Hydroxyurea_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.0627264
RPS8 ribosomal protein S8 0.0581978
DLG1 discs, large homolog 1 (Drosophila) 0.0564758
RPL35A ribosomal protein L35a 0.0512819
RAB7A RAB7A, member RAS oncogene family 0.0427562
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0421322
ERRFI1 ERBB receptor feedback inhibitor 1 0.040463
RPL5 ribosomal protein L5 0.0394062
HMGA1 high mobility group AT-hook 1 0.0390598
EFNA5 ephrin-A5 0.0381658
RPL12 ribosomal protein L12 0.0378197
PTMA prothymosin, alpha 0.0373502
ZNF292 zinc finger protein 292 0.037022
WSB1 WD repeat and SOCS box containing 1 0.0366675
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0358667
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0357308
FTL ferritin, light polypeptide 0.0340444
RPL37A ribosomal protein L37a 0.0309325
RPL31 ribosomal protein L31 0.0296613
RPL11 ribosomal protein L11 0.0290287
RPL36 ribosomal protein L36 0.0287515
RPL26 ribosomal protein L26 0.0286002
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0284534
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0283614
ESYT2 extended synaptotagmin-like protein 2 0.0280253
FNIP1 folliculin interacting protein 1 0.0266927
BIRC6 baculoviral IAP repeat containing 6 0.0261246
SPAG9 sperm associated antigen 9 0.0260554
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0259733
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0258167
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0252318
SETD5 SET domain containing 5 0.0248591
GOLGA4 golgin A4 0.0246223
RPS23 ribosomal protein S23 0.024287
RPS29 ribosomal protein S29 0.0240989
RPL38 ribosomal protein L38 0.023883
RPL13A ribosomal protein L13a 0.0235003
NAMPT nicotinamide phosphoribosyltransferase 0.0229577
RNF145 ring finger protein 145 0.0228366
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0226943
RPS25 ribosomal protein S25 0.0226207
TMSB4X thymosin beta 4, X-linked 0.0224381
YEATS2 YEATS domain containing 2 0.0218802
RPL27 ribosomal protein L27 0.0209694
RPL7A ribosomal protein L7a 0.0209539
MBNL2 muscleblind-like splicing regulator 2 0.0205627
RPS12 ribosomal protein S12 0.0205574
RPL36A ribosomal protein L36a 0.0205548
ANKRD17 ankyrin repeat domain 17 0.0201364
CENPF centromere protein F, 350/400kDa 0.0199868
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0199296
RPS10 ribosomal protein S10 0.0198755
RPL37 ribosomal protein L37 0.0198505
SBF2 SET binding factor 2 0.0196612
RPS13 ribosomal protein S13 0.0196199
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0195348
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0194999
RPL35 ribosomal protein L35 0.0193418
RPLP1 ribosomal protein, large, P1 0.0193053
RACK1 receptor for activated C kinase 1 0.0192995
PNISR PNN-interacting serine/arginine-rich protein 0.0192469
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0192187
QKI QKI, KH domain containing, RNA binding 0.0188451
RPS24 ribosomal protein S24 0.0187243
RPL34 ribosomal protein L34 0.0185095
KPNB1 karyopherin (importin) beta 1 0.0184998
MORF4L2 mortality factor 4 like 2 0.018423
TRIO trio Rho guanine nucleotide exchange factor 0.0184125
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0183544
MINDY2 MINDY lysine 48 deubiquitinase 2 0.018332
ANKRD12 ankyrin repeat domain 12 0.0182127
RPS27 ribosomal protein S27 0.0181801
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0181571
EHBP1 EH domain binding protein 1 0.01797
NUP58 nucleoporin 58 0.0179264
TNPO3 transportin 3 0.0179182
RAB6A RAB6A, member RAS oncogene family 0.0177573
RPLP2 ribosomal protein, large, P2 0.0177487
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.017531
PUM2 pumilio RNA-binding family member 2 0.0175201
RPLP0 ribosomal protein, large, P0 0.0174828
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0169411
EIF1 eukaryotic translation initiation factor 1 0.0165142
WAC WW domain containing adaptor with coiled-coil 0.0164786
AKAP9 A kinase (PRKA) anchor protein 9 0.0164027
EIF5B eukaryotic translation initiation factor 5B 0.0163791
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0163772
SPIRE1 spire-type actin nucleation factor 1 0.0161287
EPHA4 EPH receptor A4 0.016112
GARS1 glycyl-tRNA synthetase 1 0.0159907
RPL19 ribosomal protein L19 0.0159264
CDK19 cyclin-dependent kinase 19 0.0159264
PIAS2 protein inhibitor of activated STAT, 2 0.0156769
MEF2A myocyte enhancer factor 2A 0.0155312
RPS21 ribosomal protein S21 0.0155197
RLF rearranged L-myc fusion 0.0154738
RPS16 ribosomal protein S16 0.0154417
S100A9 S100 calcium binding protein A9 0.0154184
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0153988
RPS19 ribosomal protein S19 0.0153889

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.152474
VIM vimentin -0.146187
AHNAK AHNAK nucleoprotein -0.121674
TM4SF1 transmembrane 4 L six family member 1 -0.113259
EEF2 eukaryotic translation elongation factor 2 -0.109238
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.101162
TMSB10 thymosin beta 10 -0.0944302
JUN jun proto-oncogene -0.0874327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0816959
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0815541
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0733082
PSD3 pleckstrin and Sec7 domain containing 3 -0.0709169
MT1X metallothionein 1X -0.0631484
LOC112694756 uncharaterized LOC112694756 -0.0583595
ENO1 enolase 1, (alpha) -0.0569064
CANX calnexin -0.0544969
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0535355
TP63 tumor protein p63 -0.0524651
POTEF POTE ankyrin domain family, member F -0.0520139
RPS27A ribosomal protein S27a -0.0516252
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0488263
BIRC3 baculoviral IAP repeat containing 3 -0.0484981
EMP1 epithelial membrane protein 1 -0.0443489
MT2A metallothionein 2A -0.0439102
MYH9 myosin, heavy chain 9, non-muscle -0.0423567
EIF4A1 eukaryotic translation initiation factor 4A1 -0.039827
SRRM2 serine/arginine repetitive matrix 2 -0.0396444
CMIP c-Maf inducing protein -0.0393659
MACF1 microtubule-actin crosslinking factor 1 -0.0388633
APP amyloid beta (A4) precursor protein -0.0382514
DST dystonin -0.0381404
LDHA lactate dehydrogenase A -0.0377548
PDIA4 protein disulfide isomerase family A, member 4 -0.0367435
BCAR3 breast cancer anti-estrogen resistance 3 -0.0365879
CD44 CD44 molecule (Indian blood group) -0.0365307
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0358245
MCL1 myeloid cell leukemia 1 -0.0346725
SDC4 syndecan 4 -0.0338286
PCBP2 poly(rC) binding protein 2 -0.0325578
WWTR1 WW domain containing transcription regulator 1 -0.0311742
CAPRIN2 caprin family member 2 -0.0309292
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.03015
SET SET nuclear proto-oncogene -0.0296118
SFPQ splicing factor proline/glutamine-rich -0.0292451
EZR ezrin -0.0291479
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0287657
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0280585
CFLAR CASP8 and FADD-like apoptosis regulator -0.0279914
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0277957
ARHGAP5 Rho GTPase activating protein 5 -0.0276953
SOD2 superoxide dismutase 2, mitochondrial -0.0275144
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0274298
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0268309
NT5E 5'-nucleotidase, ecto (CD73) -0.0266778
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0261404
KTN1 kinectin 1 (kinesin receptor) -0.0260077
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0256759
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0254932
TGM2 transglutaminase 2 -0.0252591
CALR calreticulin -0.0250701
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0249722
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0248295
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0242698
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0238746
ZBTB38 zinc finger and BTB domain containing 38 -0.0237633
NPAS2 neuronal PAS domain protein 2 -0.0235973
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.02354
RPL3 ribosomal protein L3 -0.0235178
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0231175
SETX senataxin -0.0228782
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0228257
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -0.0226159
TPM3 tropomyosin 3 -0.0225015
RNF213 ring finger protein 213 -0.0224857
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0223989
RIGI RNA sensor RIG-I -0.0223912
TXNRD1 thioredoxin reductase 1 -0.0223573
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0221851
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0217661
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0217052
VMP1 vacuole membrane protein 1 -0.0215185
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0214899
ZMYND8 zinc finger, MYND-type containing 8 -0.0208392
TRIP12 thyroid hormone receptor interactor 12 -0.0208311
PKM pyruvate kinase, muscle -0.020341
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0199099
BICD1 bicaudal D homolog 1 (Drosophila) -0.0198695
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0195961
DIAPH1 diaphanous-related formin 1 -0.0195646
PLSCR1 phospholipid scramblase 1 -0.0195269
BRD2 bromodomain containing 2 -0.0193077
HDLBP high density lipoprotein binding protein -0.018878
SP100 SP100 nuclear antigen -0.0185002
DSCAM Down syndrome cell adhesion molecule -0.0183197
MLPH melanophilin -0.0181676
S100A6 S100 calcium binding protein A6 -0.0181043
WDR27 WD repeat domain 27 -0.0180883
H1-0 H1.0 linker histone -0.0180652
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0177831
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0172858