| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Hydroxyfasudil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.336466 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.253521 |
| AREG | amphiregulin | 0.171256 |
| RPS12 | ribosomal protein S12 | 0.106536 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.10425 |
| RPS8 | ribosomal protein S8 | 0.0888663 |
| RPS6 | ribosomal protein S6 | 0.0834672 |
| FTL | ferritin, light polypeptide | 0.0830158 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0782289 |
| RPS3 | ribosomal protein S3 | 0.0751335 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0673393 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.067271 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0657783 |
| ANXA1 | annexin A1 | 0.0628244 |
| RPL11 | ribosomal protein L11 | 0.0602035 |
| TENM3 | teneurin transmembrane protein 3 | 0.0541466 |
| PCBP2 | poly(rC) binding protein 2 | 0.0536829 |
| HDAC9 | histone deacetylase 9 | 0.052508 |
| RPL37A | ribosomal protein L37a | 0.0511427 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0499909 |
| RPL12 | ribosomal protein L12 | 0.0498196 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0479963 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0466246 |
| RPL23 | ribosomal protein L23 | 0.0450992 |
| RPLP2 | ribosomal protein, large, P2 | 0.0448169 |
| RPL7 | ribosomal protein L7 | 0.0444553 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0435595 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0435046 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.043465 |
| GOLGA4 | golgin A4 | 0.0418004 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0408736 |
| TPI1 | triosephosphate isomerase 1 | 0.0390541 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0387257 |
| RPS19 | ribosomal protein S19 | 0.0382776 |
| RPL21 | ribosomal protein L21 | 0.0382337 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0378983 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0377075 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.035309 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0347898 |
| POTEF | POTE ankyrin domain family, member F | 0.0347428 |
| EPHA6 | EPH receptor A6 | 0.0337694 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0334255 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0331407 |
| RPL26 | ribosomal protein L26 | 0.03278 |
| CDK6 | cyclin-dependent kinase 6 | 0.032598 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0323784 |
| PDGFC | platelet derived growth factor C | 0.032348 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0322154 |
| HMGA2 | high mobility group AT-hook 2 | 0.0322075 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0318149 |
| MPG | N-methylpurine-DNA glycosylase | 0.0314637 |
| MED13L | mediator complex subunit 13-like | 0.0314449 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0314181 |
| SON | SON DNA binding protein | 0.0313646 |
| GOLGB1 | golgin B1 | 0.0307382 |
| RPL36 | ribosomal protein L36 | 0.0306449 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0304873 |
| BRD2 | bromodomain containing 2 | 0.0303354 |
| RPL19 | ribosomal protein L19 | 0.0302689 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0300994 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0294329 |
| OXR1 | oxidation resistance 1 | 0.0293599 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0284443 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0282258 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0281155 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0275569 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0274431 |
| PLK2 | polo-like kinase 2 | 0.0274006 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0273564 |
| RPS26 | ribosomal protein S26 | 0.0273486 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0271164 |
| DSPP | dentin sialophosphoprotein | 0.0268479 |
| RPL3 | ribosomal protein L3 | 0.0268207 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0267561 |
| CPOX | coproporphyrinogen oxidase | 0.0265757 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0265059 |
| ZNF638 | zinc finger protein 638 | 0.0261602 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0260699 |
| EXOC6B | exocyst complex component 6B | 0.0260358 |
| RPS13 | ribosomal protein S13 | 0.025961 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0258084 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0256911 |
| PCDH9 | protocadherin 9 | 0.0256686 |
| INTS6 | integrator complex subunit 6 | 0.0254352 |
| SYT1 | synaptotagmin I | 0.0250371 |
| RPL31 | ribosomal protein L31 | 0.025001 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0247293 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0246607 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0245945 |
| WWOX | WW domain containing oxidoreductase | 0.024562 |
| SET | SET nuclear proto-oncogene | 0.0243139 |
| DSTN | destrin (actin depolymerizing factor) | 0.024197 |
| EZR | ezrin | 0.0241366 |
| YAP1 | Yes-associated protein 1 | 0.0238464 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0237484 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0237219 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0235087 |
| RACK1 | receptor for activated C kinase 1 | 0.0233051 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0232193 |
| YBX1 | Y box binding protein 1 | 0.0228915 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.117717 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.1097 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.101609 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.085249 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0742301 |
| NHSL1 | NHS-like 1 | -0.0684798 |
| ACTG1 | actin gamma 1 | -0.0627831 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0593751 |
| TMEM123 | transmembrane protein 123 | -0.0584105 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0549741 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0544475 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0515528 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.051424 |
| CLDN1 | claudin 1 | -0.0500399 |
| ZNF804A | zinc finger protein 804A | -0.0496955 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0488949 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.043146 |
| PGK1 | phosphoglycerate kinase 1 | -0.0392954 |
| YBX3 | Y box binding protein 3 | -0.0389514 |
| JMJD1C | jumonji domain containing 1C | -0.0389161 |
| TMEM41B | transmembrane protein 41B | -0.0377547 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0370642 |
| GNAS | GNAS complex locus | -0.0366912 |
| AHNAK | AHNAK nucleoprotein | -0.0353324 |
| FUS | FUS RNA binding protein | -0.0348037 |
| RASAL2 | RAS protein activator like 2 | -0.0335179 |
| BRI3BP | BRI3 binding protein | -0.0327454 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0320591 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0318481 |
| MKI67 | marker of proliferation Ki-67 | -0.0316205 |
| RPL35A | ribosomal protein L35a | -0.0310754 |
| H1-0 | H1.0 linker histone | -0.0300807 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0295685 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029253 |
| TUBB | tubulin, beta class I | -0.0289312 |
| TXNRD1 | thioredoxin reductase 1 | -0.0288759 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0286875 |
| MAP1B | microtubule-associated protein 1B | -0.0285747 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0284846 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0272546 |
| TMEM131 | transmembrane protein 131 | -0.026753 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0266632 |
| KIF18B | kinesin family member 18B | -0.0263912 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0263911 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0260383 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.025907 |
| XPO1 | exportin 1 | -0.0252583 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0249036 |
| S100A6 | S100 calcium binding protein A6 | -0.0246785 |
| CCND1 | cyclin D1 | -0.0245608 |
| RPL38 | ribosomal protein L38 | -0.0245542 |
| RPL6 | ribosomal protein L6 | -0.0242688 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.024264 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.0241787 |
| PEG10 | paternally expressed 10 | -0.0240948 |
| FAM110C | family with sequence similarity 110, member C | -0.0236179 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0236085 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0235687 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.023253 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0231634 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0230532 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0227395 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.022461 |
| TPM4 | tropomyosin 4 | -0.0223235 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0222238 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0219304 |
| WDR45B | WD repeat domain 45B | -0.0216656 |
| EHBP1 | EH domain binding protein 1 | -0.0214884 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0213056 |
| CDK12 | cyclin-dependent kinase 12 | -0.0211995 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0211608 |
| TUBA1C | tubulin, alpha 1c | -0.0208523 |
| KHSRP | KH-type splicing regulatory protein | -0.0207454 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0206233 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0205964 |
| NF1 | neurofibromin 1 | -0.0203751 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0203581 |
| DENND5B | DENN/MADD domain containing 5B | -0.020263 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0200193 |
| MTAP | methylthioadenosine phosphorylase | -0.019845 |
| MMP12 | matrix metallopeptidase 12 | -0.0194872 |
| AFG3L2 | AFG3-like AAA ATPase 2 | -0.0194637 |
| SMYD3 | SET and MYND domain containing 3 | -0.0194384 |
| RAB1A | RAB1A, member RAS oncogene family | -0.019139 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.018969 |
| ZNF217 | zinc finger protein 217 | -0.0189294 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0189039 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0188447 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0188247 |
| CDK17 | cyclin-dependent kinase 17 | -0.0187025 |
| TUBB6 | tubulin, beta 6 class V | -0.0185817 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.018579 |
| VCL | vinculin | -0.0185213 |
| LMO7 | LIM domain 7 | -0.0185213 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0185098 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0182765 |
| NAV3 | neuron navigator 3 | -0.018229 |
| UBTF | upstream binding transcription factor, RNA polymerase I | -0.0181658 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0181413 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0181158 |
