| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Hydroxyurea_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.15278 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0687702 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0673024 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0611308 |
| PDGFC | platelet derived growth factor C | 0.0597919 |
| MMP12 | matrix metallopeptidase 12 | 0.0554726 |
| RPS12 | ribosomal protein S12 | 0.0542267 |
| VMP1 | vacuole membrane protein 1 | 0.0541276 |
| MED13L | mediator complex subunit 13-like | 0.0499524 |
| YAP1 | Yes-associated protein 1 | 0.0490942 |
| BCHE | butyrylcholinesterase | 0.0461078 |
| HMGA1 | high mobility group AT-hook 1 | 0.0460877 |
| JMJD1C | jumonji domain containing 1C | 0.0453792 |
| MGAT4C | MGAT4 family, member C | 0.0442705 |
| TENM3 | teneurin transmembrane protein 3 | 0.0416521 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0412035 |
| TXNRD1 | thioredoxin reductase 1 | 0.0410321 |
| TMEM41B | transmembrane protein 41B | 0.0403783 |
| PCBP2 | poly(rC) binding protein 2 | 0.039739 |
| CDK17 | cyclin-dependent kinase 17 | 0.0395638 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0390002 |
| NUP58 | nucleoporin 58 | 0.0388352 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0377275 |
| NHSL1 | NHS-like 1 | 0.0360751 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0353457 |
| CCNL1 | cyclin L1 | 0.0353132 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0352608 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0349664 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0341331 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0339831 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0339804 |
| RTN4 | reticulon 4 | 0.0338691 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0334344 |
| NBAS | neuroblastoma amplified sequence | 0.0333633 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0320026 |
| TNPO1 | transportin 1 | 0.0311123 |
| ZNF292 | zinc finger protein 292 | 0.0300398 |
| WDR43 | WD repeat domain 43 | 0.0291192 |
| MTAP | methylthioadenosine phosphorylase | 0.0290324 |
| YEATS2 | YEATS domain containing 2 | 0.0288458 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0281614 |
| NCKAP1 | NCK-associated protein 1 | 0.0275512 |
| TBK1 | TANK-binding kinase 1 | 0.027323 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0272828 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0271589 |
| XPO1 | exportin 1 | 0.0268953 |
| CPOX | coproporphyrinogen oxidase | 0.0267977 |
| RBM25 | RNA binding motif protein 25 | 0.02678 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.026473 |
| RNF13 | ring finger protein 13 | 0.0259743 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.025895 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0258668 |
| CLDND1 | claudin domain containing 1 | 0.0250874 |
| NEK7 | NIMA-related kinase 7 | 0.0249164 |
| RSF1 | remodeling and spacing factor 1 | 0.0246347 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0236447 |
| ANKRD28 | ankyrin repeat domain 28 | 0.022876 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0228272 |
| PTPRZ1 | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | 0.0227971 |
| EPHA6 | EPH receptor A6 | 0.0225783 |
| PTEN | phosphatase and tensin homolog | 0.0223766 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.0222678 |
| TPM3 | tropomyosin 3 | 0.0218721 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0218275 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0216359 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0215881 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0215567 |
| ETNK1 | ethanolamine kinase 1 | 0.0215159 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0213801 |
| SESN2 | sestrin 2 | 0.0213165 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.021254 |
| MEMO1 | mediator of cell motility 1 | 0.0210805 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0210282 |
| ANXA5 | annexin A5 | 0.0209901 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0209802 |
| NEBL | nebulette | 0.0206942 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0205966 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0200713 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0200107 |
| RPL5 | ribosomal protein L5 | 0.0198899 |
| KLHL24 | kelch-like family member 24 | 0.0197453 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0196617 |
| ATP11B | ATPase, class VI, type 11B | 0.019586 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0193756 |
| SMYD3 | SET and MYND domain containing 3 | 0.0193414 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0192916 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0192571 |
| VCL | vinculin | 0.0191729 |
| WDR41 | WD repeat domain 41 | 0.0191578 |
| TFG | TRK-fused gene | 0.0190362 |
| SLC49A4 | solute carrier family 49 member 4 | 0.0186292 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0185367 |
| ARRDC3 | arrestin domain containing 3 | 0.0185134 |
| PRELID2 | PRELI domain containing 2 | 0.01847 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.018152 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.018137 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0180442 |
| SS18 | synovial sarcoma translocation, chromosome 18 | 0.0180102 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.017782 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.017486 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.241513 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.197047 |
| TMSB10 | thymosin beta 10 | -0.182817 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.115646 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0881439 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0850509 |
| AHNAK | AHNAK nucleoprotein | -0.0815306 |
| FTL | ferritin, light polypeptide | -0.0784051 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0755548 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0741235 |
| ACTG1 | actin gamma 1 | -0.0711256 |
| NLGN1 | neuroligin 1 | -0.0677183 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0653837 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.059391 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0583952 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0537487 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0534456 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0524913 |
| CCND1 | cyclin D1 | -0.0514442 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0504527 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0493355 |
| PTMA | prothymosin, alpha | -0.0477689 |
| H1-0 | H1.0 linker histone | -0.045726 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0450441 |
| GCG | glucagon | -0.0443062 |
| GNAS | GNAS complex locus | -0.0436512 |
| HSPB1 | heat shock 27kDa protein 1 | -0.043581 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0429986 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0423212 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0420101 |
| CANX | calnexin | -0.0418482 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.041643 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0395118 |
| RPLP1 | ribosomal protein, large, P1 | -0.0391571 |
| RPL35A | ribosomal protein L35a | -0.0387255 |
| RPS19 | ribosomal protein S19 | -0.0384751 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0367058 |
| CALR | calreticulin | -0.0362441 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0356159 |
| CLDN1 | claudin 1 | -0.0350844 |
| HDLBP | high density lipoprotein binding protein | -0.0342338 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.034199 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0332973 |
| YBX1 | Y box binding protein 1 | -0.0331558 |
| RPL8 | ribosomal protein L8 | -0.0331171 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0325225 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0321339 |
| EZR | ezrin | -0.0317726 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0313899 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.031352 |
| YBX3 | Y box binding protein 3 | -0.0306532 |
| PGK1 | phosphoglycerate kinase 1 | -0.030274 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0300227 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0300065 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0296557 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0295659 |
| TPI1 | triosephosphate isomerase 1 | -0.0292707 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0288435 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028586 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0282258 |
| CDK6 | cyclin-dependent kinase 6 | -0.0280387 |
| RPS24 | ribosomal protein S24 | -0.0278925 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.027787 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0274174 |
| UBB | ubiquitin B | -0.0271725 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.027117 |
| PEG10 | paternally expressed 10 | -0.0265736 |
| CAVIN1 | caveolae associated protein 1 | -0.02654 |
| FUS | FUS RNA binding protein | -0.0264382 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0263271 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0256713 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0256166 |
| ZNF638 | zinc finger protein 638 | -0.0252393 |
| RPS14 | ribosomal protein S14 | -0.0252201 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0246112 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0244754 |
| HMGB1 | high mobility group box 1 | -0.0244486 |
| CCDC47 | coiled-coil domain containing 47 | -0.0243821 |
| LDHA | lactate dehydrogenase A | -0.0243448 |
| ARF1 | ADP-ribosylation factor 1 | -0.0241888 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0240194 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0238024 |
| MKI67 | marker of proliferation Ki-67 | -0.0237728 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.023703 |
| HMGB2 | high mobility group box 2 | -0.0236737 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0232659 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.0231314 |
| S100A6 | S100 calcium binding protein A6 | -0.0230013 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0229301 |
| RPL19 | ribosomal protein L19 | -0.0228852 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0227544 |
| PCDH7 | protocadherin 7 | -0.0226682 |
| PTMS | parathymosin | -0.0223649 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0222182 |
| LRRC23 | leucine rich repeat containing 23 | -0.0221762 |
| RPLP0 | ribosomal protein, large, P0 | -0.0220223 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0218147 |
| TUBB | tubulin, beta class I | -0.0217912 |
| S100A10 | S100 calcium binding protein A10 | -0.0217536 |
| NPR2 | natriuretic peptide receptor 2 | -0.0213478 |
