Hydroxyfasudil_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.148889
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.140798
MT2A metallothionein 2A 0.135628
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0831841
B2M beta-2-microglobulin 0.0625541
GPBP1 GC-rich promoter binding protein 1 0.0590701
DSCAM Down syndrome cell adhesion molecule 0.0586355
FTH1 ferritin, heavy polypeptide 1 0.0581499
SEPTIN7 septin 7 0.0529601
MYOF myoferlin 0.0493924
ENO1 enolase 1, (alpha) 0.0480969
RPL11 ribosomal protein L11 0.0453314
FAM13A family with sequence similarity 13, member A 0.04165
PCBP2 poly(rC) binding protein 2 0.0416451
ZSWIM6 zinc finger, SWIM-type containing 6 0.0403138
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0392688
GOLGB1 golgin B1 0.0392198
IGFBP7 insulin-like growth factor binding protein 7 0.0371601
POLK polymerase (DNA directed) kappa 0.0365564
RSRC2 arginine/serine-rich coiled-coil 2 0.0360671
C1R complement component 1, r subcomponent 0.0359879
KIF16B kinesin family member 16B 0.0359067
KYNU kynureninase 0.0357614
UBC ubiquitin C 0.0354998
RPS8 ribosomal protein S8 0.0352736
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0352679
C1S complement component 1, s subcomponent 0.0351674
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0349714
SETD5 SET domain containing 5 0.0348055
NCOR2 nuclear receptor corepressor 2 0.0340339
JUN jun proto-oncogene 0.0338333
NAV2 neuron navigator 2 0.0335565
EEF2 eukaryotic translation elongation factor 2 0.0330201
TPI1 triosephosphate isomerase 1 0.0329321
MAGT1 magnesium transporter 1 0.0329304
TXNIP thioredoxin interacting protein 0.0327378
HSPH1 heat shock 105kDa/110kDa protein 1 0.0327082
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0323609
PRKN parkin RBR E3 ubiquitin protein ligase 0.0323408
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0315635
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0315608
HSPA8 heat shock 70kDa protein 8 0.0314939
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0306512
TPM2 tropomyosin 2 (beta) 0.0296645
TPR translocated promoter region, nuclear basket protein 0.0293186
MYH9 myosin, heavy chain 9, non-muscle 0.0292158
TTC3 tetratricopeptide repeat domain 3 0.0290363
OPTN optineurin 0.0282668
CHD9 chromodomain helicase DNA binding protein 9 0.0279296
GIGYF2 GRB10 interacting GYF protein 2 0.0278997
LDHA lactate dehydrogenase A 0.027653
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0274885
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0272485
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0265709
TGFBI transforming growth factor, beta-induced, 68kDa 0.0261726
C1D C1D nuclear receptor corepressor 0.026157
MT1X metallothionein 1X 0.0259209
DSTN destrin (actin depolymerizing factor) 0.0258821
DDIT4 DNA-damage-inducible transcript 4 0.0257195
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0257007
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0256389
SRRM1 serine/arginine repetitive matrix 1 0.0252872
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0251156
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0250259
DCAF6 DDB1 and CUL4 associated factor 6 0.0246522
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.0245728
ANXA1 annexin A1 0.024564
EIF5B eukaryotic translation initiation factor 5B 0.0241295
TMED4 transmembrane emp24 protein transport domain containing 4 0.0241135
SYAP1 synapse associated protein 1 0.0239425
CYLD cylindromatosis (turban tumor syndrome) 0.0238676
C6ORF62 chromosome 6 open reading frame 62 0.0234745
SMTN smoothelin 0.0234294
ZNF146 zinc finger protein 146 0.0232234
SDCCAG8 serologically defined colon cancer antigen 8 0.0231698
COPA coatomer protein complex, subunit alpha 0.0229276
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0229215
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0228964
RPL7 ribosomal protein L7 0.0228831
ANLN anillin, actin binding protein 0.0228258
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0227407
NRXN3 neurexin 3 0.0227071
PTN pleiotrophin 0.0224079
COX7C cytochrome c oxidase subunit VIIc 0.0223207
ANKRD17 ankyrin repeat domain 17 0.022207
MTDH metadherin 0.0221238
RAB31 RAB31, member RAS oncogene family 0.0221007
SMG6 SMG6 nonsense mediated mRNA decay factor 0.0220891
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 0.0219075
RAB8B RAB8B, member RAS oncogene family 0.0218366
FKBP9 FK506 binding protein 9, 63 kDa 0.0217987
PATJ PATJ crumbs cell polarity complex component 0.021752
AHNAK AHNAK nucleoprotein 0.0217514
FNIP1 folliculin interacting protein 1 0.0216965
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0216826
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0216804
TTC27 tetratricopeptide repeat domain 27 0.021464
RPL12 ribosomal protein L12 0.0213644
NDEL1 nudE neurodevelopment protein 1-like 1 0.021262
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0212251

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.2918
FN1 fibronectin 1 -0.182953
IGFBP3 insulin-like growth factor binding protein 3 -0.146343
TMSB10 thymosin beta 10 -0.0934263
TRIO trio Rho guanine nucleotide exchange factor -0.093105
LOX lysyl oxidase -0.0765615
PRSS23 protease, serine, 23 -0.0694373
F3 coagulation factor III (thromboplastin, tissue factor) -0.0659036
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.065577
VCL vinculin -0.0616577
CDH13 cadherin 13 -0.0606486
CLINT1 clathrin interactor 1 -0.0578318
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.057498
LOXL2 lysyl oxidase-like 2 -0.0570004
GLIS3 GLIS family zinc finger 3 -0.0538606
PGK1 phosphoglycerate kinase 1 -0.0524921
COL1A2 collagen, type I, alpha 2 -0.0518259
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0516172
HMGA2 high mobility group AT-hook 2 -0.0502356
NAV1 neuron navigator 1 -0.0501399
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0499569
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0497788
MAP4 microtubule-associated protein 4 -0.0495198
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0484075
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0481487
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0475953
GLS2 glutaminase 2 (liver, mitochondrial) -0.0471815
UBE2H ubiquitin-conjugating enzyme E2H -0.0471511
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0464769
ATP13A3 ATPase type 13A3 -0.0460705
CALU calumenin -0.0454935
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0441206
COL6A1 collagen, type VI, alpha 1 -0.0440031
PRKCA protein kinase C, alpha -0.043372
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0426924
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0415744
HM13 histocompatibility (minor) 13 -0.0412968
COL5A1 collagen, type V, alpha 1 -0.0397164
TFPI2 tissue factor pathway inhibitor 2 -0.0376743
CANX calnexin -0.03762
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0369581
SEC24D SEC24 family member D -0.0367602
GNAS GNAS complex locus -0.0362427
LMAN1 lectin, mannose-binding, 1 -0.0361612
TPM4 tropomyosin 4 -0.0358166
PDIA5 protein disulfide isomerase family A, member 5 -0.0355865
AUTS2 autism susceptibility candidate 2 -0.0352196
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0350535
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0347677
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0345232
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.034462
POTEF POTE ankyrin domain family, member F -0.0342889
TPST1 tyrosylprotein sulfotransferase 1 -0.0342579
RTN4 reticulon 4 -0.0337799
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0336917
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0336541
AVL9 AVL9 homolog (S. cerevisiase) -0.0330693
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0328865
OXR1 oxidation resistance 1 -0.0327838
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.032361
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0322185
KAZN kazrin, periplakin interacting protein -0.0321051
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0320662
TENT5A terminal nucleotidyltransferase 5A -0.0315607
ZFAND3 zinc finger, AN1-type domain 3 -0.0310596
FRMD4A FERM domain containing 4A -0.0308508
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0307244
CAMTA1 calmodulin binding transcription activator 1 -0.0303669
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0303018
RUNX1 runt-related transcription factor 1 -0.0298791
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.029805
NRP1 neuropilin 1 -0.0291279
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0290803
RPL38 ribosomal protein L38 -0.0290646
NUP58 nucleoporin 58 -0.0288603
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0287578
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.028645
TNNC1 troponin C type 1 (slow) -0.0284299
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0284032
RASAL2 RAS protein activator like 2 -0.0281314
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0280272
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0276794
MARCHF6 membrane associated ring-CH-type finger 6 -0.0276063
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0275849
NDRG1 N-myc downstream regulated 1 -0.0274469
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0274187
ZFC3H1 zinc finger, C3H1-type containing -0.0273238
ZMYND8 zinc finger, MYND-type containing 8 -0.0270439
EGFR epidermal growth factor receptor -0.0266202
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0265932
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 -0.0265197
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0264865
RRBP1 ribosome binding protein 1 -0.0263434
TAS2R14 taste receptor, type 2, member 14 -0.0260903
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0259428
RPS24 ribosomal protein S24 -0.0256737
FER fer (fps/fes related) tyrosine kinase -0.0255831
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0253604
RAI14 retinoic acid induced 14 -0.0246803
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0245957