| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Homoharringtonine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.17879 |
| TXNRD1 | thioredoxin reductase 1 | 0.157679 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.132139 |
| MCL1 | myeloid cell leukemia 1 | 0.120095 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.109397 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.108743 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.09688 |
| HDAC9 | histone deacetylase 9 | 0.0886183 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0845455 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0814981 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0790922 |
| AHNAK | AHNAK nucleoprotein | 0.0755905 |
| MT2A | metallothionein 2A | 0.074387 |
| RPL23 | ribosomal protein L23 | 0.0740769 |
| TPM3 | tropomyosin 3 | 0.0729353 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0652135 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0624932 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0624518 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0621883 |
| SQSTM1 | sequestosome 1 | 0.060012 |
| GRAMD1B | GRAM domain containing 1B | 0.0599733 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0586104 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0551591 |
| ENO1 | enolase 1, (alpha) | 0.0548052 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0543334 |
| ADM | adrenomedullin | 0.0542694 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0538672 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0523517 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0522355 |
| BRD2 | bromodomain containing 2 | 0.0508731 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0487027 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0485788 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0475628 |
| H3-3B | H3.3 histone B | 0.0470798 |
| ATF4 | activating transcription factor 4 | 0.0466819 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0438461 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | 0.0435747 |
| PKM | pyruvate kinase, muscle | 0.0416995 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0414464 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0387696 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0387103 |
| RPS8 | ribosomal protein S8 | 0.0385806 |
| HLA-A | major histocompatibility complex, class I, A | 0.0381585 |
| RPL7 | ribosomal protein L7 | 0.038057 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0380146 |
| KIF5B | kinesin family member 5B | 0.0376615 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0374524 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0367667 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0359929 |
| RPS17 | ribosomal protein S17 | 0.0355239 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0354845 |
| STC1 | stanniocalcin 1 | 0.0353177 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0346285 |
| RPL37A | ribosomal protein L37a | 0.0340436 |
| MED13 | mediator complex subunit 13 | 0.033173 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0331371 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.032991 |
| S100A11 | S100 calcium binding protein A11 | 0.0328748 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0322635 |
| FAM107B | family with sequence similarity 107, member B | 0.032251 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.031774 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0314179 |
| CLU | clusterin | 0.0312761 |
| RPS6 | ribosomal protein S6 | 0.0309359 |
| SEPTIN7 | septin 7 | 0.0308458 |
| FTL | ferritin, light polypeptide | 0.03078 |
| DST | dystonin | 0.0307063 |
| MSN | moesin | 0.0306308 |
| H1-0 | H1.0 linker histone | 0.030473 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0302385 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0302169 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0302077 |
| AFF4 | AF4/FMR2 family, member 4 | 0.029668 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0292152 |
| RSPO3 | R-spondin 3 | 0.0289883 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0288749 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0280869 |
| S100A9 | S100 calcium binding protein A9 | 0.0278349 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0275875 |
| PGK1 | phosphoglycerate kinase 1 | 0.0269812 |
| PFN1 | profilin 1 | 0.0265985 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0264251 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0263632 |
| RAN | RAN, member RAS oncogene family | 0.0263434 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0261832 |
| PFDN2 | prefoldin subunit 2 | 0.0260486 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0259986 |
| RPLP1 | ribosomal protein, large, P1 | 0.0259294 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0259026 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0258999 |
| GPATCH2L | G patch domain containing 2-like | 0.0258709 |
| TPI1 | triosephosphate isomerase 1 | 0.0257217 |
| IER3 | immediate early response 3 | 0.0256845 |
| FOSL1 | FOS-like antigen 1 | 0.0256431 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | 0.0254937 |
| S100A6 | S100 calcium binding protein A6 | 0.0253713 |
| FOXO3 | forkhead box O3 | 0.0252296 |
| HLA-B | major histocompatibility complex, class I, B | 0.0251375 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0250626 |
| FNIP1 | folliculin interacting protein 1 | 0.0248097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115737 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0910137 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0741862 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0679831 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0670264 |
| IGF2 | insulin-like growth factor 2 | -0.0587426 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0568277 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0527244 |
| BICC1 | BicC family RNA binding protein 1 | -0.0488705 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0484271 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0471763 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.046908 |
| PYGL | phosphorylase, glycogen, liver | -0.0430162 |
| CALU | calumenin | -0.0426213 |
| EFNA5 | ephrin-A5 | -0.0409358 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0407247 |
| JUN | jun proto-oncogene | -0.0401343 |
| YME1L1 | YME1-like 1 ATPase | -0.0398843 |
| NHSL1 | NHS-like 1 | -0.0394981 |
| GLIS3 | GLIS family zinc finger 3 | -0.0393362 |
| VIM | vimentin | -0.0390386 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.038997 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0383255 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0377522 |
| NEBL | nebulette | -0.0376451 |
| TPD52 | tumor protein D52 | -0.036846 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.036287 |
| COPA | coatomer protein complex, subunit alpha | -0.0361107 |
| FGB | fibrinogen beta chain | -0.0359191 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0350349 |
| PDE8A | phosphodiesterase 8A | -0.0344924 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0341904 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0337338 |
| VMP1 | vacuole membrane protein 1 | -0.0325191 |
| MT1X | metallothionein 1X | -0.0324118 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0313501 |
| PRR16 | proline rich 16 | -0.0308783 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0306893 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0306327 |
| COG5 | component of oligomeric golgi complex 5 | -0.0304649 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0290356 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0287941 |
| EHBP1 | EH domain binding protein 1 | -0.0285795 |
| MKI67 | marker of proliferation Ki-67 | -0.0281121 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0279084 |
| GLG1 | golgi glycoprotein 1 | -0.0272256 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0268326 |
| RTN4 | reticulon 4 | -0.0264989 |
| UTRN | utrophin | -0.0263408 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0261588 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0258344 |
| ZNF292 | zinc finger protein 292 | -0.0257895 |
| TMEM131 | transmembrane protein 131 | -0.0254733 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0252182 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.024837 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.024749 |
| ASPH | aspartate beta-hydroxylase | -0.0247473 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0247118 |
| APP | amyloid beta (A4) precursor protein | -0.0246189 |
| GOLT1B | golgi transport 1B | -0.0242989 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0242549 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.024237 |
| OSMR | oncostatin M receptor | -0.0240513 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0239084 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0237946 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0233718 |
| QKI | QKI, KH domain containing, RNA binding | -0.0233576 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0232699 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0230676 |
| CNKSR3 | CNKSR family member 3 | -0.0230004 |
| SEC24D | SEC24 family member D | -0.0229944 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0227279 |
| ACTN1 | actinin, alpha 1 | -0.0226691 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0225385 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.022282 |
| RPS2 | ribosomal protein S2 | -0.0221875 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0219263 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0218995 |
| SEC24A | SEC24 family member A | -0.0218348 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0218128 |
| GNAS | GNAS complex locus | -0.0217446 |
| EGR1 | early growth response 1 | -0.0214338 |
| CHN1 | chimerin 1 | -0.0214308 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0210688 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0208463 |
| NFIA | nuclear factor I/A | -0.0207063 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | -0.0206286 |
| FBXO11 | F-box protein 11 | -0.0206115 |
| BMP5 | bone morphogenetic protein 5 | -0.0203493 |
| UBE4B | ubiquitination factor E4B | -0.020329 |
| FGA | fibrinogen alpha chain | -0.0200125 |
| FAM168A | family with sequence similarity 168, member A | -0.019999 |
| EPC1 | enhancer of polycomb homolog 1 (Drosophila) | -0.0199925 |
| NEGR1 | neuronal growth regulator 1 | -0.0196853 |
| TMED10 | transmembrane emp24-like trafficking protein 10 (yeast) | -0.0196482 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0196416 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.0195928 |
| RPN2 | ribophorin II | -0.019517 |
| TMEM123 | transmembrane protein 123 | -0.0195151 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0194849 |
