| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Homoharringtonine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.268192 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.235683 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.102396 |
| MCL1 | myeloid cell leukemia 1 | 0.0923729 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0916015 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0906238 |
| SLTM | SAFB-like, transcription modulator | 0.0876722 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0811687 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0780522 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0772201 |
| FAT1 | FAT atypical cadherin 1 | 0.0736607 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0727004 |
| INTS6 | integrator complex subunit 6 | 0.0687196 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0685136 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0673052 |
| FOSL1 | FOS-like antigen 1 | 0.0665191 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0664162 |
| HOMER1 | homer scaffolding protein 1 | 0.064641 |
| ENO1 | enolase 1, (alpha) | 0.0636158 |
| LAMC2 | laminin, gamma 2 | 0.0632449 |
| HDAC9 | histone deacetylase 9 | 0.0631405 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.06029 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0598685 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0591658 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0571588 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0566072 |
| STC1 | stanniocalcin 1 | 0.0541925 |
| NABP1 | nucleic acid binding protein 1 | 0.0533558 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.050139 |
| LAMB3 | laminin, beta 3 | 0.0501006 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0473201 |
| SP100 | SP100 nuclear antigen | 0.046826 |
| DTNA | dystrobrevin, alpha | 0.0468195 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0458698 |
| AHNAK | AHNAK nucleoprotein | 0.045602 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0452004 |
| MT2A | metallothionein 2A | 0.0446243 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0421666 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0414883 |
| CDCP1 | CUB domain containing protein 1 | 0.0402756 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0402367 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0400179 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0396252 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.039497 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.038049 |
| PKM | pyruvate kinase, muscle | 0.0368303 |
| SKIL | SKI-like proto-oncogene | 0.0367918 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0365215 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363434 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0362948 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0353153 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0352419 |
| FAM110C | family with sequence similarity 110, member C | 0.0350308 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0347807 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0336576 |
| BRD2 | bromodomain containing 2 | 0.0335283 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0333715 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0328161 |
| GPC5 | glypican 5 | 0.0326835 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | 0.0323743 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0307348 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0307155 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.030398 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0302616 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.029717 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0296607 |
| KRT18 | keratin 18, type I | 0.0296212 |
| SEC61G | Sec61 gamma subunit | 0.0288452 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0287935 |
| TPM4 | tropomyosin 4 | 0.0284628 |
| PYGL | phosphorylase, glycogen, liver | 0.0283723 |
| GOLGB1 | golgin B1 | 0.0282926 |
| PLEC | plectin | 0.0282596 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0280753 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.027393 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0273642 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0271754 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.026854 |
| TPM3 | tropomyosin 3 | 0.0258405 |
| GPATCH2L | G patch domain containing 2-like | 0.0256627 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0253971 |
| DST | dystonin | 0.0252729 |
| MX1 | MX dynamin-like GTPase 1 | 0.0252106 |
| SDC1 | syndecan 1 | 0.0249356 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0247985 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.02463 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.024524 |
| ANXA5 | annexin A5 | 0.0244858 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0244181 |
| LAMA4 | laminin, alpha 4 | 0.0243166 |
| KLF10 | Kruppel-like factor 10 | 0.0242497 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0241918 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.023925 |
| TRIM56 | tripartite motif containing 56 | 0.0238202 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0236013 |
| DSPP | dentin sialophosphoprotein | 0.0234944 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.023397 |
| RAD51B | RAD51 paralog B | 0.02335 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.0232422 |
| SMYD3 | SET and MYND domain containing 3 | 0.0231765 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.129207 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.127574 |
| TMSB10 | thymosin beta 10 | -0.078089 |
| PTMA | prothymosin, alpha | -0.0742908 |
| FAM13A | family with sequence similarity 13, member A | -0.0732832 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0706337 |
| TOP1 | topoisomerase (DNA) I | -0.0633914 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0625103 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0609545 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0594493 |
| EGFR | epidermal growth factor receptor | -0.0575764 |
| ASPH | aspartate beta-hydroxylase | -0.0561955 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0481303 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0478975 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0476438 |
| TMEM165 | transmembrane protein 165 | -0.0459109 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0445119 |
| LMO7 | LIM domain 7 | -0.0441157 |
| RBM39 | RNA binding motif protein 39 | -0.0437964 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0425489 |
| UVRAG | UV radiation resistance associated | -0.0420541 |
| WASF2 | WAS protein family, member 2 | -0.041705 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0410343 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0410111 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0409829 |
| PDE8A | phosphodiesterase 8A | -0.0406582 |
| TPD52 | tumor protein D52 | -0.0398534 |
| RNF145 | ring finger protein 145 | -0.0397543 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0396146 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0392605 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0366538 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0362523 |
| SEPTIN2 | septin 2 | -0.0361131 |
| FTL | ferritin, light polypeptide | -0.0357315 |
| NDRG1 | N-myc downstream regulated 1 | -0.0356171 |
| AREG | amphiregulin | -0.0344543 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0344137 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0340571 |
| SPAG9 | sperm associated antigen 9 | -0.0340008 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0321825 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0317392 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0309784 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0309153 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0306741 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0304165 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0301994 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0300167 |
| HDLBP | high density lipoprotein binding protein | -0.0299318 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0296241 |
| RPLP0 | ribosomal protein, large, P0 | -0.0294056 |
| CCNL1 | cyclin L1 | -0.0293852 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0292618 |
| USP36 | ubiquitin specific peptidase 36 | -0.0292122 |
| CES1 | carboxylesterase 1 | -0.0287581 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.028665 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0285641 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0284505 |
| HELZ | helicase with zinc finger | -0.0282867 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0280946 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0280348 |
| WDR45B | WD repeat domain 45B | -0.0279656 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0275894 |
| ATG12 | autophagy related 12 | -0.0271952 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0269692 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0265793 |
| GPC6 | glypican 6 | -0.0262285 |
| CPE | carboxypeptidase E | -0.0262252 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0261636 |
| MKI67 | marker of proliferation Ki-67 | -0.0258805 |
| UBC | ubiquitin C | -0.0258729 |
| SBF2 | SET binding factor 2 | -0.0257037 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0254924 |
| SETD5 | SET domain containing 5 | -0.0253412 |
| NPTN | neuroplastin | -0.0246734 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0246347 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0244718 |
| SRP54 | signal recognition particle 54kDa | -0.0243437 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0241271 |
| RPS24 | ribosomal protein S24 | -0.0240228 |
| HBP1 | HMG-box transcription factor 1 | -0.0238925 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0237903 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0237841 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0237151 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0234689 |
| SLMAP | sarcolemma associated protein | -0.023361 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.023219 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0227864 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.022672 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0224378 |
| NGLY1 | N-glycanase 1 | -0.0223247 |
| MGAT4C | MGAT4 family, member C | -0.0221792 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0221191 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0221149 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0219026 |
| FRY | furry homolog (Drosophila) | -0.0218797 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0218007 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0216656 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0214918 |
| MORF4L2 | mortality factor 4 like 2 | -0.021461 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0212852 |
