Hydroxyfasudil_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Hydroxyfasudil_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.212888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.154921
TRIO trio Rho guanine nucleotide exchange factor 0.132158
SQSTM1 sequestosome 1 0.06821
CDH13 cadherin 13 0.0650062
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0635847
AHNAK AHNAK nucleoprotein 0.0535297
CENPF centromere protein F, 350/400kDa 0.0520035
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0480534
HDAC9 histone deacetylase 9 0.0465026
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0457525
SP100 SP100 nuclear antigen 0.0433162
DST dystonin 0.0409935
APP amyloid beta (A4) precursor protein 0.0399571
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0392338
ALCAM activated leukocyte cell adhesion molecule 0.0383211
TPM3 tropomyosin 3 0.0378802
RSAD2 radical S-adenosyl methionine domain containing 2 0.0376302
HSPH1 heat shock 105kDa/110kDa protein 1 0.03638
ASPH aspartate beta-hydroxylase 0.0362891
MAP1B microtubule-associated protein 1B 0.0357866
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354714
MYOF myoferlin 0.0354022
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0348767
PICALM phosphatidylinositol binding clathrin assembly protein 0.0342509
CD44 CD44 molecule (Indian blood group) 0.0334908
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0334225
AHNAK2 AHNAK nucleoprotein 2 0.0325447
SON SON DNA binding protein 0.0325147
LDHA lactate dehydrogenase A 0.0324902
HSPB1 heat shock 27kDa protein 1 0.0305913
CEP350 centrosomal protein 350kDa 0.0294075
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0293734
EGFR epidermal growth factor receptor 0.0293525
MACF1 microtubule-actin crosslinking factor 1 0.0293406
RUNX1 runt-related transcription factor 1 0.0289502
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0288079
PRRC2C proline-rich coiled-coil 2C 0.028483
DSPP dentin sialophosphoprotein 0.0282907
SEPTIN7 septin 7 0.0279566
SDCCAG8 serologically defined colon cancer antigen 8 0.0273829
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0273501
SPDL1 spindle apparatus coiled-coil protein 1 0.0271979
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0266242
FSTL1 follistatin-like 1 0.0264602
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0264328
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0263031
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.02578
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0254848
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0249456
PLXNA2 plexin A2 0.0249113
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0244317
ANKRD11 ankyrin repeat domain 11 0.0239344
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0239197
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0231007
SAMD9 sterile alpha motif domain containing 9 0.0230944
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0229683
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0228534
UBC ubiquitin C 0.0227299
TMSB4X thymosin beta 4, X-linked 0.0221511
CDK6 cyclin-dependent kinase 6 0.0219612
DIAPH3 diaphanous-related formin 3 0.021886
MSN moesin 0.0218576
FAT1 FAT atypical cadherin 1 0.021769
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.021759
LNPEP leucyl/cystinyl aminopeptidase 0.02154
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0213692
BAG3 BCL2-associated athanogene 3 0.021349
RNF213 ring finger protein 213 0.0211571
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0210889
RSRC2 arginine/serine-rich coiled-coil 2 0.0208285
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0206258
BZW1 basic leucine zipper and W2 domains 1 0.0205686
GOLGB1 golgin B1 0.0205177
RIGI RNA sensor RIG-I 0.0204565
ENO1 enolase 1, (alpha) 0.0204326
MYH9 myosin, heavy chain 9, non-muscle 0.0203136
HSPA8 heat shock 70kDa protein 8 0.0195138
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0192893
TLE4 transducin-like enhancer of split 4 0.0192726
EXT1 exostosin glycosyltransferase 1 0.0192286
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0191872
DIAPH1 diaphanous-related formin 1 0.0190047
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0188825
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0188434
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0187713
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0187389
TUSC3 tumor suppressor candidate 3 0.0186584
ZC3H11A zinc finger CCCH-type containing 11A 0.0186278
SRRM2 serine/arginine repetitive matrix 2 0.0185203
SH3KBP1 SH3-domain kinase binding protein 1 0.0184607
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0182888
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.0182862
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0181614
MBNL1 muscleblind-like splicing regulator 1 0.0178043
MKI67 marker of proliferation Ki-67 0.0177858
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0176426
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0176233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0172384
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0172343

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.215478
TMSB10 thymosin beta 10 -0.201056
IGFBP3 insulin-like growth factor binding protein 3 -0.199571
VIM vimentin -0.175158
NDRG1 N-myc downstream regulated 1 -0.127356
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.107505
MT2A metallothionein 2A -0.0962615
PLAT plasminogen activator, tissue -0.0950267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0781087
LOX lysyl oxidase -0.0688657
HLA-B major histocompatibility complex, class I, B -0.0599512
COL1A2 collagen, type I, alpha 2 -0.0560472
COL8A1 collagen, type VIII, alpha 1 -0.0511498
CSTB cystatin B (stefin B) -0.045298
MYADM myeloid-associated differentiation marker -0.0432396
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0431803
S100A6 S100 calcium binding protein A6 -0.0427269
PTMA prothymosin, alpha -0.04265
MT1X metallothionein 1X -0.0422507
FBN1 fibrillin 1 -0.0416263
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0411043
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0400924
TAGLN2 transgelin 2 -0.0333893
DLG1 discs, large homolog 1 (Drosophila) -0.0332808
ABI3BP ABI family, member 3 (NESH) binding protein -0.0329625
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0321164
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0314174
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304281
LOC112694756 uncharaterized LOC112694756 -0.0292821
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0292805
HLA-C major histocompatibility complex, class I, C -0.0288614
PLAUR plasminogen activator, urokinase receptor -0.0284927
CALR calreticulin -0.0279007
S100A4 S100 calcium binding protein A4 -0.0274485
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.027226
ARL4C ADP-ribosylation factor-like 4C -0.0251365
IFITM1 interferon induced transmembrane protein 1 -0.0250872
TPT1 tumor protein, translationally-controlled 1 -0.0248694
SOD2 superoxide dismutase 2, mitochondrial -0.0246916
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0246879
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0246147
LOXL2 lysyl oxidase-like 2 -0.0243369
BSG basigin (Ok blood group) -0.023629
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0235494
FN1 fibronectin 1 -0.023077
MRPS6 mitochondrial ribosomal protein S6 -0.0230528
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0229942
RPL35A ribosomal protein L35a -0.0223468
CTSB cathepsin B -0.0218824
HLA-A major histocompatibility complex, class I, A -0.0217758
PSD3 pleckstrin and Sec7 domain containing 3 -0.0216165
CD81 CD81 molecule -0.0215099
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0215044
TAPBP TAP binding protein (tapasin) -0.0211928
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.020068
MMP12 matrix metallopeptidase 12 -0.0194993
MRC2 mannose receptor, C type 2 -0.0193378
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.01908
MAP4 microtubule-associated protein 4 -0.0189857
RTN4 reticulon 4 -0.0189579
COL6A1 collagen, type VI, alpha 1 -0.0189249
RPS27A ribosomal protein S27a -0.0189071
CYB5R3 cytochrome b5 reductase 3 -0.0186722
ENO2 enolase 2 (gamma, neuronal) -0.0186466
RPL37A ribosomal protein L37a -0.018512
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0184634
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0183891
VEGFA vascular endothelial growth factor A -0.0180687
CTSD cathepsin D -0.01806
S100A9 S100 calcium binding protein A9 -0.0180202
GNAS GNAS complex locus -0.0177961
TTC3 tetratricopeptide repeat domain 3 -0.0177009
FLNB filamin B, beta -0.0176365
LMNA lamin A/C -0.0175124
PEA15 phosphoprotein enriched in astrocytes 15 -0.0173553
CCND1 cyclin D1 -0.0171161
DPYSL3 dihydropyrimidinase-like 3 -0.0170147
IFI6 interferon, alpha-inducible protein 6 -0.0170126
CD99 CD99 molecule -0.0169858
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0169653
ZNF395 zinc finger protein 395 -0.0169646
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0166231
RAB6A RAB6A, member RAS oncogene family -0.0162988
RPS24 ribosomal protein S24 -0.0162691
TMEM165 transmembrane protein 165 -0.0160921
MEIS2 Meis homeobox 2 -0.0160699
HLA-E major histocompatibility complex, class I, E -0.0160555
DYNLT1 dynein, light chain, Tctex-type 1 -0.0156474
KDM5B lysine (K)-specific demethylase 5B -0.0156297
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0155447
RAB10 RAB10, member RAS oncogene family -0.0154404
NT5C2 5'-nucleotidase, cytosolic II -0.0154292
SRPK2 SRSF protein kinase 2 -0.0153889
UBE2B ubiquitin-conjugating enzyme E2B -0.0153247
FRMD5 FERM domain containing 5 -0.0153237
ACTN4 actinin, alpha 4 -0.0151686
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0151072
DEPP1 DEPP autophagy regulator 1 -0.0146089
LMAN1 lectin, mannose-binding, 1 -0.0145647
RPS15 ribosomal protein S15 -0.0145255