Homoharringtonine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Homoharringtonine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Homoharringtonine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BIRC3 baculoviral IAP repeat containing 3 0.0814154
EZR ezrin 0.0704725
TXNIP thioredoxin interacting protein 0.0621592
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0500927
SQSTM1 sequestosome 1 0.0476168
KLF10 Kruppel-like factor 10 0.0452099
JUN jun proto-oncogene 0.0438092
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0402822
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0393179
PLK2 polo-like kinase 2 0.0387898
NOCT nocturnin 0.0373586
PRRC2C proline-rich coiled-coil 2C 0.0345125
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0327569
GPC5 glypican 5 0.0307842
BRD2 bromodomain containing 2 0.0300654
ANXA2 annexin A2 0.0286325
GADD45B growth arrest and DNA-damage-inducible, beta 0.0274205
KDM6B lysine (K)-specific demethylase 6B 0.0251399
SAMD4A sterile alpha motif domain containing 4A 0.0251154
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0246584
SFPQ splicing factor proline/glutamine-rich 0.0241597
RTN4 reticulon 4 0.0238785
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0231298
GADD45A growth arrest and DNA-damage-inducible, alpha 0.022967
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0225023
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.022205
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0219414
RSRC2 arginine/serine-rich coiled-coil 2 0.0215305
ZC3H7B zinc finger CCCH-type containing 7B 0.0211491
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0204191
TSC22D2 TSC22 domain family, member 2 0.0196874
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.0191201
ARRDC3 arrestin domain containing 3 0.0189206
OGA O-GlcNAcase 0.0187991
SGMS2 sphingomyelin synthase 2 0.0187471
FLNA filamin A, alpha 0.0173553
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171069
EGR1 early growth response 1 0.0168936
GPATCH2L G patch domain containing 2-like 0.0162931
KMT2E lysine (K)-specific methyltransferase 2E 0.0162781
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0160922
CXCL8 chemokine (C-X-C motif) ligand 8 0.0160813
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0160682
EIF5 eukaryotic translation initiation factor 5 0.0160109
ZBTB10 zinc finger and BTB domain containing 10 0.0158932
IL6ST interleukin 6 signal transducer 0.0158752
FOXN2 forkhead box N2 0.0157679
MCL1 myeloid cell leukemia 1 0.0157324
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0155112
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0152737
CSF1 colony stimulating factor 1 (macrophage) 0.015173
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0151094
KLF2 Kruppel-like factor 2 0.0145853
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) 0.0144454
AFF4 AF4/FMR2 family, member 4 0.0141054
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0140271
FOSL1 FOS-like antigen 1 0.0138873
RANBP2 RAN binding protein 2 0.0138426
MED13 mediator complex subunit 13 0.0136715
GATA6 GATA binding protein 6 0.0136669
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0135817
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0131624
DAAM1 dishevelled associated activator of morphogenesis 1 0.0129433
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0129233
ZC3H11A zinc finger CCCH-type containing 11A 0.0128762
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.0127871
EP300 E1A binding protein p300 0.0126887
RASAL2 RAS protein activator like 2 0.0126667
TUT7 terminal uridylyl transferase 7 0.0126292
BIRC2 baculoviral IAP repeat containing 2 0.0125157
RHOB ras homolog family member B 0.0124778
TASOR2 transcription activation suppressor family member 2 0.0124473
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0121359
AHNAK AHNAK nucleoprotein 0.011883
H3-3B H3.3 histone B 0.0118599
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0117743
RBMS2 RNA binding motif, single stranded interacting protein 2 0.011774
ZBTB21 zinc finger and BTB domain containing 21 0.0117422
FOXO3 forkhead box O3 0.0117384
GLS2 glutaminase 2 (liver, mitochondrial) 0.0117077
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0116815
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0116146
MIDEAS mitotic deacetylase associated SANT domain protein 0.0115299
AZIN1 antizyme inhibitor 1 0.0114732
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0113617
HMGA1 high mobility group AT-hook 1 0.0111926
TUFT1 tuftelin 1 0.0111141
TMEM41B transmembrane protein 41B 0.0111048
S100A11 S100 calcium binding protein A11 0.0110576
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0110385
ELOVL5 ELOVL fatty acid elongase 5 0.0109456
DSCAM Down syndrome cell adhesion molecule 0.0109369
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0107548
NABP1 nucleic acid binding protein 1 0.0107052
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0106949
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0106694
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0105194
RYK receptor-like tyrosine kinase 0.0101078
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 0.0100755
GPATCH4 G patch domain containing 4 0.0100695

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.231996
PTMA prothymosin, alpha -0.209959
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18891
PDE4D phosphodiesterase 4D, cAMP-specific -0.170281
VCL vinculin -0.143199
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.139656
FOXP1 forkhead box P1 -0.133615
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.131007
NBEA neurobeachin -0.113203
HDAC9 histone deacetylase 9 -0.107398
SOX6 SRY (sex determining region Y)-box 6 -0.100081
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0997285
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0993435
PKM pyruvate kinase, muscle -0.0975274
DLG1 discs, large homolog 1 (Drosophila) -0.0898955
ADAM10 ADAM metallopeptidase domain 10 -0.0868584
TJP1 tight junction protein 1 -0.0868353
CPED1 cadherin-like and PC-esterase domain containing 1 -0.08571
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0821682
BMP10 bone morphogenetic protein 10 -0.081125
SSBP2 single-stranded DNA binding protein 2 -0.074549
NPAS2 neuronal PAS domain protein 2 -0.0733374
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0684237
EFNA5 ephrin-A5 -0.0672271
SMYD3 SET and MYND domain containing 3 -0.0669426
TPT1 tumor protein, translationally-controlled 1 -0.0652098
GLI3 GLI family zinc finger 3 -0.0639581
PRELID2 PRELI domain containing 2 -0.0635026
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.059824
EGFR epidermal growth factor receptor -0.0560221
RPS6 ribosomal protein S6 -0.0555907
ZMYND8 zinc finger, MYND-type containing 8 -0.0552702
NFIA nuclear factor I/A -0.0538351
TMSB4X thymosin beta 4, X-linked -0.0535803
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0532547
MKI67 marker of proliferation Ki-67 -0.052716
TTC28 tetratricopeptide repeat domain 28 -0.0517928
EVI5 ecotropic viral integration site 5 -0.0516107
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0514698
ZEB1 zinc finger E-box binding homeobox 1 -0.0506929
MYO5C myosin VC -0.0504833
CCND1 cyclin D1 -0.0503122
CAMKMT calmodulin-lysine N-methyltransferase -0.0489668
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0482042
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0480236
PDGFC platelet derived growth factor C -0.0476383
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0471995
LPP LIM domain containing preferred translocation partner in lipoma -0.0457377
TMEM65 transmembrane protein 65 -0.044698
GSE1 Gse1 coiled-coil protein -0.0442389
SBF2 SET binding factor 2 -0.0428293
STAT1 signal transducer and activator of transcription 1, 91kDa -0.042195
FLNB filamin B, beta -0.0419436
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0411402
DPYD dihydropyrimidine dehydrogenase -0.0410894
TAS2R14 taste receptor, type 2, member 14 -0.0410158
PYGB phosphorylase, glycogen; brain -0.0409059
GLI2 GLI family zinc finger 2 -0.0406107
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0401054
ZNF438 zinc finger protein 438 -0.0390289
PRUNE2 prune homolog 2 (Drosophila) -0.0379715
BMP2K BMP2 inducible kinase -0.0379389
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0374782
ZBTB20 zinc finger and BTB domain containing 20 -0.0369453
RPS8 ribosomal protein S8 -0.0362647
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0356246
LOXL3 lysyl oxidase-like 3 -0.0354169
FHIT fragile histidine triad -0.0353979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0353906
TRERF1 transcriptional regulating factor 1 -0.0352564
RPLP1 ribosomal protein, large, P1 -0.0351413
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0350768
TCF12 transcription factor 12 -0.0349653
DIAPH2 diaphanous-related formin 2 -0.0345546
MACROD2 MACRO domain containing 2 -0.0339749
NAV2 neuron navigator 2 -0.0337592
CENPF centromere protein F, 350/400kDa -0.0336474
ENO1 enolase 1, (alpha) -0.0330859
RPL34 ribosomal protein L34 -0.0330136
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0327523
SDK1 sidekick cell adhesion molecule 1 -0.0325818
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0322634
UNC13A unc-13 homolog A (C. elegans) -0.0322129
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0321657
RPLP0 ribosomal protein, large, P0 -0.0319519
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0315841
DOCK3 dedicator of cytokinesis 3 -0.0311659
MBNL1 muscleblind-like splicing regulator 1 -0.0310633
LDHA lactate dehydrogenase A -0.0309041
GNAS GNAS complex locus -0.0309028
RAD51B RAD51 paralog B -0.0307307
PTPRG protein tyrosine phosphatase, receptor type, G -0.0304955
TGFBR3 transforming growth factor, beta receptor III -0.0304928
CUX1 cut-like homeobox 1 -0.0303479
RPL35A ribosomal protein L35a -0.0303371
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0300007
KPNB1 karyopherin (importin) beta 1 -0.0299475
HEG1 heart development protein with EGF-like domains 1 -0.029674
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0296605
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0294712