| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyfasudil perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyfasudil_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.158692 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.113987 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.102273 |
| HDAC9 | histone deacetylase 9 | 0.0781608 |
| GLI3 | GLI family zinc finger 3 | 0.0625671 |
| EZR | ezrin | 0.0591888 |
| ANXA1 | annexin A1 | 0.0493786 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0436872 |
| RPL3 | ribosomal protein L3 | 0.0432267 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0413831 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0380384 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0327626 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0308047 |
| DIAPH3 | diaphanous-related formin 3 | 0.0303513 |
| BRD2 | bromodomain containing 2 | 0.0283555 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0281466 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0273507 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0271488 |
| CENPF | centromere protein F, 350/400kDa | 0.0267697 |
| FER1L6 | fer-1-like family member 6 | 0.0264421 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0260826 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0255529 |
| DIAPH1 | diaphanous-related formin 1 | 0.0247262 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0241235 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0225863 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0224384 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0223442 |
| MYOF | myoferlin | 0.0220221 |
| BPTF | bromodomain PHD finger transcription factor | 0.02135 |
| RPS6 | ribosomal protein S6 | 0.0212418 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0209275 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0209244 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0207306 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0205112 |
| CRY1 | cryptochrome circadian clock 1 | 0.0204244 |
| FOXP1 | forkhead box P1 | 0.0202034 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0201361 |
| PDGFC | platelet derived growth factor C | 0.0200103 |
| POTEF | POTE ankyrin domain family, member F | 0.0197162 |
| SON | SON DNA binding protein | 0.0196454 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0194986 |
| DUSP6 | dual specificity phosphatase 6 | 0.019393 |
| MACROD2 | MACRO domain containing 2 | 0.019121 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0190651 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0188834 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.018851 |
| RPL21 | ribosomal protein L21 | 0.0188375 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0184733 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0182388 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0172295 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0171988 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0171775 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0170215 |
| ANXA3 | annexin A3 | 0.0169022 |
| INTS6 | integrator complex subunit 6 | 0.0168711 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0167388 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.0166242 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0165685 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0163778 |
| TRIM24 | tripartite motif containing 24 | 0.0163676 |
| KIF5B | kinesin family member 5B | 0.0163373 |
| EXOC4 | exocyst complex component 4 | 0.0161636 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0160578 |
| MKI67 | marker of proliferation Ki-67 | 0.0158569 |
| ZNF638 | zinc finger protein 638 | 0.0158139 |
| PDE7B | phosphodiesterase 7B | 0.0156923 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.015393 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | 0.0153176 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0152813 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0152351 |
| HDGF | hepatoma-derived growth factor | 0.0151097 |
| CEP128 | centrosomal protein 128kDa | 0.0149871 |
| ANKRD36B | ankyrin repeat domain 36B | 0.0149733 |
| FNIP1 | folliculin interacting protein 1 | 0.0149123 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0148789 |
| FMN1 | formin 1 | 0.0148552 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0148192 |
| EP400 | E1A binding protein p400 | 0.0148055 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0147793 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0146419 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0146367 |
| AFG2A | AFG2 AAA ATPase homolog A | 0.0145881 |
| DAPK3 | death-associated protein kinase 3 | 0.0144014 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0143767 |
| AEBP2 | AE binding protein 2 | 0.0142808 |
| CCDC88A | coiled-coil domain containing 88A | 0.0141918 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0139287 |
| RNF38 | ring finger protein 38 | 0.0139255 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0139017 |
| CCNY | cyclin Y | 0.0138355 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0136367 |
| TNRC6C | trinucleotide repeat containing 6C | 0.0136357 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0136118 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0135225 |
| RBM6 | RNA binding motif protein 6 | 0.0134107 |
| BSDC1 | BSD domain containing 1 | 0.0133921 |
| STMN1 | stathmin 1 | 0.0132649 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0132172 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 0.013197 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0131848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.215144 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.211638 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.156173 |
| TMSB4X | thymosin beta 4, X-linked | -0.13724 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.116097 |
| PTMA | prothymosin, alpha | -0.102375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0849753 |
| RPL35A | ribosomal protein L35a | -0.0688183 |
| RPL34 | ribosomal protein L34 | -0.0666135 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0665605 |
| RBM39 | RNA binding motif protein 39 | -0.0645839 |
| PKM | pyruvate kinase, muscle | -0.0639314 |
| S100A6 | S100 calcium binding protein A6 | -0.0636085 |
| PGK1 | phosphoglycerate kinase 1 | -0.0632987 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0625374 |
| GOLGA4 | golgin A4 | -0.0617601 |
| RPS23 | ribosomal protein S23 | -0.060852 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0594971 |
| VCL | vinculin | -0.0569616 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0565497 |
| ACTG1 | actin gamma 1 | -0.0564191 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0562389 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0535192 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0534204 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0533659 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0522822 |
| AHNAK | AHNAK nucleoprotein | -0.0518862 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0510945 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0494646 |
| QKI | QKI, KH domain containing, RNA binding | -0.0490311 |
| RPS24 | ribosomal protein S24 | -0.0483401 |
| HDLBP | high density lipoprotein binding protein | -0.0477969 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0474656 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0460338 |
| NFIA | nuclear factor I/A | -0.0456161 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0439828 |
| RPLP1 | ribosomal protein, large, P1 | -0.0431972 |
| RPL13A | ribosomal protein L13a | -0.0415252 |
| NF1 | neurofibromin 1 | -0.0403644 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.040091 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0397302 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0396827 |
| GNAS | GNAS complex locus | -0.0394119 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0392613 |
| TMSB10 | thymosin beta 10 | -0.0390674 |
| LDHA | lactate dehydrogenase A | -0.0387264 |
| RPL31 | ribosomal protein L31 | -0.0383912 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0375251 |
| RPL5 | ribosomal protein L5 | -0.0372889 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0366906 |
| RPLP0 | ribosomal protein, large, P0 | -0.0366717 |
| TMEM41B | transmembrane protein 41B | -0.036609 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0365414 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0360681 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.034927 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0346792 |
| SMYD3 | SET and MYND domain containing 3 | -0.0343321 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0341894 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0338099 |
| TJP1 | tight junction protein 1 | -0.0336954 |
| FLNB | filamin B, beta | -0.0334205 |
| NBAS | neuroblastoma amplified sequence | -0.0332083 |
| FAM162A | family with sequence similarity 162, member A | -0.0331368 |
| RPL11 | ribosomal protein L11 | -0.0330069 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0328517 |
| RPL32 | ribosomal protein L32 | -0.0328042 |
| TLK1 | tousled-like kinase 1 | -0.032583 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0325725 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0317581 |
| RTN4 | reticulon 4 | -0.0317373 |
| RPL4 | ribosomal protein L4 | -0.031708 |
| FBXO11 | F-box protein 11 | -0.0316063 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0313165 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0310127 |
| RPS19 | ribosomal protein S19 | -0.0309454 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0309284 |
| TXNRD1 | thioredoxin reductase 1 | -0.0306227 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0305178 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0304719 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0302845 |
| RPS25 | ribosomal protein S25 | -0.0300419 |
| SQSTM1 | sequestosome 1 | -0.030003 |
| NCKAP1 | NCK-associated protein 1 | -0.0300022 |
| FUS | FUS RNA binding protein | -0.0299871 |
| MAP4 | microtubule-associated protein 4 | -0.0298346 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.0293149 |
| ZNF217 | zinc finger protein 217 | -0.0290683 |
| CALR | calreticulin | -0.029007 |
| RPS11 | ribosomal protein S11 | -0.0288412 |
| ENOSF1 | enolase superfamily member 1 | -0.0286975 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0283081 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0279971 |
| TMEM263 | transmembrane protein 263 | -0.02795 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0277101 |
| CANX | calnexin | -0.0270196 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.026976 |
| PHIP | pleckstrin homology domain interacting protein | -0.0269147 |
| TNPO1 | transportin 1 | -0.026399 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0263713 |
| RPS27A | ribosomal protein S27a | -0.0262619 |
