| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. (Chemical Entities of Biological Interest Ontology, CHEBI_78330) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/449069 |
| Similar Terms | |
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200 proteins with high or low expression in Huperzine A relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PIP | prolactin-induced protein | 0.69 |
| WASHC2C | WASH complex subunit 2C | 0.62 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | 0.55 |
| HDAC7 | histone deacetylase 7 | 0.52 |
| TXN2 | thioredoxin 2 | 0.5 |
| PXDN | peroxidasin | 0.48 |
| PHF1 | PHD finger protein 1 | 0.47 |
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | 0.47 |
| TCF7 | transcription factor 7 (T-cell specific, HMG-box) | 0.45 |
| TEPSIN | TEPSIN adaptor related protein complex 4 accessory protein | 0.43 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.43 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.42 |
| TINF2 | TERF1 (TRF1)-interacting nuclear factor 2 | 0.4 |
| TM7SF2 | transmembrane 7 superfamily member 2 | 0.4 |
| TGFBRAP1 | transforming growth factor, beta receptor associated protein 1 | 0.39 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.38 |
| TP53 | tumor protein p53 | 0.37 |
| FGD1 | FYVE, RhoGEF and PH domain containing 1 | 0.37 |
| CRAMP1 | cramped chromatin regulator homolog 1 | 0.37 |
| ARG2 | arginase 2 | 0.36 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.36 |
| FBXO17 | F-box protein 17 | 0.35 |
| MAGEA12 | melanoma antigen family A12 | 0.35 |
| USP19 | ubiquitin specific peptidase 19 | 0.35 |
| ZNF280B | zinc finger protein 280B | 0.35 |
| ZNF518B | zinc finger protein 518B | 0.35 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.35 |
| MEF2A | myocyte enhancer factor 2A | 0.35 |
| CD320 | CD320 molecule | 0.34 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.34 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.34 |
| ING2 | inhibitor of growth family, member 2 | 0.34 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.34 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.33 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.33 |
| ANKRD54 | ankyrin repeat domain 54 | 0.33 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | 0.33 |
| NRBF2 | nuclear receptor binding factor 2 | 0.33 |
| B3GLCT | beta 3-glucosyltransferase | 0.32 |
| DIXDC1 | DIX domain containing 1 | 0.32 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.32 |
| TUBB4A | tubulin, beta 4A class IVa | 0.31 |
| CCAR2 | cell cycle and apoptosis regulator 2 | 0.31 |
| PIMREG | PICALM interacting mitotic regulator | 0.31 |
| SYN2 | synapsin II | 0.31 |
| DNAH12 | dynein, axonemal, heavy chain 12 | 0.31 |
| SNX11 | sorting nexin 11 | 0.31 |
| ZNF395 | zinc finger protein 395 | 0.31 |
| PRX | periaxin | 0.3 |
| TMCO4 | transmembrane and coiled-coil domains 4 | 0.3 |
| ZNF776 | zinc finger protein 776 | 0.3 |
| NHEJ1 | nonhomologous end-joining factor 1 | 0.3 |
| XPA | xeroderma pigmentosum, complementation group A | 0.3 |
| DUOX1 | dual oxidase 1 | 0.3 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.3 |
| MXRA7 | matrix-remodelling associated 7 | 0.3 |
| MAD2L2 | MAD2 mitotic arrest deficient-like 2 (yeast) | 0.29 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.29 |
| FAM133A | family with sequence similarity 133, member A | 0.29 |
| MCM8 | minichromosome maintenance complex component 8 | 0.29 |
| ATF1 | activating transcription factor 1 | 0.29 |
| GATA6 | GATA binding protein 6 | 0.28 |
| CCHCR1 | coiled-coil alpha-helical rod protein 1 | 0.28 |
| RAD54L | RAD54-like (S. cerevisiae) | 0.28 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.28 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.28 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.28 |
| KLHL20 | kelch-like family member 20 | 0.28 |
| ZNF777 | zinc finger protein 777 | 0.27 |
| ADAT2 | adenosine deaminase, tRNA-specific 2 | 0.27 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.27 |
| CDC6 | cell division cycle 6 | 0.27 |
| GMNN | geminin, DNA replication inhibitor | 0.27 |
| DCAF12 | DDB1 and CUL4 associated factor 12 | 0.27 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.27 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 0.26 |
| POF1B | premature ovarian failure, 1B | 0.26 |
| TSTD2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 | 0.26 |
| STMN3 | stathmin-like 3 | 0.26 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.26 |
| ZNF561 | zinc finger protein 561 | 0.26 |
| GCSH | glycine cleavage system protein H (aminomethyl carrier) | 0.26 |
| RPLP2 | ribosomal protein, large, P2 | 0.26 |
| MATR3 | matrin 3 | 0.26 |
| BRD8 | bromodomain containing 8 | 0.26 |
| TMCO6 | transmembrane and coiled-coil domains 6 | 0.26 |
| SPATA2 | spermatogenesis associated 2 | 0.26 |
| EWSR1 | EWS RNA-binding protein 1 | 0.26 |
| ATF6B | activating transcription factor 6 beta | 0.25 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.25 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.25 |
| CHMP4C | charged multivesicular body protein 4C | 0.25 |
| MCL1 | myeloid cell leukemia 1 | 0.25 |
| GSDME | gasdermin E | 0.25 |
| HPSE | heparanase | 0.25 |
| C12ORF4 | chromosome 12 open reading frame 4 | 0.25 |
| SPOP | speckle-type POZ protein | 0.25 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | 0.25 |
| SUFU | suppressor of fused homolog (Drosophila) | 0.25 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.25 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TYRO3 | TYRO3 protein tyrosine kinase | -0.66 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.56 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.55 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.51 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.5 |
| TTC31 | tetratricopeptide repeat domain 31 | -0.48 |
| SPPL2B | signal peptide peptidase like 2B | -0.47 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.47 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | -0.46 |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | -0.44 |
| CES3 | carboxylesterase 3 | -0.42 |
| ACTN4 | actinin, alpha 4 | -0.42 |
| SERINC1 | serine incorporator 1 | -0.41 |
| ZNF771 | zinc finger protein 771 | -0.41 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.41 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.39 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | -0.39 |
| TSPAN9 | tetraspanin 9 | -0.39 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.37 |
| RNF13 | ring finger protein 13 | -0.37 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.36 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -0.36 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.36 |
| KIF3C | kinesin family member 3C | -0.36 |
| RGS12 | regulator of G-protein signaling 12 | -0.35 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.34 |
| TMEM199 | transmembrane protein 199 | -0.34 |
| CNST | consortin, connexin sorting protein | -0.34 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.33 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.33 |
| GDF15 | growth differentiation factor 15 | -0.32 |
| TTN | titin | -0.32 |
| ZMYM6 | zinc finger, MYM-type 6 | -0.32 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.32 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | -0.32 |
| MKRN1 | makorin ring finger protein 1 | -0.31 |
| TBC1D22B | TBC1 domain family, member 22B | -0.31 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | -0.31 |
| ADPRH | ADP-ribosylarginine hydrolase | -0.3 |
| PANK3 | pantothenate kinase 3 | -0.3 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.3 |
| DALRD3 | DALR anticodon binding domain containing 3 | -0.29 |
| FCHO1 | FCH domain only 1 | -0.29 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.29 |
| PPIL2 | peptidylprolyl isomerase (cyclophilin)-like 2 | -0.29 |
| FBXW4 | F-box and WD repeat domain containing 4 | -0.28 |
| KIAA0319L | KIAA0319-like | -0.28 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.28 |
| EMB | embigin | -0.28 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.27 |
| TECPR1 | tectonin beta-propeller repeat containing 1 | -0.27 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.27 |
| SLC25A52 | solute carrier family 25, member 52 | -0.27 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.27 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | -0.27 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.26 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.26 |
| UBL7 | ubiquitin-like 7 | -0.26 |
| SPATA20 | spermatogenesis associated 20 | -0.25 |
| RUNDC1 | RUN domain containing 1 | -0.25 |
| HRH1 | histamine receptor H1 | -0.25 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.25 |
| KCTD6 | potassium channel tetramerization domain containing 6 | -0.25 |
| OTULINL | OTU deubiquitinase with linear linkage specificity like | -0.25 |
| EPHB2 | EPH receptor B2 | -0.25 |
| SCAP | SREBF chaperone | -0.25 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.25 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.24 |
| CUX1 | cut-like homeobox 1 | -0.24 |
| PGPEP1 | pyroglutamyl-peptidase I | -0.24 |
| CEP63 | centrosomal protein 63kDa | -0.24 |
| USP30 | ubiquitin specific peptidase 30 | -0.24 |
| PLPP3 | phospholipid phosphatase 3 | -0.24 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.24 |
| PTGES | prostaglandin E synthase | -0.24 |
| VAMP4 | vesicle-associated membrane protein 4 | -0.24 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.24 |
| RPP25 | ribonuclease P/MRP 25kDa subunit | -0.23 |
| SDF2 | stromal cell-derived factor 2 | -0.23 |
| KLC1 | kinesin light chain 1 | -0.23 |
| ALS2CL | ALS2 C-terminal like | -0.23 |
| SLC31A1 | solute carrier family 31 (copper transporter), member 1 | -0.23 |
| TP53I11 | tumor protein p53 inducible protein 11 | -0.22 |
| NDRG1 | N-myc downstream regulated 1 | -0.22 |
| CCNQ | cyclin Q | -0.22 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.22 |
| MCM9 | minichromosome maintenance complex component 9 | -0.22 |
| PLEC | plectin | -0.22 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.22 |
| VPS37A | vacuolar protein sorting 37 homolog A (S. cerevisiae) | -0.22 |
| EPDR1 | ependymin related 1 | -0.22 |
| C1ORF43 | chromosome 1 open reading frame 43 | -0.22 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | -0.21 |
| ENO1 | enolase 1, (alpha) | -0.21 |
| CDK11A | cyclin-dependent kinase 11A | -0.21 |
| FABP6 | fatty acid binding protein 6, ileal | -0.21 |
| HM13 | histocompatibility (minor) 13 | -0.21 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.21 |
| KLHL2 | kelch-like family member 2 | -0.21 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.21 |
