Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE5786 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE5786
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Genes

600 genes differentially expressed during Huntington's Disease_CNS - Brain - Striatum (MMHCC)_GSE5786 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
SYNGR3 synaptogyrin 3 4.70948
GPATCH8 G patch domain containing 8 4.28918
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 4.16193
ADRM1 adhesion regulating molecule 1 4.06234
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 3.65236
FAM192A family with sequence similarity 192, member A 3.4873
PEA15 phosphoprotein enriched in astrocytes 15 3.34224
RTN3 reticulon 3 3.34004
TSPAN13 tetraspanin 13 3.20291
RAB28 RAB28, member RAS oncogene family 3.1732
GTF2H5 general transcription factor IIH, polypeptide 5 3.12574
MFAP1 microfibrillar-associated protein 1 2.89957
SIRPA signal-regulatory protein alpha 2.77917
PLXNA2 plexin A2 2.76533
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 2.75536
TFR2 transferrin receptor 2 2.73106
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 2.72686
RBBP7 retinoblastoma binding protein 7 2.68047
THOC2 THO complex 2 2.68042
CHKA choline kinase alpha 2.52604
BAIAP2 BAI1-associated protein 2 2.51674
WDR7 WD repeat domain 7 2.44756
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.44588
CCNL1 cyclin L1 2.37875
PIAS1 protein inhibitor of activated STAT, 1 2.34473
CSNK2A1 casein kinase 2, alpha 1 polypeptide 2.33666
BAG4 BCL2-associated athanogene 4 2.33526
TULP4 tubby like protein 4 2.32059
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 2.32004
SLC35F3 solute carrier family 35, member F3 2.29864
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.29227
SRPX sushi-repeat containing protein, X-linked 2.29133
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.26958
FAM102B family with sequence similarity 102, member B 2.26817
PDE7B phosphodiesterase 7B 2.23561
TROVE2 TROVE domain family, member 2 2.22214
TMEM70 transmembrane protein 70 2.1413
SH3BP1 SH3-domain binding protein 1 2.09
TXLNA taxilin alpha 2.08934
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 2.06429
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 2.05769
THOP1 thimet oligopeptidase 1 2.04079
RBM22 RNA binding motif protein 22 2.03504
PFKP phosphofructokinase, platelet 1.99565
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 1.96787
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 1.96075
KIAA1324 KIAA1324 1.94471
STK24 serine/threonine kinase 24 1.92486
PKNOX1 PBX/knotted 1 homeobox 1 1.89429
SFPQ splicing factor proline/glutamine-rich 1.8488
FBXO33 F-box protein 33 1.83367
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 1.83177
SRRT serrate, RNA effector molecule 1.83171
SMAP2 small ArfGAP2 1.80043
SPRY2 sprouty homolog 2 (Drosophila) 1.79804
SAP30 Sin3A-associated protein, 30kDa 1.79735
SELM selenoprotein M 1.79213
NKX2-8 NK2 homeobox 8 1.78249
SCRG1 stimulator of chondrogenesis 1 1.78124
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.77274
CAPRIN1 cell cycle associated protein 1 1.76151
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.7613
SNX27 sorting nexin family member 27 1.75953
COMMD3-BMI1 COMMD3-BMI1 readthrough 1.75099
ZNF367 zinc finger protein 367 1.74948
MYO5A myosin VA (heavy chain 12, myoxin) 1.74704
HMP19 HMP19 protein 1.7461
ZCCHC24 zinc finger, CCHC domain containing 24 1.74475
ZNF212 zinc finger protein 212 1.74232
RPS9 ribosomal protein S9 1.73049
RIF1 replication timing regulatory factor 1 1.72418
PDLIM4 PDZ and LIM domain 4 1.71568
FRMD6 FERM domain containing 6 1.71466
ZNF536 zinc finger protein 536 1.70721
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 1.69982
EVI5 ecotropic viral integration site 5 1.69416
SGMS1 sphingomyelin synthase 1 1.67438
BOD1 biorientation of chromosomes in cell division 1 1.67327
TXNDC16 thioredoxin domain containing 16 1.67311
M6PR mannose-6-phosphate receptor (cation dependent) 1.66988
HSPH1 heat shock 105kDa/110kDa protein 1 1.66691
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 1.65731
TNPO1 transportin 1 1.64848
MORN4 MORN repeat containing 4 1.63436
PAPD5 PAP associated domain containing 5 1.62787
CDC23 cell division cycle 23 1.61559
LIN7C lin-7 homolog C (C. elegans) 1.61373
TMEM59L transmembrane protein 59-like 1.60966
PHAX phosphorylated adaptor for RNA export 1.60237
BZW1 basic leucine zipper and W2 domains 1 1.60161
CCDC9 coiled-coil domain containing 9 1.58175
AMOTL2 angiomotin like 2 1.57525
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.57525
PHTF1 putative homeodomain transcription factor 1 1.56492
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.55965
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 1.55443
MTRF1L mitochondrial translational release factor 1-like 1.545
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 1.53626
CD79B CD79b molecule, immunoglobulin-associated beta 1.52713
AMD1 adenosylmethionine decarboxylase 1 1.52707
CDH22 cadherin 22, type 2 1.52202
KIAA0368 KIAA0368 1.52111
FAM98B family with sequence similarity 98, member B 1.51997
HDGFRP3 hepatoma-derived growth factor, related protein 3 1.51631
EI24 etoposide induced 2.4 1.51478
TPP1 tripeptidyl peptidase I 1.50466
SERP1 stress-associated endoplasmic reticulum protein 1 1.49603
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.48401
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 1.48222
TLN1 talin 1 1.47728
PHF5A PHD finger protein 5A 1.47284
UFL1 UFM1-specific ligase 1 1.47259
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 1.47111
ZFYVE21 zinc finger, FYVE domain containing 21 1.47001
SNX3 sorting nexin 3 1.46392
SFXN1 sideroflexin 1 1.46235
PTP4A1 protein tyrosine phosphatase type IVA, member 1 1.45388
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 1.43832
PIAS2 protein inhibitor of activated STAT, 2 1.43703
PTGES3 prostaglandin E synthase 3 (cytosolic) 1.43464
RPL18 ribosomal protein L18 1.43228
CDHR1 cadherin-related family member 1 1.42512
LMAN2L lectin, mannose-binding 2-like 1.41431
C18ORF21 chromosome 18 open reading frame 21 1.41402
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 1.40796
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 1.40606
MYO18A myosin XVIIIA 1.40538
ADD3 adducin 3 (gamma) 1.39814
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.39347
MTSS1 metastasis suppressor 1 1.37495
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 1.37179
LY6E lymphocyte antigen 6 complex, locus E 1.36304
DEK DEK proto-oncogene 1.36142
ZNF236 zinc finger protein 236 1.35983
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 1.35954
B2M beta-2-microglobulin 1.35937
HIATL1 hippocampus abundant transcript-like 1 1.35732
JAK1 Janus kinase 1 1.35504
RAMP2 receptor (G protein-coupled) activity modifying protein 2 1.35038
MORF4L2 mortality factor 4 like 2 1.34522
ZNF277 zinc finger protein 277 1.3387
LENEP lens epithelial protein 1.33695
FBXO11 F-box protein 11 1.33645
NAP1L1 nucleosome assembly protein 1-like 1 1.33511
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 1.3344
RPL6 ribosomal protein L6 1.33351
TMEM131 transmembrane protein 131 1.33063
MCF2L MCF.2 cell line derived transforming sequence-like 1.32615
RPN2 ribophorin II 1.32101
PRPF39 pre-mRNA processing factor 39 1.31078
ZNF148 zinc finger protein 148 1.29428
ARID1A AT rich interactive domain 1A (SWI-like) 1.29116
TJP1 tight junction protein 1 1.28876
AGTPBP1 ATP/GTP binding protein 1 1.28679
UBA2 ubiquitin-like modifier activating enzyme 2 1.28373
PPP1R3D protein phosphatase 1, regulatory subunit 3D 1.2816
CARM1 coactivator-associated arginine methyltransferase 1 1.2803
RANBP9 RAN binding protein 9 1.27522
HAX1 HCLS1 associated protein X-1 1.27453
SNX25 sorting nexin 25 1.27317
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 1.27315
THOC3 THO complex 3 1.26345
VGF VGF nerve growth factor inducible 1.26029
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.2561
GTF2A2 general transcription factor IIA, 2, 12kDa 1.25525
OAZ1 ornithine decarboxylase antizyme 1 1.25489
C4ORF32 chromosome 4 open reading frame 32 1.25363
PRPF38B pre-mRNA processing factor 38B 1.25222
RBL2 retinoblastoma-like 2 1.25061
ARPP19 cAMP-regulated phosphoprotein, 19kDa 1.24588
EXOC2 exocyst complex component 2 1.24542
TRIM9 tripartite motif containing 9 1.24451
ARCN1 archain 1 1.24105
POR P450 (cytochrome) oxidoreductase 1.24088
LCMT1 leucine carboxyl methyltransferase 1 1.2402
PRKD1 protein kinase D1 1.23774
RHEB Ras homolog enriched in brain 1.23164
TRAPPC8 trafficking protein particle complex 8 1.22803
PQBP1 polyglutamine binding protein 1 1.228
SAR1A secretion associated, Ras related GTPase 1A 1.22646
CCNT2 cyclin T2 1.22222
NPDC1 neural proliferation, differentiation and control, 1 1.21785
COPB1 coatomer protein complex, subunit beta 1 1.21178
DUSP1 dual specificity phosphatase 1 1.21131
KAZN kazrin, periplakin interacting protein 1.20891
HSPB1 heat shock 27kDa protein 1 1.20729
ERI1 exoribonuclease 1 1.20721
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 1.20301
GPX8 glutathione peroxidase 8 (putative) 1.20138
TMEM33 transmembrane protein 33 1.20075
TSPYL4 TSPY-like 4 1.19171
GRAMD1A GRAM domain containing 1A 1.18918
H2AFX H2A histone family, member X 1.18641
RNF40 ring finger protein 40, E3 ubiquitin protein ligase 1.18461
CCDC132 coiled-coil domain containing 132 1.18438
SPAG7 sperm associated antigen 7 1.1821
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 1.17784
PSAT1 phosphoserine aminotransferase 1 1.17636
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 1.17627
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.17437
C16ORF45 chromosome 16 open reading frame 45 1.17055
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 1.16878
PELI2 pellino E3 ubiquitin protein ligase family member 2 1.16854
MCL1 myeloid cell leukemia 1 1.16811
LRRC8C leucine rich repeat containing 8 family, member C 1.16549
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 1.16477
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 1.15825
TSSK3 testis-specific serine kinase 3 1.15542
CLU clusterin 1.15098
PSIP1 PC4 and SFRS1 interacting protein 1 1.147
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 1.14292
INTS8 integrator complex subunit 8 1.14086
PLTP phospholipid transfer protein 1.14065
UBR4 ubiquitin protein ligase E3 component n-recognin 4 1.13573
LAMP2 lysosomal-associated membrane protein 2 1.13211
TMEM248 transmembrane protein 248 1.12957
NRF1 nuclear respiratory factor 1 1.12928
PMM1 phosphomannomutase 1 1.12705
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 1.1246
TCEA1 transcription elongation factor A (SII), 1 1.12312
MSL1 male-specific lethal 1 homolog (Drosophila) 1.1218
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 1.12105
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 1.11605
ZMYM1 zinc finger, MYM-type 1 1.11567
SLIRP SRA stem-loop interacting RNA binding protein 1.11418
SPRYD3 SPRY domain containing 3 1.1139
AUP1 ancient ubiquitous protein 1 1.11372
SH2D5 SH2 domain containing 5 1.11328
DHODH dihydroorotate dehydrogenase (quinone) 1.11319
SOWAHA sosondowah ankyrin repeat domain family member A 1.10916
NUPL1 nucleoporin like 1 1.10828
SSBP3 single stranded DNA binding protein 3 1.10808
FAM8A1 family with sequence similarity 8, member A1 1.10688
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 1.102
DERL2 derlin 2 1.09985
SCOC short coiled-coil protein 1.09912
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 1.09067
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae) 1.09035
XPR1 xenotropic and polytropic retrovirus receptor 1 1.08923
PKP4 plakophilin 4 1.08836
TMEM55A transmembrane protein 55A 1.08796
H2AFZ H2A histone family, member Z 1.08776
SPNS1 spinster homolog 1 (Drosophila) 1.08679
SLC30A5 solute carrier family 30 (zinc transporter), member 5 1.08534
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 1.08215
KLHDC2 kelch domain containing 2 1.08205
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.08049
PTPDC1 protein tyrosine phosphatase domain containing 1 1.08034
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) 1.07337
PSPH phosphoserine phosphatase 1.07185
HEXA hexosaminidase A (alpha polypeptide) 1.07164
SRSF4 serine/arginine-rich splicing factor 4 1.07148
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 1.06805
FUBP1 far upstream element (FUSE) binding protein 1 1.0674
SSRP1 structure specific recognition protein 1 1.06737
CLIP1 CAP-GLY domain containing linker protein 1 1.06546
CANX calnexin 1.06404
ARPP21 cAMP-regulated phosphoprotein, 21kDa 1.06288
PLEKHA5 pleckstrin homology domain containing, family A member 5 1.0609
RAB3IP RAB3A interacting protein 1.05729
BCL2 B-cell CLL/lymphoma 2 1.05421
ELOVL2 ELOVL fatty acid elongase 2 1.05307
TNK2 tyrosine kinase, non-receptor, 2 1.05136
HEPH hephaestin 1.04977
ATG4B autophagy related 4B, cysteine peptidase 1.04094
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 1.04085
NCOR2 nuclear receptor corepressor 2 1.03853
SEPP1 selenoprotein P, plasma, 1 1.03646
MFSD2A major facilitator superfamily domain containing 2A 1.03314
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.02969
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 1.02911
SUCO SUN domain containing ossification factor 1.02777
CLIC4 chloride intracellular channel 4 1.02721
SYNE1 spectrin repeat containing, nuclear envelope 1 1.02616
ZCCHC18 zinc finger, CCHC domain containing 18 1.02135
SCG3 secretogranin III 1.01999
GBA glucosidase, beta, acid 1.01977
RPA1 replication protein A1, 70kDa 1.01924
REM2 RAS (RAD and GEM)-like GTP binding 2 1.01501
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 1.01342
PCBP3 poly(rC) binding protein 3 1.01191
TBC1D10A TBC1 domain family, member 10A 1.00828
LXN latexin 1.00765
SLC19A1 solute carrier family 19 (folate transporter), member 1 1.00761
RBMS3 RNA binding motif, single stranded interacting protein 3 1.00723
PNMAL2 paraneoplastic Ma antigen family-like 2 1.00686
KIAA1143 KIAA1143 1.00536
TMX1 thioredoxin-related transmembrane protein 1 1.0041
GSTP1 glutathione S-transferase pi 1 1.00331
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 1.00298
C1ORF198 chromosome 1 open reading frame 198 1.00213
SDC4 syndecan 4 1.00095
TMEM50A transmembrane protein 50A 1.00094
TTC19 tetratricopeptide repeat domain 19 0.997615
SV2C synaptic vesicle glycoprotein 2C 0.995805
PUM1 pumilio RNA-binding family member 1 0.994503
TMEM64 transmembrane protein 64 0.993202
ETV5 ets variant 5 0.991769
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 0.989994
FAM171B family with sequence similarity 171, member B 0.987203

decreased expression

Symbol Name Standardized Value
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -4.0933
GHITM growth hormone inducible transmembrane protein -4.04731
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -3.80275
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -3.79699
CAND1 cullin-associated and neddylation-dissociated 1 -3.79147
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -3.74989
OMG oligodendrocyte myelin glycoprotein -3.56912
TRIT1 tRNA isopentenyltransferase 1 -3.55656
BSG basigin (Ok blood group) -3.54573
MYEF2 myelin expression factor 2 -3.47198
SCG5 secretogranin V -3.46904
PDCD5 programmed cell death 5 -3.45837
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -3.45074
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -3.30265
TMX2 thioredoxin-related transmembrane protein 2 -3.30139
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -3.30061
PFAS phosphoribosylformylglycinamidine synthase -3.29588
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -3.28307
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.21135
ARGLU1 arginine and glutamate rich 1 -3.20718
UQCRB ubiquinol-cytochrome c reductase binding protein -3.02167
AHCYL1 adenosylhomocysteinase-like 1 -2.95121
TRAP1 TNF receptor-associated protein 1 -2.94313
SYT11 synaptotagmin XI -2.91666
CS citrate synthase -2.80812
TRIM41 tripartite motif containing 41 -2.8032
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit -2.80184
ECI2 enoyl-CoA delta isomerase 2 -2.74277
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.74237
GLUD1 glutamate dehydrogenase 1 -2.71632
C15ORF57 chromosome 15 open reading frame 57 -2.6965
SRR serine racemase -2.67672
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -2.6289
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -2.62064
ARF3 ADP-ribosylation factor 3 -2.58669
SNX24 sorting nexin 24 -2.5595
HIGD2A HIG1 hypoxia inducible domain family, member 2A -2.5471
ECH1 enoyl CoA hydratase 1, peroxisomal -2.54314
KIF3A kinesin family member 3A -2.51355
DCAF11 DDB1 and CUL4 associated factor 11 -2.49084
EVX1 even-skipped homeobox 1 -2.45588
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.4367
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) -2.41827
CYCS cytochrome c, somatic -2.41559
LRRC38 leucine rich repeat containing 38 -2.39873
C1ORF27 chromosome 1 open reading frame 27 -2.39622
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.38908
DYNLT3 dynein, light chain, Tctex-type 3 -2.37462
TMEM87B transmembrane protein 87B -2.36078
LRRTM3 leucine rich repeat transmembrane neuronal 3 -2.34024
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -2.31504
CISD1 CDGSH iron sulfur domain 1 -2.29006
S100A1 S100 calcium binding protein A1 -2.28405
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -2.28044
YDJC YdjC homolog (bacterial) -2.27668
MCEE methylmalonyl CoA epimerase -2.24079
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.20643
DUSP15 dual specificity phosphatase 15 -2.19587
IL2RB interleukin 2 receptor, beta -2.19116
COX5A cytochrome c oxidase subunit Va -2.1895
SUMO2 small ubiquitin-like modifier 2 -2.18562
GUK1 guanylate kinase 1 -2.18505
TRAPPC1 trafficking protein particle complex 1 -2.1356
WASF1 WAS protein family, member 1 -2.12874
TBCA tubulin folding cofactor A -2.12423
SLTM SAFB-like, transcription modulator -2.11616
ZNF414 zinc finger protein 414 -2.11068
RAP1A RAP1A, member of RAS oncogene family -2.0729
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d -2.04723
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -2.04696
DSTN destrin (actin depolymerizing factor) -2.00369
TLR3 toll-like receptor 3 -1.99261
UQCRC2 ubiquinol-cytochrome c reductase core protein II -1.98897
IPO8 importin 8 -1.9854
GLRX2 glutaredoxin 2 -1.96426
EID1 EP300 interacting inhibitor of differentiation 1 -1.95977
ECI1 enoyl-CoA delta isomerase 1 -1.93768
GPR37L1 G protein-coupled receptor 37 like 1 -1.92745
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -1.92622
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa -1.92323
VDAC3 voltage-dependent anion channel 3 -1.92024
LRRC34 leucine rich repeat containing 34 -1.91701
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -1.90192
EBAG9 estrogen receptor binding site associated, antigen, 9 -1.89155
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -1.88263
SYNPR synaptoporin -1.86839
IDE insulin-degrading enzyme -1.86706
RPL10A ribosomal protein L10a -1.85594
DBNL drebrin-like -1.85509
BMP6 bone morphogenetic protein 6 -1.85484
COMMD8 COMM domain containing 8 -1.85221
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -1.84184
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -1.81809
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -1.80992
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -1.80835
BATF2 basic leucine zipper transcription factor, ATF-like 2 -1.80677
AP1AR adaptor-related protein complex 1 associated regulatory protein -1.79309
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B) -1.78506
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -1.78489
ZNF784 zinc finger protein 784 -1.78437
USP28 ubiquitin specific peptidase 28 -1.77314
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) -1.77165
APC adenomatous polyposis coli -1.76616
TBCEL tubulin folding cofactor E-like -1.75586
XAB2 XPA binding protein 2 -1.75145
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.74832
PDCD10 programmed cell death 10 -1.74767
PLK4 polo-like kinase 4 -1.74379
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae) -1.73822
FABP5 fatty acid binding protein 5 (psoriasis-associated) -1.73726
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.73436
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -1.73177
UFC1 ubiquitin-fold modifier conjugating enzyme 1 -1.73161
COG6 component of oligomeric golgi complex 6 -1.73028
TMEM246 transmembrane protein 246 -1.73023
NOL11 nucleolar protein 11 -1.72111
PARK7 parkinson protein 7 -1.71985
USP16 ubiquitin specific peptidase 16 -1.71812
FBXL4 F-box and leucine-rich repeat protein 4 -1.69992
MYO9A myosin IXA -1.69561
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -1.68436
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -1.68091
HDDC2 HD domain containing 2 -1.67965
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -1.67595
PHYH phytanoyl-CoA 2-hydroxylase -1.67274
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -1.65765
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI -1.65172
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -1.64202
MPC1 mitochondrial pyruvate carrier 1 -1.6353
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) -1.62962
SRSF11 serine/arginine-rich splicing factor 11 -1.62613
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa -1.62201
MRPS31 mitochondrial ribosomal protein S31 -1.61626
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like -1.61415
GLO1 glyoxalase I -1.61053
EPHA7 EPH receptor A7 -1.60217
UHRF1BP1L UHRF1 binding protein 1-like -1.60119
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -1.59934
PER1 period circadian clock 1 -1.5981
C17ORF89 chromosome 17 open reading frame 89 -1.5926
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) -1.58149
FAHD1 fumarylacetoacetate hydrolase domain containing 1 -1.5801
MRPL2 mitochondrial ribosomal protein L2 -1.57793
NARS asparaginyl-tRNA synthetase -1.5693
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -1.56661
EPDR1 ependymin related 1 -1.5599
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -1.55734
LTV1 LTV1 ribosome biogenesis factor -1.5502
COG1 component of oligomeric golgi complex 1 -1.54792
RPS17 ribosomal protein S17 -1.54732
UNC13C unc-13 homolog C (C. elegans) -1.54675
FGF1 fibroblast growth factor 1 (acidic) -1.5211
ACO2 aconitase 2, mitochondrial -1.52103
DUSP26 dual specificity phosphatase 26 (putative) -1.5207
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 -1.51746
MAK16 MAK16 homolog (S. cerevisiae) -1.51182
PTPRE protein tyrosine phosphatase, receptor type, E -1.50764
UBE3B ubiquitin protein ligase E3B -1.50711
NRG2 neuregulin 2 -1.50548
MED8 mediator complex subunit 8 -1.49949
PCNXL3 pecanex-like 3 (Drosophila) -1.497
AMMECR1L AMMECR1-like -1.49608
TUBA4A tubulin, alpha 4a -1.49348
TK2 thymidine kinase 2, mitochondrial -1.49105
POLR2F polymerase (RNA) II (DNA directed) polypeptide F -1.48003
TPRG1L tumor protein p63 regulated 1-like -1.47722
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -1.47659
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -1.46232
TMEM144 transmembrane protein 144 -1.46043
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -1.46005
DENR density-regulated protein -1.459
ZMAT5 zinc finger, matrin-type 5 -1.45732
ADCY3 adenylate cyclase 3 -1.45017
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -1.44969
RPUSD1 RNA pseudouridylate synthase domain containing 1 -1.44848
TRAPPC2 trafficking protein particle complex 2 -1.43922
ATR ATR serine/threonine kinase -1.43448
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -1.43448
ZFP37 ZFP37 zinc finger protein -1.43276
AKAP6 A kinase (PRKA) anchor protein 6 -1.43048
ETFA electron-transfer-flavoprotein, alpha polypeptide -1.42895
ACSL1 acyl-CoA synthetase long-chain family member 1 -1.42496
KLHDC8A kelch domain containing 8A -1.41304
PCBP2 poly(rC) binding protein 2 -1.40902
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -1.39794
ABHD4 abhydrolase domain containing 4 -1.3975
FAM63B family with sequence similarity 63, member B -1.3891
ELAC2 elaC ribonuclease Z 2 -1.38641
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -1.38632
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -1.38538
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -1.38195
MBLAC2 metallo-beta-lactamase domain containing 2 -1.37821
LDHB lactate dehydrogenase B -1.37703
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -1.37466
UFSP2 UFM1-specific peptidase 2 -1.37311
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10 -1.37145
RNF24 ring finger protein 24 -1.37065
TDRKH tudor and KH domain containing -1.36699
MACROD1 MACRO domain containing 1 -1.36527
STARD4 StAR-related lipid transfer (START) domain containing 4 -1.36507
TMEM68 transmembrane protein 68 -1.35095
SEMA4F sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F -1.35057
RFTN2 raftlin family member 2 -1.35034
BAG6 BCL2-associated athanogene 6 -1.3482
CACFD1 calcium channel flower domain containing 1 -1.34713
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -1.34314
SLC25A39 solute carrier family 25, member 39 -1.3425
RPS2 ribosomal protein S2 -1.34019
ANKRD37 ankyrin repeat domain 37 -1.33992
ARRDC1 arrestin domain containing 1 -1.33375
PLLP plasmolipin -1.32366
ACOT7 acyl-CoA thioesterase 7 -1.31662
PRPF4 pre-mRNA processing factor 4 -1.31474
C6ORF89 chromosome 6 open reading frame 89 -1.3135
CNTN1 contactin 1 -1.30988
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -1.29911
NUBP2 nucleotide binding protein 2 -1.29891
SEPT8 septin 8 -1.29514
OXNAD1 oxidoreductase NAD-binding domain containing 1 -1.2928
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.29148
PGD phosphogluconate dehydrogenase -1.29085
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -1.29078
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -1.29028
TWF1 twinfilin actin binding protein 1 -1.28483
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -1.28472
REXO2 RNA exonuclease 2 -1.28385
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -1.27937
UBAC2 UBA domain containing 2 -1.27531
MAN2C1 mannosidase, alpha, class 2C, member 1 -1.27485
ADAL adenosine deaminase-like -1.27391
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -1.26813
TRIP4 thyroid hormone receptor interactor 4 -1.26772
DTNBP1 dystrobrevin binding protein 1 -1.2602
SNX32 sorting nexin 32 -1.25375
MDH1 malate dehydrogenase 1, NAD (soluble) -1.24978
KCTD9 potassium channel tetramerization domain containing 9 -1.24659
CRLF3 cytokine receptor-like factor 3 -1.24472
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -1.24206
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -1.24021
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -1.23235
C22ORF15 chromosome 22 open reading frame 15 -1.23201
CYC1 cytochrome c-1 -1.23145
ATM ATM serine/threonine kinase -1.22626
TMEM9 transmembrane protein 9 -1.22319
PGAM1 phosphoglycerate mutase 1 (brain) -1.22251
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -1.22169
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -1.22108
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 -1.22031
GPR180 G protein-coupled receptor 180 -1.21745
DDX26B DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B -1.21693
ENDOG endonuclease G -1.21288
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -1.21202
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 -1.21162
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) -1.20988
PPP1R7 protein phosphatase 1, regulatory subunit 7 -1.20901
EMP3 epithelial membrane protein 3 -1.20658
CAPNS1 calpain, small subunit 1 -1.2006
OXCT1 3-oxoacid CoA transferase 1 -1.19936
LCMT2 leucine carboxyl methyltransferase 2 -1.1985
SBF1 SET binding factor 1 -1.19718
DPY30 dpy-30 homolog (C. elegans) -1.19511
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 -1.19485
TPI1 triosephosphate isomerase 1 -1.19467
TCTA T-cell leukemia translocation altered -1.1941
CRYZ crystallin, zeta (quinone reductase) -1.19326
FAM49B family with sequence similarity 49, member B -1.18734
FGFBP3 fibroblast growth factor binding protein 3 -1.18645
ACOT9 acyl-CoA thioesterase 9 -1.1789
CST3 cystatin C -1.17872
MTX3 metaxin 3 -1.1782
IFT46 intraflagellar transport 46 -1.17522
GTPBP2 GTP binding protein 2 -1.17226
AURKAIP1 aurora kinase A interacting protein 1 -1.16219
LGI3 leucine-rich repeat LGI family, member 3 -1.15467
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -1.15267
ACYP1 acylphosphatase 1, erythrocyte (common) type -1.14819
DPY19L1 dpy-19-like 1 (C. elegans) -1.14468
APOO apolipoprotein O -1.14271
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 -1.14142
ZRANB1 zinc finger, RAN-binding domain containing 1 -1.14045
KDSR 3-ketodihydrosphingosine reductase -1.14043
IWS1 IWS1 homolog (S. cerevisiae) -1.14043
TMEM106B transmembrane protein 106B -1.14024
RAB1A RAB1A, member RAS oncogene family -1.13788
HMOX2 heme oxygenase 2 -1.13736
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -1.13198
SEC63 SEC63 homolog (S. cerevisiae) -1.13194
APOA1BP apolipoprotein A-I binding protein -1.13073
CAPN10 calpain 10 -1.13014
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 -1.12433
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -1.12167
IKZF5 IKAROS family zinc finger 5 (Pegasus) -1.11861
NUP62 nucleoporin 62kDa -1.11823
CLCC1 chloride channel CLIC-like 1 -1.1175
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) -1.11537
SLC35E2B solute carrier family 35, member E2B -1.11026
SYTL2 synaptotagmin-like 2 -1.10989
S100B S100 calcium binding protein B -1.10955
MEGF10 multiple EGF-like-domains 10 -1.10789
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -1.10077
Funding