| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.305185 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.186792 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.15356 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.14875 |
| FTL | ferritin, light polypeptide | 0.139513 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.139269 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.135312 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.103075 |
| ENO1 | enolase 1, (alpha) | 0.0954597 |
| LAMB3 | laminin, beta 3 | 0.0941248 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0799847 |
| TXNRD1 | thioredoxin reductase 1 | 0.0798372 |
| POTEF | POTE ankyrin domain family, member F | 0.0795243 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0786487 |
| UBC | ubiquitin C | 0.0782638 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0716485 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0710862 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0707135 |
| G0S2 | G0/G1 switch 2 | 0.068039 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0672553 |
| SQSTM1 | sequestosome 1 | 0.0671561 |
| RPS3 | ribosomal protein S3 | 0.0623212 |
| LAMC2 | laminin, gamma 2 | 0.060915 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0597423 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0584899 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0562556 |
| RACK1 | receptor for activated C kinase 1 | 0.0546456 |
| ASPH | aspartate beta-hydroxylase | 0.0538337 |
| RPS12 | ribosomal protein S12 | 0.0534136 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0534094 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0533337 |
| SGMS2 | sphingomyelin synthase 2 | 0.0531672 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0520725 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0518331 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0515979 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0513862 |
| ANXA2 | annexin A2 | 0.0513663 |
| LDHA | lactate dehydrogenase A | 0.050905 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0507524 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0502558 |
| LMO7 | LIM domain 7 | 0.0502082 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0499375 |
| RPS6 | ribosomal protein S6 | 0.0480484 |
| RPL12 | ribosomal protein L12 | 0.0471651 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0470144 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.046836 |
| DSPP | dentin sialophosphoprotein | 0.0464662 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.043706 |
| RPL7A | ribosomal protein L7a | 0.0435004 |
| EZR | ezrin | 0.0428136 |
| SGPP2 | sphingosine-1-phosphate phosphatase 2 | 0.0416441 |
| PGK1 | phosphoglycerate kinase 1 | 0.0401212 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0393396 |
| ANXA1 | annexin A1 | 0.0393139 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0390253 |
| KLF6 | Kruppel-like factor 6 | 0.0389531 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0387539 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0385018 |
| KIAA1217 | KIAA1217 | 0.0381646 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0379787 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.037886 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0378361 |
| DSG2 | desmoglein 2 | 0.0376226 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0374738 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0373196 |
| ANO6 | anoctamin 6 | 0.0371404 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0362688 |
| EGR1 | early growth response 1 | 0.0360183 |
| GOLGB1 | golgin B1 | 0.0353499 |
| ARRDC3 | arrestin domain containing 3 | 0.0346608 |
| CANX | calnexin | 0.034442 |
| CTSB | cathepsin B | 0.0329783 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0329478 |
| RPL11 | ribosomal protein L11 | 0.0327083 |
| UPP1 | uridine phosphorylase 1 | 0.0327056 |
| RPS8 | ribosomal protein S8 | 0.0325422 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0323032 |
| EGFR | epidermal growth factor receptor | 0.0323002 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0322036 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0321802 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0321562 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0320494 |
| TCIM | transcriptional and immune response regulator | 0.0318731 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0318409 |
| CLDN1 | claudin 1 | 0.0315479 |
| ACTG1 | actin gamma 1 | 0.0312659 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0311435 |
| FAM107B | family with sequence similarity 107, member B | 0.0310215 |
| VGLL3 | vestigial-like family member 3 | 0.0309086 |
| FAM13A | family with sequence similarity 13, member A | 0.0298205 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0297639 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0292691 |
| NDRG1 | N-myc downstream regulated 1 | 0.0292276 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0290764 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 0.0289431 |
| TMF1 | TATA element modulatory factor 1 | 0.0288914 |
| VEGFA | vascular endothelial growth factor A | 0.0288261 |
| SDC4 | syndecan 4 | 0.0285375 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.028519 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0283759 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0917216 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0778758 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.043148 |
| TMEM165 | transmembrane protein 165 | -0.0417898 |
| CCND1 | cyclin D1 | -0.0411077 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0407721 |
| VCL | vinculin | -0.0395559 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0390358 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0373998 |
| RRBP1 | ribosome binding protein 1 | -0.0371019 |
| FAM3C | family with sequence similarity 3, member C | -0.0349515 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0331906 |
| PTK2 | protein tyrosine kinase 2 | -0.0330387 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0329845 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0328547 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0321107 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0315157 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0312104 |
| ZNF207 | zinc finger protein 207 | -0.0309763 |
| CD2AP | CD2-associated protein | -0.0308547 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0305074 |
| FBXO34 | F-box protein 34 | -0.0301856 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0300113 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0297421 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.029509 |
| AOPEP | aminopeptidase O (putative) | -0.0293936 |
| GNAS | GNAS complex locus | -0.0291259 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0280494 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0280125 |
| PARD3 | par-3 family cell polarity regulator | -0.0276214 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0272971 |
| KRT8 | keratin 8, type II | -0.0267074 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0266191 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0261039 |
| MX2 | MX dynamin-like GTPase 2 | -0.0260715 |
| SEC24D | SEC24 family member D | -0.0256641 |
| RNF213 | ring finger protein 213 | -0.0255892 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0253924 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0252401 |
| PLSCR1 | phospholipid scramblase 1 | -0.0251573 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0249914 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0248841 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.024812 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0247771 |
| ZNF148 | zinc finger protein 148 | -0.0246765 |
| RBM47 | RNA binding motif protein 47 | -0.0245798 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.024535 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0240442 |
| ERBIN | erbb2 interacting protein | -0.0239185 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0238973 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0238747 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0237412 |
| COPA | coatomer protein complex, subunit alpha | -0.0237144 |
| RPL35A | ribosomal protein L35a | -0.0237015 |
| SRPK2 | SRSF protein kinase 2 | -0.0236556 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0234988 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | -0.0232073 |
| MCU | mitochondrial calcium uniporter | -0.0230867 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0230135 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0226649 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0225869 |
| MGLL | monoglyceride lipase | -0.0225206 |
| ATXN1 | ataxin 1 | -0.0222815 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.022241 |
| CDK13 | cyclin-dependent kinase 13 | -0.0222382 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0220825 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0218177 |
| BBX | bobby sox homolog (Drosophila) | -0.0217705 |
| SLMAP | sarcolemma associated protein | -0.0214926 |
| CERT1 | ceramide transporter 1 | -0.021277 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.02122 |
| WDR20 | WD repeat domain 20 | -0.0211681 |
| CD109 | CD109 molecule | -0.0211338 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0211175 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0209947 |
| WASF2 | WAS protein family, member 2 | -0.0208585 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0208133 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0205665 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.020485 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0203714 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0203 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0202979 |
| ACTN4 | actinin, alpha 4 | -0.0202873 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0201687 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0200609 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0199686 |
| UBAP1 | ubiquitin associated protein 1 | -0.0198339 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0198108 |
| HLA-B | major histocompatibility complex, class I, B | -0.01978 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0197764 |
| POU2F1 | POU class 2 homeobox 1 | -0.019495 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0192989 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0192849 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0191217 |
| SP3 | Sp3 transcription factor | -0.0191213 |
| CUX1 | cut-like homeobox 1 | -0.0189871 |
| HMGA2 | high mobility group AT-hook 2 | -0.0189868 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0189397 |
| LMNA | lamin A/C | -0.0189137 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0186971 |
