| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Hydroxyurea_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.102158 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.081191 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0546037 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0440596 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0373542 |
| APOB | apolipoprotein B | 0.0354155 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0341504 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0340566 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0305546 |
| ZNF292 | zinc finger protein 292 | 0.0301211 |
| KIAA1217 | KIAA1217 | 0.030103 |
| GPC6 | glypican 6 | 0.0270367 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0233175 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0229654 |
| FAT1 | FAT atypical cadherin 1 | 0.0227387 |
| ATXN1 | ataxin 1 | 0.0221037 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0213395 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0208324 |
| MRTFA | myocardin related transcription factor A | 0.0206238 |
| SMAD3 | SMAD family member 3 | 0.0203623 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0203392 |
| FLNB | filamin B, beta | 0.0202931 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0201959 |
| TF | transferrin | 0.0199124 |
| BCL2L1 | BCL2-like 1 | 0.019533 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0190253 |
| FOXO1 | forkhead box O1 | 0.0187767 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0186145 |
| VMP1 | vacuole membrane protein 1 | 0.0185127 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0184864 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0184381 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0183437 |
| JMJD1C | jumonji domain containing 1C | 0.0181913 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0180013 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0179387 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0177524 |
| DENND1A | DENN/MADD domain containing 1A | 0.017562 |
| FN1 | fibronectin 1 | 0.0167947 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0163406 |
| MTSS1 | metastasis suppressor 1 | 0.0162015 |
| RUNX1 | runt-related transcription factor 1 | 0.0160899 |
| AFDN | afadin, adherens junction formation factor | 0.0160423 |
| ANXA5 | annexin A5 | 0.0160161 |
| SBF2 | SET binding factor 2 | 0.0158341 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0156492 |
| SVIL | supervillin | 0.0156256 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0155535 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0155496 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0153132 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0153124 |
| PDE8A | phosphodiesterase 8A | 0.0151936 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0151769 |
| MED13L | mediator complex subunit 13-like | 0.0151409 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0150927 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0150679 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0148875 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0148661 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0148232 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0145301 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.014467 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0141418 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0140904 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0140787 |
| DENND5A | DENN/MADD domain containing 5A | 0.0140168 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0139982 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0139387 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0139193 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0139185 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0138319 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0138272 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0135054 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0134007 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0132986 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0132692 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0132579 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0132486 |
| NF1 | neurofibromin 1 | 0.0130901 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0130616 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0130264 |
| PLAC8 | placenta-specific 8 | 0.0130244 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0130212 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.012931 |
| RAB10 | RAB10, member RAS oncogene family | 0.0128478 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.012829 |
| FBXO42 | F-box protein 42 | 0.0128251 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0128202 |
| FAM193A | family with sequence similarity 193, member A | 0.0127499 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0126444 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0126005 |
| CDK8 | cyclin-dependent kinase 8 | 0.0125943 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0125341 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0125258 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0125222 |
| ARFGEF3 | ARFGEF family member 3 | 0.0124983 |
| SEC24A | SEC24 family member A | 0.012464 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0124417 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0124378 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0124227 |
| HPCAL1 | hippocalcin-like 1 | 0.0124076 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0123728 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.196792 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.121856 |
| APOA2 | apolipoprotein A-II | -0.0907834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0861679 |
| TMSB10 | thymosin beta 10 | -0.0807012 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0662943 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0639637 |
| GPC3 | glypican 3 | -0.0613152 |
| RPL11 | ribosomal protein L11 | -0.0610471 |
| AHSG | alpha-2-HS-glycoprotein | -0.0547147 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.054474 |
| RPL35A | ribosomal protein L35a | -0.052357 |
| ENO1 | enolase 1, (alpha) | -0.0491057 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0475369 |
| CPE | carboxypeptidase E | -0.0473855 |
| PLIN2 | perilipin 2 | -0.0447195 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0429423 |
| RPLP0 | ribosomal protein, large, P0 | -0.0393171 |
| GNAS | GNAS complex locus | -0.0371464 |
| VCL | vinculin | -0.0368674 |
| DSPP | dentin sialophosphoprotein | -0.0368297 |
| RPS24 | ribosomal protein S24 | -0.0362128 |
| FTL | ferritin, light polypeptide | -0.0354824 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0352131 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0346814 |
| PERP | PERP, TP53 apoptosis effector | -0.0339698 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0334936 |
| EGR1 | early growth response 1 | -0.0332845 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0332264 |
| HLA-A | major histocompatibility complex, class I, A | -0.0329837 |
| RPL34 | ribosomal protein L34 | -0.032805 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0327339 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0323736 |
| UBC | ubiquitin C | -0.031186 |
| NPR2 | natriuretic peptide receptor 2 | -0.0309938 |
| CP | ceruloplasmin (ferroxidase) | -0.0307711 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0307352 |
| APOE | apolipoprotein E | -0.0302255 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0295781 |
| LYZ | lysozyme | -0.0293562 |
| HMGA1 | high mobility group AT-hook 1 | -0.0292581 |
| RPS14 | ribosomal protein S14 | -0.029214 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0290476 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0272905 |
| RPLP1 | ribosomal protein, large, P1 | -0.0269263 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0263065 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0254963 |
| ASPH | aspartate beta-hydroxylase | -0.0254617 |
| RPS19 | ribosomal protein S19 | -0.0253383 |
| TMEM123 | transmembrane protein 123 | -0.0252674 |
| RPL23 | ribosomal protein L23 | -0.0252659 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.02491 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0248269 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0245775 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0245616 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0240805 |
| RPL9 | ribosomal protein L9 | -0.0237446 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0234001 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0232543 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0232004 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0231979 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0228983 |
| ATF4 | activating transcription factor 4 | -0.0226314 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0225619 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0220242 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0218739 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0212828 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0211685 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.021079 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0209057 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0206389 |
| RPL12 | ribosomal protein L12 | -0.0204299 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0202585 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0201398 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0198848 |
| RRBP1 | ribosome binding protein 1 | -0.0197222 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0195213 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.01928 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.0191713 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0191419 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0191295 |
| RPS6 | ribosomal protein S6 | -0.0191112 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0190748 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0189881 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0188269 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.018801 |
| CALR | calreticulin | -0.018724 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0185025 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0182648 |
| CTSB | cathepsin B | -0.0181575 |
| MCL1 | myeloid cell leukemia 1 | -0.0173488 |
| A2M | alpha-2-macroglobulin | -0.0172403 |
| CANX | calnexin | -0.0172126 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0171845 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0170436 |
| RPL37 | ribosomal protein L37 | -0.016986 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0169635 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0169525 |
| KIF21A | kinesin family member 21A | -0.016804 |
| KRT18 | keratin 18, type I | -0.0165129 |
