| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Hydroxyurea_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.0939248 |
| GRAMD1B | GRAM domain containing 1B | 0.0800972 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0555151 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0431992 |
| TXNRD1 | thioredoxin reductase 1 | 0.0361035 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0336526 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.033607 |
| WWOX | WW domain containing oxidoreductase | 0.0330504 |
| NUP58 | nucleoporin 58 | 0.0321164 |
| RPS12 | ribosomal protein S12 | 0.0292132 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0275174 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0273365 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0267818 |
| VMP1 | vacuole membrane protein 1 | 0.026397 |
| RTN4 | reticulon 4 | 0.0262881 |
| MKI67 | marker of proliferation Ki-67 | 0.0249092 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0249053 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0248944 |
| MIS18BP1 | MIS18 binding protein 1 | 0.024471 |
| HMGA1 | high mobility group AT-hook 1 | 0.0241565 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0237828 |
| CENPF | centromere protein F, 350/400kDa | 0.0236933 |
| ANXA5 | annexin A5 | 0.023693 |
| TPM3 | tropomyosin 3 | 0.0236535 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0232647 |
| IGF2 | insulin-like growth factor 2 | 0.0223163 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0219829 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0213023 |
| WDR43 | WD repeat domain 43 | 0.0211443 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0202363 |
| SP3 | Sp3 transcription factor | 0.0201503 |
| RPL5 | ribosomal protein L5 | 0.0200483 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0192788 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.019249 |
| KIF23 | kinesin family member 23 | 0.0191466 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0188727 |
| HDGF | hepatoma-derived growth factor | 0.018818 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0184446 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0183043 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0182435 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0181818 |
| XPO1 | exportin 1 | 0.0180236 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0169169 |
| ANKRD28 | ankyrin repeat domain 28 | 0.016616 |
| BMP6 | bone morphogenetic protein 6 | 0.0165836 |
| PFN1 | profilin 1 | 0.0163996 |
| NCKAP1 | NCK-associated protein 1 | 0.0163975 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0163694 |
| RNF145 | ring finger protein 145 | 0.0162953 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0162944 |
| CCNL1 | cyclin L1 | 0.0161492 |
| MSN | moesin | 0.0161245 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.016069 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0160164 |
| RPL13A | ribosomal protein L13a | 0.015802 |
| TBK1 | TANK-binding kinase 1 | 0.0154089 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0151051 |
| TPX2 | TPX2, microtubule-associated | 0.0150777 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0150292 |
| AREG | amphiregulin | 0.0149352 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0146178 |
| PHIP | pleckstrin homology domain interacting protein | 0.0144377 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.014399 |
| CHN1 | chimerin 1 | 0.0142533 |
| PCBP2 | poly(rC) binding protein 2 | 0.0141691 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | 0.0139527 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.013817 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0138031 |
| ZNF277 | zinc finger protein 277 | 0.0137993 |
| TNPO3 | transportin 3 | 0.0137702 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0136329 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0135467 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0135435 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0134949 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0132382 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0132295 |
| FAM168B | family with sequence similarity 168, member B | 0.0132009 |
| PTCD3 | pentatricopeptide repeat domain 3 | 0.0131917 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0131394 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.013128 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0130552 |
| KIF18B | kinesin family member 18B | 0.0129306 |
| OSMR | oncostatin M receptor | 0.012837 |
| CDC42SE2 | CDC42 small effector 2 | 0.0127365 |
| SNX9 | sorting nexin 9 | 0.0126867 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0126815 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0126642 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0126044 |
| TGFB2 | transforming growth factor, beta 2 | 0.0125192 |
| ATXN3 | ataxin 3 | 0.0124794 |
| AURKA | aurora kinase A | 0.0124645 |
| IMMT | inner membrane protein, mitochondrial | 0.0124446 |
| ANLN | anillin, actin binding protein | 0.0124365 |
| CEP95 | centrosomal protein 95kDa | 0.0123095 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0122838 |
| KLF6 | Kruppel-like factor 6 | 0.0122381 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0122335 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0122024 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.01205 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.012008 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.199466 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19044 |
| FTL | ferritin, light polypeptide | -0.168434 |
| TMSB10 | thymosin beta 10 | -0.157266 |
| ACTG1 | actin gamma 1 | -0.0926181 |
| IER3 | immediate early response 3 | -0.08638 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0862801 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0840974 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0800634 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0779539 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0693135 |
| RPL19 | ribosomal protein L19 | -0.0682513 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0680669 |
| S100A6 | S100 calcium binding protein A6 | -0.0662397 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0656969 |
| VIM | vimentin | -0.0652067 |
| ASPH | aspartate beta-hydroxylase | -0.0577851 |
| CAVIN1 | caveolae associated protein 1 | -0.0556405 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0541923 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0535155 |
| RPL23 | ribosomal protein L23 | -0.0528857 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0497823 |
| AHNAK | AHNAK nucleoprotein | -0.0491749 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0470284 |
| RPLP1 | ribosomal protein, large, P1 | -0.0446355 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0441998 |
| PTMA | prothymosin, alpha | -0.0423596 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0419773 |
| GNAS | GNAS complex locus | -0.0417342 |
| DENND4A | DENN/MADD domain containing 4A | -0.0408782 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0398488 |
| CANX | calnexin | -0.0394904 |
| UTRN | utrophin | -0.0377192 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0366337 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0365813 |
| PTK2 | protein tyrosine kinase 2 | -0.0360746 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0348704 |
| LDHA | lactate dehydrogenase A | -0.0342483 |
| RPL35A | ribosomal protein L35a | -0.0342023 |
| KYNU | kynureninase | -0.0341541 |
| S100A10 | S100 calcium binding protein A10 | -0.0340003 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0335311 |
| YBX1 | Y box binding protein 1 | -0.0330428 |
| RAB1A | RAB1A, member RAS oncogene family | -0.032414 |
| APP | amyloid beta (A4) precursor protein | -0.0323086 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0311809 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0311073 |
| RPL8 | ribosomal protein L8 | -0.0309414 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0306703 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0305678 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0304119 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0299737 |
| SVIL | supervillin | -0.0298049 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0295267 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0294579 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0293839 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0293162 |
| RPL4 | ribosomal protein L4 | -0.0292232 |
| DST | dystonin | -0.0289066 |
| RPLP0 | ribosomal protein, large, P0 | -0.0287021 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0284718 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0277963 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0276054 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0273039 |
| CUX1 | cut-like homeobox 1 | -0.0268331 |
| UBC | ubiquitin C | -0.0267178 |
| PARD3 | par-3 family cell polarity regulator | -0.0266877 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.026523 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0264198 |
| RPL11 | ribosomal protein L11 | -0.0262408 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0262063 |
| MORF4L2 | mortality factor 4 like 2 | -0.0260911 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0258677 |
| ANXA2 | annexin A2 | -0.0258376 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0257975 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0257965 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.025714 |
| ARF1 | ADP-ribosylation factor 1 | -0.024956 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0243992 |
| JUN | jun proto-oncogene | -0.0241942 |
| RBM39 | RNA binding motif protein 39 | -0.0239489 |
| RHOA | ras homolog family member A | -0.0238318 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0236983 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0234211 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0229107 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.022637 |
| LMNA | lamin A/C | -0.0225428 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0225385 |
| RPL34 | ribosomal protein L34 | -0.0225313 |
| HDAC9 | histone deacetylase 9 | -0.0224355 |
| DOCK5 | dedicator of cytokinesis 5 | -0.022331 |
| UBB | ubiquitin B | -0.0223302 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0223278 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0222201 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0221868 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0221519 |
| CALR | calreticulin | -0.0220911 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0220631 |
| PKM | pyruvate kinase, muscle | -0.0220158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0219073 |
