Hydroxyfasudil_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.193146
MT2A metallothionein 2A 0.159794
B2M beta-2-microglobulin 0.155949
RPS6 ribosomal protein S6 0.144788
RPS8 ribosomal protein S8 0.128858
ENO1 enolase 1, (alpha) 0.115542
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.111638
RPL11 ribosomal protein L11 0.109247
CLU clusterin 0.103526
RPLP2 ribosomal protein, large, P2 0.101704
RPS3 ribosomal protein S3 0.100255
PDE4D phosphodiesterase 4D, cAMP-specific 0.0916785
TPT1 tumor protein, translationally-controlled 1 0.0869838
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0838081
FTH1 ferritin, heavy polypeptide 1 0.0812506
IFITM3 interferon induced transmembrane protein 3 0.0808573
CD44 CD44 molecule (Indian blood group) 0.078909
RPS21 ribosomal protein S21 0.0779832
RPS12 ribosomal protein S12 0.0779533
RPL12 ribosomal protein L12 0.0753533
RPS19 ribosomal protein S19 0.0725021
KRT17 keratin 17, type I 0.0721329
RPL37 ribosomal protein L37 0.0718428
IFITM1 interferon induced transmembrane protein 1 0.068831
RACK1 receptor for activated C kinase 1 0.0671944
FTL ferritin, light polypeptide 0.0670758
RPL31 ribosomal protein L31 0.0632538
TMSB10 thymosin beta 10 0.0611296
RPS13 ribosomal protein S13 0.060842
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0604534
RPL21 ribosomal protein L21 0.0601708
RPLP1 ribosomal protein, large, P1 0.0596942
SQSTM1 sequestosome 1 0.0575578
LDHA lactate dehydrogenase A 0.0551303
MYOF myoferlin 0.0548535
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0544582
RPL30 ribosomal protein L30 0.0530292
RPL37A ribosomal protein L37a 0.0528805
RPL23 ribosomal protein L23 0.0523455
HLA-B major histocompatibility complex, class I, B 0.051242
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0510822
RPS27 ribosomal protein S27 0.0499876
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0497806
KTN1 kinectin 1 (kinesin receptor) 0.0496824
APLP2 amyloid beta (A4) precursor-like protein 2 0.0489093
RPL26 ribosomal protein L26 0.048696
RPS4X ribosomal protein S4, X-linked 0.0483037
EEF2 eukaryotic translation elongation factor 2 0.0474664
SRRM2 serine/arginine repetitive matrix 2 0.0460479
HSPA1A heat shock 70kDa protein 1A 0.0458029
RPS14 ribosomal protein S14 0.0458021
KRT14 keratin 14, type I 0.0453824
RAI14 retinoic acid induced 14 0.0449883
LMO7 LIM domain 7 0.044946
TIMP3 TIMP metallopeptidase inhibitor 3 0.0448412
RPL7A ribosomal protein L7a 0.0447146
MRPS6 mitochondrial ribosomal protein S6 0.044679
DSTN destrin (actin depolymerizing factor) 0.0444122
CAV1 caveolin 1, caveolae protein, 22kDa 0.0434833
RPL36 ribosomal protein L36 0.0433738
IFI27 interferon, alpha-inducible protein 27 0.0433505
ARHGAP29 Rho GTPase activating protein 29 0.0431074
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0430202
PRRC2C proline-rich coiled-coil 2C 0.0421462
RPL9 ribosomal protein L9 0.0418041
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0417617
NAV2 neuron navigator 2 0.0412907
RPL35 ribosomal protein L35 0.0408388
TXNIP thioredoxin interacting protein 0.0407529
HLA-E major histocompatibility complex, class I, E 0.0407472
RPS23 ribosomal protein S23 0.0406445
RPL5 ribosomal protein L5 0.0406366
AKAP13 A kinase (PRKA) anchor protein 13 0.0396524
RPS25 ribosomal protein S25 0.0394534
RASAL2 RAS protein activator like 2 0.039317
RPL8 ribosomal protein L8 0.0388928
TGM2 transglutaminase 2 0.0387131
RPL13A ribosomal protein L13a 0.038604
EIF1 eukaryotic translation initiation factor 1 0.0383781
MT1E metallothionein 1E 0.0378374
RPL32 ribosomal protein L32 0.0377169
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0374421
MBNL2 muscleblind-like splicing regulator 2 0.0372175
MACF1 microtubule-actin crosslinking factor 1 0.0371364
PRSS23 protease, serine, 23 0.0365892
S100A10 S100 calcium binding protein A10 0.0365599
RPL35A ribosomal protein L35a 0.0364731
NAP1L1 nucleosome assembly protein 1-like 1 0.0364267
RPL19 ribosomal protein L19 0.0363744
S100A9 S100 calcium binding protein A9 0.0363526
PCDH1 protocadherin 1 0.0362394
RPS11 ribosomal protein S11 0.0362004
IFI6 interferon, alpha-inducible protein 6 0.0354434
ASTN2 astrotactin 2 0.0352369
SEPTIN7 septin 7 0.0351904
S100A11 S100 calcium binding protein A11 0.0351672
SVIL supervillin 0.0351571
RB1CC1 RB1-inducible coiled-coil 1 0.0350322
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0346248
IRS2 insulin receptor substrate 2 0.0345829

decreased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.144605
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0821099
MTSS1 metastasis suppressor 1 -0.0785546
FLNB filamin B, beta -0.0708525
SULF1 sulfatase 1 -0.0706868
INTS6 integrator complex subunit 6 -0.0619243
NDRG1 N-myc downstream regulated 1 -0.0609116
NAMPT nicotinamide phosphoribosyltransferase -0.0532879
RBM39 RNA binding motif protein 39 -0.0517346
MEF2A myocyte enhancer factor 2A -0.0512846
PALLD palladin, cytoskeletal associated protein -0.0497855
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.048039
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.045962
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0446892
DPYD dihydropyrimidine dehydrogenase -0.0432419
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0418154
KIAA1217 KIAA1217 -0.0410164
CLIC4 chloride intracellular channel 4 -0.0408278
ITCH itchy E3 ubiquitin protein ligase -0.03989
SEC31A SEC31 homolog A (S. cerevisiae) -0.0378886
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0378067
SLC35F3 solute carrier family 35, member F3 -0.0373133
ALCAM activated leukocyte cell adhesion molecule -0.0357341
HM13 histocompatibility (minor) 13 -0.0353199
VCL vinculin -0.034813
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0333598
AHNAK AHNAK nucleoprotein -0.0324554
ACTN4 actinin, alpha 4 -0.0321175
ANLN anillin, actin binding protein -0.0316316
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.03156
COG6 component of oligomeric golgi complex 6 -0.0307526
SMYD3 SET and MYND domain containing 3 -0.0306301
SEC24D SEC24 family member D -0.0306132
GLG1 golgi glycoprotein 1 -0.0305857
RCOR1 REST corepressor 1 -0.0303791
BCAR3 breast cancer anti-estrogen resistance 3 -0.0295553
TSC22D1 TSC22 domain family, member 1 -0.0290627
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0290508
CANX calnexin -0.0287557
NRIP1 nuclear receptor interacting protein 1 -0.0287345
BCL2L1 BCL2-like 1 -0.0283555
MARCHF6 membrane associated ring-CH-type finger 6 -0.0280145
LDLR low density lipoprotein receptor -0.0275473
COG5 component of oligomeric golgi complex 5 -0.0274916
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0274214
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0271658
SPAG9 sperm associated antigen 9 -0.0268014
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0265171
STAU1 staufen double-stranded RNA binding protein 1 -0.02604
FOXO1 forkhead box O1 -0.0257738
FNDC3B fibronectin type III domain containing 3B -0.0254375
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.025343
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0252489
AFAP1 actin filament associated protein 1 -0.0252379
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0248979
BLCAP bladder cancer associated protein -0.024769
CLINT1 clathrin interactor 1 -0.0244222
ITGA6 integrin, alpha 6 -0.0243101
ASPH aspartate beta-hydroxylase -0.0241349
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0240316
NCOA3 nuclear receptor coactivator 3 -0.0237436
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0237333
MAML2 mastermind-like 2 (Drosophila) -0.0237116
OSBPL3 oxysterol binding protein-like 3 -0.0234835
MON2 MON2 homolog (S. cerevisiae) -0.0232038
PTK2 protein tyrosine kinase 2 -0.0232032
IARS1 isoleucyl-tRNA synthetase 1 -0.0228973
CLTC clathrin, heavy chain (Hc) -0.0228008
COL4A5 collagen, type IV, alpha 5 -0.022738
CDK13 cyclin-dependent kinase 13 -0.0226683
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.022632
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0225777
PSD3 pleckstrin and Sec7 domain containing 3 -0.0224706
SERTAD2 SERTA domain containing 2 -0.0219708
HOOK2 hook microtubule-tethering protein 2 -0.0217248
MECOM MDS1 and EVI1 complex locus -0.0216455
RAB6A RAB6A, member RAS oncogene family -0.0216338
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0216312
ZFC3H1 zinc finger, C3H1-type containing -0.0216214
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0216084
TMEM263 transmembrane protein 263 -0.021574
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0214592
WDFY2 WD repeat and FYVE domain containing 2 -0.0212941
SUCO SUN domain containing ossification factor -0.0211088
ZMYM2 zinc finger, MYM-type 2 -0.02102
RAP1B RAP1B, member of RAS oncogene family -0.020979
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0208221
CALU calumenin -0.0203367
SOX13 SRY (sex determining region Y)-box 13 -0.0202892
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0200868
ABI3BP ABI family, member 3 (NESH) binding protein -0.0199868
MYH9 myosin, heavy chain 9, non-muscle -0.0197608
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0197162
RAB10 RAB10, member RAS oncogene family -0.0196084
KDM3A lysine (K)-specific demethylase 3A -0.0195083
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0193937
TM9SF2 transmembrane 9 superfamily member 2 -0.0191021
CUL4B cullin 4B -0.019054
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0189715
FNIP1 folliculin interacting protein 1 -0.0189261