Hydroxyurea_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Hydroxyurea perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Hydroxyurea_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.158733
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0794914
ELL2 elongation factor, RNA polymerase II, 2 0.0684476
RICTOR RPTOR independent companion of MTOR, complex 2 0.0601691
RBM39 RNA binding motif protein 39 0.0501185
ATP13A3 ATPase type 13A3 0.0492939
KDM3A lysine (K)-specific demethylase 3A 0.0437095
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0418547
OGA O-GlcNAcase 0.0407292
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0400172
FAM13A family with sequence similarity 13, member A 0.0393384
FNDC3B fibronectin type III domain containing 3B 0.0374676
SPAG9 sperm associated antigen 9 0.0344072
GOLGA4 golgin A4 0.0336177
USP3 ubiquitin specific peptidase 3 0.033379
UBA6 ubiquitin-like modifier activating enzyme 6 0.032675
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0326307
ZEB2 zinc finger E-box binding homeobox 2 0.0316912
WAC WW domain containing adaptor with coiled-coil 0.0302656
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0294757
RAP1B RAP1B, member of RAS oncogene family 0.0288819
PELI1 pellino E3 ubiquitin protein ligase 1 0.0286065
ZNF292 zinc finger protein 292 0.0284512
SIK3 SIK family kinase 3 0.0279297
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0274678
NPC1 Niemann-Pick disease, type C1 0.0263258
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0259012
KMT2C lysine (K)-specific methyltransferase 2C 0.0258814
MARCHF6 membrane associated ring-CH-type finger 6 0.0257834
STRN3 striatin, calmodulin binding protein 3 0.0257533
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0249294
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0245679
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0242462
BASP1 brain abundant, membrane attached signal protein 1 0.0240824
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0240311
ZFAND3 zinc finger, AN1-type domain 3 0.0239269
SPRED2 sprouty-related, EVH1 domain containing 2 0.023579
NPEPPS aminopeptidase puromycin sensitive 0.0235564
WSB1 WD repeat and SOCS box containing 1 0.023387
RUNX1 runt-related transcription factor 1 0.0229864
RAB8B RAB8B, member RAS oncogene family 0.0224005
CTNND1 catenin (cadherin-associated protein), delta 1 0.0223362
SMAD3 SMAD family member 3 0.0217348
KDM2A lysine (K)-specific demethylase 2A 0.0216717
AHR aryl hydrocarbon receptor 0.0215947
ABI1 abl-interactor 1 0.0211919
CD44 CD44 molecule (Indian blood group) 0.0211443
AGFG1 ArfGAP with FG repeats 1 0.0211078
JMJD1C jumonji domain containing 1C 0.0210745
ITCH itchy E3 ubiquitin protein ligase 0.021017
COG5 component of oligomeric golgi complex 5 0.0203999
HELZ helicase with zinc finger 0.0203688
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0199544
NGLY1 N-glycanase 1 0.0199483
UBE2H ubiquitin-conjugating enzyme E2H 0.0198644
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0196013
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0194362
RAB27B RAB27B, member RAS oncogene family 0.0193149
ARHGAP5 Rho GTPase activating protein 5 0.0192201
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0192042
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0191369
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0191271
CDC73 cell division cycle 73 0.0190333
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0188497
HAS2 hyaluronan synthase 2 0.0186916
RNF145 ring finger protein 145 0.0186753
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0186435
RLF rearranged L-myc fusion 0.0185926
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0184074
UGCG UDP-glucose ceramide glucosyltransferase 0.0181275
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0178821
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0178681
LCORL ligand dependent nuclear receptor corepressor-like 0.0176312
ADD3 adducin 3 (gamma) 0.0175343
PTBP2 polypyrimidine tract binding protein 2 0.0174762
EPS8 epidermal growth factor receptor pathway substrate 8 0.0174632
EREG epiregulin 0.0174062
NEK7 NIMA-related kinase 7 0.0173266
RUNX2 runt-related transcription factor 2 0.0172674
NIPBL Nipped-B homolog (Drosophila) 0.0172609
ZEB1 zinc finger E-box binding homeobox 1 0.0171815
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0171642
PHIP pleckstrin homology domain interacting protein 0.0171217
PARD3 par-3 family cell polarity regulator 0.0169939
ZFAND6 zinc finger, AN1-type domain 6 0.016965
XPO1 exportin 1 0.0169509
FLNB filamin B, beta 0.0168318
SETD5 SET domain containing 5 0.016687
TRIO trio Rho guanine nucleotide exchange factor 0.016411
MIS18BP1 MIS18 binding protein 1 0.0163586
PUM2 pumilio RNA-binding family member 2 0.0163465
CHD1 chromodomain helicase DNA binding protein 1 0.0163325
RARB retinoic acid receptor, beta 0.0163307
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0162021
DOCK5 dedicator of cytokinesis 5 0.0158594
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0157268
ARRDC3 arrestin domain containing 3 0.0156714
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0156306
FOXJ3 forkhead box J3 0.0156037
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0154782

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.119783
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.11764
FN1 fibronectin 1 -0.0912768
IGFBP3 insulin-like growth factor binding protein 3 -0.0709258
CDH13 cadherin 13 -0.0609172
LOX lysyl oxidase -0.0581156
AKAP12 A kinase (PRKA) anchor protein 12 -0.051737
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0507281
TMSB10 thymosin beta 10 -0.0497223
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0413519
FTH1 ferritin, heavy polypeptide 1 -0.0389478
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0380989
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0360782
DPYD dihydropyrimidine dehydrogenase -0.0357415
HMGA2 high mobility group AT-hook 2 -0.0356388
DST dystonin -0.034695
EGR1 early growth response 1 -0.0343737
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0343509
PKM pyruvate kinase, muscle -0.0331338
RPLP1 ribosomal protein, large, P1 -0.032787
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0320324
NRG1 neuregulin 1 -0.0287645
MAML3 mastermind-like 3 (Drosophila) -0.0285044
FTL ferritin, light polypeptide -0.028253
AADAC arylacetamide deacetylase -0.0280569
RPS8 ribosomal protein S8 -0.0264511
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0262651
PSD3 pleckstrin and Sec7 domain containing 3 -0.0262078
RPS6 ribosomal protein S6 -0.0260105
RPS19 ribosomal protein S19 -0.0258899
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253659
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0248409
FBN1 fibrillin 1 -0.0245687
POTEF POTE ankyrin domain family, member F -0.0240623
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0233195
LDHA lactate dehydrogenase A -0.023304
MSRB3 methionine sulfoxide reductase B3 -0.0226517
STC1 stanniocalcin 1 -0.0222485
SYT1 synaptotagmin I -0.0221354
RPL31 ribosomal protein L31 -0.0221317
RPL35A ribosomal protein L35a -0.0220244
TGFB1 transforming growth factor, beta 1 -0.0216632
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0215226
PDE4D phosphodiesterase 4D, cAMP-specific -0.0212923
LRMDA leucine rich melanocyte differentiation associated -0.0212272
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0202736
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0198861
DDIT3 DNA-damage-inducible transcript 3 -0.0196605
RAD51B RAD51 paralog B -0.0195256
SUMF1 sulfatase modifying factor 1 -0.0194727
CA12 carbonic anhydrase XII -0.0194545
NCOR2 nuclear receptor corepressor 2 -0.0191985
LOC112694756 uncharaterized LOC112694756 -0.0189459
KTN1 kinectin 1 (kinesin receptor) -0.0187949
MTSS1 metastasis suppressor 1 -0.0187823
GREB1L growth regulation by estrogen in breast cancer-like -0.0187566
EEF2 eukaryotic translation elongation factor 2 -0.0186836
MCL1 myeloid cell leukemia 1 -0.0185921
OXR1 oxidation resistance 1 -0.0185135
RNF213 ring finger protein 213 -0.0183238
MAP1B microtubule-associated protein 1B -0.0182823
S100A6 S100 calcium binding protein A6 -0.0182533
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0180543
RPS29 ribosomal protein S29 -0.0180035
EHBP1 EH domain binding protein 1 -0.0177617
PTPRB protein tyrosine phosphatase, receptor type, B -0.0175999
RPL37 ribosomal protein L37 -0.0175206
LOC102724023 ES1 protein homolog, mitochondrial -0.0174607
EIF1 eukaryotic translation initiation factor 1 -0.0174174
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0173491
INTS6 integrator complex subunit 6 -0.0173019
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0172296
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0171224
GOLGB1 golgin B1 -0.0170222
RPL28 ribosomal protein L28 -0.0170205
RPS12 ribosomal protein S12 -0.0169657
IFI6 interferon, alpha-inducible protein 6 -0.0167877
NDRG1 N-myc downstream regulated 1 -0.0167472
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0166907
ASPH aspartate beta-hydroxylase -0.0165934
RPL32 ribosomal protein L32 -0.0163884
RASAL2 RAS protein activator like 2 -0.0163318
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0162563
PRH1 proline-rich protein HaeIII subfamily 1 -0.0162486
FAM20C family with sequence similarity 20, member C -0.016231
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0161887
RPL34 ribosomal protein L34 -0.0161307
PLIN2 perilipin 2 -0.0158987
RAI14 retinoic acid induced 14 -0.0157644
RPL36 ribosomal protein L36 -0.0156545
EFCAB13 EF-hand calcium binding domain 13 -0.0156375
SOS1 son of sevenless homolog 1 (Drosophila) -0.0156252
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0155819
CANX calnexin -0.0155613
B2M beta-2-microglobulin -0.0155227
ENO1 enolase 1, (alpha) -0.0154668
PRKCA protein kinase C, alpha -0.0154596
SEPTIN9 septin 9 -0.0154061
RPL37A ribosomal protein L37a -0.0153602
WLS wntless Wnt ligand secretion mediator -0.0152871