Hydroxyfasudil_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyfasudil perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyfasudil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.373397
FTH1 ferritin, heavy polypeptide 1 0.146694
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.130826
AKAP12 A kinase (PRKA) anchor protein 12 0.101403
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.09703
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.090303
FNDC3B fibronectin type III domain containing 3B 0.0856125
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0852667
FTL ferritin, light polypeptide 0.0809965
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0726644
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0694044
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0663829
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0645718
LOC102724023 ES1 protein homolog, mitochondrial 0.0642178
TPR translocated promoter region, nuclear basket protein 0.0629275
FAM13A family with sequence similarity 13, member A 0.0619907
HILPDA hypoxia inducible lipid droplet-associated 0.0606258
CXCL8 chemokine (C-X-C motif) ligand 8 0.0589429
IFI27 interferon, alpha-inducible protein 27 0.057895
MBNL1 muscleblind-like splicing regulator 1 0.0571997
ENO1 enolase 1, (alpha) 0.0546345
CD109 CD109 molecule 0.0541156
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0513357
MRPS6 mitochondrial ribosomal protein S6 0.0508551
ZFP36L1 ZFP36 ring finger protein-like 1 0.0500561
UBC ubiquitin C 0.0491052
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0485551
PTMA prothymosin, alpha 0.0483604
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0464771
FAT1 FAT atypical cadherin 1 0.0463406
PRRC2C proline-rich coiled-coil 2C 0.0456327
ZSWIM6 zinc finger, SWIM-type containing 6 0.0450003
HSPA8 heat shock 70kDa protein 8 0.044176
DSTN destrin (actin depolymerizing factor) 0.043477
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0431789
TOP1 topoisomerase (DNA) I 0.0426836
HSPH1 heat shock 105kDa/110kDa protein 1 0.0424571
SFTPA2 surfactant protein A2 0.0422165
ITGA1 integrin, alpha 1 0.041805
SIK3 SIK family kinase 3 0.0415483
ANKRD28 ankyrin repeat domain 28 0.0403123
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0395173
NAMPT nicotinamide phosphoribosyltransferase 0.039458
HIPK2 homeodomain interacting protein kinase 2 0.0394572
RB1CC1 RB1-inducible coiled-coil 1 0.0394182
RND3 Rho family GTPase 3 0.0392392
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0389334
KMT2C lysine (K)-specific methyltransferase 2C 0.0385146
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.036842
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0368151
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0366538
GPBP1 GC-rich promoter binding protein 1 0.0360942
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0357336
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0353796
RNF145 ring finger protein 145 0.0352565
MAP1B microtubule-associated protein 1B 0.0343369
HSPA1A heat shock 70kDa protein 1A 0.034318
BZW1 basic leucine zipper and W2 domains 1 0.0341972
TPM3 tropomyosin 3 0.0341156
SUCO SUN domain containing ossification factor 0.0338955
ZC3H11A zinc finger CCCH-type containing 11A 0.033725
KMT2E lysine (K)-specific methyltransferase 2E 0.0336363
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0335349
ESYT2 extended synaptotagmin-like protein 2 0.0332871
BCLAF1 BCL2-associated transcription factor 1 0.0324004
SRRM2 serine/arginine repetitive matrix 2 0.0319776
DOCK5 dedicator of cytokinesis 5 0.0317378
PDIA3 protein disulfide isomerase family A, member 3 0.0315276
MYO1B myosin IB 0.0315025
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0312174
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0304924
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0303871
UBA6 ubiquitin-like modifier activating enzyme 6 0.0303516
AKAP13 A kinase (PRKA) anchor protein 13 0.0302889
STC2 stanniocalcin 2 0.0302627
NOTCH2 notch 2 0.0299207
PLIN2 perilipin 2 0.0297391
POTEF POTE ankyrin domain family, member F 0.0296787
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0295783
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.029508
CHD1 chromodomain helicase DNA binding protein 1 0.0294847
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0294049
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0293454
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0289592
VEGFA vascular endothelial growth factor A 0.0288251
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0283905
IL6 interleukin 6 0.0283867
KTN1 kinectin 1 (kinesin receptor) 0.0282618
GOLGB1 golgin B1 0.0277724
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0277441
MGST1 microsomal glutathione S-transferase 1 0.0276164
GOLGA4 golgin A4 0.0274033
BASP1 brain abundant, membrane attached signal protein 1 0.0272798
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0272664
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0270092
ANXA1 annexin A1 0.0270041
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0268785
LMNA lamin A/C 0.026839
WBP11 WW domain binding protein 11 0.0267502
UBE2K ubiquitin-conjugating enzyme E2K 0.0264621

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.126398
VCL vinculin -0.125274
NRG1 neuregulin 1 -0.103228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0814582
HMGA2 high mobility group AT-hook 2 -0.0569105
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0553466
TPT1 tumor protein, translationally-controlled 1 -0.0543826
MT2A metallothionein 2A -0.0539199
TMSB10 thymosin beta 10 -0.0528429
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0518071
NDRG1 N-myc downstream regulated 1 -0.0503824
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0464011
BICD1 bicaudal D homolog 1 (Drosophila) -0.0451701
AEBP2 AE binding protein 2 -0.0446847
H1-0 H1.0 linker histone -0.0423828
RPLP1 ribosomal protein, large, P1 -0.0407964
IER3 immediate early response 3 -0.0402266
RPL38 ribosomal protein L38 -0.0393729
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0392506
INTS6 integrator complex subunit 6 -0.0391892
SYT1 synaptotagmin I -0.038231
OGA O-GlcNAcase -0.0378834
MYH9 myosin, heavy chain 9, non-muscle -0.0377822
NCOA7 nuclear receptor coactivator 7 -0.037775
EFNA5 ephrin-A5 -0.0371821
HPCAL1 hippocalcin-like 1 -0.036634
TRIO trio Rho guanine nucleotide exchange factor -0.0349558
AHNAK AHNAK nucleoprotein -0.0344987
SOX5 SRY (sex determining region Y)-box 5 -0.0338168
DNAH5 dynein, axonemal, heavy chain 5 -0.033654
ACTG1 actin gamma 1 -0.0332893
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0324879
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0323862
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0318935
TENM4 teneurin transmembrane protein 4 -0.031334
RPL35A ribosomal protein L35a -0.0312683
GNAS GNAS complex locus -0.0309341
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0306188
FAM20C family with sequence similarity 20, member C -0.0304524
RPS24 ribosomal protein S24 -0.0302294
LRRC23 leucine rich repeat containing 23 -0.0302052
RBM39 RNA binding motif protein 39 -0.0300946
TAS2R14 taste receptor, type 2, member 14 -0.0300125
FBXO11 F-box protein 11 -0.0297544
RPS21 ribosomal protein S21 -0.0297333
NT5C2 5'-nucleotidase, cytosolic II -0.0291498
DIAPH3 diaphanous-related formin 3 -0.0291283
SMYD3 SET and MYND domain containing 3 -0.0288462
RPS27A ribosomal protein S27a -0.0281492
RPS20 ribosomal protein S20 -0.0281253
GRB10 growth factor receptor-bound protein 10 -0.0278594
LOC112694756 uncharaterized LOC112694756 -0.0276204
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0273475
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0273468
IGFBP3 insulin-like growth factor binding protein 3 -0.0272905
UGDH UDP-glucose 6-dehydrogenase -0.026681
GOLGA3 golgin A3 -0.0266594
ARF1 ADP-ribosylation factor 1 -0.0266524
RPS19 ribosomal protein S19 -0.0262763
RAD51B RAD51 paralog B -0.026084
TUFT1 tuftelin 1 -0.0259327
TTC28 tetratricopeptide repeat domain 28 -0.0259314
RCOR1 REST corepressor 1 -0.0259123
KDM3A lysine (K)-specific demethylase 3A -0.0258407
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0254574
DPYD dihydropyrimidine dehydrogenase -0.0253691
RPS29 ribosomal protein S29 -0.0247726
RPL23 ribosomal protein L23 -0.0246348
ARMH4 armadillo like helical domain containing 4 -0.0244399
TGFA transforming growth factor, alpha -0.0243922
MKI67 marker of proliferation Ki-67 -0.0243768
FOXO3 forkhead box O3 -0.0241962
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0239107
ANLN anillin, actin binding protein -0.023839
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0236316
RPLP2 ribosomal protein, large, P2 -0.0235811
WDR1 WD repeat domain 1 -0.0230711
RTN3 reticulon 3 -0.0230505
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0229985
AHNAK2 AHNAK nucleoprotein 2 -0.0228159
NSD2 nuclear receptor binding SET domain protein 2 -0.0226491
CAVIN1 caveolae associated protein 1 -0.0226339
ANXA2 annexin A2 -0.0225345
FAM193A family with sequence similarity 193, member A -0.0224867
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0222643
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0222446
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0222334
HMGB1 high mobility group box 1 -0.0219505
LTBP3 latent transforming growth factor beta binding protein 3 -0.021867
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0218256
LPP LIM domain containing preferred translocation partner in lipoma -0.021761
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0216883
MAPK8 mitogen-activated protein kinase 8 -0.021557
VMP1 vacuole membrane protein 1 -0.0215244
TSC22D1 TSC22 domain family, member 1 -0.021412
LRMDA leucine rich melanocyte differentiation associated -0.0212245
CLINT1 clathrin interactor 1 -0.0211345
HDLBP high density lipoprotein binding protein -0.0211102
LCORL ligand dependent nuclear receptor corepressor-like -0.0211098
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0209968