Hydroxyfasudil_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.191503
COL11A1 collagen, type XI, alpha 1 0.0781994
CADM2 cell adhesion molecule 2 0.0690408
VIM vimentin 0.0626876
RPL26 ribosomal protein L26 0.0559195
HSPA1A heat shock 70kDa protein 1A 0.0542502
RPS3 ribosomal protein S3 0.053173
RPS12 ribosomal protein S12 0.0504771
FTL ferritin, light polypeptide 0.0488101
RPS8 ribosomal protein S8 0.0459997
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0459963
RPS6 ribosomal protein S6 0.0456498
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0449964
RPL23 ribosomal protein L23 0.0447821
RPL31 ribosomal protein L31 0.0445049
TMSB10 thymosin beta 10 0.0442636
RPL11 ribosomal protein L11 0.0431206
RPL12 ribosomal protein L12 0.0387601
TPT1 tumor protein, translationally-controlled 1 0.0386857
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0384797
RPS16 ribosomal protein S16 0.0380117
FOXP2 forkhead box P2 0.0377312
RPL37A ribosomal protein L37a 0.0377065
SLIT2 slit homolog 2 (Drosophila) 0.0365969
RPS19 ribosomal protein S19 0.0356011
FN1 fibronectin 1 0.035342
LDHA lactate dehydrogenase A 0.0350623
RPL28 ribosomal protein L28 0.0349307
SRRM2 serine/arginine repetitive matrix 2 0.0344775
RPL9 ribosomal protein L9 0.0335189
RPS25 ribosomal protein S25 0.0329839
ENO1 enolase 1, (alpha) 0.0327207
RPL37 ribosomal protein L37 0.0322807
RPS14 ribosomal protein S14 0.0318475
RPS13 ribosomal protein S13 0.0314953
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0312547
RPS27 ribosomal protein S27 0.0307784
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0307759
NACA nascent polypeptide-associated complex alpha subunit 0.0304876
HMGA2 high mobility group AT-hook 2 0.0288514
RPL21 ribosomal protein L21 0.0283485
HSPB1 heat shock 27kDa protein 1 0.0271937
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0271584
UBC ubiquitin C 0.0270585
GPC6 glypican 6 0.0268874
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0264899
BPTF bromodomain PHD finger transcription factor 0.0259185
CDH19 cadherin 19, type 2 0.0258349
RPL7A ribosomal protein L7a 0.0257177
DOK6 docking protein 6 0.0254317
CNRIP1 cannabinoid receptor interacting protein 1 0.0252836
RPL27 ribosomal protein L27 0.0251851
MT2A metallothionein 2A 0.0250907
ISG15 ISG15 ubiquitin-like modifier 0.0250583
RPS17 ribosomal protein S17 0.0245418
S100A10 S100 calcium binding protein A10 0.0241782
IGF2 insulin-like growth factor 2 0.0239496
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0233842
B2M beta-2-microglobulin 0.0230723
FNDC3A fibronectin type III domain containing 3A 0.0229882
APLP2 amyloid beta (A4) precursor-like protein 2 0.0223339
PDE4D phosphodiesterase 4D, cAMP-specific 0.0222199
PCDH18 protocadherin 18 0.0220961
RACK1 receptor for activated C kinase 1 0.0218468
RPS11 ribosomal protein S11 0.0216163
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0213255
PRRC2C proline-rich coiled-coil 2C 0.0213014
RIGI RNA sensor RIG-I 0.0212143
PSEN1 presenilin 1 0.0211012
EGFR epidermal growth factor receptor 0.0205383
RSF1 remodeling and spacing factor 1 0.0203419
NFE2L2 nuclear factor, erythroid 2-like 2 0.0198027
RPL19 ribosomal protein L19 0.019706
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0186564
ASPH aspartate beta-hydroxylase 0.0184437
GSE1 Gse1 coiled-coil protein 0.0183938
RPLP0 ribosomal protein, large, P0 0.0183785
RNF213 ring finger protein 213 0.0183027
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0182544
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0182181
TTC28 tetratricopeptide repeat domain 28 0.0181404
TTC3 tetratricopeptide repeat domain 3 0.0179747
FLNB filamin B, beta 0.0176173
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0175485
SMAD3 SMAD family member 3 0.0174308
ATM ATM serine/threonine kinase 0.0173482
TENM3 teneurin transmembrane protein 3 0.0172293
BRD2 bromodomain containing 2 0.0171848
RPL13A ribosomal protein L13a 0.0171753
TUBA1A tubulin, alpha 1a 0.0171013
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0169346
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0168994
RPL36 ribosomal protein L36 0.0168731
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0167305
SOS1 son of sevenless homolog 1 (Drosophila) 0.0166264
TM4SF1 transmembrane 4 L six family member 1 0.0163915
OXR1 oxidation resistance 1 0.0163845
ATP5F1E ATP synthase F1 subunit epsilon 0.0163664
RPL36AL ribosomal protein L36a-like 0.0163536
SOD2 superoxide dismutase 2, mitochondrial 0.0163514

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.218671
TSC22D2 TSC22 domain family, member 2 -0.124943
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108989
TOP2A topoisomerase (DNA) II alpha 170kDa -0.101728
HDAC9 histone deacetylase 9 -0.0980029
ITGAV integrin, alpha V -0.0915874
SRP54 signal recognition particle 54kDa -0.0910212
ADGRL2 adhesion G protein-coupled receptor L2 -0.0849855
TMSB4X thymosin beta 4, X-linked -0.08396
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0822474
PHIP pleckstrin homology domain interacting protein -0.0790891
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0767232
FNDC3B fibronectin type III domain containing 3B -0.0748091
DST dystonin -0.0731216
MARCHF6 membrane associated ring-CH-type finger 6 -0.069896
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0698208
NTM neurotrimin -0.0680814
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0676544
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0667132
SFRP4 secreted frizzled-related protein 4 -0.0664242
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0659175
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0654623
ANKRD33B ankyrin repeat domain 33B -0.0651493
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0643356
CENPF centromere protein F, 350/400kDa -0.0638481
PTMA prothymosin, alpha -0.0633129
POTEF POTE ankyrin domain family, member F -0.0615111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0569367
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0559496
CHD1 chromodomain helicase DNA binding protein 1 -0.05544
ZFAND3 zinc finger, AN1-type domain 3 -0.0545351
EMP1 epithelial membrane protein 1 -0.0536608
TPX2 TPX2, microtubule-associated -0.0530268
MKI67 marker of proliferation Ki-67 -0.0528821
CLTC clathrin, heavy chain (Hc) -0.0517105
TFRC transferrin receptor -0.051271
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0504488
H1-4 H1.4 linker histone, cluster member -0.0495541
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0495096
NOP58 NOP58 ribonucleoprotein -0.0489937
KDM3A lysine (K)-specific demethylase 3A -0.0487711
NPAS3 neuronal PAS domain protein 3 -0.0481342
NCOR1 nuclear receptor corepressor 1 -0.0474886
PGAP1 post-GPI attachment to proteins 1 -0.0462429
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0458404
KIF4A kinesin family member 4A -0.0457473
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0449584
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0448747
STAG2 stromal antigen 2 -0.0442887
SAMD4A sterile alpha motif domain containing 4A -0.044086
SRPK2 SRSF protein kinase 2 -0.0422919
USP53 ubiquitin specific peptidase 53 -0.0422002
RBM39 RNA binding motif protein 39 -0.0418541
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0418211
HNRNPM heterogeneous nuclear ribonucleoprotein M -0.0414828
CKAP5 cytoskeleton associated protein 5 -0.0412372
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0403665
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0393222
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0382269
MED13L mediator complex subunit 13-like -0.0381474
TEX11 testis expressed 11 -0.0381029
OGA O-GlcNAcase -0.0380926
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0380331
ZNF292 zinc finger protein 292 -0.0378446
RAI1 retinoic acid induced 1 -0.0368982
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0367561
APP amyloid beta (A4) precursor protein -0.0365635
SMC4 structural maintenance of chromosomes 4 -0.0365142
STRN3 striatin, calmodulin binding protein 3 -0.0363827
NHSL1 NHS-like 1 -0.0363329
COG5 component of oligomeric golgi complex 5 -0.0361559
HDAC2 histone deacetylase 2 -0.0361519
ZEB2 zinc finger E-box binding homeobox 2 -0.0356128
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0354646
NFIA nuclear factor I/A -0.035429
CAMTA1 calmodulin binding transcription activator 1 -0.0354014
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0348532
ADAM9 ADAM metallopeptidase domain 9 -0.0347815
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0343772
NEBL nebulette -0.034377
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0337673
ANXA2 annexin A2 -0.0337136
XPO1 exportin 1 -0.0334868
ANLN anillin, actin binding protein -0.0334418
MAP4 microtubule-associated protein 4 -0.0333947
FAF1 Fas (TNFRSF6) associated factor 1 -0.0331165
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0331121
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0328945
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.0325714
FUBP1 far upstream element (FUSE) binding protein 1 -0.0324553
NUSAP1 nucleolar and spindle associated protein 1 -0.0324369
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0320501
ATAD2 ATPase family, AAA domain containing 2 -0.0320019
PDCD5 programmed cell death 5 -0.0319291
PLPP1 phospholipid phosphatase 1 -0.0318308
LIN28B lin-28 homolog B (C. elegans) -0.0317917
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0316712
UBA2 ubiquitin-like modifier activating enzyme 2 -0.0316468
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0314783
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0313948