| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.134496 |
| FN1 | fibronectin 1 | 0.0984664 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0797751 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0662396 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0642797 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0619499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0609152 |
| SMAD3 | SMAD family member 3 | 0.0569862 |
| HMGA2 | high mobility group AT-hook 2 | 0.0565054 |
| DTNA | dystrobrevin, alpha | 0.0563747 |
| ATXN1 | ataxin 1 | 0.0558509 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.053428 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0521914 |
| MT2A | metallothionein 2A | 0.0517294 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0516129 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0500827 |
| VEGFA | vascular endothelial growth factor A | 0.0498497 |
| EGFR | epidermal growth factor receptor | 0.0498134 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0483951 |
| NAV1 | neuron navigator 1 | 0.0483005 |
| HELZ | helicase with zinc finger | 0.0481732 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0479078 |
| LDHA | lactate dehydrogenase A | 0.0469804 |
| NAV2 | neuron navigator 2 | 0.0463536 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0462798 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0460153 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0459554 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.045695 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0456927 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0449711 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0447395 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0436948 |
| KDM3B | lysine (K)-specific demethylase 3B | 0.0434416 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0433777 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0432225 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0431377 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.042684 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0415046 |
| SNX13 | sorting nexin 13 | 0.039876 |
| SMYD3 | SET and MYND domain containing 3 | 0.0395168 |
| GPATCH2L | G patch domain containing 2-like | 0.0395011 |
| GPC6 | glypican 6 | 0.0392445 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0391587 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0389145 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0388948 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0387381 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0384175 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0382103 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0374517 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0370731 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0369219 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0368984 |
| TMEM165 | transmembrane protein 165 | 0.036226 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0360464 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358738 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0357506 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.035375 |
| IPMK | inositol polyphosphate multikinase | 0.0352687 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0351004 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0348949 |
| TENM3 | teneurin transmembrane protein 3 | 0.0345485 |
| INHBA | inhibin, beta A | 0.0343168 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0341478 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.033735 |
| RBM33 | RNA binding motif protein 33 | 0.033709 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0336788 |
| RPL15 | ribosomal protein L15 | 0.0336159 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0334705 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0334422 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0334114 |
| CORO1C | coronin, actin binding protein, 1C | 0.032608 |
| ATP13A3 | ATPase type 13A3 | 0.0325697 |
| DIAPH2 | diaphanous-related formin 2 | 0.0325204 |
| NOP58 | NOP58 ribonucleoprotein | 0.032384 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0323678 |
| RAD51B | RAD51 paralog B | 0.0323197 |
| CD44 | CD44 molecule (Indian blood group) | 0.0322342 |
| SEM1 | SEM1 26S proteasome subunit | 0.0320285 |
| DST | dystonin | 0.0318725 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0318493 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0317719 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0316796 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0316576 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0315639 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0315528 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0313232 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0312588 |
| CD163L1 | CD163 molecule-like 1 | 0.0311868 |
| RPS3 | ribosomal protein S3 | 0.0311559 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0311036 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0310515 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0309756 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.030856 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0308454 |
| COG5 | component of oligomeric golgi complex 5 | 0.0308322 |
| NFIA | nuclear factor I/A | 0.0308083 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0307144 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0305227 |
| KLF10 | Kruppel-like factor 10 | 0.0304866 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0304501 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.168537 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.132067 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.117333 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.115397 |
| FTL | ferritin, light polypeptide | -0.111061 |
| ATOSA | atos homolog A | -0.109536 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.099283 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0906283 |
| LAMB3 | laminin, beta 3 | -0.0885189 |
| SVIL | supervillin | -0.0834447 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0818416 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.079691 |
| PTMA | prothymosin, alpha | -0.0777413 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0750419 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0746787 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.073526 |
| TXNRD1 | thioredoxin reductase 1 | -0.0729203 |
| TMSB10 | thymosin beta 10 | -0.0722112 |
| ASPH | aspartate beta-hydroxylase | -0.0721385 |
| SNX9 | sorting nexin 9 | -0.0694893 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0690126 |
| SRPK2 | SRSF protein kinase 2 | -0.0652632 |
| MYO1E | myosin IE | -0.0644436 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0641511 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0632876 |
| NPTN | neuroplastin | -0.0631842 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0624463 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0621593 |
| MUC16 | mucin 16, cell surface associated | -0.0617981 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0611528 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0609839 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0608513 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.059751 |
| RBM39 | RNA binding motif protein 39 | -0.0591616 |
| SPAG9 | sperm associated antigen 9 | -0.0588843 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0585642 |
| H3-3B | H3.3 histone B | -0.0574414 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0574201 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0573036 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0569126 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0569063 |
| DICER1 | dicer 1, ribonuclease type III | -0.0559865 |
| RPS24 | ribosomal protein S24 | -0.0558 |
| ANXA2 | annexin A2 | -0.0548918 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0543269 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0527637 |
| SSH2 | slingshot protein phosphatase 2 | -0.0521049 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0511015 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0507926 |
| ACVR1 | activin A receptor, type I | -0.0507425 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.050201 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0500677 |
| S100A6 | S100 calcium binding protein A6 | -0.0497803 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0494442 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0491707 |
| AFF4 | AF4/FMR2 family, member 4 | -0.04873 |
| RPL35A | ribosomal protein L35a | -0.048025 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0472967 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0472602 |
| FAM107B | family with sequence similarity 107, member B | -0.046624 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0458947 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0456079 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0454236 |
| ABHD17C | abhydrolase domain containing 17C | -0.0449026 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0446357 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0442878 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0440948 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0439886 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0438912 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.043862 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0437558 |
| OGA | O-GlcNAcase | -0.043644 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0428455 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0424989 |
| JUN | jun proto-oncogene | -0.0423359 |
| USP3 | ubiquitin specific peptidase 3 | -0.0417438 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0412439 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0408286 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0405646 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0404165 |
| FOXO3 | forkhead box O3 | -0.0400664 |
| TNPO1 | transportin 1 | -0.039839 |
| RBM47 | RNA binding motif protein 47 | -0.0394273 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0376827 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0374188 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.0373429 |
| CD2AP | CD2-associated protein | -0.0371162 |
| UBC | ubiquitin C | -0.0370214 |
| RPL12 | ribosomal protein L12 | -0.0370053 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0365789 |
| XPO1 | exportin 1 | -0.0358667 |
| CANX | calnexin | -0.0355385 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0352688 |
| JMJD1C | jumonji domain containing 1C | -0.0352684 |
| MEF2A | myocyte enhancer factor 2A | -0.0352409 |
| DENND4A | DENN/MADD domain containing 4A | -0.034691 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0346158 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0345954 |
| TMSB4X | thymosin beta 4, X-linked | -0.0338907 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0336614 |
