Hydroxyurea_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.0667438
FNDC3B fibronectin type III domain containing 3B 0.0610032
AKAP9 A kinase (PRKA) anchor protein 9 0.0599296
MBNL2 muscleblind-like splicing regulator 2 0.0489164
ZCCHC7 zinc finger, CCHC domain containing 7 0.0482017
GARS1 glycyl-tRNA synthetase 1 0.040544
ZFAND3 zinc finger, AN1-type domain 3 0.0396371
ZNF292 zinc finger protein 292 0.039596
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0388933
HM13 histocompatibility (minor) 13 0.0387856
COG5 component of oligomeric golgi complex 5 0.0383043
VEGFA vascular endothelial growth factor A 0.0379965
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0370466
SEC31A SEC31 homolog A (S. cerevisiae) 0.0336786
BIRC6 baculoviral IAP repeat containing 6 0.0333216
ARHGAP32 Rho GTPase activating protein 32 0.032605
IARS1 isoleucyl-tRNA synthetase 1 0.0309022
CDK13 cyclin-dependent kinase 13 0.0305156
ESRP1 epithelial splicing regulatory protein 1 0.0300258
ATXN1 ataxin 1 0.0299189
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0298028
HYOU1 hypoxia up-regulated 1 0.0292105
KMT2C lysine (K)-specific methyltransferase 2C 0.0288962
PGM3 phosphoglucomutase 3 0.0288585
FAM13A family with sequence similarity 13, member A 0.0278678
HMGA1 high mobility group AT-hook 1 0.0273885
ITCH itchy E3 ubiquitin protein ligase 0.0267285
KMT2E lysine (K)-specific methyltransferase 2E 0.0260477
SETD5 SET domain containing 5 0.0259006
MBNL1 muscleblind-like splicing regulator 1 0.0258778
SNX13 sorting nexin 13 0.0252561
TRAM1 translocation associated membrane protein 1 0.0249625
RAB6A RAB6A, member RAS oncogene family 0.0248831
SRP54 signal recognition particle 54kDa 0.0248061
SSR1 signal sequence receptor, alpha 0.0245228
VMP1 vacuole membrane protein 1 0.024184
NBAS neuroblastoma amplified sequence 0.0241712
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0238964
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0238508
TRIM2 tripartite motif containing 2 0.0234071
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0232757
KLHL29 kelch-like family member 29 0.0225308
MON2 MON2 homolog (S. cerevisiae) 0.0225068
KDM2A lysine (K)-specific demethylase 2A 0.0224093
HELZ helicase with zinc finger 0.0223665
PTEN phosphatase and tensin homolog 0.0223491
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0222491
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0221963
ARCN1 archain 1 0.0214895
AVL9 AVL9 homolog (S. cerevisiase) 0.0214777
EXT1 exostosin glycosyltransferase 1 0.0213457
SERP1 stress-associated endoplasmic reticulum protein 1 0.0211002
PICALM phosphatidylinositol binding clathrin assembly protein 0.021082
NFE2L1 nuclear factor, erythroid 2-like 1 0.0206972
CALU calumenin 0.0201129
AKAP13 A kinase (PRKA) anchor protein 13 0.0199907
MKRN1 makorin ring finger protein 1 0.0198109
PNPLA8 patatin-like phospholipase domain containing 8 0.0194775
DSCAM Down syndrome cell adhesion molecule 0.0193872
MORF4L2 mortality factor 4 like 2 0.0193354
ESYT2 extended synaptotagmin-like protein 2 0.0193099
ANKRD17 ankyrin repeat domain 17 0.0191814
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0191586
SND1 staphylococcal nuclease and tudor domain containing 1 0.0190963
FNDC3A fibronectin type III domain containing 3A 0.0189119
CDK19 cyclin-dependent kinase 19 0.0188342
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0186567
RNF145 ring finger protein 145 0.0186228
SEC24D SEC24 family member D 0.0185738
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0185024
LPP LIM domain containing preferred translocation partner in lipoma 0.0184442
TTC3 tetratricopeptide repeat domain 3 0.0184355
PIBF1 progesterone immunomodulatory binding factor 1 0.0184099
EPB41 erythrocyte membrane protein band 4.1 0.0183636
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0182045
TMF1 TATA element modulatory factor 1 0.0180081
NDRG1 N-myc downstream regulated 1 0.0179326
RBM39 RNA binding motif protein 39 0.017821
SPAG9 sperm associated antigen 9 0.017775
SAMD12 sterile alpha motif domain containing 12 0.0176249
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0174429
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0174348
ERRFI1 ERBB receptor feedback inhibitor 1 0.0173959
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0173733
AHR aryl hydrocarbon receptor 0.0170625
RSBN1L round spermatid basic protein 1-like 0.0170155
KDM6A lysine (K)-specific demethylase 6A 0.0169464
UBE4A ubiquitination factor E4A 0.0169067
USP9X ubiquitin specific peptidase 9, X-linked 0.0167975
FAM135A family with sequence similarity 135, member A 0.0166967
ALPK1 alpha-kinase 1 0.016587
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0165436
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0165027
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0164175
TXNRD1 thioredoxin reductase 1 0.0163598
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0163208
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0163144
N4BP2L2 NEDD4 binding protein 2-like 2 0.0161264
SCFD1 sec1 family domain containing 1 0.0160726
UBA6 ubiquitin-like modifier activating enzyme 6 0.015994

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.188871
TPT1 tumor protein, translationally-controlled 1 -0.0900467
RPL35A ribosomal protein L35a -0.0897401
PTMA prothymosin, alpha -0.0858313
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0722566
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.067244
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0623991
RPS19 ribosomal protein S19 -0.05974
EMP1 epithelial membrane protein 1 -0.0573446
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0559499
EZR ezrin -0.0506272
KRT18 keratin 18, type I -0.0498183
EPCAM epithelial cell adhesion molecule -0.0483925
IFI27 interferon, alpha-inducible protein 27 -0.0483738
LOC102724023 ES1 protein homolog, mitochondrial -0.0454711
IFI6 interferon, alpha-inducible protein 6 -0.0452546
ASPH aspartate beta-hydroxylase -0.0449682
RPL23 ribosomal protein L23 -0.0441621
S100A10 S100 calcium binding protein A10 -0.042653
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0419772
ACTG1 actin gamma 1 -0.0409518
RPLP1 ribosomal protein, large, P1 -0.0409072
LMO7 LIM domain 7 -0.0398579
B2M beta-2-microglobulin -0.0382536
TM4SF1 transmembrane 4 L six family member 1 -0.0376283
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0374806
LOC112694756 uncharaterized LOC112694756 -0.0365712
POTEF POTE ankyrin domain family, member F -0.0359368
GMDS GDP-mannose 4,6-dehydratase -0.035068
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0347842
LCN2 lipocalin 2 -0.0342758
ATF5 activating transcription factor 5 -0.0333627
S100A9 S100 calcium binding protein A9 -0.0332174
RPS21 ribosomal protein S21 -0.0324693
S100A6 S100 calcium binding protein A6 -0.0318384
RPS24 ribosomal protein S24 -0.0303126
HLA-C major histocompatibility complex, class I, C -0.0301646
ACTN4 actinin, alpha 4 -0.0299437
KRT8 keratin 8, type II -0.0294836
RPL34 ribosomal protein L34 -0.0281529
LAMA4 laminin, alpha 4 -0.0280985
IFITM3 interferon induced transmembrane protein 3 -0.0280494
SEC61G Sec61 gamma subunit -0.0272187
HLA-E major histocompatibility complex, class I, E -0.0271806
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.027159
TMSB4X thymosin beta 4, X-linked -0.0270672
HLA-A major histocompatibility complex, class I, A -0.0270184
PGK1 phosphoglycerate kinase 1 -0.026968
KPNB1 karyopherin (importin) beta 1 -0.0265204
UBB ubiquitin B -0.0264272
ITGA6 integrin, alpha 6 -0.0262862
HMGB1 high mobility group box 1 -0.0261418
S100A11 S100 calcium binding protein A11 -0.0259893
LMNA lamin A/C -0.0257469
AGR2 anterior gradient 2 -0.0252403
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0252095
IER3 immediate early response 3 -0.0245582
EGR1 early growth response 1 -0.0244457
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0242224
MYL12B myosin, light chain 12B, regulatory -0.0240303
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0238668
H1-0 H1.0 linker histone -0.0236996
RPL38 ribosomal protein L38 -0.0236873
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0235153
FTL ferritin, light polypeptide -0.0231844
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0231776
DEK DEK proto-oncogene -0.0227245
AHNAK AHNAK nucleoprotein -0.02264
TUBB4B tubulin, beta 4B class IVb -0.0223119
SOX4 SRY (sex determining region Y)-box 4 -0.0218773
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0216112
RPL12 ribosomal protein L12 -0.0212164
MYO1E myosin IE -0.0211118
RRBP1 ribosome binding protein 1 -0.0210794
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0209468
CALR calreticulin -0.0206924
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0205259
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0203406
H3-3B H3.3 histone B -0.0203003
NDUFA4 NDUFA4, mitochondrial complex associated -0.0202316
AREG amphiregulin -0.0197788
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0196432
PKM pyruvate kinase, muscle -0.0193153
HLA-B major histocompatibility complex, class I, B -0.0186002
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0185748
MT2A metallothionein 2A -0.0184021
RPL11 ribosomal protein L11 -0.0180572
RRM2 ribonucleotide reductase M2 -0.0178854
COTL1 coactosin-like F-actin binding protein 1 -0.0178337
CCND1 cyclin D1 -0.0178268
KLF6 Kruppel-like factor 6 -0.0176342
TUBA1B tubulin, alpha 1b -0.0173413
KRT7 keratin 7, type II -0.0171246
RPS14 ribosomal protein S14 -0.0170467
GNAS GNAS complex locus -0.0169193
SP100 SP100 nuclear antigen -0.016651
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.01659
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0165467
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0163919
EDN1 endothelin 1 -0.0163784