| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Homoharringtonine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ADM | adrenomedullin | 0.141385 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.128471 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.113756 |
| HDAC9 | histone deacetylase 9 | 0.10883 |
| ENO1 | enolase 1, (alpha) | 0.100471 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0997323 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0952863 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0928849 |
| VEGFA | vascular endothelial growth factor A | 0.0911973 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0899394 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0786832 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0779059 |
| AHNAK | AHNAK nucleoprotein | 0.0754367 |
| NDRG1 | N-myc downstream regulated 1 | 0.0754236 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0743517 |
| CADM1 | cell adhesion molecule 1 | 0.0698455 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0697169 |
| NAV2 | neuron navigator 2 | 0.0691464 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0687834 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0679241 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0618327 |
| RIGI | RNA sensor RIG-I | 0.0613119 |
| EGFR | epidermal growth factor receptor | 0.0537732 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0514212 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0504603 |
| ARRDC3 | arrestin domain containing 3 | 0.0492238 |
| FOSL1 | FOS-like antigen 1 | 0.048069 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0475349 |
| SQSTM1 | sequestosome 1 | 0.0461621 |
| LDHA | lactate dehydrogenase A | 0.0435387 |
| RUNX1 | runt-related transcription factor 1 | 0.0432026 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0427301 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0425714 |
| PLEC | plectin | 0.0425439 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.0416032 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0408482 |
| MT2A | metallothionein 2A | 0.0381513 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0380831 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0380756 |
| CLMP | CXADR-like membrane protein | 0.037365 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0368202 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0367956 |
| APOL6 | apolipoprotein L, 6 | 0.0366904 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0344711 |
| H1-0 | H1.0 linker histone | 0.0341562 |
| ZNF292 | zinc finger protein 292 | 0.033465 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0334061 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0328633 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0326932 |
| PKM | pyruvate kinase, muscle | 0.0322522 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.032173 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0319311 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0318977 |
| ANGPTL4 | angiopoietin-like 4 | 0.0317869 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0309009 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0305453 |
| PGK1 | phosphoglycerate kinase 1 | 0.0302787 |
| MX1 | MX dynamin-like GTPase 1 | 0.0294231 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.029339 |
| RLF | rearranged L-myc fusion | 0.029323 |
| H3-3B | H3.3 histone B | 0.0287044 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0285473 |
| ZNF395 | zinc finger protein 395 | 0.0283752 |
| IER3 | immediate early response 3 | 0.0279383 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0279363 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.027665 |
| RND3 | Rho family GTPase 3 | 0.0276619 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0274578 |
| SAMD9L | sterile alpha motif domain containing 9-like | 0.0273232 |
| SP100 | SP100 nuclear antigen | 0.0271807 |
| RPL7 | ribosomal protein L7 | 0.0269171 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0268023 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.026787 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0267028 |
| BBX | bobby sox homolog (Drosophila) | 0.0265769 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0265684 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0265291 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0265125 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0263487 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.026026 |
| ATL1 | atlastin GTPase 1 | 0.0260127 |
| S100A9 | S100 calcium binding protein A9 | 0.0252196 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0249917 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0249422 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.024662 |
| MX2 | MX dynamin-like GTPase 2 | 0.0245956 |
| RYBP | RING1 and YY1 binding protein | 0.0245127 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0244363 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | 0.0240081 |
| OGA | O-GlcNAcase | 0.023757 |
| GBP4 | guanylate binding protein 4 | 0.0237106 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.023693 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0234813 |
| KIAA1217 | KIAA1217 | 0.0231569 |
| CDK6 | cyclin-dependent kinase 6 | 0.0229484 |
| IL6 | interleukin 6 | 0.0228456 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0225512 |
| TMSB4X | thymosin beta 4, X-linked | 0.0225125 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0223285 |
| RSF1 | remodeling and spacing factor 1 | 0.022243 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.237126 |
| COL6A3 | collagen, type VI, alpha 3 | -0.196388 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.138364 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.126037 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.114387 |
| EGR1 | early growth response 1 | -0.105468 |
| COL1A1 | collagen, type I, alpha 1 | -0.104366 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.091607 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0914454 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0899037 |
| CALU | calumenin | -0.0660741 |
| COL1A2 | collagen, type I, alpha 2 | -0.0648868 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0586607 |
| ASPH | aspartate beta-hydroxylase | -0.0584624 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0568063 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0567759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0566511 |
| INHBA | inhibin, beta A | -0.0562788 |
| HMGA2 | high mobility group AT-hook 2 | -0.0546415 |
| CDH13 | cadherin 13 | -0.0540522 |
| GLIS3 | GLIS family zinc finger 3 | -0.0539034 |
| CD44 | CD44 molecule (Indian blood group) | -0.0531037 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0519485 |
| FBN1 | fibrillin 1 | -0.050422 |
| LOXL2 | lysyl oxidase-like 2 | -0.0489055 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.046799 |
| LOX | lysyl oxidase | -0.0452528 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0452038 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0440336 |
| CENPE | centromere protein E, 312kDa | -0.0436342 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0412837 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0407251 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0402154 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0399944 |
| IER2 | immediate early response 2 | -0.0399564 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0390874 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0381415 |
| COL5A1 | collagen, type V, alpha 1 | -0.0377238 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0359972 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0345127 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0341717 |
| MAP1B | microtubule-associated protein 1B | -0.0337242 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0335479 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0322966 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0320351 |
| SEC24D | SEC24 family member D | -0.0317705 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0315059 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0314702 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0311876 |
| ATP13A3 | ATPase type 13A3 | -0.0310649 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0305546 |
| VCAN | versican | -0.0287921 |
| VCL | vinculin | -0.0282982 |
| SDC2 | syndecan 2 | -0.0276405 |
| SQLE | squalene epoxidase | -0.0273256 |
| GOLGA4 | golgin A4 | -0.0272406 |
| COG5 | component of oligomeric golgi complex 5 | -0.0265131 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0261574 |
| POSTN | periostin, osteoblast specific factor | -0.0261189 |
| SMYD3 | SET and MYND domain containing 3 | -0.0260817 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0257808 |
| CLINT1 | clathrin interactor 1 | -0.0257759 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0256079 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0254891 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0248331 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0247104 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0246188 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0243533 |
| CENPF | centromere protein F, 350/400kDa | -0.023866 |
| PDE10A | phosphodiesterase 10A | -0.0237743 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0234913 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0230746 |
| MAP4 | microtubule-associated protein 4 | -0.0229275 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0225631 |
| CALR | calreticulin | -0.0225395 |
| NAV1 | neuron navigator 1 | -0.0222814 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.022245 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.022191 |
| ANKRD28 | ankyrin repeat domain 28 | -0.021761 |
| MKI67 | marker of proliferation Ki-67 | -0.0217519 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0215896 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0215516 |
| JUN | jun proto-oncogene | -0.0215259 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0214818 |
| GLG1 | golgi glycoprotein 1 | -0.0209674 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.020907 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0206825 |
| TMEM263 | transmembrane protein 263 | -0.020357 |
| COPA | coatomer protein complex, subunit alpha | -0.0203542 |
| SBF2 | SET binding factor 2 | -0.0203352 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0202775 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0201663 |
| TFG | TRK-fused gene | -0.0201234 |
| DIAPH3 | diaphanous-related formin 3 | -0.0200939 |
| SH3PXD2B | SH3 and PX domains 2B | -0.0200088 |
| TMEM39A | transmembrane protein 39A | -0.0195245 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0193091 |
| ATM | ATM serine/threonine kinase | -0.0191031 |
| ECE1 | endothelin converting enzyme 1 | -0.0189397 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0188725 |
