| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.14503 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0928093 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0909553 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0894961 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0582093 |
| RPS12 | ribosomal protein S12 | 0.0569442 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0560988 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0560389 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0506281 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0500632 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0494032 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0454576 |
| RPL37A | ribosomal protein L37a | 0.0427474 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0427238 |
| KYNU | kynureninase | 0.0414902 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0400198 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0400018 |
| EGFR | epidermal growth factor receptor | 0.0396903 |
| HLA-A | major histocompatibility complex, class I, A | 0.0389358 |
| SVIL | supervillin | 0.0388664 |
| FLNB | filamin B, beta | 0.0388209 |
| RPS6 | ribosomal protein S6 | 0.0386287 |
| TPM3 | tropomyosin 3 | 0.0385267 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0382508 |
| MYOF | myoferlin | 0.0376978 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0366658 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0358079 |
| VIM | vimentin | 0.0356706 |
| KIAA0319 | KIAA0319 | 0.0350444 |
| STC1 | stanniocalcin 1 | 0.0348486 |
| MSN | moesin | 0.0345488 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0341378 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0339905 |
| HSPA8 | heat shock 70kDa protein 8 | 0.033249 |
| FMNL2 | formin-like 2 | 0.0332444 |
| RPS8 | ribosomal protein S8 | 0.031621 |
| HLA-B | major histocompatibility complex, class I, B | 0.031522 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.031147 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0309954 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0309839 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0309641 |
| ANGPTL4 | angiopoietin-like 4 | 0.0309549 |
| CD44 | CD44 molecule (Indian blood group) | 0.0306304 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0305759 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0304016 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0300437 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0296806 |
| GOLGA4 | golgin A4 | 0.0296303 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0294866 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.029381 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0292454 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0291109 |
| CMIP | c-Maf inducing protein | 0.0291011 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0289889 |
| RPS3 | ribosomal protein S3 | 0.0288037 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0285134 |
| B2M | beta-2-microglobulin | 0.0283821 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0276479 |
| RPS17 | ribosomal protein S17 | 0.0276084 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0275896 |
| RPL3 | ribosomal protein L3 | 0.0273309 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0271529 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0271125 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0264509 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.02597 |
| ITSN2 | intersectin 2 | 0.0258679 |
| ANO6 | anoctamin 6 | 0.0257159 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0257057 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0256963 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0254967 |
| GLIS3 | GLIS family zinc finger 3 | 0.0254683 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0252666 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0246473 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0244819 |
| MT2A | metallothionein 2A | 0.0244626 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0243974 |
| DIAPH1 | diaphanous-related formin 1 | 0.0243945 |
| PYGL | phosphorylase, glycogen, liver | 0.0243771 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0241618 |
| CDCP1 | CUB domain containing protein 1 | 0.0233236 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0232237 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0231339 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0230557 |
| ATXN1 | ataxin 1 | 0.0229605 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0225626 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0224778 |
| NEBL | nebulette | 0.0222435 |
| UBC | ubiquitin C | 0.021784 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0216139 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0215895 |
| USP36 | ubiquitin specific peptidase 36 | 0.0215862 |
| TMF1 | TATA element modulatory factor 1 | 0.0215599 |
| EHBP1 | EH domain binding protein 1 | 0.0214342 |
| MAP7 | microtubule-associated protein 7 | 0.0214144 |
| KIF13A | kinesin family member 13A | 0.0212316 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0211748 |
| EXOC6B | exocyst complex component 6B | 0.0211044 |
| MYO1E | myosin IE | 0.0210531 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0210178 |
| AXL | AXL receptor tyrosine kinase | 0.0209562 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.189095 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.185643 |
| TMSB10 | thymosin beta 10 | -0.175679 |
| TXNRD1 | thioredoxin reductase 1 | -0.164929 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.135894 |
| FTL | ferritin, light polypeptide | -0.114835 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.100008 |
| GRAMD1B | GRAM domain containing 1B | -0.0971185 |
| PTMA | prothymosin, alpha | -0.0957222 |
| RBM39 | RNA binding motif protein 39 | -0.0886669 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0847594 |
| ACTG1 | actin gamma 1 | -0.0779317 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0688624 |
| IGF2 | insulin-like growth factor 2 | -0.0668694 |
| RPL35A | ribosomal protein L35a | -0.0653183 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0648037 |
| RTN4 | reticulon 4 | -0.0594417 |
| FUS | FUS RNA binding protein | -0.0560854 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0549234 |
| RPS21 | ribosomal protein S21 | -0.0544975 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0517027 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0507035 |
| RPL4 | ribosomal protein L4 | -0.0506707 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0506669 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0506362 |
| WDR43 | WD repeat domain 43 | -0.0497214 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0492624 |
| ECT2 | epithelial cell transforming 2 | -0.0483365 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0471206 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0470864 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0465973 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0462192 |
| YBX3 | Y box binding protein 3 | -0.0461884 |
| NOP58 | NOP58 ribonucleoprotein | -0.045863 |
| USP3 | ubiquitin specific peptidase 3 | -0.0447802 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0446905 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0445145 |
| RPL8 | ribosomal protein L8 | -0.0429997 |
| RPS24 | ribosomal protein S24 | -0.042618 |
| S100A10 | S100 calcium binding protein A10 | -0.0423484 |
| IER3 | immediate early response 3 | -0.0417436 |
| MORF4L1 | mortality factor 4 like 1 | -0.041698 |
| ANLN | anillin, actin binding protein | -0.0415405 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.041524 |
| S100A6 | S100 calcium binding protein A6 | -0.0411944 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0407359 |
| RPS5 | ribosomal protein S5 | -0.0406346 |
| ZNF292 | zinc finger protein 292 | -0.0405856 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0403644 |
| RPLP1 | ribosomal protein, large, P1 | -0.040232 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0402161 |
| TMEM123 | transmembrane protein 123 | -0.0398068 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0390682 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0388164 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0379789 |
| KPNB1 | karyopherin (importin) beta 1 | -0.037664 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0376582 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0376528 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0375838 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0372105 |
| GNAS | GNAS complex locus | -0.0371811 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0369061 |
| TUBB | tubulin, beta class I | -0.0361256 |
| ANXA2 | annexin A2 | -0.0359009 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0358928 |
| HMGB1 | high mobility group box 1 | -0.0358422 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0357836 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0355462 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0354473 |
| RPL19 | ribosomal protein L19 | -0.0351945 |
| RFWD3 | ring finger and WD repeat domain 3 | -0.0350384 |
| FBXO11 | F-box protein 11 | -0.0350266 |
| WTAP | Wilms tumor 1 associated protein | -0.0349068 |
| DENND4A | DENN/MADD domain containing 4A | -0.0335869 |
| PKM | pyruvate kinase, muscle | -0.0334254 |
| QKI | QKI, KH domain containing, RNA binding | -0.0332894 |
| TPX2 | TPX2, microtubule-associated | -0.0328684 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0323912 |
| YBX1 | Y box binding protein 1 | -0.0322063 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0312779 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311093 |
| TFRC | transferrin receptor | -0.0310191 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.030953 |
| AHR | aryl hydrocarbon receptor | -0.0309462 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0308953 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0305417 |
| RPL6 | ribosomal protein L6 | -0.0297455 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.029551 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0295404 |
| TUBA1B | tubulin, alpha 1b | -0.0293551 |
| NHSL1 | NHS-like 1 | -0.0293173 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0289983 |
| RHEB | Ras homolog enriched in brain | -0.0289205 |
| RPL38 | ribosomal protein L38 | -0.0288288 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.02858 |
| NPR2 | natriuretic peptide receptor 2 | -0.0285574 |
| NCOA7 | nuclear receptor coactivator 7 | -0.028509 |
| RPS23 | ribosomal protein S23 | -0.0284917 |
| GOLT1B | golgi transport 1B | -0.0281633 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0281537 |
