Homoharringtonine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Homoharringtonine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Homoharringtonine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.188751
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.16613
AKAP12 A kinase (PRKA) anchor protein 12 0.159604
MYH9 myosin, heavy chain 9, non-muscle 0.110805
TRIO trio Rho guanine nucleotide exchange factor 0.109509
ADM adrenomedullin 0.0766879
ERRFI1 ERBB receptor feedback inhibitor 1 0.0757705
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0727335
ZBTB38 zinc finger and BTB domain containing 38 0.0725059
PGK1 phosphoglycerate kinase 1 0.0720984
PLIN2 perilipin 2 0.0716377
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0681461
NAV3 neuron navigator 3 0.0635483
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0617166
RND3 Rho family GTPase 3 0.0606921
HMGA2 high mobility group AT-hook 2 0.0587929
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0587599
NAV2 neuron navigator 2 0.057567
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0567826
BIRC3 baculoviral IAP repeat containing 3 0.0553833
CDCP1 CUB domain containing protein 1 0.0537799
CDH13 cadherin 13 0.0525753
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0520774
CD44 CD44 molecule (Indian blood group) 0.0517959
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0506539
ENO1 enolase 1, (alpha) 0.0505198
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0487183
FRMD6 FERM domain containing 6 0.046186
TXNRD1 thioredoxin reductase 1 0.0461
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0459491
AHNAK AHNAK nucleoprotein 0.0453404
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.0448997
AMPD3 adenosine monophosphate deaminase 3 0.0441772
ADAMTSL1 ADAMTS-like 1 0.0431565
FOSL1 FOS-like antigen 1 0.043105
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0422983
MSN moesin 0.0422883
FAT1 FAT atypical cadherin 1 0.0402891
BTG1 B-cell translocation gene 1, anti-proliferative 0.0401953
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0394954
STC1 stanniocalcin 1 0.0381235
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0376905
MACF1 microtubule-actin crosslinking factor 1 0.0370638
TXNIP thioredoxin interacting protein 0.0367585
BASP1 brain abundant, membrane attached signal protein 1 0.0351571
ARL4C ADP-ribosylation factor-like 4C 0.0351343
IL6ST interleukin 6 signal transducer 0.0345896
ZC3H12C zinc finger CCCH-type containing 12C 0.034237
COL12A1 collagen, type XII, alpha 1 0.0332179
CEP250 centrosomal protein 250kDa 0.032352
INHBA inhibin, beta A 0.0322463
NRXN3 neurexin 3 0.0319804
MCL1 myeloid cell leukemia 1 0.0316739
ANGPTL4 angiopoietin-like 4 0.0315863
DIO2 deiodinase, iodothyronine, type II 0.0315796
ZC3H11D zinc finger CCCH-type containing 11D 0.0315445
MARCHF1 membrane associated ring-CH-type finger 1 0.0312765
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0310956
NDRG1 N-myc downstream regulated 1 0.0305262
CD83 CD83 molecule 0.0302893
SAMD3 sterile alpha motif domain containing 3 0.0295752
DST dystonin 0.0292111
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0291723
TBC1D19 TBC1 domain family, member 19 0.0290054
AFF3 AF4/FMR2 family, member 3 0.0285806
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281118
PCLO piccolo presynaptic cytomatrix protein 0.0278603
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0270477
OGFRL1 opioid growth factor receptor-like 1 0.0268698
PTK2 protein tyrosine kinase 2 0.0265845
SAMD9 sterile alpha motif domain containing 9 0.0263347
MYO10 myosin X 0.0261459
TNIP1 TNFAIP3 interacting protein 1 0.0254471
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0252268
CREB5 cAMP responsive element binding protein 5 0.0249739
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0249067
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0246832
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0246524
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0246059
RAI14 retinoic acid induced 14 0.0244128
CLMP CXADR-like membrane protein 0.0238904
VEGFA vascular endothelial growth factor A 0.0237222
LDHA lactate dehydrogenase A 0.0236932
NT5E 5'-nucleotidase, ecto (CD73) 0.0235058
TMSB4X thymosin beta 4, X-linked 0.0232403
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0230439
ZBTB10 zinc finger and BTB domain containing 10 0.0228982
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0222483
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0222132
ASPH aspartate beta-hydroxylase 0.0222029
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0218518
FMNL2 formin-like 2 0.0217319
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0214685
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0211555
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.0209405
TUSC3 tumor suppressor candidate 3 0.0207772
CDK6 cyclin-dependent kinase 6 0.0207231
SERTAD2 SERTA domain containing 2 0.0204849
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0203852
CSF1 colony stimulating factor 1 (macrophage) 0.0202326

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.145392
MT2A metallothionein 2A -0.133568
FRMD4A FERM domain containing 4A -0.124898
FN1 fibronectin 1 -0.111177
VCL vinculin -0.10918
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.100061
EGR1 early growth response 1 -0.0926469
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0878911
HLA-B major histocompatibility complex, class I, B -0.0861228
IER2 immediate early response 2 -0.0762067
VIM vimentin -0.0743988
COL6A3 collagen, type VI, alpha 3 -0.0723972
MKI67 marker of proliferation Ki-67 -0.066594
CADM1 cell adhesion molecule 1 -0.0659494
GOLGA4 golgin A4 -0.0649429
UGCG UDP-glucose ceramide glucosyltransferase -0.0640527
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.060074
CCNL1 cyclin L1 -0.0596685
MT1G metallothionein 1G -0.0590584
VCAN versican -0.0577614
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.056605
GADD45B growth arrest and DNA-damage-inducible, beta -0.0542416
FNDC3B fibronectin type III domain containing 3B -0.0536609
RBM39 RNA binding motif protein 39 -0.0534055
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0525746
CENPF centromere protein F, 350/400kDa -0.0525521
BICC1 BicC family RNA binding protein 1 -0.0517562
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0505405
PDE10A phosphodiesterase 10A -0.0492645
EXT1 exostosin glycosyltransferase 1 -0.0476656
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0465487
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0463287
TPT1 tumor protein, translationally-controlled 1 -0.0438687
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.043783
MYOF myoferlin -0.0423244
PTMA prothymosin, alpha -0.0411514
SMC4 structural maintenance of chromosomes 4 -0.0408509
VMP1 vacuole membrane protein 1 -0.0399224
LOC102724023 ES1 protein homolog, mitochondrial -0.0395878
DLG1 discs, large homolog 1 (Drosophila) -0.0390201
SMAD3 SMAD family member 3 -0.0389077
GNAS GNAS complex locus -0.0387404
IER3 immediate early response 3 -0.0385981
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0380078
TNS3 tensin 3 -0.0376594
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.03733
CTSD cathepsin D -0.0371552
TOP1 topoisomerase (DNA) I -0.0357275
RSRC2 arginine/serine-rich coiled-coil 2 -0.0349491
FTH1 ferritin, heavy polypeptide 1 -0.0348433
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0327889
MORF4L2 mortality factor 4 like 2 -0.0321921
SLC38A2 solute carrier family 38, member 2 -0.0318465
SBF2 SET binding factor 2 -0.0315215
TENT5A terminal nucleotidyltransferase 5A -0.0313429
DIAPH2 diaphanous-related formin 2 -0.0311627
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0303707
SFTPA2 surfactant protein A2 -0.0300052
SPAG9 sperm associated antigen 9 -0.0297413
SOD2 superoxide dismutase 2, mitochondrial -0.0291853
KMT2C lysine (K)-specific methyltransferase 2C -0.0285149
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0283973
IRF1 interferon regulatory factor 1 -0.0283405
KIF4A kinesin family member 4A -0.0283093
COL1A2 collagen, type I, alpha 2 -0.0279377
RPS6 ribosomal protein S6 -0.0277512
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276418
KMT2E lysine (K)-specific methyltransferase 2E -0.0275849
DIAPH3 diaphanous-related formin 3 -0.027241
IGFBP3 insulin-like growth factor binding protein 3 -0.0272008
UBC ubiquitin C -0.0270232
COPA coatomer protein complex, subunit alpha -0.0267748
JUN jun proto-oncogene -0.0263874
RPS24 ribosomal protein S24 -0.0259622
KLF10 Kruppel-like factor 10 -0.0259602
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0254881
SYNE1 spectrin repeat containing, nuclear envelope 1 -0.0252804
LRRC7 leucine rich repeat containing 7 -0.0252145
TPX2 TPX2, microtubule-associated -0.0251569
ACTG1 actin gamma 1 -0.0251023
SETD5 SET domain containing 5 -0.0250817
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0250635
CREBRF CREB3 regulatory factor -0.0249678
COL8A1 collagen, type VIII, alpha 1 -0.0249561
ZMIZ1 zinc finger, MIZ-type containing 1 -0.024833
EPAS1 endothelial PAS domain protein 1 -0.0247744
FTL ferritin, light polypeptide -0.0246963
THOC2 THO complex 2 -0.0246163
PRRC2C proline-rich coiled-coil 2C -0.0245253
CENPE centromere protein E, 312kDa -0.0244449
NT5C2 5'-nucleotidase, cytosolic II -0.0243299
SMYD3 SET and MYND domain containing 3 -0.0242983
RTN4 reticulon 4 -0.0241836
MATR3 matrin 3 -0.024069
ASXL1 additional sex combs like transcriptional regulator 1 -0.0240596
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0240316
WAC WW domain containing adaptor with coiled-coil -0.0237464
NXN nucleoredoxin -0.0234997
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0234791
GPBP1 GC-rich promoter binding protein 1 -0.0234357