| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.32882 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.149239 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.128922 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.109138 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.101444 |
| VIM | vimentin | 0.0933544 |
| EGR1 | early growth response 1 | 0.0900701 |
| GRAMD1B | GRAM domain containing 1B | 0.0867986 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0817625 |
| YBX3 | Y box binding protein 3 | 0.0806253 |
| RAD51B | RAD51 paralog B | 0.0802569 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0704825 |
| MCL1 | myeloid cell leukemia 1 | 0.0657739 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0641606 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0625439 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0604688 |
| SMAD3 | SMAD family member 3 | 0.0593678 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0590072 |
| HMGA2 | high mobility group AT-hook 2 | 0.0580017 |
| TMSB10 | thymosin beta 10 | 0.056797 |
| MT2A | metallothionein 2A | 0.0535544 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0532481 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0526646 |
| EXOC4 | exocyst complex component 4 | 0.0516191 |
| EGFR | epidermal growth factor receptor | 0.0501586 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0499508 |
| RPL11 | ribosomal protein L11 | 0.0496623 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0471481 |
| PRKCE | protein kinase C, epsilon | 0.0465725 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0458288 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0443344 |
| RNF213 | ring finger protein 213 | 0.0439386 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0438397 |
| ACTG1 | actin gamma 1 | 0.0436331 |
| WWOX | WW domain containing oxidoreductase | 0.0423469 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0420183 |
| TPM2 | tropomyosin 2 (beta) | 0.0408799 |
| HLA-B | major histocompatibility complex, class I, B | 0.040014 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0399284 |
| RPS3 | ribosomal protein S3 | 0.0398722 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.03872 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0386394 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0385689 |
| PFN1 | profilin 1 | 0.0379792 |
| RPS4X | ribosomal protein S4, X-linked | 0.0378962 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0376282 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0371286 |
| R3HDM2 | R3H domain containing 2 | 0.0361123 |
| FMNL2 | formin-like 2 | 0.0359002 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0351843 |
| RPL37 | ribosomal protein L37 | 0.0348107 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0347335 |
| RPS27 | ribosomal protein S27 | 0.0345371 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0341343 |
| OSMR | oncostatin M receptor | 0.0340731 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0340254 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0339412 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0337979 |
| RPL37A | ribosomal protein L37a | 0.0324406 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0320963 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0319974 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.031864 |
| RPL8 | ribosomal protein L8 | 0.0309711 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0308588 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0307649 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0305815 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0305213 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.030166 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0300239 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0297844 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0294841 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.029116 |
| PDE10A | phosphodiesterase 10A | 0.0291037 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0282483 |
| BPTF | bromodomain PHD finger transcription factor | 0.0282464 |
| HDGF | hepatoma-derived growth factor | 0.0278845 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0276184 |
| TCIM | transcriptional and immune response regulator | 0.0272401 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.026978 |
| ATXN1 | ataxin 1 | 0.0266583 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0259749 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0257324 |
| TPI1 | triosephosphate isomerase 1 | 0.0256886 |
| RYR3 | ryanodine receptor 3 | 0.0254739 |
| FTL | ferritin, light polypeptide | 0.0253431 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0253425 |
| ETV6 | ets variant 6 | 0.0253337 |
| RPL26 | ribosomal protein L26 | 0.0252704 |
| RPL28 | ribosomal protein L28 | 0.0250964 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0250172 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0248116 |
| THADA | thyroid adenoma associated | 0.0245303 |
| RPL23 | ribosomal protein L23 | 0.0245016 |
| RPL35 | ribosomal protein L35 | 0.0243977 |
| RPS8 | ribosomal protein S8 | 0.0243629 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0242837 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0239169 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0238465 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0237277 |
| RPL5 | ribosomal protein L5 | 0.0234833 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | -0.166569 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.16054 |
| TXNRD1 | thioredoxin reductase 1 | -0.104643 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0754425 |
| XPO1 | exportin 1 | -0.0739637 |
| CCND2 | cyclin D2 | -0.0674334 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0661758 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0629379 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.061417 |
| RBM39 | RNA binding motif protein 39 | -0.0567771 |
| RTN4 | reticulon 4 | -0.0560598 |
| CLTC | clathrin, heavy chain (Hc) | -0.0543736 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0516875 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.051637 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0494548 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0483445 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0438564 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0420234 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0403503 |
| CANX | calnexin | -0.0402485 |
| RAB10 | RAB10, member RAS oncogene family | -0.0384577 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0376071 |
| STK4 | serine/threonine kinase 4 | -0.037217 |
| MORF4L2 | mortality factor 4 like 2 | -0.03509 |
| GOLT1B | golgi transport 1B | -0.0350574 |
| PHIP | pleckstrin homology domain interacting protein | -0.0344221 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0337023 |
| SRPK1 | SRSF protein kinase 1 | -0.0335577 |
| SPAG9 | sperm associated antigen 9 | -0.0334482 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0334375 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0328732 |
| OGA | O-GlcNAcase | -0.0324642 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0317725 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0317557 |
| PREPL | prolyl endopeptidase-like | -0.0316901 |
| GOLGA4 | golgin A4 | -0.0316046 |
| NOP58 | NOP58 ribonucleoprotein | -0.0313305 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0312417 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0310584 |
| ZNF207 | zinc finger protein 207 | -0.0309639 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0307571 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0304285 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0300958 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0297272 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0294707 |
| RECQL | RecQ helicase-like | -0.0293343 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0291723 |
| ANLN | anillin, actin binding protein | -0.0286458 |
| ZFR | zinc finger RNA binding protein | -0.0285551 |
| TAOK1 | TAO kinase 1 | -0.0284361 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0281991 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0281693 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0280672 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0277752 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0277375 |
| TNPO3 | transportin 3 | -0.0277048 |
| RPL6 | ribosomal protein L6 | -0.0272301 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0271542 |
| PTMA | prothymosin, alpha | -0.0270556 |
| SSR1 | signal sequence receptor, alpha | -0.0268906 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0268257 |
| ETNK1 | ethanolamine kinase 1 | -0.0267162 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0266896 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.026434 |
| UBQLN1 | ubiquilin 1 | -0.0262736 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0261719 |
| RPS2 | ribosomal protein S2 | -0.0260462 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0256283 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0253899 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0253642 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0253285 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0252754 |
| AFF4 | AF4/FMR2 family, member 4 | -0.02521 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0248023 |
| SRP72 | signal recognition particle 72kDa | -0.0247412 |
| CEP95 | centrosomal protein 95kDa | -0.0247288 |
| TFG | TRK-fused gene | -0.0247194 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0247183 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0246743 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0245863 |
| ZNF292 | zinc finger protein 292 | -0.024489 |
| ZNF217 | zinc finger protein 217 | -0.0240692 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.0236836 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0236771 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0236507 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0235964 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0234006 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0233076 |
| CDC27 | cell division cycle 27 | -0.0232748 |
| TNRC6A | trinucleotide repeat containing 6A | -0.0230631 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0228475 |
| NUP58 | nucleoporin 58 | -0.0228303 |
| PPME1 | protein phosphatase methylesterase 1 | -0.0227077 |
| HELZ | helicase with zinc finger | -0.0226359 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0224517 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0222767 |
| OLA1 | Obg-like ATPase 1 | -0.0222726 |
| NUP153 | nucleoporin 153kDa | -0.0221872 |
| RLF | rearranged L-myc fusion | -0.0221352 |
| IMMT | inner membrane protein, mitochondrial | -0.0219073 |
