| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.255667 |
| EGFR | epidermal growth factor receptor | 0.151751 |
| ENO1 | enolase 1, (alpha) | 0.112009 |
| RPS3 | ribosomal protein S3 | 0.101008 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0968257 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0954268 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0801296 |
| FAM13A | family with sequence similarity 13, member A | 0.078872 |
| UBC | ubiquitin C | 0.0730405 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0703991 |
| SLTM | SAFB-like, transcription modulator | 0.0701744 |
| TBC1D22A | TBC1 domain family, member 22A | 0.067724 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0664715 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0617387 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0582066 |
| TES | testin LIM domain protein | 0.0581854 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0574677 |
| FTL | ferritin, light polypeptide | 0.0551776 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0547855 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.054503 |
| RPS8 | ribosomal protein S8 | 0.0518907 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0518375 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0505524 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0481979 |
| HSPA1A | heat shock 70kDa protein 1A | 0.048105 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0479186 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0465637 |
| SEC61G | Sec61 gamma subunit | 0.0461711 |
| PCBP2 | poly(rC) binding protein 2 | 0.0456736 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0450383 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0440701 |
| RPLP1 | ribosomal protein, large, P1 | 0.0440594 |
| RPL11 | ribosomal protein L11 | 0.0432495 |
| IRS2 | insulin receptor substrate 2 | 0.043185 |
| GPHN | gephyrin | 0.0431505 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0430981 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0430223 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0428654 |
| CUL4A | cullin 4A | 0.0426165 |
| CPE | carboxypeptidase E | 0.042544 |
| RPS17 | ribosomal protein S17 | 0.0425054 |
| MT2A | metallothionein 2A | 0.0407161 |
| UVRAG | UV radiation resistance associated | 0.0402012 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0400898 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0399957 |
| RUNX1 | runt-related transcription factor 1 | 0.0393939 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.038828 |
| RPS6 | ribosomal protein S6 | 0.0383771 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0377911 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0376021 |
| SON | SON DNA binding protein | 0.0373764 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0369497 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0365878 |
| HOMER1 | homer scaffolding protein 1 | 0.036519 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0363606 |
| RPS12 | ribosomal protein S12 | 0.0357722 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.035589 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0355528 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0354339 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0351365 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.034812 |
| TOP1 | topoisomerase (DNA) I | 0.0346089 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0343774 |
| AREG | amphiregulin | 0.0343142 |
| ASPH | aspartate beta-hydroxylase | 0.0336994 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0335513 |
| RAD51B | RAD51 paralog B | 0.0332008 |
| RPL37A | ribosomal protein L37a | 0.0329716 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.032957 |
| SGMS2 | sphingomyelin synthase 2 | 0.0329131 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0327738 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0327473 |
| PTK2 | protein tyrosine kinase 2 | 0.0327069 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.032452 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0322709 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0315468 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.031379 |
| LAMB3 | laminin, beta 3 | 0.0313242 |
| RPS27 | ribosomal protein S27 | 0.0312063 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0310135 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0308032 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0307094 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0306723 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0305919 |
| TPI1 | triosephosphate isomerase 1 | 0.0303809 |
| RPL12 | ribosomal protein L12 | 0.0302652 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0301619 |
| KIAA1217 | KIAA1217 | 0.0300051 |
| LAMA4 | laminin, alpha 4 | 0.0299921 |
| KIAA0040 | KIAA0040 | 0.0299457 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0295403 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0294083 |
| RBM26 | RNA binding motif protein 26 | 0.0289866 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0289057 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0286332 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0282246 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0280733 |
| MAP7 | microtubule-associated protein 7 | 0.0280546 |
| RPL7 | ribosomal protein L7 | 0.0279109 |
| RACK1 | receptor for activated C kinase 1 | 0.0277893 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.260283 |
| NDRG1 | N-myc downstream regulated 1 | -0.158407 |
| TXNRD1 | thioredoxin reductase 1 | -0.119157 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.117645 |
| EGR1 | early growth response 1 | -0.105797 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0761052 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0659118 |
| TMSB10 | thymosin beta 10 | -0.062156 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0613089 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0594397 |
| H1-0 | H1.0 linker histone | -0.0566246 |
| HDLBP | high density lipoprotein binding protein | -0.0545805 |
| ACTG1 | actin gamma 1 | -0.0540537 |
| OSMR | oncostatin M receptor | -0.0514248 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0512422 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0502189 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0495243 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0459603 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0459567 |
| LDHA | lactate dehydrogenase A | -0.0452789 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0446169 |
| TMEM165 | transmembrane protein 165 | -0.0438613 |
| VCL | vinculin | -0.0432499 |
| TPM4 | tropomyosin 4 | -0.0420638 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.040238 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0394519 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0386177 |
| KRT7 | keratin 7, type II | -0.0377593 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0371437 |
| CCND1 | cyclin D1 | -0.0368322 |
| NABP1 | nucleic acid binding protein 1 | -0.0353846 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0347504 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0339851 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0336595 |
| SCEL | sciellin | -0.0335977 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0309515 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0301808 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0299941 |
| ANXA2 | annexin A2 | -0.0297179 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0294118 |
| MCU | mitochondrial calcium uniporter | -0.029398 |
| PKM | pyruvate kinase, muscle | -0.0289852 |
| PYGL | phosphorylase, glycogen, liver | -0.0289712 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0285776 |
| HMGA1 | high mobility group AT-hook 1 | -0.0276042 |
| CANX | calnexin | -0.0274872 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0263899 |
| ATG7 | autophagy related 7 | -0.0262273 |
| AGR2 | anterior gradient 2 | -0.0255351 |
| PTMA | prothymosin, alpha | -0.0254064 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0250393 |
| GNAS | GNAS complex locus | -0.0250323 |
| ABLIM1 | actin binding LIM protein 1 | -0.0249798 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0245952 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0242945 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.023904 |
| IER3 | immediate early response 3 | -0.0237125 |
| SRP54 | signal recognition particle 54kDa | -0.023694 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0233256 |
| PERP | PERP, TP53 apoptosis effector | -0.0230985 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0230284 |
| CD163L1 | CD163 molecule-like 1 | -0.0226381 |
| WASF2 | WAS protein family, member 2 | -0.0220041 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0218849 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0218302 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0212924 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0211819 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0211429 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0209245 |
| ZNF217 | zinc finger protein 217 | -0.0208711 |
| TRAM1 | translocation associated membrane protein 1 | -0.0208535 |
| MCL1 | myeloid cell leukemia 1 | -0.0205529 |
| GM2A | GM2 ganglioside activator | -0.0204607 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.020242 |
| MKI67 | marker of proliferation Ki-67 | -0.0200743 |
| KRT8 | keratin 8, type II | -0.0198609 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0196639 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0193762 |
| POTEF | POTE ankyrin domain family, member F | -0.0192722 |
| RIGI | RNA sensor RIG-I | -0.01925 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0190668 |
| N4BP2 | NEDD4 binding protein 2 | -0.0188432 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.0187244 |
| EFNA5 | ephrin-A5 | -0.0186831 |
| CST3 | cystatin C | -0.0186526 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0185198 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0184848 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0184093 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0182801 |
| BMP7 | bone morphogenetic protein 7 | -0.0182048 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0181486 |
| FRY | furry homolog (Drosophila) | -0.0179393 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0178449 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0178442 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0178117 |
| S100A11 | S100 calcium binding protein A11 | -0.0177542 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0177147 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0176715 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.0174765 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0173339 |
