 1 1.0