| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Homoharringtonine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.125033 |
| HDAC9 | histone deacetylase 9 | 0.118797 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.113457 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0983802 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0882856 |
| RASAL2 | RAS protein activator like 2 | 0.0846143 |
| AHNAK | AHNAK nucleoprotein | 0.0831183 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0745567 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0721428 |
| SQSTM1 | sequestosome 1 | 0.0710603 |
| DST | dystonin | 0.0668546 |
| TXNRD1 | thioredoxin reductase 1 | 0.0665626 |
| FNIP1 | folliculin interacting protein 1 | 0.0625793 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0618633 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0616052 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0594875 |
| EZR | ezrin | 0.0555874 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0535021 |
| HMGA2 | high mobility group AT-hook 2 | 0.051655 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0514867 |
| ZNF217 | zinc finger protein 217 | 0.0506249 |
| INTS6 | integrator complex subunit 6 | 0.0498441 |
| KLF6 | Kruppel-like factor 6 | 0.0476778 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0444796 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0438759 |
| NLGN1 | neuroligin 1 | 0.0429494 |
| FOSL1 | FOS-like antigen 1 | 0.0420585 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0412002 |
| RPS29 | ribosomal protein S29 | 0.0396385 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0379253 |
| ERBIN | erbb2 interacting protein | 0.0379131 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0377187 |
| IL6ST | interleukin 6 signal transducer | 0.0353538 |
| LMO7 | LIM domain 7 | 0.03489 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0346957 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0341917 |
| USP53 | ubiquitin specific peptidase 53 | 0.0338279 |
| PLK2 | polo-like kinase 2 | 0.0336165 |
| YAP1 | Yes-associated protein 1 | 0.0327045 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0324897 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0319596 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0316714 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.031513 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0314719 |
| BCHE | butyrylcholinesterase | 0.0313444 |
| EGFR | epidermal growth factor receptor | 0.0311702 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0309721 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0307906 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0304042 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0304013 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0302545 |
| CENPE | centromere protein E, 312kDa | 0.0300751 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.029586 |
| MCL1 | myeloid cell leukemia 1 | 0.0295122 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0291468 |
| RSF1 | remodeling and spacing factor 1 | 0.0290235 |
| RTN4 | reticulon 4 | 0.0289052 |
| OGA | O-GlcNAcase | 0.0275873 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0273804 |
| PHF20 | PHD finger protein 20 | 0.0273166 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0271914 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0271688 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0267929 |
| DTNA | dystrobrevin, alpha | 0.0267079 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0266382 |
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.0259203 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0259084 |
| NABP1 | nucleic acid binding protein 1 | 0.0258452 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0257952 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0256189 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0255702 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0255502 |
| CEP295 | centrosomal protein 295kDa | 0.0255449 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0254636 |
| RPS23 | ribosomal protein S23 | 0.0253484 |
| BPTF | bromodomain PHD finger transcription factor | 0.0252271 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0250912 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0250588 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0248726 |
| NOP56 | NOP56 ribonucleoprotein | 0.0248001 |
| TRIM37 | tripartite motif containing 37 | 0.0246807 |
| ITGA6 | integrin, alpha 6 | 0.0246768 |
| FBXO38 | F-box protein 38 | 0.0243473 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0242731 |
| GOLGB1 | golgin B1 | 0.0242386 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0242351 |
| C1S | complement component 1, s subcomponent | 0.0237969 |
| RPS12 | ribosomal protein S12 | 0.0237348 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0235428 |
| RAN | RAN, member RAS oncogene family | 0.0235105 |
| WDR43 | WD repeat domain 43 | 0.02342 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0232687 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0232656 |
| VCAN | versican | 0.0231438 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0229363 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0228465 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0227394 |
| RPL37A | ribosomal protein L37a | 0.0223479 |
| RPL35A | ribosomal protein L35a | 0.0222876 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0221863 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.156937 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.153637 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.102188 |
| AREG | amphiregulin | -0.0943613 |
| TMEM41B | transmembrane protein 41B | -0.0887682 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0858714 |
| VMP1 | vacuole membrane protein 1 | -0.0776897 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.077012 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0766892 |
| PCBP2 | poly(rC) binding protein 2 | -0.0726572 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0697561 |
| MMP12 | matrix metallopeptidase 12 | -0.0631678 |
| TMEM123 | transmembrane protein 123 | -0.0608189 |
| SETX | senataxin | -0.0575027 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0571335 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0570238 |
| KIF5B | kinesin family member 5B | -0.0554985 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0554247 |
| NHSL1 | NHS-like 1 | -0.0500586 |
| PFN1 | profilin 1 | -0.0498211 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0493052 |
| EHBP1 | EH domain binding protein 1 | -0.0483072 |
| NEK7 | NIMA-related kinase 7 | -0.0478416 |
| ANXA1 | annexin A1 | -0.0474935 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0464069 |
| PTMS | parathymosin | -0.0461731 |
| YBX1 | Y box binding protein 1 | -0.0434505 |
| SMYD3 | SET and MYND domain containing 3 | -0.0430983 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0430564 |
| MED13L | mediator complex subunit 13-like | -0.0428525 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0427147 |
| NEBL | nebulette | -0.0423552 |
| DPYD | dihydropyrimidine dehydrogenase | -0.042221 |
| EDARADD | EDAR-associated death domain | -0.0419841 |
| MT2A | metallothionein 2A | -0.0416511 |
| TPI1 | triosephosphate isomerase 1 | -0.0408832 |
| EPHA6 | EPH receptor A6 | -0.0408719 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0406054 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.040539 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0401607 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.037953 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0376769 |
| EDN1 | endothelin 1 | -0.0370245 |
| CCNL1 | cyclin L1 | -0.0367962 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | -0.036521 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0364029 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0362032 |
| MAP1B | microtubule-associated protein 1B | -0.036194 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0355049 |
| IPO7 | importin 7 | -0.0354917 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0349089 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0348444 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0347398 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0346057 |
| FBXO11 | F-box protein 11 | -0.0345236 |
| EXOC6B | exocyst complex component 6B | -0.0342115 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0340084 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0338099 |
| POTEF | POTE ankyrin domain family, member F | -0.0337087 |
| OXR1 | oxidation resistance 1 | -0.0335272 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0334277 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0332497 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0331059 |
| TBK1 | TANK-binding kinase 1 | -0.0324204 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0320179 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.031974 |
| TENM3 | teneurin transmembrane protein 3 | -0.0318064 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0316169 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0316138 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0314516 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0311089 |
| UBC | ubiquitin C | -0.0310625 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0307121 |
| ATP11A | ATPase, class VI, type 11A | -0.0303872 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0302426 |
| KLHL24 | kelch-like family member 24 | -0.0301475 |
| NBEAL1 | neurobeachin-like 1 | -0.030111 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0298794 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0296584 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0290257 |
| RACK1 | receptor for activated C kinase 1 | -0.0289904 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0289102 |
| USP34 | ubiquitin specific peptidase 34 | -0.0288765 |
| RPLP0 | ribosomal protein, large, P0 | -0.0286275 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0285128 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0282121 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0280788 |
| YME1L1 | YME1-like 1 ATPase | -0.0280443 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0279656 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0278724 |
| RBM39 | RNA binding motif protein 39 | -0.0278644 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0278336 |
| OLA1 | Obg-like ATPase 1 | -0.0277261 |
| LOC112694756 | uncharaterized LOC112694756 | -0.027262 |
| VIM | vimentin | -0.0272057 |
| COG5 | component of oligomeric golgi complex 5 | -0.0271726 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0270847 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0269893 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0269585 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0269432 |
