Homoharringtonine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Homoharringtonine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Homoharringtonine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.11222
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0676082
PCLO piccolo presynaptic cytomatrix protein 0.0667968
MED13 mediator complex subunit 13 0.0605406
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0544761
CHD9 chromodomain helicase DNA binding protein 9 0.0474173
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0451247
KDM4C lysine (K)-specific demethylase 4C 0.0435328
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0406679
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0400702
AKAP9 A kinase (PRKA) anchor protein 9 0.0394487
ZC3H11A zinc finger CCCH-type containing 11A 0.0374772
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.03692
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.036798
PDE10A phosphodiesterase 10A 0.0363863
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0363349
ANGPTL4 angiopoietin-like 4 0.035862
LPIN1 lipin 1 0.0350346
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0349607
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0347683
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0333725
ARHGAP5 Rho GTPase activating protein 5 0.0331284
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0329114
ADAR adenosine deaminase, RNA-specific 0.0328387
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0327666
SKIL SKI-like proto-oncogene 0.0327161
H1-0 H1.0 linker histone 0.0323733
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 0.0320715
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.032036
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.031956
MED13L mediator complex subunit 13-like 0.0316731
ZNF292 zinc finger protein 292 0.0316667
RAD51B RAD51 paralog B 0.0311723
SAMD5 sterile alpha motif domain containing 5 0.030763
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0302496
RB1CC1 RB1-inducible coiled-coil 1 0.0298479
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0296454
ENAH enabled homolog (Drosophila) 0.0295946
CREBBP CREB binding protein 0.0290615
CADM1 cell adhesion molecule 1 0.0289671
TNRC6A trinucleotide repeat containing 6A 0.0289637
NPAS2 neuronal PAS domain protein 2 0.0289281
MX2 MX dynamin-like GTPase 2 0.0284366
DDIT4 DNA-damage-inducible transcript 4 0.0283359
DSCAM Down syndrome cell adhesion molecule 0.0282712
SQSTM1 sequestosome 1 0.0281159
ARRDC3 arrestin domain containing 3 0.0279297
EGFR epidermal growth factor receptor 0.0278791
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0276933
RIGI RNA sensor RIG-I 0.027459
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0272266
ZSWIM6 zinc finger, SWIM-type containing 6 0.0272057
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0271464
BBX bobby sox homolog (Drosophila) 0.0268789
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0267663
CYLD cylindromatosis (turban tumor syndrome) 0.0264012
VEGFA vascular endothelial growth factor A 0.0263397
LPP LIM domain containing preferred translocation partner in lipoma 0.0262192
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0261213
EXT1 exostosin glycosyltransferase 1 0.0261157
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0257259
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0257013
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0252279
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0248652
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0246243
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0245889
GPC5 glypican 5 0.0245636
GOLGB1 golgin B1 0.0241958
VCL vinculin 0.0241634
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.023339
KMT2C lysine (K)-specific methyltransferase 2C 0.0231518
ITSN2 intersectin 2 0.0226925
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0224487
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.0224343
FAT1 FAT atypical cadherin 1 0.0223637
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.022312
XPC xeroderma pigmentosum, complementation group C 0.0223113
ELL2 elongation factor, RNA polymerase II, 2 0.0223071
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0218722
DENND1A DENN/MADD domain containing 1A 0.0217845
SMAD3 SMAD family member 3 0.0213771
SON SON DNA binding protein 0.0210769
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0210127
PTPRD protein tyrosine phosphatase, receptor type, D 0.0210019
CHD1 chromodomain helicase DNA binding protein 1 0.0209332
PDZRN3 PDZ domain containing ring finger 3 0.0207168
RYBP RING1 and YY1 binding protein 0.0204666
LCOR ligand dependent nuclear receptor corepressor 0.0204259
TWIST2 twist family bHLH transcription factor 2 0.0204243
EP300 E1A binding protein p300 0.0203313
LOC102724023 ES1 protein homolog, mitochondrial 0.0200675
BHLHE40 basic helix-loop-helix family, member e40 0.0199576
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0199408
SEPTIN11 septin 11 0.0199188
UVRAG UV radiation resistance associated 0.0197646
ETV1 ets variant 1 0.0197634
RPS8 ribosomal protein S8 0.0197274
SERTAD2 SERTA domain containing 2 0.019538
CDPF1 cysteine-rich, DPF motif domain containing 1 0.019356
RNF150 ring finger protein 150 0.0193176

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.193843
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.143871
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.126216
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.115917
LSAMP limbic system-associated membrane protein -0.111489
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0903612
SYT1 synaptotagmin I -0.0875637
NCAM2 neural cell adhesion molecule 2 -0.0812084
MAP1B microtubule-associated protein 1B -0.0788259
DPH6 diphthamine biosynthesis 6 -0.0761287
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0740087
LIMCH1 LIM and calponin homology domains 1 -0.0734113
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0724291
MEIS2 Meis homeobox 2 -0.0677281
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0641238
SOS1 son of sevenless homolog 1 (Drosophila) -0.0603429
GARS1 glycyl-tRNA synthetase 1 -0.0555499
NREP neuronal regeneration related protein -0.0547442
CD36 CD36 molecule (thrombospondin receptor) -0.0537515
FMN1 formin 1 -0.053477
COL3A1 collagen, type III, alpha 1 -0.0531822
PLAT plasminogen activator, tissue -0.0520942
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0512764
CENPF centromere protein F, 350/400kDa -0.0511723
TENT5A terminal nucleotidyltransferase 5A -0.0510118
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.049543
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0492731
PTMA prothymosin, alpha -0.0478755
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.04613
MBD5 methyl-CpG binding domain protein 5 -0.0453554
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0449816
TPST1 tyrosylprotein sulfotransferase 1 -0.044714
PCDH9 protocadherin 9 -0.0446551
MKI67 marker of proliferation Ki-67 -0.0444388
NPEPPS aminopeptidase puromycin sensitive -0.0432925
DLC1 DLC1 Rho GTPase activating protein -0.0423658
VIM vimentin -0.0422986
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0404816
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0403881
ADGRG6 adhesion G protein-coupled receptor G6 -0.040061
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.039969
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0388034
UNC5C unc-5 homolog C (C. elegans) -0.0373331
CADM2 cell adhesion molecule 2 -0.0368547
FNDC3B fibronectin type III domain containing 3B -0.0366011
MBNL2 muscleblind-like splicing regulator 2 -0.0364063
ATRNL1 attractin-like 1 -0.0362171
CDC27 cell division cycle 27 -0.0360097
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0350037
GOLGA4 golgin A4 -0.0349141
COPA coatomer protein complex, subunit alpha -0.0343469
TOP1 topoisomerase (DNA) I -0.034293
TXNIP thioredoxin interacting protein -0.0331759
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0328264
CSDE1 cold shock domain containing E1, RNA-binding -0.0326289
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0324704
APP amyloid beta (A4) precursor protein -0.0322257
FNBP1 formin binding protein 1 -0.0317104
AKAP12 A kinase (PRKA) anchor protein 12 -0.0313163
CEMIP cell migration inducing protein, hyaluronan binding -0.0311654
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0309975
YME1L1 YME1-like 1 ATPase -0.0304573
SBF2 SET binding factor 2 -0.0299771
KPNB1 karyopherin (importin) beta 1 -0.0299022
ADGRB3 adhesion G protein-coupled receptor B3 -0.0295271
PIBF1 progesterone immunomodulatory binding factor 1 -0.0290291
CEP170 centrosomal protein 170kDa -0.0288353
KCNIP4 Kv channel interacting protein 4 -0.0287334
KLHL13 kelch-like family member 13 -0.0285102
MYO6 myosin VI -0.0282883
ANGPT1 angiopoietin 1 -0.0280455
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0272173
PRR11 proline rich 11 -0.0271808
TTC3 tetratricopeptide repeat domain 3 -0.0269416
PTRH2 peptidyl-tRNA hydrolase 2 -0.0266633
P4HB prolyl 4-hydroxylase, beta polypeptide -0.02657
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0260962
ZFAND3 zinc finger, AN1-type domain 3 -0.0260732
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259918
CCND1 cyclin D1 -0.0259784
IARS1 isoleucyl-tRNA synthetase 1 -0.0259091
RBM39 RNA binding motif protein 39 -0.0256775
RTN4 reticulon 4 -0.0256089
RHOBTB3 Rho-related BTB domain containing 3 -0.025428
ANTXR2 anthrax toxin receptor 2 -0.0252138
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0250904
SCG2 secretogranin II -0.0248306
USP3 ubiquitin specific peptidase 3 -0.0246205
B2M beta-2-microglobulin -0.0243365
CLTC clathrin, heavy chain (Hc) -0.0243015
EIF1 eukaryotic translation initiation factor 1 -0.0242674
NOP58 NOP58 ribonucleoprotein -0.0242528
MARCHF6 membrane associated ring-CH-type finger 6 -0.0242325
COL18A1 collagen, type XVIII, alpha 1 -0.0241051
TNRC6B trinucleotide repeat containing 6B -0.0239956
HDLBP high density lipoprotein binding protein -0.0237564
PRRC2B proline-rich coiled-coil 2B -0.0237332
MORF4L2 mortality factor 4 like 2 -0.0236026
CALU calumenin -0.0235955
NAMPT nicotinamide phosphoribosyltransferase -0.0235747