Hydroxyfasudil_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.161642
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.148449
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.117292
FMN1 formin 1 0.0954488
BPTF bromodomain PHD finger transcription factor 0.0887882
EXT1 exostosin glycosyltransferase 1 0.0779829
PRKCA protein kinase C, alpha 0.0759174
ZSWIM6 zinc finger, SWIM-type containing 6 0.0683108
VCL vinculin 0.0599602
ZBTB20 zinc finger and BTB domain containing 20 0.0592588
NALF1 NALCN channel auxiliary factor 1 0.0580959
RPL23 ribosomal protein L23 0.0571772
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0569762
TRIO trio Rho guanine nucleotide exchange factor 0.0565669
PLAT plasminogen activator, tissue 0.0562427
CPED1 cadherin-like and PC-esterase domain containing 1 0.0550243
ACTG1 actin gamma 1 0.0517845
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0505221
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0478048
SYT1 synaptotagmin I 0.0466697
SEPTIN9 septin 9 0.0462711
PTPRK protein tyrosine phosphatase, receptor type, K 0.0438195
PRRC2C proline-rich coiled-coil 2C 0.0437301
SRRM2 serine/arginine repetitive matrix 2 0.0429147
PTPRD protein tyrosine phosphatase, receptor type, D 0.0426443
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0425717
DST dystonin 0.0411738
ANTXR1 anthrax toxin receptor 1 0.0411027
EIF1 eukaryotic translation initiation factor 1 0.0410124
NREP neuronal regeneration related protein 0.0402851
SLIT2 slit homolog 2 (Drosophila) 0.0399085
LPP LIM domain containing preferred translocation partner in lipoma 0.0387879
CENPF centromere protein F, 350/400kDa 0.038494
TPR translocated promoter region, nuclear basket protein 0.0383577
RPS8 ribosomal protein S8 0.0380136
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0379355
AKAP12 A kinase (PRKA) anchor protein 12 0.036906
PCDH9 protocadherin 9 0.0368083
NRG1 neuregulin 1 0.0367122
MSI2 musashi RNA-binding protein 2 0.0359868
RAD51B RAD51 paralog B 0.0359096
DPH6 diphthamine biosynthesis 6 0.0356451
RPL37A ribosomal protein L37a 0.0349711
HSPA8 heat shock 70kDa protein 8 0.0349588
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0339922
AEBP2 AE binding protein 2 0.0334578
ATXN1 ataxin 1 0.0334205
SLC39A11 solute carrier family 39, member 11 0.0333439
TIMP3 TIMP metallopeptidase inhibitor 3 0.033146
MAML2 mastermind-like 2 (Drosophila) 0.0324186
EGR1 early growth response 1 0.032185
RPS3 ribosomal protein S3 0.0314227
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0313608
SMAD3 SMAD family member 3 0.0312954
RPS12 ribosomal protein S12 0.0308914
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0306151
INTS6 integrator complex subunit 6 0.0303314
N4BP2L2 NEDD4 binding protein 2-like 2 0.029981
ATXN10 ataxin 10 0.0298533
RPS6 ribosomal protein S6 0.029674
VIM vimentin 0.0296576
GSE1 Gse1 coiled-coil protein 0.0295708
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.029045
SET SET nuclear proto-oncogene 0.0289406
ADGRB3 adhesion G protein-coupled receptor B3 0.0289227
TLE4 transducin-like enhancer of split 4 0.0288566
NPAS2 neuronal PAS domain protein 2 0.02875
ATM ATM serine/threonine kinase 0.028731
BCAS3 breast carcinoma amplified sequence 3 0.0282839
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0281848
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0281806
ZNF804A zinc finger protein 804A 0.0278865
CADM2 cell adhesion molecule 2 0.0278703
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0278084
CALD1 caldesmon 1 0.0276288
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0272711
RPL7 ribosomal protein L7 0.0269756
SMYD3 SET and MYND domain containing 3 0.02675
RPL18 ribosomal protein L18 0.0267215
TPT1 tumor protein, translationally-controlled 1 0.0264759
PACS1 phosphofurin acidic cluster sorting protein 1 0.0264382
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0263283
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0256683
FN1 fibronectin 1 0.0255685
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0255011
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0253746
NAV2 neuron navigator 2 0.0253679
SLITRK6 SLIT and NTRK-like family, member 6 0.0253408
SOX4 SRY (sex determining region Y)-box 4 0.0249413
ENO1 enolase 1, (alpha) 0.0249308
TAS2R14 taste receptor, type 2, member 14 0.0248809
GOLGB1 golgin B1 0.0247763
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0247152
MAPK10 mitogen-activated protein kinase 10 0.0245444
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0244125
RPS15 ribosomal protein S15 0.0242531
RPL31 ribosomal protein L31 0.0242414
RPL19 ribosomal protein L19 0.0241016
FAM107B family with sequence similarity 107, member B 0.0240111
GPC5 glypican 5 0.0237685

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.252066
NPEPPS aminopeptidase puromycin sensitive -0.0508455
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0453571
HELZ helicase with zinc finger -0.043526
MARCHF6 membrane associated ring-CH-type finger 6 -0.0386725
MEIS2 Meis homeobox 2 -0.0370212
RAB6A RAB6A, member RAS oncogene family -0.0326765
WDR45B WD repeat domain 45B -0.0310836
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0306166
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0303917
KDM3A lysine (K)-specific demethylase 3A -0.0298728
USP3 ubiquitin specific peptidase 3 -0.0278944
TMEM123 transmembrane protein 123 -0.0276951
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0273542
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0270553
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.02663
FNBP1 formin binding protein 1 -0.0261441
DENND4C DENN/MADD domain containing 4C -0.0257147
TFG TRK-fused gene -0.0255862
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0251969
NRP1 neuropilin 1 -0.0250351
MAP1B microtubule-associated protein 1B -0.0236463
GARS1 glycyl-tRNA synthetase 1 -0.0235734
HILPDA hypoxia inducible lipid droplet-associated -0.0230174
AOPEP aminopeptidase O (putative) -0.0228578
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0225016
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0223933
QKI QKI, KH domain containing, RNA binding -0.022228
KMT2E lysine (K)-specific methyltransferase 2E -0.0222068
PUM2 pumilio RNA-binding family member 2 -0.0218626
FBXL20 F-box and leucine-rich repeat protein 20 -0.0209603
HDAC2 histone deacetylase 2 -0.0208346
MXI1 MAX interactor 1, dimerization protein -0.0207835
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0207787
NUP58 nucleoporin 58 -0.0207738
RAB2A RAB2A, member RAS oncogene family -0.0205665
ANXA2 annexin A2 -0.0202893
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0202732
CADM1 cell adhesion molecule 1 -0.0200427
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0198909
SRP54 signal recognition particle 54kDa -0.0197692
CUL3 cullin 3 -0.0197559
MYO6 myosin VI -0.0196727
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0194227
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0192988
RAB5A RAB5A, member RAS oncogene family -0.0191118
RAD23B RAD23 homolog B (S. cerevisiae) -0.0188031
HBP1 HMG-box transcription factor 1 -0.0187864
RTN4 reticulon 4 -0.0186804
PCBP2 poly(rC) binding protein 2 -0.0186785
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0186749
KLHL24 kelch-like family member 24 -0.018637
SPAG9 sperm associated antigen 9 -0.0185435
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.0185096
RSRC1 arginine/serine-rich coiled-coil 1 -0.0184437
RPL38 ribosomal protein L38 -0.0184302
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.018311
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0179896
RNMT RNA (guanine-7-) methyltransferase -0.0178889
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0176817
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0175948
TRIM33 tripartite motif containing 33 -0.0173949
TMEM87A transmembrane protein 87A -0.0173525
C1ORF21 chromosome 1 open reading frame 21 -0.0173475
KPNB1 karyopherin (importin) beta 1 -0.0172587
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0170609
MEF2A myocyte enhancer factor 2A -0.017016
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0169904
CANX calnexin -0.0169202
CALR calreticulin -0.0167692
SUCO SUN domain containing ossification factor -0.0167118
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.016563
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0165505
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0165231
AKAP10 A kinase (PRKA) anchor protein 10 -0.0163805
RPS24 ribosomal protein S24 -0.0159588
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0159407
FUBP3 far upstream element (FUSE) binding protein 3 -0.0159031
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0157364
NUP160 nucleoporin 160kDa -0.015678
LMAN1 lectin, mannose-binding, 1 -0.0156656
WTAP Wilms tumor 1 associated protein -0.0156229
S100A10 S100 calcium binding protein A10 -0.0155941
TCOF1 Treacher Collins-Franceschetti syndrome 1 -0.015503
TRAM1 translocation associated membrane protein 1 -0.0154418
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0153464
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0152856
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0152184
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0151838
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.015023
UBAP2L ubiquitin associated protein 2-like -0.0149291
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0148937
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.014864
SNX1 sorting nexin 1 -0.0148255
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0148061
GATAD2B GATA zinc finger domain containing 2B -0.0147422
ZNF33A zinc finger protein 33A -0.014733
FAM133B family with sequence similarity 133, member B -0.0147312
USP9X ubiquitin specific peptidase 9, X-linked -0.014691
ZNF451 zinc finger protein 451 -0.0145463