Hydroxyfasudil_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.250146
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.115525
RPS6 ribosomal protein S6 0.113737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.112397
VIM vimentin 0.0942773
RPS8 ribosomal protein S8 0.0711633
SMOC1 SPARC related modular calcium binding 1 0.0688636
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0649583
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0594484
RPL26 ribosomal protein L26 0.05309
RPS3 ribosomal protein S3 0.0515332
FMNL2 formin-like 2 0.0507288
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0505961
ENO1 enolase 1, (alpha) 0.050053
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0487259
SH3KBP1 SH3-domain kinase binding protein 1 0.0475615
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.04621
RPL21 ribosomal protein L21 0.0458713
LSAMP limbic system-associated membrane protein 0.0453302
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0441865
RPS17 ribosomal protein S17 0.0435254
RPS12 ribosomal protein S12 0.0429386
EEF2 eukaryotic translation elongation factor 2 0.0418694
MAP7 microtubule-associated protein 7 0.0417365
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0412045
RPL12 ribosomal protein L12 0.040733
RPL31 ribosomal protein L31 0.0402234
ZSWIM6 zinc finger, SWIM-type containing 6 0.0401654
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383948
RPL3 ribosomal protein L3 0.0381253
AUTS2 autism susceptibility candidate 2 0.0375625
UBC ubiquitin C 0.0369055
BZW1 basic leucine zipper and W2 domains 1 0.0364016
AKAP13 A kinase (PRKA) anchor protein 13 0.036136
FNIP1 folliculin interacting protein 1 0.0361015
TPT1 tumor protein, translationally-controlled 1 0.0350117
LDHA lactate dehydrogenase A 0.0348663
CTIF CBP80/20-dependent translation initiation factor 0.0345999
SQSTM1 sequestosome 1 0.03445
KYNU kynureninase 0.0344308
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0337721
HSPA8 heat shock 70kDa protein 8 0.0329397
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.032797
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0327599
RACK1 receptor for activated C kinase 1 0.0318874
PRELID2 PRELI domain containing 2 0.0318544
XYLT1 xylosyltransferase I 0.0317697
LOC102724023 ES1 protein homolog, mitochondrial 0.0317584
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.031703
MCL1 myeloid cell leukemia 1 0.0310778
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0308878
RPLP1 ribosomal protein, large, P1 0.0308623
MSN moesin 0.030703
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0303865
PRKN parkin RBR E3 ubiquitin protein ligase 0.0302188
HSPA1A heat shock 70kDa protein 1A 0.030151
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0299118
RPS19 ribosomal protein S19 0.029602
FTH1 ferritin, heavy polypeptide 1 0.0295656
KRT19 keratin 19, type I 0.0295009
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0289754
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0289201
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0287719
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0283924
CD44 CD44 molecule (Indian blood group) 0.0281018
CHL1 cell adhesion molecule L1-like 0.027431
ASTN2 astrotactin 2 0.0273976
SVIL supervillin 0.0269676
LMNA lamin A/C 0.0268693
CLU clusterin 0.0258598
CHD1 chromodomain helicase DNA binding protein 1 0.0257312
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0256694
RPL7A ribosomal protein L7a 0.0254471
HSPH1 heat shock 105kDa/110kDa protein 1 0.0254215
PTPRM protein tyrosine phosphatase, receptor type, M 0.0252845
DNER delta/notch-like EGF repeat containing 0.0252794
ANXA1 annexin A1 0.0248151
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.024636
SET SET nuclear proto-oncogene 0.0243
SRRM2 serine/arginine repetitive matrix 2 0.0239742
IRS2 insulin receptor substrate 2 0.0238257
RPS27 ribosomal protein S27 0.0237835
RPL18 ribosomal protein L18 0.0236696
PCBP2 poly(rC) binding protein 2 0.0236194
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0236085
MACF1 microtubule-actin crosslinking factor 1 0.0235854
RPS14 ribosomal protein S14 0.0233687
NRXN3 neurexin 3 0.0232161
GPC6 glypican 6 0.0231787
PSD3 pleckstrin and Sec7 domain containing 3 0.0228809
EZR ezrin 0.0225246
B2M beta-2-microglobulin 0.0223038
KTN1 kinectin 1 (kinesin receptor) 0.0219984
RPL19 ribosomal protein L19 0.0217529
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0216257
ZMIZ1 zinc finger, MIZ-type containing 1 0.0214429
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.02119
FNDC3A fibronectin type III domain containing 3A 0.0210974
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0210402
RPL7 ribosomal protein L7 0.0207491

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.210066
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.167674
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.1406
NAMPT nicotinamide phosphoribosyltransferase -0.137064
GDA guanine deaminase -0.124044
FN1 fibronectin 1 -0.122027
TXNRD1 thioredoxin reductase 1 -0.112955
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.107253
PDE4D phosphodiesterase 4D, cAMP-specific -0.105445
SMYD3 SET and MYND domain containing 3 -0.0915395
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0878478
LIMCH1 LIM and calponin homology domains 1 -0.0874434
NALF1 NALCN channel auxiliary factor 1 -0.0851606
TRIO trio Rho guanine nucleotide exchange factor -0.0750098
TFPI2 tissue factor pathway inhibitor 2 -0.0746852
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0728068
NRCAM neuronal cell adhesion molecule -0.0719562
NEK7 NIMA-related kinase 7 -0.0665278
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0663324
RTN4 reticulon 4 -0.0596005
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.057349
RBM39 RNA binding motif protein 39 -0.0573062
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.056148
NPAS2 neuronal PAS domain protein 2 -0.0552816
TM4SF1 transmembrane 4 L six family member 1 -0.0533004
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0532967
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0511439
PCBP3 poly(rC) binding protein 3 -0.0489233
TMSB10 thymosin beta 10 -0.0479646
TNPO1 transportin 1 -0.0467448
ASPH aspartate beta-hydroxylase -0.045572
PDE10A phosphodiesterase 10A -0.0455672
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0443052
COL5A2 collagen, type V, alpha 2 -0.0442102
GNAS GNAS complex locus -0.042055
ELL2 elongation factor, RNA polymerase II, 2 -0.0420281
COL4A5 collagen, type IV, alpha 5 -0.0416329
TGFBI transforming growth factor, beta-induced, 68kDa -0.0415273
SAMD4A sterile alpha motif domain containing 4A -0.0411027
OGA O-GlcNAcase -0.0387983
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0385069
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0384694
PTGR1 prostaglandin reductase 1 -0.0375035
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0374719
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0364711
FNDC3B fibronectin type III domain containing 3B -0.0361485
VCL vinculin -0.035857
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0357394
BCAR3 breast cancer anti-estrogen resistance 3 -0.0351624
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0351496
KPNB1 karyopherin (importin) beta 1 -0.0342427
PBX1 pre-B-cell leukemia homeobox 1 -0.0341634
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335688
AOPEP aminopeptidase O (putative) -0.0334738
RPS24 ribosomal protein S24 -0.032342
CTSC cathepsin C -0.0319532
ATAD1 ATPase family, AAA domain containing 1 -0.0317953
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0316094
BMERB1 bMERB domain containing 1 -0.0313052
DOCK4 dedicator of cytokinesis 4 -0.0311257
ITPRID2 ITPR interacting domain containing 2 -0.0305079
PRRC2B proline-rich coiled-coil 2B -0.0304764
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0304022
COL8A1 collagen, type VIII, alpha 1 -0.0293635
MON2 MON2 homolog (S. cerevisiae) -0.02858
BRWD3 bromodomain and WD repeat domain containing 3 -0.0283403
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0282046
ZMYND8 zinc finger, MYND-type containing 8 -0.0280381
BCAS3 breast carcinoma amplified sequence 3 -0.0279602
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0276366
ENAH enabled homolog (Drosophila) -0.027617
NCOA7 nuclear receptor coactivator 7 -0.0271798
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0269047
ADGRB3 adhesion G protein-coupled receptor B3 -0.0268681
MARCHF6 membrane associated ring-CH-type finger 6 -0.0264938
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0264524
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.026412
PALLD palladin, cytoskeletal associated protein -0.0263931
PUM2 pumilio RNA-binding family member 2 -0.0263731
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0260622
PRKD3 protein kinase D3 -0.026018
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0252389
USP3 ubiquitin specific peptidase 3 -0.0252339
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0252275
AGFG1 ArfGAP with FG repeats 1 -0.0251969
PNISR PNN-interacting serine/arginine-rich protein -0.0248858
RAB1A RAB1A, member RAS oncogene family -0.0244795
ZBTB38 zinc finger and BTB domain containing 38 -0.0240976
COL4A6 collagen, type IV, alpha 6 -0.0240312
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0239968
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0239174
CEP95 centrosomal protein 95kDa -0.0238319
CANX calnexin -0.0237627
TRA2A transformer 2 alpha homolog (Drosophila) -0.0232185
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0230255
PDLIM5 PDZ and LIM domain 5 -0.0230055
PTEN phosphatase and tensin homolog -0.022719
TAOK1 TAO kinase 1 -0.0224092
COG5 component of oligomeric golgi complex 5 -0.0223197
FBXL13 F-box and leucine-rich repeat protein 13 -0.0222455