Hydroxyurea_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.120873
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.103109
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0822051
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0656201
DLG1 discs, large homolog 1 (Drosophila) 0.0656089
FNDC3B fibronectin type III domain containing 3B 0.0652233
FLNB filamin B, beta 0.052338
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0480167
SBF2 SET binding factor 2 0.0456727
ATP13A3 ATPase type 13A3 0.0433675
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0432928
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0419423
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0417353
RUNX1 runt-related transcription factor 1 0.041289
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0395659
ELL2 elongation factor, RNA polymerase II, 2 0.0386915
OGA O-GlcNAcase 0.0369769
AUTS2 autism susceptibility candidate 2 0.0366889
NAV2 neuron navigator 2 0.0364719
MYOF myoferlin 0.0357725
ZEB1 zinc finger E-box binding homeobox 1 0.0329579
FBN1 fibrillin 1 0.0325007
ZNF292 zinc finger protein 292 0.0315429
GPC6 glypican 6 0.0311184
NDRG1 N-myc downstream regulated 1 0.0303905
SOD2 superoxide dismutase 2, mitochondrial 0.030009
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0297574
BHLHE40 basic helix-loop-helix family, member e40 0.0297104
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296218
CYLD cylindromatosis (turban tumor syndrome) 0.0291201
MXI1 MAX interactor 1, dimerization protein 0.028884
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0287548
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0282381
SPAG9 sperm associated antigen 9 0.0281075
DST dystonin 0.0279739
HELZ helicase with zinc finger 0.0268451
LOXL2 lysyl oxidase-like 2 0.026427
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.026323
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.02567
ERRFI1 ERBB receptor feedback inhibitor 1 0.0255702
CCND1 cyclin D1 0.0255055
THBS2 thrombospondin 2 0.0252398
ANXA2 annexin A2 0.0252239
PRELID2 PRELI domain containing 2 0.0247326
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0244375
CDH13 cadherin 13 0.0239342
XPO1 exportin 1 0.0233845
SSBP2 single-stranded DNA binding protein 2 0.0225605
RHOBTB3 Rho-related BTB domain containing 3 0.0222723
NAMPT nicotinamide phosphoribosyltransferase 0.0222573
C1ORF21 chromosome 1 open reading frame 21 0.0220039
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0219754
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0217915
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.021589
COL8A1 collagen, type VIII, alpha 1 0.0212691
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0211034
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0209584
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0209365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0207459
PICALM phosphatidylinositol binding clathrin assembly protein 0.0206336
MEF2A myocyte enhancer factor 2A 0.02062
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0200916
DTNA dystrobrevin, alpha 0.0199542
ANO6 anoctamin 6 0.0198921
LDHA lactate dehydrogenase A 0.0198093
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0196388
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0196108
KMT2E lysine (K)-specific methyltransferase 2E 0.0192854
MSI2 musashi RNA-binding protein 2 0.0192283
NT5C2 5'-nucleotidase, cytosolic II 0.0189399
RLF rearranged L-myc fusion 0.018768
RICTOR RPTOR independent companion of MTOR, complex 2 0.0185201
PSD3 pleckstrin and Sec7 domain containing 3 0.0184594
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0183366
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0182748
MARCHF6 membrane associated ring-CH-type finger 6 0.0181572
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0181368
ARRDC3 arrestin domain containing 3 0.0180442
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0180391
ZBTB20 zinc finger and BTB domain containing 20 0.0178802
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0177933
ZMIZ1 zinc finger, MIZ-type containing 1 0.017745
KDM6A lysine (K)-specific demethylase 6A 0.0177346
ESYT2 extended synaptotagmin-like protein 2 0.0176623
USP9X ubiquitin specific peptidase 9, X-linked 0.0175768
CDC73 cell division cycle 73 0.0175441
SP3 Sp3 transcription factor 0.01747
DPYSL3 dihydropyrimidinase-like 3 0.0174074
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0172863
SDK1 sidekick cell adhesion molecule 1 0.0171369
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0170814
MMP12 matrix metallopeptidase 12 0.0170621
ADAM9 ADAM metallopeptidase domain 9 0.0170287
SETD5 SET domain containing 5 0.0169435
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0169185
TENM3 teneurin transmembrane protein 3 0.0168291
SKIC3 SKI3 subunit of superkiller complex 0.0168279
WDFY1 WD repeat and FYVE domain containing 1 0.0168232
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167646
AFF4 AF4/FMR2 family, member 4 0.0167492

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.136666
VIM vimentin -0.136008
IGFBP3 insulin-like growth factor binding protein 3 -0.0881424
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0760108
MT2A metallothionein 2A -0.0544247
MAP1B microtubule-associated protein 1B -0.0514698
HLA-B major histocompatibility complex, class I, B -0.0328653
S100A6 S100 calcium binding protein A6 -0.026333
B2M beta-2-microglobulin -0.026012
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0256845
CSTB cystatin B (stefin B) -0.0228554
LMNA lamin A/C -0.0219074
FTL ferritin, light polypeptide -0.0204304
MYADM myeloid-associated differentiation marker -0.0201183
FN1 fibronectin 1 -0.0195698
PTMA prothymosin, alpha -0.0194983
TAGLN2 transgelin 2 -0.0191276
HLA-C major histocompatibility complex, class I, C -0.0185166
HLA-A major histocompatibility complex, class I, A -0.0183662
MT1X metallothionein 1X -0.0183142
COL5A1 collagen, type V, alpha 1 -0.0182098
POTEF POTE ankyrin domain family, member F -0.0178209
S100A10 S100 calcium binding protein A10 -0.0176391
IFITM3 interferon induced transmembrane protein 3 -0.0175799
S100A11 S100 calcium binding protein A11 -0.0156632
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0153766
IFITM1 interferon induced transmembrane protein 1 -0.0152726
PODXL podocalyxin-like -0.0152683
SRRM2 serine/arginine repetitive matrix 2 -0.015173
EIF1 eukaryotic translation initiation factor 1 -0.0150841
LOC112694756 uncharaterized LOC112694756 -0.0149709
FTH1 ferritin, heavy polypeptide 1 -0.0147579
PFN1 profilin 1 -0.0146874
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0140717
CALR calreticulin -0.0139886
AKAP12 A kinase (PRKA) anchor protein 12 -0.0132243
ENO2 enolase 2 (gamma, neuronal) -0.0130865
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0121747
MCL1 myeloid cell leukemia 1 -0.0121108
RPS19 ribosomal protein S19 -0.0120047
SLC38A2 solute carrier family 38, member 2 -0.0119068
ACTG1 actin gamma 1 -0.0117942
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.011706
TPT1 tumor protein, translationally-controlled 1 -0.0110741
MX2 MX dynamin-like GTPase 2 -0.0110308
RPS6 ribosomal protein S6 -0.0109867
RPLP1 ribosomal protein, large, P1 -0.0109752
IFI6 interferon, alpha-inducible protein 6 -0.0108998
RPLP2 ribosomal protein, large, P2 -0.0108318
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0106013
ISG15 ISG15 ubiquitin-like modifier -0.010577
RPL26 ribosomal protein L26 -0.0105648
LGALS1 lectin, galactoside-binding, soluble, 1 -0.010484
TBCA tubulin folding cofactor A -0.0104158
RPS8 ribosomal protein S8 -0.0104046
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0100026
CHD9 chromodomain helicase DNA binding protein 9 -0.00993504
SUCNR1 succinate receptor 1 -0.00990486
RPL37A ribosomal protein L37a -0.00972947
BSG basigin (Ok blood group) -0.00971996
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.00954591
CYTH3 cytohesin 3 -0.00949384
SERF2 small EDRK-rich factor 2 -0.00943243
LY6E lymphocyte antigen 6 complex, locus E -0.00942204
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00936289
MRPS6 mitochondrial ribosomal protein S6 -0.00922902
RPL35A ribosomal protein L35a -0.009223
CENPF centromere protein F, 350/400kDa -0.00919167
AKAP9 A kinase (PRKA) anchor protein 9 -0.00899623
RPS3 ribosomal protein S3 -0.00894349
RPS13 ribosomal protein S13 -0.00892271
RPL36 ribosomal protein L36 -0.00876898
IFI27 interferon, alpha-inducible protein 27 -0.00870722
TPI1 triosephosphate isomerase 1 -0.00848454
TUBB4B tubulin, beta 4B class IVb -0.00847583
BPTF bromodomain PHD finger transcription factor -0.00840789
C6ORF62 chromosome 6 open reading frame 62 -0.00839379
SEC16A SEC16 homolog A (S. cerevisiae) -0.00838779
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00833218
RPS27 ribosomal protein S27 -0.00831366
MNT MAX network transcriptional repressor -0.0082417
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0082331
C1D C1D nuclear receptor corepressor -0.00809493
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00808698
S100A4 S100 calcium binding protein A4 -0.00806452
MRC2 mannose receptor, C type 2 -0.00804387
TAPBP TAP binding protein (tapasin) -0.00801921
ECM1 extracellular matrix protein 1 -0.00797403
CYB5R3 cytochrome b5 reductase 3 -0.00796636
RPL28 ribosomal protein L28 -0.00796386
RPS15 ribosomal protein S15 -0.00796046
HSPB1 heat shock 27kDa protein 1 -0.00779755
RRBP1 ribosome binding protein 1 -0.00779541
SMIM44 small integral membrane protein 44 -0.00776234
RPL31 ribosomal protein L31 -0.00774497
RPL7A ribosomal protein L7a -0.00772008
GOLGB1 golgin B1 -0.00765572
PCDH7 protocadherin 7 -0.0076391
TPM4 tropomyosin 4 -0.00757726
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00756905