| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.211367 |
| CADM1 | cell adhesion molecule 1 | 0.145041 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0933199 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0856082 |
| NAV2 | neuron navigator 2 | 0.0724564 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0720181 |
| RIGI | RNA sensor RIG-I | 0.0694993 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0690156 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0670681 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0610446 |
| HDAC9 | histone deacetylase 9 | 0.0593827 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0571446 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0544619 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0542933 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.052225 |
| CDH13 | cadherin 13 | 0.0447243 |
| SP100 | SP100 nuclear antigen | 0.0443551 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0430826 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0412943 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0394346 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0385863 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0357772 |
| PTK2 | protein tyrosine kinase 2 | 0.0355805 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0348614 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0322707 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0316703 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0315824 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0311625 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0306537 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0302056 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0301571 |
| ATXN1 | ataxin 1 | 0.0298098 |
| GOLGB1 | golgin B1 | 0.029215 |
| HSPA1A | heat shock 70kDa protein 1A | 0.02915 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0289405 |
| ZNF148 | zinc finger protein 148 | 0.028895 |
| PLSCR1 | phospholipid scramblase 1 | 0.0285284 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0283901 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0283881 |
| FMNL2 | formin-like 2 | 0.0280258 |
| MLF1 | myeloid leukemia factor 1 | 0.0277339 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0276067 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0273428 |
| SMYD3 | SET and MYND domain containing 3 | 0.0270329 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0270132 |
| IRF1 | interferon regulatory factor 1 | 0.0264902 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0264524 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0263611 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0260914 |
| SQSTM1 | sequestosome 1 | 0.0258895 |
| RRBP1 | ribosome binding protein 1 | 0.0256839 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0256235 |
| USP15 | ubiquitin specific peptidase 15 | 0.0252373 |
| SPAG9 | sperm associated antigen 9 | 0.0249375 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0249128 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.02453 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0244966 |
| CLU | clusterin | 0.0244404 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.02435 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0240333 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0239832 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0239084 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0238546 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.023551 |
| RLF | rearranged L-myc fusion | 0.0234235 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0229098 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0228177 |
| ENO1 | enolase 1, (alpha) | 0.0225168 |
| AHR | aryl hydrocarbon receptor | 0.022289 |
| ATF6 | activating transcription factor 6 | 0.0221401 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0221098 |
| CEP350 | centrosomal protein 350kDa | 0.0220217 |
| EFNA5 | ephrin-A5 | 0.021623 |
| DMXL1 | Dmx-like 1 | 0.0213995 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0213509 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.021247 |
| SGMS1 | sphingomyelin synthase 1 | 0.0212403 |
| SMAD3 | SMAD family member 3 | 0.0206572 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0206031 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0205708 |
| SVIL | supervillin | 0.0204025 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0204017 |
| RAD51B | RAD51 paralog B | 0.0201716 |
| APP | amyloid beta (A4) precursor protein | 0.0199469 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.019929 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0195697 |
| RAB10 | RAB10, member RAS oncogene family | 0.0192813 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.018829 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0186599 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.0186353 |
| JAK1 | Janus kinase 1 | 0.0185595 |
| METTL15 | methyltransferase like 15 | 0.0185447 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0184653 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0184023 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0183976 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0179759 |
| MX2 | MX dynamin-like GTPase 2 | 0.017863 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0178043 |
| RCOR1 | REST corepressor 1 | 0.0177771 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0177752 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.305257 |
| VIM | vimentin | -0.225092 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.152145 |
| COL1A1 | collagen, type I, alpha 1 | -0.149575 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.147222 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.129594 |
| COL1A2 | collagen, type I, alpha 2 | -0.123166 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11583 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.113086 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0702865 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0697602 |
| TMSB10 | thymosin beta 10 | -0.0696978 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0564836 |
| TPM4 | tropomyosin 4 | -0.0516091 |
| CALD1 | caldesmon 1 | -0.0487519 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0440549 |
| PKM | pyruvate kinase, muscle | -0.0427724 |
| MAP1B | microtubule-associated protein 1B | -0.0421955 |
| S100A9 | S100 calcium binding protein A9 | -0.0398556 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0396185 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0391054 |
| EGR1 | early growth response 1 | -0.0373327 |
| ADM | adrenomedullin | -0.0368488 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0367054 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0361579 |
| VEGFA | vascular endothelial growth factor A | -0.0355512 |
| ACTG1 | actin gamma 1 | -0.0353998 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0353469 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0353336 |
| RPL35A | ribosomal protein L35a | -0.0349786 |
| POTEF | POTE ankyrin domain family, member F | -0.033499 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0307888 |
| TGFB1 | transforming growth factor, beta 1 | -0.0304285 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0298537 |
| CD109 | CD109 molecule | -0.0286878 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0284226 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0282619 |
| PTMA | prothymosin, alpha | -0.0275292 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0272649 |
| AXL | AXL receptor tyrosine kinase | -0.0256505 |
| CALR | calreticulin | -0.0248915 |
| EHD2 | EH-domain containing 2 | -0.0244925 |
| TPM1 | tropomyosin 1 (alpha) | -0.0244098 |
| TMEM165 | transmembrane protein 165 | -0.0243164 |
| MT2A | metallothionein 2A | -0.024089 |
| PFN1 | profilin 1 | -0.0237158 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0232005 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0229274 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0224154 |
| NREP | neuronal regeneration related protein | -0.0222909 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0221176 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.021387 |
| LOX | lysyl oxidase | -0.0213401 |
| RTN4 | reticulon 4 | -0.021332 |
| SULF1 | sulfatase 1 | -0.0211284 |
| TAPBP | TAP binding protein (tapasin) | -0.0209833 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0208968 |
| TUBB6 | tubulin, beta 6 class V | -0.0204251 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.019903 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.019623 |
| OXR1 | oxidation resistance 1 | -0.019177 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0190723 |
| PLIN3 | perilipin 3 | -0.0188412 |
| IER3 | immediate early response 3 | -0.0187128 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0187066 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0186791 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0186789 |
| HLA-A | major histocompatibility complex, class I, A | -0.0186725 |
| GLIS3 | GLIS family zinc finger 3 | -0.0186184 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0183637 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.018361 |
| LAMA5 | laminin, alpha 5 | -0.0178052 |
| CTSB | cathepsin B | -0.0177791 |
| TUBB | tubulin, beta class I | -0.0176029 |
| RPL28 | ribosomal protein L28 | -0.0173784 |
| HIP1 | huntingtin interacting protein 1 | -0.0173208 |
| LMO4 | LIM domain only 4 | -0.0172012 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0171099 |
| ATP13A3 | ATPase type 13A3 | -0.0169082 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0168056 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0167907 |
| LOC112694756 | uncharaterized LOC112694756 | -0.016714 |
| STC2 | stanniocalcin 2 | -0.0165842 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.016577 |
| CLIC4 | chloride intracellular channel 4 | -0.0165239 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0165085 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0164063 |
| NBAS | neuroblastoma amplified sequence | -0.0163691 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0162882 |
| TMEM39A | transmembrane protein 39A | -0.0162484 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0159321 |
| MYADM | myeloid-associated differentiation marker | -0.0157997 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0157188 |
| KIF13A | kinesin family member 13A | -0.0157172 |
| RPL30 | ribosomal protein L30 | -0.0156829 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0156623 |
| FBXO32 | F-box protein 32 | -0.0155889 |
| S100A11 | S100 calcium binding protein A11 | -0.0155087 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0154384 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0153566 |
