Hydroxyurea_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.25031
CXCL8 chemokine (C-X-C motif) ligand 8 0.215446
ATP13A3 ATPase type 13A3 0.169966
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0985216
CD44 CD44 molecule (Indian blood group) 0.097371
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0752311
FNDC3B fibronectin type III domain containing 3B 0.0696237
NAMPT nicotinamide phosphoribosyltransferase 0.0692007
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0691168
STC1 stanniocalcin 1 0.0684245
KLF7 Kruppel-like factor 7 (ubiquitous) 0.066706
TM4SF1 transmembrane 4 L six family member 1 0.0658904
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0644269
ELL2 elongation factor, RNA polymerase II, 2 0.0643311
MTSS1 metastasis suppressor 1 0.060256
TRIO trio Rho guanine nucleotide exchange factor 0.0592574
POSTN periostin, osteoblast specific factor 0.0561921
ARRDC3 arrestin domain containing 3 0.0518875
SMAD3 SMAD family member 3 0.0495319
COL1A2 collagen, type I, alpha 2 0.0485046
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0474349
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0455264
HAS2 hyaluronan synthase 2 0.0451099
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0431605
LTBP1 latent transforming growth factor beta binding protein 1 0.0423354
SPAG9 sperm associated antigen 9 0.0418255
PTK2 protein tyrosine kinase 2 0.0398622
ZNF292 zinc finger protein 292 0.0398375
DPYSL3 dihydropyrimidinase-like 3 0.0391287
LDHA lactate dehydrogenase A 0.0390956
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0380526
ALCAM activated leukocyte cell adhesion molecule 0.0371142
ERRFI1 ERBB receptor feedback inhibitor 1 0.0358951
CADM1 cell adhesion molecule 1 0.0358574
RIPK2 receptor-interacting serine-threonine kinase 2 0.0356094
IL6ST interleukin 6 signal transducer 0.0342179
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0336827
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0335337
LOXL2 lysyl oxidase-like 2 0.0334229
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0318634
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0312151
USP3 ubiquitin specific peptidase 3 0.0308296
NRIP1 nuclear receptor interacting protein 1 0.0297352
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0296475
ICAM1 intercellular adhesion molecule 1 0.0294397
ZFAND3 zinc finger, AN1-type domain 3 0.0293488
ADAM17 ADAM metallopeptidase domain 17 0.028658
KDM7A lysine (K)-specific demethylase 7A 0.0285796
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0282254
RICTOR RPTOR independent companion of MTOR, complex 2 0.0280387
SOD2 superoxide dismutase 2, mitochondrial 0.0276425
GOLT1B golgi transport 1B 0.0272024
ARHGAP29 Rho GTPase activating protein 29 0.0269603
DLG1 discs, large homolog 1 (Drosophila) 0.0267323
ANTXR2 anthrax toxin receptor 2 0.0266809
BZW1 basic leucine zipper and W2 domains 1 0.0265958
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0265869
GOLGA4 golgin A4 0.0265759
ANXA2 annexin A2 0.0265316
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0259741
SNX9 sorting nexin 9 0.02572
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0253211
INHBA inhibin, beta A 0.0253157
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0250021
AGFG1 ArfGAP with FG repeats 1 0.0249793
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0249385
ENO1 enolase 1, (alpha) 0.0245233
TNIP1 TNFAIP3 interacting protein 1 0.0245179
VCAN versican 0.0243808
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0242946
BHLHE40 basic helix-loop-helix family, member e40 0.0240344
HIPK2 homeodomain interacting protein kinase 2 0.0239323
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0236903
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0236322
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0232717
ITCH itchy E3 ubiquitin protein ligase 0.022631
PTBP2 polypyrimidine tract binding protein 2 0.0224174
PDE10A phosphodiesterase 10A 0.0223571
MED13L mediator complex subunit 13-like 0.0223056
FAT1 FAT atypical cadherin 1 0.0221023
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0220323
TMEM39A transmembrane protein 39A 0.0220093
MRTFA myocardin related transcription factor A 0.0219867
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0218454
OSMR oncostatin M receptor 0.0218237
SQLE squalene epoxidase 0.0217663
ELOVL5 ELOVL fatty acid elongase 5 0.0215375
NFE2L1 nuclear factor, erythroid 2-like 1 0.0212849
ESYT2 extended synaptotagmin-like protein 2 0.0210622
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0210421
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0208705
SCARB2 scavenger receptor class B, member 2 0.020849
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.020797
RNF145 ring finger protein 145 0.0207583
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0205865
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0203836
DCTN4 dynactin 4 (p62) 0.0202946
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0200705
WDPCP WD repeat containing planar cell polarity effector 0.020022
DPYD dihydropyrimidine dehydrogenase 0.0199613

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.133199
CDH13 cadherin 13 -0.111363
TMSB10 thymosin beta 10 -0.0966566
NDRG1 N-myc downstream regulated 1 -0.0922551
IGFBP3 insulin-like growth factor binding protein 3 -0.081183
COL5A1 collagen, type V, alpha 1 -0.0810943
MT2A metallothionein 2A -0.0735608
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0639145
VIM vimentin -0.06083
AHNAK AHNAK nucleoprotein -0.0521133
COL7A1 collagen, type VII, alpha 1 -0.0465745
COL6A3 collagen, type VI, alpha 3 -0.0463476
COL6A1 collagen, type VI, alpha 1 -0.0456764
FBN1 fibrillin 1 -0.0449372
PTMA prothymosin, alpha -0.0442019
RRBP1 ribosome binding protein 1 -0.0438878
PSD3 pleckstrin and Sec7 domain containing 3 -0.0425095
GOLGB1 golgin B1 -0.0422548
CALR calreticulin -0.0421999
FTL ferritin, light polypeptide -0.0417549
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0414608
ACTG1 actin gamma 1 -0.0407074
COL6A2 collagen, type VI, alpha 2 -0.0378624
SQSTM1 sequestosome 1 -0.0358685
IER3 immediate early response 3 -0.0350919
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0339499
IARS1 isoleucyl-tRNA synthetase 1 -0.0323229
GARS1 glycyl-tRNA synthetase 1 -0.0321706
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0320696
HDAC9 histone deacetylase 9 -0.031481
ABI3BP ABI family, member 3 (NESH) binding protein -0.0307037
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0306216
RPL35A ribosomal protein L35a -0.0304143
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0302134
RPS8 ribosomal protein S8 -0.0301197
PLEC plectin -0.0295499
PDIA5 protein disulfide isomerase family A, member 5 -0.0289289
PDLIM5 PDZ and LIM domain 5 -0.0288405
TBC1D22A TBC1 domain family, member 22A -0.0279204
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0278398
STC2 stanniocalcin 2 -0.0277323
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.027076
LMNA lamin A/C -0.0266684
SPDYA speedy/RINGO cell cycle regulator family member A -0.0265566
RPLP2 ribosomal protein, large, P2 -0.0264803
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.026466
ATF4 activating transcription factor 4 -0.0264401
MYH9 myosin, heavy chain 9, non-muscle -0.0263268
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260322
ASPH aspartate beta-hydroxylase -0.0259701
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0259203
GLIS3 GLIS family zinc finger 3 -0.0257162
VCL vinculin -0.0256814
RPS6 ribosomal protein S6 -0.0253203
NABP1 nucleic acid binding protein 1 -0.0248268
TRPS1 trichorhinophalangeal syndrome I -0.0246469
PTPRG protein tyrosine phosphatase, receptor type, G -0.0243525
RPL31 ribosomal protein L31 -0.0242577
INTS6 integrator complex subunit 6 -0.0239085
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0237103
TPT1 tumor protein, translationally-controlled 1 -0.0233004
EGR1 early growth response 1 -0.0231625
RPL28 ribosomal protein L28 -0.0230205
CANX calnexin -0.022982
SP100 SP100 nuclear antigen -0.0229224
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0228808
RPS19 ribosomal protein S19 -0.0226198
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0225702
DST dystonin -0.0225365
TTC3 tetratricopeptide repeat domain 3 -0.0225136
HYOU1 hypoxia up-regulated 1 -0.0224549
ENO2 enolase 2 (gamma, neuronal) -0.0224315
NCOR2 nuclear receptor corepressor 2 -0.0223231
NEK10 NIMA-related kinase 10 -0.0221482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0218305
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0215399
ANKRD11 ankyrin repeat domain 11 -0.021514
PRKCA protein kinase C, alpha -0.0214114
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0213688
ATXN1 ataxin 1 -0.0213313
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0210912
DGKI diacylglycerol kinase, iota -0.0210343
RPS3 ribosomal protein S3 -0.0206272
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0205367
TGFB1 transforming growth factor, beta 1 -0.0201344
KDM4B lysine (K)-specific demethylase 4B -0.0200981
EPHB1 EPH receptor B1 -0.0195627
SORBS2 sorbin and SH3 domain containing 2 -0.0191912
COL8A1 collagen, type VIII, alpha 1 -0.0191158
MTDH metadherin -0.019105
TENM3 teneurin transmembrane protein 3 -0.019047
SRRM2 serine/arginine repetitive matrix 2 -0.0190155
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0190112
WSB1 WD repeat and SOCS box containing 1 -0.0187173
RPS17 ribosomal protein S17 -0.0184049
MACF1 microtubule-actin crosslinking factor 1 -0.0183373
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0181161
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0181145
SLC38A2 solute carrier family 38, member 2 -0.0180331
RPS29 ribosomal protein S29 -0.0179813