| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Hydroxyurea perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Hydroxyurea_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.222732 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0722191 |
| RPS6 | ribosomal protein S6 | 0.0658317 |
| TENM1 | teneurin transmembrane protein 1 | 0.0590208 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0589181 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0586437 |
| APP | amyloid beta (A4) precursor protein | 0.0560779 |
| HELZ | helicase with zinc finger | 0.0541932 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0533069 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0531446 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0523287 |
| FAM13A | family with sequence similarity 13, member A | 0.0509663 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0489997 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0486447 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0477564 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0469328 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0436272 |
| NEK7 | NIMA-related kinase 7 | 0.0434734 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0433966 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.042724 |
| PFKP | phosphofructokinase, platelet | 0.0426908 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0423047 |
| NDRG1 | N-myc downstream regulated 1 | 0.0414201 |
| ZNF638 | zinc finger protein 638 | 0.040627 |
| PDE10A | phosphodiesterase 10A | 0.0400556 |
| VCL | vinculin | 0.0399461 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0393643 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0388561 |
| NUP58 | nucleoporin 58 | 0.0386281 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0385267 |
| OGA | O-GlcNAcase | 0.0383259 |
| PGK1 | phosphoglycerate kinase 1 | 0.0378983 |
| TUSC3 | tumor suppressor candidate 3 | 0.0375214 |
| CARD16 | caspase recruitment domain family, member 16 | 0.037443 |
| KRIT1 | KRIT1, ankyrin repeat containing | 0.0373721 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0371319 |
| KIF1B | kinesin family member 1B | 0.0369838 |
| TMEM39A | transmembrane protein 39A | 0.0369751 |
| RBM15 | RNA binding motif protein 15 | 0.0368134 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0365605 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0359687 |
| ITGA6 | integrin, alpha 6 | 0.0354515 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0351196 |
| PAPOLA | poly(A) polymerase alpha | 0.0348854 |
| PHIP | pleckstrin homology domain interacting protein | 0.0348463 |
| IGF2R | insulin-like growth factor 2 receptor | 0.034778 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0337121 |
| H1-0 | H1.0 linker histone | 0.0336138 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0335924 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0335047 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0330611 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0326506 |
| HMGA2 | high mobility group AT-hook 2 | 0.0326332 |
| FLNB | filamin B, beta | 0.0323083 |
| AHI1 | Abelson helper integration site 1 | 0.0322596 |
| IRS2 | insulin receptor substrate 2 | 0.0320729 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0312505 |
| MAP1B | microtubule-associated protein 1B | 0.0310815 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0310774 |
| H3-3B | H3.3 histone B | 0.031028 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0309756 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0307868 |
| DST | dystonin | 0.0307067 |
| RPL5 | ribosomal protein L5 | 0.0306858 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0305537 |
| RUNX1 | runt-related transcription factor 1 | 0.0303162 |
| PCDH7 | protocadherin 7 | 0.0300405 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0298774 |
| TXNIP | thioredoxin interacting protein | 0.0297537 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0295308 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0295032 |
| PER2 | period circadian clock 2 | 0.029457 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0294495 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | 0.0292627 |
| R3HDM1 | R3H domain containing 1 | 0.0291512 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.029065 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0290369 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0289479 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0289403 |
| AGO3 | argonaute RISC catalytic component 3 | 0.028937 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0289032 |
| MYO1D | myosin ID | 0.0284954 |
| XPO1 | exportin 1 | 0.0281709 |
| TAOK1 | TAO kinase 1 | 0.0280624 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0279132 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | 0.0277977 |
| PTK2 | protein tyrosine kinase 2 | 0.0277484 |
| CD47 | CD47 molecule | 0.0276856 |
| RPS27A | ribosomal protein S27a | 0.0276305 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0276168 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0273848 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.02713 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0270602 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0268322 |
| CEP95 | centrosomal protein 95kDa | 0.0266538 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0263316 |
| RLF | rearranged L-myc fusion | 0.0261831 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0261665 |
| CD2AP | CD2-associated protein | 0.0261161 |
| USP15 | ubiquitin specific peptidase 15 | 0.0258112 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.14056 |
| LAMB3 | laminin, beta 3 | -0.111678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.109704 |
| KYNU | kynureninase | -0.106229 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0995314 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0962184 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0936739 |
| TXNRD1 | thioredoxin reductase 1 | -0.093611 |
| KRT17 | keratin 17, type I | -0.0929762 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0918367 |
| PARD3 | par-3 family cell polarity regulator | -0.0803436 |
| LMO7 | LIM domain 7 | -0.0766975 |
| LAMC2 | laminin, gamma 2 | -0.0738261 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0703998 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0695705 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0680556 |
| MYO1E | myosin IE | -0.0660661 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0648405 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.064345 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.064329 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0621559 |
| VIM | vimentin | -0.0619672 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0612744 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0608304 |
| ATOSA | atos homolog A | -0.0604617 |
| EZR | ezrin | -0.0599864 |
| CD44 | CD44 molecule (Indian blood group) | -0.0587904 |
| FMNL2 | formin-like 2 | -0.0587638 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0564699 |
| ENO1 | enolase 1, (alpha) | -0.0556062 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.055298 |
| TJP1 | tight junction protein 1 | -0.05465 |
| QKI | QKI, KH domain containing, RNA binding | -0.0535621 |
| ASPH | aspartate beta-hydroxylase | -0.0531854 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0530876 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0523075 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.051223 |
| AK1 | adenylate kinase 1 | -0.0502741 |
| CUX1 | cut-like homeobox 1 | -0.0498266 |
| MUC16 | mucin 16, cell surface associated | -0.049789 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0497801 |
| MCL1 | myeloid cell leukemia 1 | -0.0494584 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0491356 |
| TMSB10 | thymosin beta 10 | -0.0476498 |
| ACTG1 | actin gamma 1 | -0.0474122 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0471161 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0466656 |
| POTEF | POTE ankyrin domain family, member F | -0.0466352 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0461741 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0451664 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0447361 |
| SMAD3 | SMAD family member 3 | -0.0439534 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0432686 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0430862 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0430185 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0426543 |
| KLHL24 | kelch-like family member 24 | -0.0423552 |
| SBF2 | SET binding factor 2 | -0.0415618 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0408117 |
| TNPO1 | transportin 1 | -0.0405449 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0404527 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0403673 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0399136 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0398272 |
| JUN | jun proto-oncogene | -0.0389845 |
| SVIL | supervillin | -0.0387645 |
| JUP | junction plakoglobin | -0.0383267 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0383082 |
| RAI14 | retinoic acid induced 14 | -0.0378486 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.03732 |
| RRBP1 | ribosome binding protein 1 | -0.0372989 |
| RNF145 | ring finger protein 145 | -0.037101 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0369799 |
| KIF13B | kinesin family member 13B | -0.0368838 |
| MSN | moesin | -0.0367708 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0365181 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0364981 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0360889 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0360684 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0355814 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0355549 |
| ANXA2 | annexin A2 | -0.0354998 |
| OSMR | oncostatin M receptor | -0.0354745 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0352525 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0351682 |
| SETD5 | SET domain containing 5 | -0.0351175 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0350974 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0350631 |
| LSAMP | limbic system-associated membrane protein | -0.0347796 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0343391 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0343081 |
| IGF2 | insulin-like growth factor 2 | -0.0342842 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0342267 |
| MED13 | mediator complex subunit 13 | -0.034038 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0338016 |
| RPL31 | ribosomal protein L31 | -0.0334812 |
| B2M | beta-2-microglobulin | -0.0333665 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0333378 |
| NHSL1 | NHS-like 1 | -0.0331388 |
| DENND4A | DENN/MADD domain containing 4A | -0.0329927 |
