| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.196227 |
| LMO7 | LIM domain 7 | 0.157197 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.110729 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0887902 |
| ASPH | aspartate beta-hydroxylase | 0.0862976 |
| ZNF292 | zinc finger protein 292 | 0.082652 |
| DIAPH1 | diaphanous-related formin 1 | 0.0786123 |
| SMAD3 | SMAD family member 3 | 0.0724673 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0674625 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0672695 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0629349 |
| PHF3 | PHD finger protein 3 | 0.0619562 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0611251 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0593237 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0541721 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0534678 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0532733 |
| LCN2 | lipocalin 2 | 0.0525012 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0518771 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0516052 |
| FAT1 | FAT atypical cadherin 1 | 0.0510244 |
| XDH | xanthine dehydrogenase | 0.050641 |
| ABHD2 | abhydrolase domain containing 2 | 0.0487614 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0486484 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.048262 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0479352 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0464633 |
| FNIP1 | folliculin interacting protein 1 | 0.0456806 |
| PDZD8 | PDZ domain containing 8 | 0.0443917 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0443729 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0442491 |
| UBC | ubiquitin C | 0.0440196 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0436682 |
| MAP7 | microtubule-associated protein 7 | 0.0433249 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0423097 |
| YAP1 | Yes-associated protein 1 | 0.0407249 |
| FTL | ferritin, light polypeptide | 0.0396594 |
| RBM33 | RNA binding motif protein 33 | 0.0392721 |
| CDHR2 | cadherin-related family member 2 | 0.0389528 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0388952 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0385827 |
| IFNGR1 | interferon gamma receptor 1 | 0.037921 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0379062 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0371224 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0370233 |
| BCL2L1 | BCL2-like 1 | 0.036814 |
| MYO5B | myosin VB | 0.036466 |
| FOXP1 | forkhead box P1 | 0.0361818 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.0360198 |
| OCLN | occludin | 0.0358696 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0351543 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0351049 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0347943 |
| JMJD1C | jumonji domain containing 1C | 0.0347237 |
| NCKAP5 | NCK-associated protein 5 | 0.0327776 |
| RND3 | Rho family GTPase 3 | 0.0327386 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0327307 |
| LAMC2 | laminin, gamma 2 | 0.0326933 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.0326801 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0326278 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0316223 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0314202 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0314154 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0311541 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0307961 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | 0.0306462 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0305494 |
| MCU | mitochondrial calcium uniporter | 0.0303914 |
| SIK3 | SIK family kinase 3 | 0.0303834 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0288825 |
| ADAMTS17 | ADAM metallopeptidase with thrombospondin type 1 motif, 17 | 0.0287891 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0287887 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0286908 |
| STK24 | serine/threonine kinase 24 | 0.0286697 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0283965 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0280981 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0279779 |
| APP | amyloid beta (A4) precursor protein | 0.027888 |
| MYO10 | myosin X | 0.0277497 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0277485 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0275599 |
| FHL2 | four and a half LIM domains 2 | 0.0268965 |
| CDCP1 | CUB domain containing protein 1 | 0.0268842 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0268321 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.026772 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.026681 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.026632 |
| MYO1E | myosin IE | 0.0263048 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0261558 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0260824 |
| DUSP16 | dual specificity phosphatase 16 | 0.0258386 |
| TC2N | tandem C2 domains, nuclear | 0.0258297 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0257255 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0253466 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0253058 |
| UBAC2 | UBA domain containing 2 | 0.0251014 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.024957 |
| SLTM | SAFB-like, transcription modulator | 0.0248801 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0246168 |
| CERT1 | ceramide transporter 1 | 0.0246102 |
| Symbol | Name | Standardized Value |
|---|---|---|
| INTS6 | integrator complex subunit 6 | -0.151621 |
| SQSTM1 | sequestosome 1 | -0.110209 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.100941 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.100397 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0961448 |
| EGR1 | early growth response 1 | -0.0925519 |
| NPSR1 | neuropeptide S receptor 1 | -0.0903402 |
| RIGI | RNA sensor RIG-I | -0.0903019 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0818611 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0739611 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0738885 |
| PTMA | prothymosin, alpha | -0.0713667 |
| EFNB2 | ephrin-B2 | -0.0670651 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0610133 |
| ANXA2 | annexin A2 | -0.0533013 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0521823 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0508893 |
| PLSCR2 | phospholipid scramblase 2 | -0.048326 |
| RNF213 | ring finger protein 213 | -0.0478903 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0477361 |
| SSH2 | slingshot protein phosphatase 2 | -0.0451863 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.045053 |
| RRBP1 | ribosome binding protein 1 | -0.044848 |
| PRKCA | protein kinase C, alpha | -0.0442159 |
| CALR | calreticulin | -0.043278 |
| IRF1 | interferon regulatory factor 1 | -0.0421307 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0419744 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.04188 |
| RPL23 | ribosomal protein L23 | -0.0417507 |
| TFRC | transferrin receptor | -0.0405314 |
| HM13 | histocompatibility (minor) 13 | -0.0402116 |
| JUN | jun proto-oncogene | -0.0401944 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0399609 |
| MX1 | MX dynamin-like GTPase 1 | -0.039954 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0395557 |
| RPS3 | ribosomal protein S3 | -0.0390233 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.037655 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.037523 |
| MORF4L2 | mortality factor 4 like 2 | -0.0371696 |
| LYZ | lysozyme | -0.0370002 |
| PKM | pyruvate kinase, muscle | -0.0367702 |
| ADIPOR2 | adiponectin receptor 2 | -0.0361936 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0353796 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0352526 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0350641 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0349696 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0349223 |
| RPS6 | ribosomal protein S6 | -0.0348275 |
| RBM39 | RNA binding motif protein 39 | -0.0343174 |
| RPLP1 | ribosomal protein, large, P1 | -0.0342946 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0327104 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0323201 |
| RPL35A | ribosomal protein L35a | -0.0321233 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.0320266 |
| POF1B | premature ovarian failure, 1B | -0.0318033 |
| FBXO39 | F-box protein 39 | -0.0314196 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0314066 |
| AREG | amphiregulin | -0.031189 |
| RPL19 | ribosomal protein L19 | -0.0311385 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0308716 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0303309 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.03021 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0301994 |
| UBAP2 | ubiquitin associated protein 2 | -0.0300977 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0299868 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0296654 |
| AHNAK | AHNAK nucleoprotein | -0.0296618 |
| NABP1 | nucleic acid binding protein 1 | -0.0293989 |
| SP100 | SP100 nuclear antigen | -0.0287017 |
| RTN3 | reticulon 3 | -0.0283656 |
| XAF1 | XIAP associated factor 1 | -0.0281371 |
| HDLBP | high density lipoprotein binding protein | -0.0280248 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0277755 |
| MKI67 | marker of proliferation Ki-67 | -0.0276868 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0276806 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0276039 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0265242 |
| HLA-C | major histocompatibility complex, class I, C | -0.0264577 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0262339 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.025957 |
| RPS24 | ribosomal protein S24 | -0.0255894 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0255038 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0251031 |
| DIAPH3 | diaphanous-related formin 3 | -0.0250821 |
| IER3 | immediate early response 3 | -0.0248527 |
| NDRG1 | N-myc downstream regulated 1 | -0.0248387 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0245008 |
| TMEM263 | transmembrane protein 263 | -0.0241884 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0239663 |
| RPS8 | ribosomal protein S8 | -0.02391 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.023677 |
| MUC13 | mucin 13, cell surface associated | -0.0236328 |
| FBXO11 | F-box protein 11 | -0.0232833 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0231676 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.0231497 |
| MX2 | MX dynamin-like GTPase 2 | -0.0231218 |
| PLIN2 | perilipin 2 | -0.0228767 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | -0.0227629 |
| FUS | FUS RNA binding protein | -0.0226217 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0225649 |
