| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Homoharringtonine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Homoharringtonine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.17132 |
| EGR1 | early growth response 1 | 0.163015 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.14605 |
| HDAC9 | histone deacetylase 9 | 0.14284 |
| LMO7 | LIM domain 7 | 0.133235 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.12947 |
| SQSTM1 | sequestosome 1 | 0.120233 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.114112 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.11398 |
| JUN | jun proto-oncogene | 0.11151 |
| KYNU | kynureninase | 0.108387 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.104106 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0997319 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0904147 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0864563 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.084024 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0812283 |
| SMAD3 | SMAD family member 3 | 0.0777713 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0771916 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0743642 |
| KLF6 | Kruppel-like factor 6 | 0.074107 |
| KRT17 | keratin 17, type I | 0.0711539 |
| MCL1 | myeloid cell leukemia 1 | 0.0680016 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0679561 |
| KLF10 | Kruppel-like factor 10 | 0.0678867 |
| EZR | ezrin | 0.0676697 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.066645 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0664448 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0645436 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.063703 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0631841 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0619873 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.061616 |
| TSC22D2 | TSC22 domain family, member 2 | 0.061023 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0607403 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0605801 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0597271 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0570143 |
| LMNA | lamin A/C | 0.0564574 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0563221 |
| RASAL2 | RAS protein activator like 2 | 0.0557825 |
| NF1 | neurofibromin 1 | 0.0555176 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0550094 |
| RIGI | RNA sensor RIG-I | 0.054488 |
| HOMER1 | homer scaffolding protein 1 | 0.05426 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.05371 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0529244 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0523218 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0515243 |
| PRKCA | protein kinase C, alpha | 0.0514443 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0502859 |
| AHI1 | Abelson helper integration site 1 | 0.0497282 |
| H3-3B | H3.3 histone B | 0.0492369 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0490596 |
| DTNA | dystrobrevin, alpha | 0.048989 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0473446 |
| DSPP | dentin sialophosphoprotein | 0.0452339 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0448815 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0446667 |
| GOLGB1 | golgin B1 | 0.0444734 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0440302 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0433928 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.043019 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0422032 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0418671 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0418229 |
| AOPEP | aminopeptidase O (putative) | 0.0416659 |
| DUSP4 | dual specificity phosphatase 4 | 0.0404116 |
| CEP350 | centrosomal protein 350kDa | 0.0403926 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0403617 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0397771 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0397153 |
| STC2 | stanniocalcin 2 | 0.0393396 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0392927 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0383757 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.038195 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.038105 |
| ADM | adrenomedullin | 0.0379573 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0379508 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0378947 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.037704 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0376208 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0371701 |
| RPL31 | ribosomal protein L31 | 0.0371674 |
| LYST | lysosomal trafficking regulator | 0.0371222 |
| MED13 | mediator complex subunit 13 | 0.0369248 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0364871 |
| EGFR | epidermal growth factor receptor | 0.0363794 |
| PDLIM5 | PDZ and LIM domain 5 | 0.036317 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0361413 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | 0.0359436 |
| GPC5 | glypican 5 | 0.0356745 |
| BRD2 | bromodomain containing 2 | 0.0355906 |
| FAT1 | FAT atypical cadherin 1 | 0.0353635 |
| RPS6 | ribosomal protein S6 | 0.0351931 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0348477 |
| RPS13 | ribosomal protein S13 | 0.0348469 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.034655 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0341705 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0341056 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.121273 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0991963 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0917413 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0913174 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0912082 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0855065 |
| VIM | vimentin | -0.0842849 |
| MYO1E | myosin IE | -0.0738801 |
| LAMB3 | laminin, beta 3 | -0.0738033 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0677385 |
| INHBA | inhibin, beta A | -0.0663523 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.062148 |
| ATOSA | atos homolog A | -0.0617452 |
| GLIS3 | GLIS family zinc finger 3 | -0.0598004 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0593304 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0581118 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.056879 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0562757 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0550471 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0535603 |
| VCL | vinculin | -0.0523707 |
| ANTXR2 | anthrax toxin receptor 2 | -0.050472 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0488551 |
| RBM47 | RNA binding motif protein 47 | -0.0483119 |
| FBXO11 | F-box protein 11 | -0.0481826 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | -0.0477818 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.04716 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0471145 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0468218 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.04639 |
| CD44 | CD44 molecule (Indian blood group) | -0.0456636 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0456087 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0449089 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0447656 |
| RRBP1 | ribosome binding protein 1 | -0.0444589 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0440136 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.043546 |
| STC1 | stanniocalcin 1 | -0.0432321 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.043031 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0427963 |
| SDC4 | syndecan 4 | -0.0427761 |
| MMP1 | matrix metallopeptidase 1 | -0.0425089 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.042359 |
| TMEM87A | transmembrane protein 87A | -0.042191 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0412697 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0411537 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0411237 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0407534 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.040695 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0406088 |
| OXSR1 | oxidative stress responsive 1 | -0.0405291 |
| RTN4 | reticulon 4 | -0.0404248 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0404022 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0391113 |
| SNX14 | sorting nexin 14 | -0.0388875 |
| TNPO1 | transportin 1 | -0.0388769 |
| OSMR | oncostatin M receptor | -0.0388612 |
| NDRG1 | N-myc downstream regulated 1 | -0.0388306 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0386734 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0385544 |
| POTEF | POTE ankyrin domain family, member F | -0.038386 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0380655 |
| STK4 | serine/threonine kinase 4 | -0.0380358 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0373397 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0368946 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0368327 |
| SEPTIN10 | septin 10 | -0.0367828 |
| CCNI | cyclin I | -0.0367319 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0366319 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0364381 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0362498 |
| EHBP1 | EH domain binding protein 1 | -0.0362466 |
| SMYD3 | SET and MYND domain containing 3 | -0.0362184 |
| CDC73 | cell division cycle 73 | -0.0362004 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0361937 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.036034 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0358256 |
| MEF2A | myocyte enhancer factor 2A | -0.035744 |
| B2M | beta-2-microglobulin | -0.0355293 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0353674 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0352954 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.0352061 |
| IGF2 | insulin-like growth factor 2 | -0.0351739 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0350752 |
| TJP1 | tight junction protein 1 | -0.034933 |
| CFDP1 | craniofacial development protein 1 | -0.0348907 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0339671 |
| PARD3 | par-3 family cell polarity regulator | -0.0337157 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0336999 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0335372 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.033495 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0334655 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0334444 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0333344 |
| COPA | coatomer protein complex, subunit alpha | -0.0331561 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0331487 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0331024 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0328679 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0328413 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0324928 |
