Hydroxyurea_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0733006
RUNX1 runt-related transcription factor 1 0.0408297
ELL2 elongation factor, RNA polymerase II, 2 0.0375683
SPAG9 sperm associated antigen 9 0.0365683
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.029574
ATP13A3 ATPase type 13A3 0.0272683
SLTM SAFB-like, transcription modulator 0.0262655
TBC1D22A TBC1 domain family, member 22A 0.0261805
AGO2 argonaute RISC catalytic component 2 0.0258875
RICTOR RPTOR independent companion of MTOR, complex 2 0.0254071
DTNA dystrobrevin, alpha 0.0241314
RAP1B RAP1B, member of RAS oncogene family 0.0238221
GSK3B glycogen synthase kinase 3 beta 0.0235409
ANKRD10 ankyrin repeat domain 10 0.0233328
ARRDC3 arrestin domain containing 3 0.022664
GLS2 glutaminase 2 (liver, mitochondrial) 0.0226213
FAM13A family with sequence similarity 13, member A 0.0221124
TSC22D2 TSC22 domain family, member 2 0.0217654
NGLY1 N-glycanase 1 0.0217157
CES1 carboxylesterase 1 0.021339
SMAD3 SMAD family member 3 0.0209675
LRP1B low density lipoprotein receptor-related protein 1B 0.0206676
PUM2 pumilio RNA-binding family member 2 0.020285
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0201504
ZNF292 zinc finger protein 292 0.0200018
ZFAND6 zinc finger, AN1-type domain 6 0.0198352
KCMF1 potassium channel modulatory factor 1 0.0197069
UVRAG UV radiation resistance associated 0.0195466
TOP1 topoisomerase (DNA) I 0.0193159
UBA6 ubiquitin-like modifier activating enzyme 6 0.0191972
KDM6A lysine (K)-specific demethylase 6A 0.0191963
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0188635
USP9X ubiquitin specific peptidase 9, X-linked 0.0186119
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.018595
HELZ helicase with zinc finger 0.0183682
SOD2 superoxide dismutase 2, mitochondrial 0.0178349
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0170272
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0164761
BRWD3 bromodomain and WD repeat domain containing 3 0.0163985
RASA2 RAS p21 protein activator 2 0.0160442
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0159815
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0155723
CSNK1A1 casein kinase 1, alpha 1 0.0155423
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0155231
ANXA5 annexin A5 0.0153415
JMJD1C jumonji domain containing 1C 0.0152971
NCKAP1 NCK-associated protein 1 0.0152501
NUP58 nucleoporin 58 0.0151482
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0151168
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0148529
RNF145 ring finger protein 145 0.0146882
CEMIP cell migration inducing protein, hyaluronan binding 0.0145168
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0144921
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0144236
RNMT RNA (guanine-7-) methyltransferase 0.0143745
CAMTA1 calmodulin binding transcription activator 1 0.0143377
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0141604
KMT2E lysine (K)-specific methyltransferase 2E 0.0139351
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0139153
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0139144
HOOK2 hook microtubule-tethering protein 2 0.013895
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0137855
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0137735
FNDC3B fibronectin type III domain containing 3B 0.0136734
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0136729
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0134189
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0134052
GRAMD1B GRAM domain containing 1B 0.0134017
ADAM17 ADAM metallopeptidase domain 17 0.0133305
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.01333
CDC73 cell division cycle 73 0.0132844
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0126225
CYLD cylindromatosis (turban tumor syndrome) 0.0125999
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0125936
OGA O-GlcNAcase 0.0125707
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0125375
TMEM165 transmembrane protein 165 0.0125261
GPATCH2L G patch domain containing 2-like 0.0125164
GPC6 glypican 6 0.0124717
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0123786
EP300 E1A binding protein p300 0.012327
ARL8B ADP-ribosylation factor-like 8B 0.012303
KIAA1217 KIAA1217 0.0122557
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0121782
FNIP1 folliculin interacting protein 1 0.0121748
STRN3 striatin, calmodulin binding protein 3 0.0121504
SLC35F5 solute carrier family 35, member F5 0.0120653
NPTN neuroplastin 0.0119952
TFG TRK-fused gene 0.011913
MARK3 MAP/microtubule affinity-regulating kinase 3 0.011683
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0116626
MED13L mediator complex subunit 13-like 0.011519
WDR26 WD repeat domain 26 0.0114218
PDE8A phosphodiesterase 8A 0.0113624
RNF24 ring finger protein 24 0.0112773
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0112615
USP34 ubiquitin specific peptidase 34 0.0110809
KDM7A lysine (K)-specific demethylase 7A 0.0109921
MAP7 microtubule-associated protein 7 0.0109297
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.010744

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165122
TMSB10 thymosin beta 10 -0.125971
ACTG1 actin gamma 1 -0.0588033
CAV1 caveolin 1, caveolae protein, 22kDa -0.0587719
PKM pyruvate kinase, muscle -0.0552883
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0523435
EGR1 early growth response 1 -0.0509834
ASPH aspartate beta-hydroxylase -0.0501156
S100A10 S100 calcium binding protein A10 -0.047276
LMO7 LIM domain 7 -0.0454554
LDHA lactate dehydrogenase A -0.0452844
PTMA prothymosin, alpha -0.0437078
TPT1 tumor protein, translationally-controlled 1 -0.041089
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0410481
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0391603
MT2A metallothionein 2A -0.0390759
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0383053
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0377415
FTL ferritin, light polypeptide -0.0373673
CST3 cystatin C -0.0336494
KRT7 keratin 7, type II -0.0322606
FTH1 ferritin, heavy polypeptide 1 -0.0300231
NDRG1 N-myc downstream regulated 1 -0.0285977
KRT18 keratin 18, type I -0.028282
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0280094
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0272373
SCEL sciellin -0.02713
RPL35A ribosomal protein L35a -0.0262243
SLC38A2 solute carrier family 38, member 2 -0.0261546
RPS3 ribosomal protein S3 -0.0259989
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0258688
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0250224
S100A6 S100 calcium binding protein A6 -0.0243446
EIF1 eukaryotic translation initiation factor 1 -0.0230095
POTEF POTE ankyrin domain family, member F -0.0225333
CAV2 caveolin 2 -0.0215214
LOC112694756 uncharaterized LOC112694756 -0.0198983
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0197054
GOLGB1 golgin B1 -0.0193912
IFI6 interferon, alpha-inducible protein 6 -0.0192676
B2M beta-2-microglobulin -0.0192151
HDLBP high density lipoprotein binding protein -0.0191228
S100P S100 calcium binding protein P -0.0191203
SEC61G Sec61 gamma subunit -0.0189739
ENO1 enolase 1, (alpha) -0.0188732
IGFBP3 insulin-like growth factor binding protein 3 -0.0186315
S100A11 S100 calcium binding protein A11 -0.018439
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0182899
CANX calnexin -0.0182158
PATJ PATJ crumbs cell polarity complex component -0.0181696
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0181273
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0180525
EGFR epidermal growth factor receptor -0.0179799
CCND1 cyclin D1 -0.0178789
AREG amphiregulin -0.0176944
PERP PERP, TP53 apoptosis effector -0.0171759
KRT8 keratin 8, type II -0.0170533
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0170363
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0167821
GNAS GNAS complex locus -0.0165987
MAML3 mastermind-like 3 (Drosophila) -0.0164
CPE carboxypeptidase E -0.0163063
INTS6 integrator complex subunit 6 -0.0162489
TPM4 tropomyosin 4 -0.0162362
CUX1 cut-like homeobox 1 -0.0161595
IGFBP5 insulin-like growth factor binding protein 5 -0.016039
WASF2 WAS protein family, member 2 -0.0158637
AGR2 anterior gradient 2 -0.0158362
DSPP dentin sialophosphoprotein -0.0157744
HLA-B major histocompatibility complex, class I, B -0.0157602
ZMYND8 zinc finger, MYND-type containing 8 -0.0157038
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0156205
S100A9 S100 calcium binding protein A9 -0.0153243
HMGA1 high mobility group AT-hook 1 -0.0151685
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0151552
ATF4 activating transcription factor 4 -0.0150781
SRRM2 serine/arginine repetitive matrix 2 -0.0149921
ANXA1 annexin A1 -0.014798
PFN1 profilin 1 -0.0147066
MCL1 myeloid cell leukemia 1 -0.0146314
LOC102724023 ES1 protein homolog, mitochondrial -0.0145168
EMP1 epithelial membrane protein 1 -0.0145147
STC1 stanniocalcin 1 -0.014483
RPS6 ribosomal protein S6 -0.0143181
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0142947
KRT19 keratin 19, type I -0.0142335
RPS8 ribosomal protein S8 -0.014155
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0139922
RPS25 ribosomal protein S25 -0.0139604
RPLP1 ribosomal protein, large, P1 -0.0139322
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.013816
THSD4 thrombospondin, type I, domain containing 4 -0.0137223
SERF2 small EDRK-rich factor 2 -0.013707
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0136399
MT1X metallothionein 1X -0.0135993
AHNAK AHNAK nucleoprotein -0.0135788
UBC ubiquitin C -0.0133161
PDIA3 protein disulfide isomerase family A, member 3 -0.013308
ANXA2 annexin A2 -0.0132388
RPL19 ribosomal protein L19 -0.0132363