Homoharringtonine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Homoharringtonine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Homoharringtonine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.158293
INTS6 integrator complex subunit 6 0.131298
LCN2 lipocalin 2 0.122309
GCLC glutamate-cysteine ligase, catalytic subunit 0.0977675
TXNRD1 thioredoxin reductase 1 0.0789962
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0696097
EFNB2 ephrin-B2 0.0588611
PTGR1 prostaglandin reductase 1 0.0560069
TRERF1 transcriptional regulating factor 1 0.0537157
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0514629
CXCL8 chemokine (C-X-C motif) ligand 8 0.0514199
KYNU kynureninase 0.0498051
DST dystonin 0.0426078
SMAD3 SMAD family member 3 0.0404628
AKR1C2 aldo-keto reductase family 1, member C2 0.0365859
C6ORF132 chromosome 6 open reading frame 132 0.0363641
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.036331
ANXA2 annexin A2 0.0348953
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0343221
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0330413
BIRC3 baculoviral IAP repeat containing 3 0.030703
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0305045
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0286457
ASPH aspartate beta-hydroxylase 0.0286445
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0283341
TRIO trio Rho guanine nucleotide exchange factor 0.0281708
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0270327
HOMER1 homer scaffolding protein 1 0.0263072
CTNND1 catenin (cadherin-associated protein), delta 1 0.0262826
EZR ezrin 0.0254301
KDM3B lysine (K)-specific demethylase 3B 0.0252739
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0252562
APOL1 apolipoprotein L, 1 0.0251641
PLSCR2 phospholipid scramblase 2 0.0250511
SAA2 serum amyloid A2 0.02447
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0240576
SAMD4A sterile alpha motif domain containing 4A 0.0235878
EXT1 exostosin glycosyltransferase 1 0.023522
PGK1 phosphoglycerate kinase 1 0.0234846
FAT1 FAT atypical cadherin 1 0.0231034
LPP LIM domain containing preferred translocation partner in lipoma 0.0229742
PLAUR plasminogen activator, urokinase receptor 0.0220462
DIAPH1 diaphanous-related formin 1 0.021781
BCL2L1 BCL2-like 1 0.0216509
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0214699
MCL1 myeloid cell leukemia 1 0.0214605
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0212637
IFNGR1 interferon gamma receptor 1 0.0209329
SLC39A11 solute carrier family 39, member 11 0.020332
TRIM69 tripartite motif containing 69 0.0202398
CEMIP cell migration inducing protein, hyaluronan binding 0.0198732
XDH xanthine dehydrogenase 0.0194229
EFNA5 ephrin-A5 0.0189119
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0189091
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0187684
AHCYL2 adenosylhomocysteinase-like 2 0.0186762
NABP1 nucleic acid binding protein 1 0.0185837
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0180438
RDH10 retinol dehydrogenase 10 (all-trans) 0.0179957
HSPH1 heat shock 105kDa/110kDa protein 1 0.0178618
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0178577
TSHZ2 teashirt zinc finger homeobox 2 0.0177212
LNX2 ligand of numb-protein X 2 0.0176185
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.017613
CEMIP2 cell migration inducing hyaluronidase 2 0.0172164
SAA2-SAA4 SAA2-SAA4 readthrough 0.0171935
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0169267
SPIDR scaffolding protein involved in DNA repair 0.0165397
SOD2 superoxide dismutase 2, mitochondrial 0.0165
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0164006
VWA8 von Willebrand factor A domain containing 8 0.0161879
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0160208
CAPN8 calpain 8 0.0160152
UTRN utrophin 0.0159774
HSPA8 heat shock 70kDa protein 8 0.0159098
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0157074
MYO5B myosin VB 0.0156702
SEPTIN9 septin 9 0.0156209
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0154296
SET SET nuclear proto-oncogene 0.0153129
XPO1 exportin 1 0.014856
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0148173
FHIT fragile histidine triad 0.0148136
ANKRD36C ankyrin repeat domain 36C 0.0144683
ARRDC3 arrestin domain containing 3 0.0143766
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0142805
WWOX WW domain containing oxidoreductase 0.0142316
NAMPT nicotinamide phosphoribosyltransferase 0.0141548
EHBP1 EH domain binding protein 1 0.0140384
SDC4 syndecan 4 0.0140312
MYO1E myosin IE 0.0138467
C15ORF48 chromosome 15 open reading frame 48 0.0136377
TMEM45B transmembrane protein 45B 0.0136211
NCEH1 neutral cholesterol ester hydrolase 1 0.0136153
MYOF myoferlin 0.0135235
SFPQ splicing factor proline/glutamine-rich 0.0134754
ZHX2 zinc fingers and homeoboxes 2 0.013277
TNIP1 TNFAIP3 interacting protein 1 0.0130944
TRIM44 tripartite motif containing 44 0.0129874
STRIP2 striatin interacting protein 2 0.0129579

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.124755
MBNL2 muscleblind-like splicing regulator 2 -0.0581566
PTMA prothymosin, alpha -0.0568963
EPSTI1 epithelial stromal interaction 1 (breast) -0.0563281
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0528229
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0522031
B2M beta-2-microglobulin -0.0495739
SPATA13 spermatogenesis associated 13 -0.0493534
LOC102724023 ES1 protein homolog, mitochondrial -0.048763
HLA-B major histocompatibility complex, class I, B -0.0477398
ZNF292 zinc finger protein 292 -0.0437021
ATP11A ATPase, class VI, type 11A -0.0420492
NDRG1 N-myc downstream regulated 1 -0.0418461
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0417043
PATJ PATJ crumbs cell polarity complex component -0.0391199
RHOBTB3 Rho-related BTB domain containing 3 -0.0388421
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0385219
IRS2 insulin receptor substrate 2 -0.0383227
LYZ lysozyme -0.0379025
ERBIN erbb2 interacting protein -0.0362968
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0362026
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0354412
JUN jun proto-oncogene -0.0349708
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0341981
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0338048
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0335125
KLF6 Kruppel-like factor 6 -0.033346
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0331299
PHF3 PHD finger protein 3 -0.0328661
EIF1 eukaryotic translation initiation factor 1 -0.0321858
RRBP1 ribosome binding protein 1 -0.0321542
ITGA6 integrin, alpha 6 -0.0314879
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0314253
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0306573
SREBF2 sterol regulatory element binding transcription factor 2 -0.0304292
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0303321
NPSR1 neuropeptide S receptor 1 -0.0297521
H3-3B H3.3 histone B -0.0296232
FNIP1 folliculin interacting protein 1 -0.0294302
SORBS1 sorbin and SH3 domain containing 1 -0.0291646
BCLAF1 BCL2-associated transcription factor 1 -0.0280953
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0279892
SRRM2 serine/arginine repetitive matrix 2 -0.027774
AREG amphiregulin -0.0276994
TUBB4B tubulin, beta 4B class IVb -0.0272671
DIAPH3 diaphanous-related formin 3 -0.0268906
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0265752
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0265631
DDIT3 DNA-damage-inducible transcript 3 -0.0264407
ESRP1 epithelial splicing regulatory protein 1 -0.0263676
SETX senataxin -0.026193
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0259735
MKI67 marker of proliferation Ki-67 -0.0250361
KLHL24 kelch-like family member 24 -0.0248098
PDIA3 protein disulfide isomerase family A, member 3 -0.0246729
HLA-E major histocompatibility complex, class I, E -0.0245503
ACTG1 actin gamma 1 -0.0244342
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242178
UBC ubiquitin C -0.0240866
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0240678
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0240435
HDLBP high density lipoprotein binding protein -0.0239904
GOLGB1 golgin B1 -0.0236493
S100A6 S100 calcium binding protein A6 -0.0235716
GNAS GNAS complex locus -0.0234468
COPA coatomer protein complex, subunit alpha -0.0233491
SEC31A SEC31 homolog A (S. cerevisiae) -0.0232361
SMC4 structural maintenance of chromosomes 4 -0.0232181
NRIP1 nuclear receptor interacting protein 1 -0.0226175
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0223424
ATXN1 ataxin 1 -0.0220901
B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 -0.0220873
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0218853
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0217115
RUNX1 runt-related transcription factor 1 -0.0216905
NKD1 naked cuticle homolog 1 (Drosophila) -0.0216641
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0215891
COG6 component of oligomeric golgi complex 6 -0.0213947
RABGAP1L RAB GTPase activating protein 1-like -0.0213387
CD2AP CD2-associated protein -0.0212269
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212156
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0210618
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0209265
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0209088
RAB7A RAB7A, member RAS oncogene family -0.0208654
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0208442
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.020657
TTC3 tetratricopeptide repeat domain 3 -0.0205288
RBM39 RNA binding motif protein 39 -0.0204773
CRYM crystallin, mu -0.0203026
ZBTB20 zinc finger and BTB domain containing 20 -0.0201842
ANKRD12 ankyrin repeat domain 12 -0.0201086
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 -0.0200997
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0199778
RAB6A RAB6A, member RAS oncogene family -0.0199396
DSCAM Down syndrome cell adhesion molecule -0.0198885
SSH2 slingshot protein phosphatase 2 -0.0197222
LIMA1 LIM domain and actin binding 1 -0.01954
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0193701
XAF1 XIAP associated factor 1 -0.0193668