| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0926332 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0910063 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0845334 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.063339 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0529889 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0477807 |
| DST | dystonin | 0.047721 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0443814 |
| CAPRIN2 | caprin family member 2 | 0.0435617 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0413596 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0406063 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0402171 |
| RPS12 | ribosomal protein S12 | 0.0395453 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0357009 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0350979 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0348951 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0346736 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0343254 |
| HDAC9 | histone deacetylase 9 | 0.0331398 |
| SQSTM1 | sequestosome 1 | 0.0320195 |
| ANGPTL4 | angiopoietin-like 4 | 0.0307702 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0298853 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0294299 |
| JMJD1C | jumonji domain containing 1C | 0.0285144 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0284755 |
| TP63 | tumor protein p63 | 0.0283104 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0279782 |
| RPS3 | ribosomal protein S3 | 0.0274438 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0264906 |
| INTS6 | integrator complex subunit 6 | 0.025255 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0246418 |
| HOMER1 | homer scaffolding protein 1 | 0.0244758 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0243892 |
| PDE10A | phosphodiesterase 10A | 0.0242904 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0233648 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.0225755 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0224719 |
| MYOF | myoferlin | 0.022144 |
| DNER | delta/notch-like EGF repeat containing | 0.0211941 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0208261 |
| NEK10 | NIMA-related kinase 10 | 0.0207469 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0195385 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.019236 |
| GOLGB1 | golgin B1 | 0.0191604 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0187523 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0182514 |
| APP | amyloid beta (A4) precursor protein | 0.0180365 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0177942 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.017546 |
| CMIP | c-Maf inducing protein | 0.0171263 |
| NAV2 | neuron navigator 2 | 0.0170552 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0170201 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0166351 |
| DOCK1 | dedicator of cytokinesis 1 | 0.01661 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0165461 |
| CACHD1 | cache domain containing 1 | 0.0154917 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0153722 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0150854 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.0150814 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0150345 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0150045 |
| SVIL | supervillin | 0.014856 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0146956 |
| RPS8 | ribosomal protein S8 | 0.0146246 |
| RPL27 | ribosomal protein L27 | 0.0145171 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0143989 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0143612 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0143223 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.0142406 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0141853 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0140845 |
| DIAPH1 | diaphanous-related formin 1 | 0.0139763 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0137741 |
| RPL37A | ribosomal protein L37a | 0.0137408 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0133892 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.0130394 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.013039 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0129853 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0129543 |
| RPL31 | ribosomal protein L31 | 0.0128647 |
| FAM120B | family with sequence similarity 120B | 0.0128183 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0127622 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.0127505 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0127366 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.012731 |
| TXNRD1 | thioredoxin reductase 1 | 0.0125436 |
| AREG | amphiregulin | 0.012509 |
| ANO6 | anoctamin 6 | 0.0123696 |
| USP34 | ubiquitin specific peptidase 34 | 0.0123198 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0121268 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0120934 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0120843 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0120327 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0119064 |
| RPL26 | ribosomal protein L26 | 0.0118827 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0118718 |
| AEBP2 | AE binding protein 2 | 0.011808 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0118025 |
| RUNX1 | runt-related transcription factor 1 | 0.0117902 |
| PODXL | podocalyxin-like | 0.011704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.191272 |
| PTMA | prothymosin, alpha | -0.177614 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.140348 |
| TMSB10 | thymosin beta 10 | -0.135603 |
| VIM | vimentin | -0.102611 |
| TMSB4X | thymosin beta 4, X-linked | -0.0872968 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0724576 |
| POTEF | POTE ankyrin domain family, member F | -0.0691781 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0674235 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.060039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0536579 |
| HMGA1 | high mobility group AT-hook 1 | -0.0487073 |
| RPL35A | ribosomal protein L35a | -0.0485045 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0445886 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.043613 |
| TXNIP | thioredoxin interacting protein | -0.0435469 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0433751 |
| HLA-B | major histocompatibility complex, class I, B | -0.0419849 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0411019 |
| PGK1 | phosphoglycerate kinase 1 | -0.0400513 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0398697 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0393552 |
| ACTG1 | actin gamma 1 | -0.0380323 |
| ZNF292 | zinc finger protein 292 | -0.0379153 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.036759 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0362226 |
| CANX | calnexin | -0.033862 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0331092 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0328316 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0323748 |
| RBM25 | RNA binding motif protein 25 | -0.0320462 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0315864 |
| TMEM123 | transmembrane protein 123 | -0.0311322 |
| GNAS | GNAS complex locus | -0.0306216 |
| CENPF | centromere protein F, 350/400kDa | -0.0306134 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0304533 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0296551 |
| EPHA4 | EPH receptor A4 | -0.0295567 |
| YBX1 | Y box binding protein 1 | -0.0294194 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0293166 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0291912 |
| XPO1 | exportin 1 | -0.0291363 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0291235 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0288334 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0287911 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0285687 |
| EFNA5 | ephrin-A5 | -0.0284025 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0279245 |
| TUBB | tubulin, beta class I | -0.0276203 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.02724 |
| ZNF207 | zinc finger protein 207 | -0.0264003 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0263581 |
| FBXO11 | F-box protein 11 | -0.0261287 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0256789 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.025602 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0256007 |
| FUS | FUS RNA binding protein | -0.0254564 |
| ZNF217 | zinc finger protein 217 | -0.0252527 |
| NOP58 | NOP58 ribonucleoprotein | -0.025049 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0249916 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0246707 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0245221 |
| EIF3M | eukaryotic translation initiation factor 3, subunit M | -0.0244978 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0243124 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0242273 |
| RPS24 | ribosomal protein S24 | -0.0241751 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0241398 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0241395 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.024063 |
| VDAC1 | voltage-dependent anion channel 1 | -0.024059 |
| TPI1 | triosephosphate isomerase 1 | -0.0239711 |
| S100A9 | S100 calcium binding protein A9 | -0.0239047 |
| NDRG1 | N-myc downstream regulated 1 | -0.0237209 |
| RBM39 | RNA binding motif protein 39 | -0.0233712 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0229408 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0228418 |
| WASF2 | WAS protein family, member 2 | -0.0227655 |
| MT1X | metallothionein 1X | -0.0226945 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0226101 |
| YY1 | YY1 transcription factor | -0.0226098 |
| WDR45B | WD repeat domain 45B | -0.0225352 |
| EZR | ezrin | -0.0223736 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0220353 |
| PHIP | pleckstrin homology domain interacting protein | -0.0220149 |
| CALR | calreticulin | -0.0219249 |
| MATR3 | matrin 3 | -0.0219033 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0218391 |
| BSG | basigin (Ok blood group) | -0.0217881 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0217753 |
| LDHA | lactate dehydrogenase A | -0.0216439 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0216208 |
| MT1E | metallothionein 1E | -0.0214154 |
| RIGI | RNA sensor RIG-I | -0.0213512 |
| TAPBP | TAP binding protein (tapasin) | -0.0213392 |
| SBF2 | SET binding factor 2 | -0.0210721 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0209316 |
| CCNL1 | cyclin L1 | -0.0208547 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0208344 |
| HMGB1 | high mobility group box 1 | -0.0208089 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0206625 |
