| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.3867 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.160498 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.144127 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.128786 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.124096 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.117362 |
| DSPP | dentin sialophosphoprotein | 0.10783 |
| SVIL | supervillin | 0.107287 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0940551 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0760334 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0755285 |
| ENO1 | enolase 1, (alpha) | 0.0744196 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0651104 |
| FOXP1 | forkhead box P1 | 0.0633288 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0632567 |
| C3 | complement component 3 | 0.0621935 |
| TF | transferrin | 0.0621568 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0605875 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0574697 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0566463 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0525501 |
| FRMD5 | FERM domain containing 5 | 0.0514651 |
| FAM107B | family with sequence similarity 107, member B | 0.0511441 |
| DST | dystonin | 0.0502947 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0475111 |
| ASPH | aspartate beta-hydroxylase | 0.0460132 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0447597 |
| DIAPH1 | diaphanous-related formin 1 | 0.042445 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0423729 |
| JMJD1C | jumonji domain containing 1C | 0.0423048 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.041543 |
| CRY1 | cryptochrome circadian clock 1 | 0.0400338 |
| ATXN1 | ataxin 1 | 0.0394434 |
| RPL11 | ribosomal protein L11 | 0.0386717 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0377418 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0365086 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0360978 |
| DUSP6 | dual specificity phosphatase 6 | 0.0352277 |
| BCL2L1 | BCL2-like 1 | 0.0349823 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.034068 |
| RPL21 | ribosomal protein L21 | 0.0338691 |
| TNS1 | tensin 1 | 0.0337104 |
| FAT1 | FAT atypical cadherin 1 | 0.0333166 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0324369 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0323113 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0310264 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0309082 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.03077 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0304788 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0303557 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0302761 |
| RPL3 | ribosomal protein L3 | 0.0297593 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0296523 |
| GRB10 | growth factor receptor-bound protein 10 | 0.02961 |
| DSTN | destrin (actin depolymerizing factor) | 0.029603 |
| TCIM | transcriptional and immune response regulator | 0.0291925 |
| CCN2 | cellular communication network factor 2 | 0.0287492 |
| SON | SON DNA binding protein | 0.0282646 |
| AHR | aryl hydrocarbon receptor | 0.0272453 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0270997 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0269872 |
| KYNU | kynureninase | 0.0265378 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0265224 |
| RAB3B | RAB3B, member RAS oncogene family | 0.02642 |
| CNKSR3 | CNKSR family member 3 | 0.0263254 |
| CPE | carboxypeptidase E | 0.0259233 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0257799 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0256243 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0252503 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0250484 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0247887 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.024548 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0245363 |
| CCNY | cyclin Y | 0.0243689 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.024171 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0239741 |
| VEGFA | vascular endothelial growth factor A | 0.0238124 |
| KALRN | kalirin, RhoGEF kinase | 0.0235862 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0234548 |
| POTEF | POTE ankyrin domain family, member F | 0.023432 |
| RASA2 | RAS p21 protein activator 2 | 0.0233092 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0231445 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0231115 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0229411 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.022728 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.022611 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0223692 |
| GPC6 | glypican 6 | 0.0220891 |
| FHL2 | four and a half LIM domains 2 | 0.0218771 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0218482 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0218205 |
| RNASET2 | ribonuclease T2 | 0.0216135 |
| ITGA6 | integrin, alpha 6 | 0.0215709 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0214626 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0212336 |
| VCAN | versican | 0.0210765 |
| HOMER1 | homer scaffolding protein 1 | 0.0210527 |
| CCDC88A | coiled-coil domain containing 88A | 0.0210214 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.020847 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0207688 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.185122 |
| GPC3 | glypican 3 | -0.151321 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.137245 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.115612 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.105268 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.101149 |
| FN1 | fibronectin 1 | -0.0986048 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0706041 |
| IGF2 | insulin-like growth factor 2 | -0.0705959 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0695181 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0657351 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0652996 |
| APOA2 | apolipoprotein A-II | -0.0635434 |
| A2M | alpha-2-macroglobulin | -0.0609226 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0604831 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0601183 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0589284 |
| RPL35A | ribosomal protein L35a | -0.0511663 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0510164 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0502329 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0473692 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0458493 |
| RBM39 | RNA binding motif protein 39 | -0.0443274 |
| RPS24 | ribosomal protein S24 | -0.0442481 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0434786 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0432694 |
| IER3 | immediate early response 3 | -0.0413291 |
| RPLP1 | ribosomal protein, large, P1 | -0.0402639 |
| NDRG1 | N-myc downstream regulated 1 | -0.0395208 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0392862 |
| TRIM26 | tripartite motif containing 26 | -0.0385132 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0381365 |
| MSI2 | musashi RNA-binding protein 2 | -0.0371988 |
| PEG3 | paternally expressed 3 | -0.0371549 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0365103 |
| TMEM123 | transmembrane protein 123 | -0.0364551 |
| RPL37A | ribosomal protein L37a | -0.0341282 |
| RPL31 | ribosomal protein L31 | -0.0337945 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0334178 |
| GNAS | GNAS complex locus | -0.0330109 |
| RPS27A | ribosomal protein S27a | -0.032773 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0321498 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0321107 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0315366 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0311128 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0303979 |
| RPL34 | ribosomal protein L34 | -0.0303948 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0296454 |
| RPL38 | ribosomal protein L38 | -0.0295957 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0295661 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0295601 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0282464 |
| RPS29 | ribosomal protein S29 | -0.0282251 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.027831 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0278248 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0276237 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0275266 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.0272139 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0269723 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0269075 |
| RPL4 | ribosomal protein L4 | -0.0268971 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0266999 |
| HDLBP | high density lipoprotein binding protein | -0.0263073 |
| SDC2 | syndecan 2 | -0.0261849 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0261299 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0258327 |
| IGF2R | insulin-like growth factor 2 receptor | -0.0255546 |
| CANX | calnexin | -0.0253723 |
| LOC112694756 | uncharaterized LOC112694756 | -0.025297 |
| RPS8 | ribosomal protein S8 | -0.0252162 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0249668 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0247824 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0246695 |
| PEG10 | paternally expressed 10 | -0.0241751 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0239411 |
| NPR2 | natriuretic peptide receptor 2 | -0.02393 |
| ATP11A | ATPase, class VI, type 11A | -0.0238723 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0238102 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0237914 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.023737 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0234061 |
| RPS21 | ribosomal protein S21 | -0.0232571 |
| H3-3B | H3.3 histone B | -0.0228907 |
| TMEM181 | transmembrane protein 181 | -0.0228543 |
| CFB | complement factor B | -0.0227794 |
| FBXO11 | F-box protein 11 | -0.0226687 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0226116 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.022408 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0222721 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0221897 |
| RAB7A | RAB7A, member RAS oncogene family | -0.022003 |
| RRBP1 | ribosome binding protein 1 | -0.0219949 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0219093 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0218197 |
| FOXN3 | forkhead box N3 | -0.0218166 |
| NFIA | nuclear factor I/A | -0.0216814 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0213746 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0213338 |
| ANGPTL8 | angiopoietin like 8 | -0.0212875 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.021212 |
