| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Homoharringtonine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BIRC3 | baculoviral IAP repeat containing 3 | 0.300932 |
| HDAC9 | histone deacetylase 9 | 0.225102 |
| DST | dystonin | 0.11122 |
| TXNRD1 | thioredoxin reductase 1 | 0.103797 |
| KLF6 | Kruppel-like factor 6 | 0.0933809 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0906626 |
| SQSTM1 | sequestosome 1 | 0.0812418 |
| MT2A | metallothionein 2A | 0.0733418 |
| HOMER1 | homer scaffolding protein 1 | 0.0718757 |
| JUN | jun proto-oncogene | 0.0703868 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0700914 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0692943 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0670842 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0659856 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0654661 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0630583 |
| ENO1 | enolase 1, (alpha) | 0.0618197 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0610007 |
| EGFR | epidermal growth factor receptor | 0.0580712 |
| RIGI | RNA sensor RIG-I | 0.056148 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0561387 |
| FOSL1 | FOS-like antigen 1 | 0.0547504 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0516492 |
| MT1E | metallothionein 1E | 0.0515929 |
| PLK2 | polo-like kinase 2 | 0.0495281 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0487733 |
| BRD2 | bromodomain containing 2 | 0.0487105 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0483631 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0461949 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0443146 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0428977 |
| ADM | adrenomedullin | 0.0409567 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0404464 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.04036 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0376593 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0368126 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.036756 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0353528 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0337711 |
| TRAF1 | TNF receptor-associated factor 1 | 0.0337547 |
| KRT18 | keratin 18, type I | 0.0332674 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0331591 |
| ZNF217 | zinc finger protein 217 | 0.0324741 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.032426 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0320193 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0317822 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.030088 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0299095 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0294674 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0294443 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.0292395 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0284096 |
| LYST | lysosomal trafficking regulator | 0.0283718 |
| NOCT | nocturnin | 0.0270455 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0262587 |
| TXNIP | thioredoxin interacting protein | 0.0259959 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0248995 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.024727 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0246634 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0246421 |
| GPC5 | glypican 5 | 0.0246398 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0246278 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0242055 |
| TRIM56 | tripartite motif containing 56 | 0.0241924 |
| RPS6 | ribosomal protein S6 | 0.0241402 |
| AHNAK | AHNAK nucleoprotein | 0.0236864 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0234931 |
| CDV3 | CDV3 homolog (mouse) | 0.0233168 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0231841 |
| SP100 | SP100 nuclear antigen | 0.0231144 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0230606 |
| RPL37A | ribosomal protein L37a | 0.0226721 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0221351 |
| FAT1 | FAT atypical cadherin 1 | 0.0219867 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0219668 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0216207 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0215904 |
| ATF4 | activating transcription factor 4 | 0.0214642 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0213156 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0208422 |
| TFRC | transferrin receptor | 0.0204848 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0204533 |
| DENND4A | DENN/MADD domain containing 4A | 0.0200247 |
| SPAG9 | sperm associated antigen 9 | 0.0200095 |
| TGM2 | transglutaminase 2 | 0.0199581 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0198141 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0198009 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0197262 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0195954 |
| SFPQ | splicing factor proline/glutamine-rich | 0.01936 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0190271 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0189825 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 0.0189743 |
| LDHA | lactate dehydrogenase A | 0.0188728 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0188419 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0188312 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0184016 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.0183399 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0182718 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0182113 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.197998 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.120009 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.108191 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.105824 |
| TP63 | tumor protein p63 | -0.103568 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0982344 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0979549 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0905659 |
| CD44 | CD44 molecule (Indian blood group) | -0.0847001 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0767276 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0750267 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0735741 |
| PTMA | prothymosin, alpha | -0.0707359 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0693755 |
| EHBP1 | EH domain binding protein 1 | -0.0673131 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0666986 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0661269 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0658159 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0605715 |
| EXOC4 | exocyst complex component 4 | -0.0543546 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0537639 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0533354 |
| RAD51B | RAD51 paralog B | -0.0532417 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0527106 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0520196 |
| SMYD3 | SET and MYND domain containing 3 | -0.0505516 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0499314 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0488082 |
| TMSB10 | thymosin beta 10 | -0.0452878 |
| RAI1 | retinoic acid induced 1 | -0.0451737 |
| PTK2 | protein tyrosine kinase 2 | -0.0412225 |
| FMNL2 | formin-like 2 | -0.0406115 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.038334 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0381388 |
| TNS3 | tensin 3 | -0.0375633 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0375131 |
| TMSB4X | thymosin beta 4, X-linked | -0.0374988 |
| TOP1 | topoisomerase (DNA) I | -0.0371635 |
| VIM | vimentin | -0.0370847 |
| SBF2 | SET binding factor 2 | -0.0369303 |
| ANKRD11 | ankyrin repeat domain 11 | -0.036519 |
| DNER | delta/notch-like EGF repeat containing | -0.0365153 |
| LOXL2 | lysyl oxidase-like 2 | -0.0364443 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0361807 |
| ACTG1 | actin gamma 1 | -0.0360725 |
| CMIP | c-Maf inducing protein | -0.0359056 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0356949 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0356608 |
| CAPRIN2 | caprin family member 2 | -0.0353597 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0352681 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0352297 |
| FBXO11 | F-box protein 11 | -0.0349435 |
| CENPF | centromere protein F, 350/400kDa | -0.0348745 |
| BMERB1 | bMERB domain containing 1 | -0.0338835 |
| ANKRD12 | ankyrin repeat domain 12 | -0.033806 |
| CANX | calnexin | -0.0335402 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0334492 |
| APP | amyloid beta (A4) precursor protein | -0.0333642 |
| CEP170 | centrosomal protein 170kDa | -0.033242 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0330176 |
| RUNX1 | runt-related transcription factor 1 | -0.0330003 |
| SRPK2 | SRSF protein kinase 2 | -0.0326131 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.0325884 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0325858 |
| VCL | vinculin | -0.032399 |
| TMEM41B | transmembrane protein 41B | -0.0323472 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0323297 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0318537 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.031669 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0313923 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0313872 |
| USP34 | ubiquitin specific peptidase 34 | -0.0313727 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0311475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0311226 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0309926 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0307222 |
| HPCAL1 | hippocalcin-like 1 | -0.0305995 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0305785 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0305185 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0304367 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0303977 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0301707 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0299518 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0298668 |
| RTTN | rotatin | -0.0297644 |
| DOCK11 | dedicator of cytokinesis 11 | -0.029733 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0297029 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0294809 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0292383 |
| EFNA5 | ephrin-A5 | -0.0292167 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0291436 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0290459 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0289674 |
| RTN4 | reticulon 4 | -0.0289044 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0288661 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0286832 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0283062 |
| COG5 | component of oligomeric golgi complex 5 | -0.0282727 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.028245 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0282336 |
