Human papillomavirus infection Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation. (Kyoto Encyclopedia of Genes and Genomes, hsa05165)
External Link https://www.kegg.jp/entry/hsa05165
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Genes

328 proteins participating in the Human papillomavirus infection pathway from the KEGG Pathways 2026 dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATM ATM serine/threonine kinase
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
AXIN1 axin 1
AXIN2 axin 2
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCAP31 B-cell receptor-associated protein 31
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCNA1 cyclin A1
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CDC42 cell division cycle 42
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDPF1 cysteine-rich, DPF motif domain containing 1
CHAD chondroadherin
CHD4 chromodomain helicase DNA binding protein 4
CHUK conserved helix-loop-helix ubiquitous kinase
CLSTN1 calsyntenin 1
CNKSR3 CNKSR family member 3
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL6A5 collagen, type VI, alpha 5
COL6A6 collagen, type VI, alpha 6
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CRB3 crumbs family member 3
CREB1 cAMP responsive element binding protein 1
CREB3L1 cAMP responsive element binding protein 3-like 1
CREB3L2 cAMP responsive element binding protein 3-like 2
CREB3L3 cAMP responsive element binding protein 3-like 3
CREB3L4 cAMP responsive element binding protein 3-like 4
CREB5 cAMP responsive element binding protein 5
CREBBP CREB binding protein
CSNK1A1 casein kinase 1, alpha 1
CSNK1A1L casein kinase 1, alpha 1-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXXC1 CXXC finger protein 1
DLG1 discs, large homolog 1 (Drosophila)
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
E2F1 E2F transcription factor 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EP300 E1A binding protein p300
FADD Fas (TNFRSF6)-associated via death domain
FASLG Fas ligand (TNF superfamily, member 6)
FASN fatty acid synthase
FN1 fibronectin 1
FOXO1 forkhead box O1
FZD1 frizzled class receptor 1
FZD10 frizzled class receptor 10
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
FZD8 frizzled class receptor 8
FZD9 frizzled class receptor 9
GNAS GNAS complex locus
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HES2 hes family bHLH transcription factor 2
HES3 hes family bHLH transcription factor 3
HES4 hes family bHLH transcription factor 4
HES5 hes family bHLH transcription factor 5
HES6 hes family bHLH transcription factor 6
HES7 hes family bHLH transcription factor 7
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HRAS Harvey rat sarcoma viral oncogene homolog
IBSP integrin-binding sialoprotein
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
ITGA1 integrin, alpha 1
ITGA10 integrin, alpha 10
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
ITGB7 integrin, beta 7
ITGB8 integrin, beta 8
JAG1 jagged 1
JAK1 Janus kinase 1
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMB3 laminin, beta 3
LAMB4 laminin, beta 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LAMC3 laminin, gamma 3
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LMNB2 lamin B2
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724023 ES1 protein homolog, mitochondrial
MAML1 mastermind-like 1 (Drosophila)
MAML2 mastermind-like 2 (Drosophila)
MAML3 mastermind-like 3 (Drosophila)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFX1 nuclear transcription factor, X-box binding 1
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
OASL 2'-5'-oligoadenylate synthetase-like
PALS1 protein associated with LIN7 1, MAGUK p55 family member
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PATJ PATJ crumbs cell polarity complex component
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKM pyruvate kinase, muscle
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PPP2R2D protein phosphatase 2, regulatory subunit B, delta
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PSEN1 presenilin 1
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PTEN phosphatase and tensin homolog
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PXDN peroxidasin
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHEB Ras homolog enriched in brain
RNASE3 ribonuclease, RNase A family, 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCRIB scribbled planar cell polarity protein
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
TADA3 transcriptional adaptor 3
TBK1 TANK-binding kinase 1
TBP TATA box binding protein
TBPL1 TBP-like 1
TBPL2 TATA box binding protein like 2
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERT telomerase reverse transcriptase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS3 thrombospondin 3
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TLR3 toll-like receptor 3
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNN tenascin N
TNNC1 troponin C type 1 (slow)
TNR tenascin R
TNXB tenascin XB
TP53 tumor protein p53
TRADD TNFRSF1A-associated via death domain
TRAF3 TNF receptor-associated factor 3
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TUBG1 tubulin, gamma 1
TUBG2 tubulin, gamma 2
TYK2 tyrosine kinase 2
UBE3A ubiquitin protein ligase E3A
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VEGFA vascular endothelial growth factor A
VTN vitronectin
VWF von Willebrand factor
WNT1 wingless-type MMTV integration site family, member 1
WNT10A wingless-type MMTV integration site family, member 10A
WNT10B wingless-type MMTV integration site family, member 10B
WNT11 wingless-type MMTV integration site family, member 11
WNT16 wingless-type MMTV integration site family, member 16
WNT2 wingless-type MMTV integration site family member 2
WNT2B wingless-type MMTV integration site family, member 2B
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A
WNT5B wingless-type MMTV integration site family, member 5B
WNT6 wingless-type MMTV integration site family, member 6
WNT7A wingless-type MMTV integration site family, member 7A
WNT7B wingless-type MMTV integration site family, member 7B
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
WNT9A wingless-type MMTV integration site family, member 9A
WNT9B wingless-type MMTV integration site family, member 9B