Hydroxyfasudil_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Hydroxyfasudil_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.201039
MUC6 mucin 6, oligomeric mucus/gel-forming 0.11723
FTH1 ferritin, heavy polypeptide 1 0.0911733
TPT1 tumor protein, translationally-controlled 1 0.062375
RPS12 ribosomal protein S12 0.0450433
RPS8 ribosomal protein S8 0.0447805
RPS6 ribosomal protein S6 0.0437404
ITGB4 integrin, beta 4 0.0421524
HSPA8 heat shock 70kDa protein 8 0.041444
SRRM2 serine/arginine repetitive matrix 2 0.0414089
RPL9 ribosomal protein L9 0.0389475
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0384438
SQSTM1 sequestosome 1 0.0365869
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0363699
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0357926
EGFR epidermal growth factor receptor 0.0343725
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0342494
ONECUT3 one cut homeobox 3 0.0328409
ALCAM activated leukocyte cell adhesion molecule 0.0317374
RPS19 ribosomal protein S19 0.0307899
ACTG1 actin gamma 1 0.0298802
NUPR1 nuclear protein, transcriptional regulator, 1 0.029577
EEF2 eukaryotic translation elongation factor 2 0.0288598
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0287348
LGALS3 lectin, galactoside-binding, soluble, 3 0.0285912
FAT1 FAT atypical cadherin 1 0.0276998
RPL37 ribosomal protein L37 0.0274357
EPHA2 EPH receptor A2 0.0267741
RPL26 ribosomal protein L26 0.0240656
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0240128
RPS3 ribosomal protein S3 0.0239685
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0236608
LAMB3 laminin, beta 3 0.0234637
KLF6 Kruppel-like factor 6 0.0232325
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0231886
RPL13A ribosomal protein L13a 0.0230078
RPL23 ribosomal protein L23 0.0228717
MARCHF3 membrane associated ring-CH-type finger 3 0.0221404
LOC102724023 ES1 protein homolog, mitochondrial 0.0221302
RPL37A ribosomal protein L37a 0.0218188
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0214006
CALB1 calbindin 1, 28kDa 0.0206636
PLXNB2 plexin B2 0.0205855
CD9 CD9 molecule 0.0203039
RPL27 ribosomal protein L27 0.019431
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0189985
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0189078
RPS26 ribosomal protein S26 0.0186746
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0186335
MUC17 mucin 17, cell surface associated 0.0184547
H1-0 H1.0 linker histone 0.0178693
RPSA ribosomal protein SA 0.0177952
ENO2 enolase 2 (gamma, neuronal) 0.017677
GRB10 growth factor receptor-bound protein 10 0.0174662
RNF213 ring finger protein 213 0.0174239
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0172588
PTPRK protein tyrosine phosphatase, receptor type, K 0.0171866
LENG8 leukocyte receptor cluster (LRC) member 8 0.0171537
SOX4 SRY (sex determining region Y)-box 4 0.0168606
JUN jun proto-oncogene 0.0167619
MT2A metallothionein 2A 0.0167447
NCOR2 nuclear receptor corepressor 2 0.0166149
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.016511
EXT1 exostosin glycosyltransferase 1 0.0164953
LAMA4 laminin, alpha 4 0.0164427
AKAP13 A kinase (PRKA) anchor protein 13 0.0162615
PDE10A phosphodiesterase 10A 0.0159902
PTPRB protein tyrosine phosphatase, receptor type, B 0.0158416
RPS14 ribosomal protein S14 0.0155217
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0152427
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0151064
INSR insulin receptor 0.0149792
EIF4A1 eukaryotic translation initiation factor 4A1 0.0149213
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 0.0147708
MYOF myoferlin 0.0146676
ENO1 enolase 1, (alpha) 0.0146415
UBB ubiquitin B 0.0146302
RPL28 ribosomal protein L28 0.0146228
SOX9 SRY (sex determining region Y)-box 9 0.0145944
HLA-A major histocompatibility complex, class I, A 0.0145477
BACE2 beta-site APP-cleaving enzyme 2 0.014301
EMP1 epithelial membrane protein 1 0.0142668
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0141724
AGRN agrin 0.0141531
RPL11 ribosomal protein L11 0.0141522
LRATD1 LRAT domain containing 1 0.0141423
ARHGAP6 Rho GTPase activating protein 6 0.0141254
DIAPH1 diaphanous-related formin 1 0.0140207
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0140134
RPL3 ribosomal protein L3 0.013998
KLK10 kallikrein-related peptidase 10 0.0139945
PLEC plectin 0.0138772
KRT8 keratin 8, type II 0.0136439
MRPS6 mitochondrial ribosomal protein S6 0.0136339
PTPRF protein tyrosine phosphatase, receptor type, F 0.0135963
KAZN kazrin, periplakin interacting protein 0.013463
UNC13B unc-13 homolog B (C. elegans) 0.0134153
FLNA filamin A, alpha 0.0132902
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0131308
RPLP2 ribosomal protein, large, P2 0.013047

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148641
PTMA prothymosin, alpha -0.112371
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100407
GPHN gephyrin -0.0961407
ITGA6 integrin, alpha 6 -0.0860776
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0858832
RBM39 RNA binding motif protein 39 -0.0850269
RPS2 ribosomal protein S2 -0.0807974
EPCAM epithelial cell adhesion molecule -0.0796935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0778717
GOLGA4 golgin A4 -0.0721092
ZFAND3 zinc finger, AN1-type domain 3 -0.0719139
CLTC clathrin, heavy chain (Hc) -0.0712624
DSPP dentin sialophosphoprotein -0.0707961
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0690788
LMO7 LIM domain 7 -0.0649173
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0625253
DSG2 desmoglein 2 -0.0601481
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0597919
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0588813
MED13L mediator complex subunit 13-like -0.0586051
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0551409
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0550991
CANX calnexin -0.0540481
NCOR1 nuclear receptor corepressor 1 -0.0536311
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0535335
DSCAM Down syndrome cell adhesion molecule -0.0531354
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0529081
GMDS GDP-mannose 4,6-dehydratase -0.0527318
GARS1 glycyl-tRNA synthetase 1 -0.0517811
PUM2 pumilio RNA-binding family member 2 -0.0504075
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.050274
SETD5 SET domain containing 5 -0.048907
SPAG9 sperm associated antigen 9 -0.0479821
RAB1A RAB1A, member RAS oncogene family -0.0457343
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0455474
RNF145 ring finger protein 145 -0.04532
RAB10 RAB10, member RAS oncogene family -0.0449104
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.044206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0429296
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0428008
TM9SF3 transmembrane 9 superfamily member 3 -0.0426237
TFRC transferrin receptor -0.0421277
ARL15 ADP-ribosylation factor-like 15 -0.041802
KDM3A lysine (K)-specific demethylase 3A -0.0410006
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0409964
EREG epiregulin -0.0409882
INSIG1 insulin induced gene 1 -0.0407141
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0405941
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0404665
ANXA2 annexin A2 -0.0390325
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0388692
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0379744
TARS1 threonyl-tRNA synthetase 1 -0.0378416
WAC WW domain containing adaptor with coiled-coil -0.0374128
XPO1 exportin 1 -0.0373997
UBE2H ubiquitin-conjugating enzyme E2H -0.0373765
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0373641
VMP1 vacuole membrane protein 1 -0.0366959
GSK3B glycogen synthase kinase 3 beta -0.0365041
IARS1 isoleucyl-tRNA synthetase 1 -0.0362331
PSAT1 phosphoserine aminotransferase 1 -0.0361479
BIRC6 baculoviral IAP repeat containing 6 -0.0360139
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0359695
PTBP3 polypyrimidine tract binding protein 3 -0.0359142
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0357378
NAMPT nicotinamide phosphoribosyltransferase -0.0356742
NIPBL Nipped-B homolog (Drosophila) -0.0356439
ASPH aspartate beta-hydroxylase -0.0355546
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0354792
SSR1 signal sequence receptor, alpha -0.0354333
ARHGAP26 Rho GTPase activating protein 26 -0.0353615
SBF2 SET binding factor 2 -0.0352361
PKM pyruvate kinase, muscle -0.0350357
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0349144
TXNRD1 thioredoxin reductase 1 -0.0348665
PAPOLA poly(A) polymerase alpha -0.0348319
NFIA nuclear factor I/A -0.0346618
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0345404
COG5 component of oligomeric golgi complex 5 -0.0343953
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0342487
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0341835
LDHA lactate dehydrogenase A -0.0340854
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0338003
PCDHB16 protocadherin beta 16 -0.0333548
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0333506
AGR2 anterior gradient 2 -0.0332911
KDM7A lysine (K)-specific demethylase 7A -0.0332167
ITPRID2 ITPR interacting domain containing 2 -0.0329165
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0329005
TAOK1 TAO kinase 1 -0.0329005
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0328182
CALR calreticulin -0.0328168
FNDC3B fibronectin type III domain containing 3B -0.0326818
ZNF207 zinc finger protein 207 -0.0326616
EIF1 eukaryotic translation initiation factor 1 -0.032567
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0325352
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0322648
KIF5B kinesin family member 5B -0.0321604